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Search results 501 to 600 out of 672 for Mpo

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Hits by Strain

Type Details Score
Allele
Del(11Mpo-Chad)18Brd | MGI:3766573
Name: deletion, Chr 11, Bradley 18; deletion, Chr 11, Allan Bradley 18
Allele Type: Targeted
Attribute String: Null/knockout
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Strain
MGI:6150821 | C57BL/6J-Tg(MVV-MPO)7027Rcl/J
Attribute String: coisogenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Del(11Mpo-Chad)18Brd/Del(11Mpo-Chad)18Brd
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(11Mpo-Chad)18Brd/+
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dp(11Mpo-Chad)18Brd/Dp(11Mpo-Chad)18Brd
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:4820537 | B6;129S7-Del(11Mpo-Chad)18Brd Dp(11Mpo-Chad)18Brd/Mmucd
Attribute String: deletion, duplication, mutant stock, targeted mutation
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Protein
A7M7R7
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: true
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Protein Domain
IPR019791 | Haem_peroxidase_animal
Type: Family
Description: Peroxidases are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyse a number of oxidative reactions.Peroxidases are found in bacteria, fungi, plants and animals. On the basis of sequence similarity, a number of animal haem peroxidases can be categorised as members of a superfamily: myeloperoxidase (MPO); eosinophil peroxidase (EPO); lactoperoxidase (LPO); thyroid peroxidase (TPO); prostaglandin H synthase (PGHS); and peroxidasin [, , ]. MPO plays a major role in the oxygen-dependent microbicidal system of neutrophils. EPO from eosinophilic granulocytes participates in immunological reactions, and potentiates tumor necrosis factor (TNF) production and hydrogen peroxide release by human monocyte-derived macrophages [, ]. In the main, MPO (and possibly EPO) utilises Cl-ions and H2O2to form hypochlorous acid (HOCl), which can effectively kill bacteria or parasites. In secreted fluids, LPO catalyses the oxidation of thiocyanate ions (SCN-) by H2O2, producing the weak oxidising agent hypothiocyanite (OSCN-), which has bacteriostatic activity []. TPO uses I-ions and H2O2to generate iodine, and plays a central role in the biosynthesis of thyroid hormones T(3) and T(4). To date, the 3D structures of MPO and PGHS have been reported. MPO is a homodimer: each monomer consists of a light (A or B) and a heavy (C or D) chain resulting from post-translational excision of 6 residues from the common precursor. Monomers are linked by a single inter-chain disulphide. Each monomer includes a bound calcium ion []. PGHS exists as a symmetric dimer, each monomer of which consists of 3 domains: an N-terminal epidermal growth factor (EGF) like module; a membrane-binding domain; and a large C-terminal catalytic domain containing the cyclooxygenase and the peroxidase active sites. The catalytic domain shows striking structural similarity to MPO. The cyclooxygenase active site, which catalyses the formation of prostaglandin G2 (PGG2) from arachidonic acid, resides at the apex of a long hydrophobic channel, extending from the membrane-binding domain to the centre of the molecule. The peroxidase active site, which catalyses the reduction of PGG2 to PGH2, is located on the other side of the molecule, at the haem binding site []. Both MPO and the catalytic domain of PGHS are mainly α-helical, 19 helices being identified as topologically and spatially equivalent; PGHS contains 5 additional N-terminal helices that have no equivalent in MPO. In both proteins, three Asn residues in each monomer are glycosylated.
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Protein Domain
IPR037120 | Haem_peroxidase_sf_animal
Type: Homologous_superfamily
Description: Peroxidases are haem-containing enzymes that use hydrogen peroxide as the electron acceptor to catalyse a number of oxidative reactions.Peroxidases are found in bacteria, fungi, plants and animals. On the basis of sequence similarity, a number of animal haem peroxidases can be categorised as members of a superfamily: myeloperoxidase (MPO); eosinophil peroxidase (EPO); lactoperoxidase (LPO); thyroid peroxidase (TPO); prostaglandin H synthase (PGHS); and peroxidasin [, , ]. MPO plays a major role in the oxygen-dependent microbicidal system of neutrophils. EPO from eosinophilic granulocytes participates in immunological reactions, and potentiates tumor necrosis factor (TNF) production and hydrogen peroxide release by human monocyte-derived macrophages [, ]. In the main, MPO (and possibly EPO) utilises Cl-ions and H2O2to form hypochlorous acid (HOCl), which can effectively kill bacteria or parasites. In secreted fluids, LPO catalyses the oxidation of thiocyanate ions (SCN-) by H2O2, producing the weak oxidising agent hypothiocyanite (OSCN-), which has bacteriostatic activity []. TPO uses I-ions and H2O2to generate iodine, and plays a central role in the biosynthesis of thyroid hormones T(3) and T(4). To date, the 3D structures of MPO and PGHS have been reported. MPO is a homodimer: each monomer consists of a light (A or B) and a heavy (C or D) chain resulting from post-translational excision of 6 residues from the common precursor. Monomers are linked by a single inter-chain disulphide. Each monomer includes a bound calcium ion []. PGHS exists as a symmetric dimer, each monomer of which consists of 3 domains: an N-terminal epidermal growth factor (EGF) like module; a membrane-binding domain; and a large C-terminal catalytic domain containing the cyclooxygenase and the peroxidase active sites. The catalytic domain shows striking structural similarity to MPO. The cyclooxygenase active site, which catalyses the formation of prostaglandin G2 (PGG2) from arachidonic acid, resides at the apex of a long hydrophobic channel, extending from the membrane-binding domain to the centre of the molecule. The peroxidase active site, which catalyses the reduction of PGG2 to PGH2, is located on the other side of the molecule, at the haem binding site []. Both MPO and the catalytic domain of PGHS are mainly α-helical, 19 helices being identified as topologically and spatially equivalent; PGHS contains 5 additional N-terminal helices that have no equivalent in MPO. In both proteins, three Asn residues in each monomer are glycosylated.
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Protein
Q91WA0
Organism: Mus musculus/domesticus
Length: 710  
Fragment?: false
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Protein
Q3TR82
Organism: Mus musculus/domesticus
Length: 183  
Fragment?: true
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Protein
Q5SW46
Organism: Mus musculus/domesticus
Length: 710  
Fragment?: false
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Publication
2548579 | -
First Author: Kimura S
Year: 1989
Journal: Biochemistry
Title: Structure of the human thyroid peroxidase gene: comparison and relationship to the human myeloperoxidase gene.
Volume: 28
Issue: 10
Pages: 4481-9
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Publication
6295491 | -
First Author: Wever R
Year: 1982
Journal: Biochim Biophys Acta
Title: The peroxidation of thiocyanate catalysed by myeloperoxidase and lactoperoxidase.
Volume: 709
Issue: 2
Pages: 212-9
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Publication
7774640 | -
First Author: Spessotto P
Year: 1995
Journal: Eur J Immunol
Title: Human eosinophil peroxidase enhances tumor necrosis factor and hydrogen peroxide release by human monocyte-derived macrophages.
Volume: 25
Issue: 5
Pages: 1366-73
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Publication
1320128 | -
First Author: Zeng J
Year: 1992
Journal: J Mol Biol
Title: X-ray crystal structure of canine myeloperoxidase at 3 A resolution.
Volume: 226
Issue: 1
Pages: 185-207
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Publication
8121489 | -
First Author: Picot D
Year: 1994
Journal: Nature
Title: The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1.
Volume: 367
Issue: 6460
Pages: 243-9
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Publication
2840655 | -
First Author: Kimura S
Year: 1988
Journal: Proteins
Title: Human myeloperoxidase and thyroid peroxidase, two enzymes with separate and distinct physiological functions, are evolutionarily related members of the same gene family.
Volume: 3
Issue: 2
Pages: 113-20
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Publication
1663499 | J:11589
First Author: Latos-Bielenska A
Year: 1991
Journal: Hereditas
Title: Refinement of localization of the human genes for myeloperoxidase (MPO), protein kinase C, alpha polypeptide, PRKCA, and the DNA fragment D17S21 on chromosome 17q.
Volume: 115
Issue: 1
Pages: 69-72
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Protein
A0A087WPT2
Organism: Mus musculus/domesticus
Length: 62  
Fragment?: true
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Protein
P49290
Organism: Mus musculus/domesticus
Length: 716  
Fragment?: false
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Protein
P22437
Organism: Mus musculus/domesticus
Length: 602  
Fragment?: false
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Protein
Q05769
Organism: Mus musculus/domesticus
Length: 604  
Fragment?: false
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Protein
Q3UMR6
Organism: Mus musculus/domesticus
Length: 604  
Fragment?: false
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Protein
Q3V1J3
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: false
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Protein
Q7TMV2
Organism: Mus musculus/domesticus
Length: 561  
Fragment?: false
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Protein
Q3TJN9
Organism: Mus musculus/domesticus
Length: 488  
Fragment?: false
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Protein
Q3UZ23
Organism: Mus musculus/domesticus
Length: 602  
Fragment?: false
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Protein
Q543T1
Organism: Mus musculus/domesticus
Length: 602  
Fragment?: false
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HT Experiment
E-GEOD-14525 | Transcription profiling of mouse wild type or nmMLCK-/- animals treated with SB/VILI reveals non muscle myosin light chain kinase isoform is an attractive molecular target in acute inflammatory lung injury
Series Id: GSE14525
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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Protein
P35419
Organism: Mus musculus/domesticus
Length: 914  
Fragment?: false
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Protein
B7ZWM4
Organism: Mus musculus/domesticus
Length: 1545  
Fragment?: false
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Protein
Q8BZ02
Organism: Mus musculus/domesticus
Length: 1058  
Fragment?: true
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Protein
A2AQ92
Organism: Mus musculus/domesticus
Length: 1551  
Fragment?: false
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Protein
A0A494BAW1
Organism: Mus musculus/domesticus
Length: 1545  
Fragment?: false
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Protein
A2AQ99
Organism: Mus musculus/domesticus
Length: 1517  
Fragment?: false
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Publication
8062820 | -
First Author: Nelson RE
Year: 1994
Journal: EMBO J
Title: Peroxidasin: a novel enzyme-matrix protein of Drosophila development.
Volume: 13
Issue: 15
Pages: 3438-47
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Publication
16091555 | J:195110
First Author: Fujino K
Year: 2006
Journal: Gut
Title: Attenuation of acid induced oesophagitis in VR-1 deficient mice.
Volume: 55
Issue: 1
Pages: 34-40
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Publication
36674855 | J:336238
 
First Author: Ford SL
Year: 2023
Journal: Int J Mol Sci
Title: Toll-like Receptor 9 Induced Dendritic Cell Activation Promotes Anti-Myeloperoxidase Autoimmunity and Glomerulonephritis.
Volume: 24
Issue: 2
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Publication
8960105 | J:37625
First Author: Friedman AD
Year: 1996
Journal: Leuk Res
Title: The murine myeloperoxidase gene contains a bipartite distal enhancer, including a novel region regulated by PEBP2/CBF.
Volume: 20
Issue: 10
Pages: 809-15
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Publication
9692891 | J:49317
First Author: Harper JM
Year: 1998
Journal: Eur J Immunol
Title: Myeloperoxidase autoantibodies distinguish vasculitis mediated by anti-neutrophil cytoplasm antibodies from immune complex disease in MRL/Mp-lpr/lpr mice: a spontaneous model for human microscopic angiitis.
Volume: 28
Issue: 7
Pages: 2217-26
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Publication
18363963 | J:141608
First Author: Iida S
Year: 2008
Journal: Genes Cells
Title: Essential role of C/EBPalpha in G-CSF-induced transcriptional activation and chromatin modification of myeloid-specific genes.
Volume: 13
Issue: 4
Pages: 313-27
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Publication
20399194 | J:164271
First Author: Arnhold J
Year: 2010
Journal: Arch Biochem Biophys
Title: Human myeloperoxidase in innate and acquired immunity.
Volume: 500
Issue: 1
Pages: 92-106
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Publication
36403522 | J:331811
First Author: Wang K
Year: 2022
Journal: Int Immunopharmacol
Title: Protective effects of chicoric acid on LPS-induced endometritis in mice via inhibiting ferroptosis by Nrf2/HO-1 signal axis.
Volume: 113
Issue: Pt B
Pages: 109435
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Protein
Q3UQ28
Organism: Mus musculus/domesticus
Length: 1475  
Fragment?: false
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Protein
A0A1W2P6L9
Organism: Mus musculus/domesticus
Length: 1295  
Fragment?: false
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Protein
B2RX13
Organism: Mus musculus/domesticus
Length: 1475  
Fragment?: false
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Protein
Q80U60
Organism: Mus musculus/domesticus
Length: 1431  
Fragment?: true
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Publication
7922023 | -
First Author: Li H
Year: 1994
Journal: Structure
Title: Structural variation in heme enzymes: a comparative analysis of peroxidase and P450 crystal structures.
Volume: 2
Issue: 6
Pages: 461-4
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Publication
17673544 | J:126720
First Author: Ghia JE
Year: 2007
Journal: Am J Physiol Gastrointest Liver Physiol
Title: The protective effect of the vagus nerve in a murine model of chronic relapsing colitis.
Volume: 293
Issue: 4
Pages: G711-8
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Publication
18202111 | J:132596
First Author: Ghia JE
Year: 2008
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Role of M-CSF-dependent macrophages in colitis is driven by the nature of the inflammatory stimulus.
Volume: 294
Issue: 3
Pages: G770-7
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Publication
23569113 | J:199517
First Author: Sugi N
Year: 2013
Journal: Infect Immun
Title: Increased resistance to Staphylococcus aureus endophthalmitis in BALB/c mice: Fas ligand is required for resolution of inflammation but not for bacterial clearance.
Volume: 81
Issue: 6
Pages: 2217-25
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Publication
24464187 | J:206959
First Author: Huang Y
Year: 2014
Journal: Nat Med
Title: An abundant dysfunctional apolipoprotein A1 in human atheroma.
Volume: 20
Issue: 2
Pages: 193-203
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Publication
17028201 | J:117239
First Author: Khan S
Year: 2007
Journal: J Leukoc Biol
Title: The role of CXC chemokine receptor 2 in Pseudomonas aeruginosa corneal infection.
Volume: 81
Issue: 1
Pages: 315-8
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Publication
34248948 | J:323905
 
First Author: Saisorn W
Year: 2021
Journal: Front Immunol
Title: Acute Kidney Injury Induced Lupus Exacerbation Through the Enhanced Neutrophil Extracellular Traps (and Apoptosis) in Fcgr2b Deficient Lupus Mice With Renal Ischemia Reperfusion Injury.
Volume: 12
Pages: 669162
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Publication
23107827 | J:325795
First Author: Soares PM
Year: 2013
Journal: Cytokine
Title: Inflammatory intestinal damage induced by 5-fluorouracil requires IL-4.
Volume: 61
Issue: 1
Pages: 46-9
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Publication
29581235 | J:264020
First Author: Zeng L
Year: 2018
Journal: J Biol Chem
Title: Myeloperoxidase-derived oxidants damage artery wall proteins in an animal model of chronic kidney disease-accelerated atherosclerosis.
Volume: 293
Issue: 19
Pages: 7238-7249
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Publication
18836554 | J:144421
First Author: Chandrasekharan B
Year: 2008
Journal: PLoS One
Title: Targeted deletion of neuropeptide Y (NPY) modulates experimental colitis.
Volume: 3
Issue: 10
Pages: e3304
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Publication
14633605 | J:86598
First Author: Speyer CL
Year: 2003
Journal: Am J Pathol
Title: Regulatory effects of iNOS on acute lung inflammatory responses in mice.
Volume: 163
Issue: 6
Pages: 2319-28
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Publication
17255317 | J:117890
First Author: Krieglstein CF
Year: 2007
Journal: Am J Pathol
Title: Role of blood- and tissue-associated inducible nitric-oxide synthase in colonic inflammation.
Volume: 170
Issue: 2
Pages: 490-6
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Publication
18684972 | J:140173
First Author: Hsieh CH
Year: 2008
Journal: J Immunol
Title: The role of MIP-1 alpha in the development of systemic inflammatory response and organ injury following trauma hemorrhage.
Volume: 181
Issue: 4
Pages: 2806-12
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Publication
10565608 | J:59655
First Author: Mahesh J
Year: 1999
Journal: Shock
Title: Elucidation of the early events contributing to zymosan-induced multiple organ dysfunction syndrome using MIP-1alpha, C3 knockout, and C5-deficient mice.
Volume: 12
Issue: 5
Pages: 340-9
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Publication
16024722 | J:115440
First Author: Lee JS
Year: 2005
Journal: Am J Physiol Lung Cell Mol Physiol
Title: TLR-4 pathway mediates the inflammatory response but not bacterial elimination in E. coli pneumonia.
Volume: 289
Issue: 5
Pages: L731-8
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Publication
16702985 | J:135725
First Author: Rocha AC
Year: 2006
Journal: Br J Pharmacol
Title: Relevance of tumour necrosis factor-alpha for the inflammatory and nociceptive responses evoked by carrageenan in the mouse paw.
Volume: 148
Issue: 5
Pages: 688-95
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Publication
21482685 | J:173497
First Author: O'Connell AE
Year: 2011
Journal: Infect Immun
Title: Major basic protein from eosinophils and myeloperoxidase from neutrophils are required for protective immunity to Strongyloides stercoralis in mice.
Volume: 79
Issue: 7
Pages: 2770-8
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Publication
24221085 | J:210383
First Author: Vigna SR
Year: 2014
Journal: FASEB J
Title: Ethanol contributes to neurogenic pancreatitis by activation of TRPV1.
Volume: 28
Issue: 2
Pages: 891-6
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Publication
28120642 | J:256180
First Author: Jiang D
Year: 2017
Journal: Innate Immun
Title: A novel mouse model of conditional IRAK-M deficiency in myeloid cells: application in lung Pseudomonas aeruginosa infection.
Volume: 23
Issue: 2
Pages: 206-215
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Publication
21070799 | J:168806
First Author: Luyendyk JP
Year: 2011
Journal: Toxicol Appl Pharmacol
Title: Tissue factor contributes to neutrophil CD11b expression in alpha-naphthylisothiocyanate-treated mice.
Volume: 250
Issue: 3
Pages: 256-62
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Publication
23908111 | J:201395
First Author: Huang Y
Year: 2013
Journal: J Clin Invest
Title: Myeloperoxidase, paraoxonase-1, and HDL form a functional ternary complex.
Volume: 123
Issue: 9
Pages: 3815-28
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Publication
24454942 | J:211107
First Author: Yamamoto T
Year: 2014
Journal: PLoS One
Title: Anti-allergic role of cholinergic neuronal pathway via α7 nicotinic ACh receptors on mucosal mast cells in a murine food allergy model.
Volume: 9
Issue: 1
Pages: e85888
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Publication
11027558 | J:114174
First Author: Kawachi S
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Nitric oxide synthase and postischemic liver injury.
Volume: 276
Issue: 3
Pages: 851-4
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Publication
15623759 | J:95809
First Author: Vij N
Year: 2005
Journal: Invest Ophthalmol Vis Sci
Title: Lumican regulates corneal inflammatory responses by modulating Fas-Fas ligand signaling.
Volume: 46
Issue: 1
Pages: 88-95
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Publication
15555924 | J:96762
First Author: Hill RA
Year: 2004
Journal: Mol Cell Neurosci
Title: Estrogen deficiency leads to apoptosis in dopaminergic neurons in the medial preoptic area and arcuate nucleus of male mice.
Volume: 27
Issue: 4
Pages: 466-76
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Publication
16322110 | J:135818
First Author: Fukui T
Year: 2006
Journal: Gut
Title: Gastric mucosal hyperplasia via upregulation of gastrin induced by persistent activation of gastric innate immunity in major histocompatibility complex class II deficient mice.
Volume: 55
Issue: 5
Pages: 607-15
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Publication
15590467 | J:94634
First Author: Thakur A
Year: 2004
Journal: Curr Eye Res
Title: Regulation of Pseudomonas aeruginosa corneal infection in IL-1 beta converting enzyme (ICE, caspase-1) deficient mice.
Volume: 29
Issue: 4-5
Pages: 225-33
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Publication
28623253 | J:323519
First Author: Lee CM
Year: 2017
Journal: Sci Rep
Title: C-C Chemokine Ligand-5 is critical for facilitating macrophage infiltration in the early phase of liver ischemia/reperfusion injury.
Volume: 7
Issue: 1
Pages: 3698
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Publication
21393420 | J:174736
First Author: Khajah M
Year: 2011
Journal: J Leukoc Biol
Title: Granulocyte-macrophage colony-stimulating factor (GM-CSF): a chemoattractive agent for murine leukocytes in vivo.
Volume: 89
Issue: 6
Pages: 945-53
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Publication
16034136 | J:107267
First Author: Werner CG
Year: 2005
Journal: J Immunol
Title: Neutrophil dysfunction in guanosine 3',5'-cyclic monophosphate-dependent protein kinase I-deficient mice.
Volume: 175
Issue: 3
Pages: 1919-29
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Publication
29930006 | J:285116
First Author: Claushuis TAM
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Nbeal2 Deficiency Increases Organ Damage but Does Not Affect Host Defense During Gram-Negative Pneumonia-Derived Sepsis.
Volume: 38
Issue: 8
Pages: 1772-1784
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Publication
28993270 | J:321033
 
First Author: Han D
Year: 2017
Journal: Free Radic Biol Med
Title: Reduced silent information regulator 1 signaling exacerbates sepsis-induced myocardial injury and mitigates the protective effect of a liver X receptor agonist.
Volume: 113
Pages: 291-303
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Publication
20299361 | J:185841
First Author: Gan PY
Year: 2010
Journal: J Am Soc Nephrol
Title: Th17 cells promote autoimmune anti-myeloperoxidase glomerulonephritis.
Volume: 21
Issue: 6
Pages: 925-31
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Publication
11514333 | J:71068
First Author: Lysiak JJ
Year: 2001
Journal: Biol Reprod
Title: Essential role of neutrophils in germ cell-specific apoptosis following ischemia/reperfusion injury of the mouse testis.
Volume: 65
Issue: 3
Pages: 718-25
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Publication
19059911 | J:147212
First Author: Maki RA
Year: 2009
Journal: J Biol Chem
Title: Aberrant expression of myeloperoxidase in astrocytes promotes phospholipid oxidation and memory deficits in a mouse model of Alzheimer disease.
Volume: 284
Issue: 5
Pages: 3158-69
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Publication
21071511 | J:168502
First Author: Banerjee S
Year: 2011
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Balance of meprin A and B in mice affects the progression of experimental inflammatory bowel disease.
Volume: 300
Issue: 2
Pages: G273-82
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Publication
30683539 | J:294924
 
First Author: Wang X
Year: 2019
Journal: Int Immunopharmacol
Title: Peroxiredoxin 6 knockout aggravates cecal ligation and puncture-induced acute lung injury.
Volume: 68
Pages: 252-258
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Publication
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