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Search results 501 to 600 out of 2287 for Mx1

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Type Details Score
Genotype
Genotype
Symbol: Rbm15/Rbm15 Tg(Mx1-cre)1Cgn/?
Background: involves: 129/Sv * C57BL/6 * CBA * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cd79a/Cd79a Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Xbp1/Xbp1 Tg(Mx1-cre)1Cgn/?
Background: involves: 129S6/SvEvTac * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Fth1/Fth1 Tg(Mx1-cre)1Cgn/?
Background: B6.Cg-Fth1 Tg(Mx1-cre)1Cgn
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rb1cc1/Rb1cc1 Tg(Mx1-cre)1Cgn/?
Background: B6.Cg-Rb1cc1 Tg(Mx1-cre)1Cgn
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tet2/Tet2 Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Slc4a2/Slc4a2 Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hdac1/Hdac1 Tg(Mx1-cre)1Cgn/?
Background: involves: C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Msi2/Msi2 Tg(Mx1-cre)1Cgn/?
Background: involves: 129S4/SvJae * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tnfaip3/Tnfaip3 Tg(Mx1-cre)1Cgn/?
Background: involves: 129S6/SvEvTac * C57BL/6J * CBA/J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ifnar1/Ifnar1 Tg(Hmgcr-MX1)LStae/Tg(Hmgcr-MX1)LStae
Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Hmgcr-MX1)LStae/Tg(Hmgcr-MX1)LStae
Background: involves: 129S2/SvPas * BALB/c * C57BL/6 * SJL
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mllt10/Mllt10 Tg(Mx1-cre)1Cgn/?
Background: involves: 129 * C57BL/6J * CBA/J
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Mx1-cre)1Cgn/? Trmt6/Trmt6
Background: involves: C57BL/6 * CBA/J
Zygosity: cn
Has Mutant Allele: true
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Publication
16753150 | -
First Author: Law PY
Year: 2006
Journal: FEBS Lett
Title: Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome-associated coronavirus.
Volume: 580
Issue: 15
Pages: 3643-8
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Publication
16876844 | -
First Author: Keng CT
Year: 2006
Journal: Virology
Title: The human severe acute respiratory syndrome coronavirus (SARS-CoV) 8b protein is distinct from its counterpart in animal SARS-CoV and down-regulates the expression of the envelope protein in infected cells.
Volume: 354
Issue: 1
Pages: 132-42
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Publication
32890763 | -
 
First Author: Pereira F
Year: 2020
Journal: Infect Genet Evol
Title: Evolutionary dynamics of the SARS-CoV-2 ORF8 accessory gene.
Volume: 85
Pages: 104525
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Publication
32015508 | -
First Author: Wu F
Year: 2020
Journal: Nature
Title: A new coronavirus associated with human respiratory disease in China.
Volume: 579
Issue: 7798
Pages: 265-269
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Publication
32825438 | -
 
First Author: Mohammad S
Year: 2020
Journal: Pathogens
Title: SARS-CoV-2 ORF8 and SARS-CoV ORF8ab: Genomic Divergence and Functional Convergence.
Volume: 9
Issue: 9
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Publication
31986261 | -
First Author: Chan JF
Year: 2020
Journal: Lancet
Title: A familial cluster of pneumonia associated with the 2019 novel coronavirus indicating person-to-person transmission: a study of a family cluster.
Volume: 395
Issue: 10223
Pages: 514-523
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Publication
34021074 | -
 
First Author: Zhang Y
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι.
Volume: 118
Issue: 23
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Publication
34177923 | -
 
First Author: Geng H
Year: 2021
Journal: Front Immunol
Title: SARS-CoV-2 ORF8 Forms Intracellular Aggregates and Inhibits IFNγ-Induced Antiviral Gene Expression in Human Lung Epithelial Cells.
Volume: 12
Pages: 679482
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Protein Domain
IPR022722 | ORF8_betacoronavirus
Type: Family
Description: This entry includes the ORF8 gene products (also known as NS8, accessory protein 8) from human SARS coronavirus (SARS-CoV), SARS-CoV-2, Bat coronavirus HKU3 and pangolin coronaviruses [].ORF8 is an accessory protein that is not shared by all members of subgenus sarbecovirus. The presence and location of ORF8 in the SARS-CoV-2 genome has led its classification with SARS-CoV [, ]. ORF8 is a potential pathogenicity factor which evolves rapidly to counter the immune response and facilitate the transmission between hosts []. ORF8 has been suggested to be one of the relevant genes in the study of human adaptation of the virus [, ].The ORF8 protein is a fast-evolving protein in SARS-related CoVs, with a tendency to recombine and undergo deletions. During the early phases of the SARS (SARS-CoV) epidemic in 2002, human isolates were found to possess a unique continuous ORF8 with 366 nucleotides and a predicted protein with 122 amino acids. During the middle and late phases of the SARS epidemic, two functional ORFs (ORF8a and ORF8b) were emerged; they are predicted to encode two small proteins, 8a with 39 amino acids and 8b with 84 amino acids. Interestingly, SARS-CoV-2 ORF8 has not undergone any significantly measurable deletion events, so its function as a full-length protein might be more important to its pathogenicity []. ORF8 plays a role in modulating host immune response []which may act by down-regulating major histocompatibility complex class I (MHC-I) []. It may inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 []. ORF8 also binds to IL17RA receptor, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors, contributing to cytokine storm during COVID-19 infection [].
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Protein Domain
IPR044391 | ORF8_SARS-CoV-2-like
Type: Family
Description: This entry represents the ORF8 immunoglobulin (Ig) domain protein of Severe acute respiratory syndrome (SARS) coronavirus 2 (SARS-CoV-2, also known as a 2019 novel coronavirus, 2019-nCoV) and related Sarbecovirus ORF8 proteins.ORF8 is an accessory protein that is not shared by all members of subgenus sarbecovirus. The presence and location of ORF8 in the SARS-CoV-2 genome has led its classification with SARS-CoV [, ]. ORF8 is a potential pathogenicity factor which evolves rapidly to counter the immune response and facilitate the transmission between hosts []. ORF8 has been suggested to be one of the relevant genes in the study of human adaptation of the virus [, ].The ORF8 protein is a fast-evolving protein in SARS-related CoVs, with a tendency to recombine and undergo deletions. During the early phases of the SARS (SARS-CoV) epidemic in 2002, human isolates were found to possess a unique continuous ORF8 with 366 nucleotides and a predicted protein with 122 amino acids. During the middle and late phases of the SARS epidemic, two functional ORFs (ORF8a and ORF8b) were emerged; they are predicted to encode two small proteins, 8a with 39 amino acids and 8b with 84 amino acids. Interestingly, SARS-CoV-2 ORF8 has not undergone any significantly measurable deletion events, so its function as a full-length protein might be more important to its pathogenicity []. ORF8 plays a role in modulating host immune response []which may act by down-regulating major histocompatibility complex class I (MHC-I) []. It may inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 []. ORF8 also binds to IL17RA receptor, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors, contributing to cytokine storm during COVID-19 infection [].
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Protein Domain
IPR044392 | ORF8_Bat_SARS_CoV_Rf1-like
Type: Family
Description: This subfamily includes the ORF8 immunoglobulin (Ig) domain proteins of bat coronavirus Rf1 (Bat SARS CoV Rf1) and Bat CoV 273/2005, which have been classified previously as type II ORF8 proteins.ORF8 is an accessory protein that is not shared by all members of subgenus sarbecovirus. The presence and location of ORF8 in the SARS-CoV-2 genome has led its classification with SARS-CoV [, ]. ORF8 is a potential pathogenicity factor which evolves rapidly to counter the immune response and facilitate the transmission between hosts []. ORF8 has been suggested to be one of the relevant genes in the study of human adaptation of the virus [, ].The ORF8 protein is a fast-evolving protein in SARS-related CoVs, with a tendency to recombine and undergo deletions. During the early phases of the SARS (SARS-CoV) epidemic in 2002, human isolates were found to possess a unique continuous ORF8 with 366 nucleotides and a predicted protein with 122 amino acids. During the middle and late phases of the SARS epidemic, two functional ORFs (ORF8a and ORF8b) were emerged; they are predicted to encode two small proteins, 8a with 39 amino acids and 8b with 84 amino acids. Interestingly, SARS-CoV-2 ORF8 has not undergone any significantly measurable deletion events, so its function as a full-length protein might be more important to its pathogenicity []. ORF8 plays a role in modulating host immune response []which may act by down-regulating major histocompatibility complex class I (MHC-I) []. It may inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 []. ORF8 also binds to IL17RA receptor, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors, contributing to cytokine storm during COVID-19 infection [].
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Protein Domain
IPR044393 | ORF8_bat_SARS-CoV_HKU3-1-like
Type: Family
Description: This entry includes the ORF8 immunoglobulin (Ig) domain proteins of Bat SARS coronavirus HKU3-1, which have been classified previously as type III ORF8's.ORF8 is an accessory protein that is not shared by all members of subgenus sarbecovirus. The presence and location of ORF8 in the SARS-CoV-2 genome has led its classification with SARS-CoV [, ]. ORF8 is a potential pathogenicity factor which evolves rapidly to counter the immune response and facilitate the transmission between hosts []. ORF8 has been suggested to be one of the relevant genes in the study of human adaptation of the virus [, ].The ORF8 protein is a fast-evolving protein in SARS-related CoVs, with a tendency to recombine and undergo deletions. During the early phases of the SARS (SARS-CoV) epidemic in 2002, human isolates were found to possess a unique continuous ORF8 with 366 nucleotides and a predicted protein with 122 amino acids. During the middle and late phases of the SARS epidemic, two functional ORFs (ORF8a and ORF8b) were emerged; they are predicted to encode two small proteins, 8a with 39 amino acids and 8b with 84 amino acids. Interestingly, SARS-CoV-2 ORF8 has not undergone any significantly measurable deletion events, so its function as a full-length protein might be more important to its pathogenicity []. ORF8 plays a role in modulating host immune response []which may act by down-regulating major histocompatibility complex class I (MHC-I) []. It may inhibit expression of some members of the IFN-stimulated gene (ISG) family including hosts IGF2BP1/ZBP1, MX1 and MX2, and DHX58 []. ORF8 also binds to IL17RA receptor, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors, contributing to cytokine storm during COVID-19 infection [].
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Publication
21518880 | J:172800
First Author: Pott J
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: IFN-lambda determines the intestinal epithelial antiviral host defense.
Volume: 108
Issue: 19
Pages: 7944-9
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Publication
29879406 | J:263189
 
First Author: Simons KH
Year: 2018
Journal: J Mol Cell Cardiol
Title: The protective role of Toll-like receptor 3 and type-I interferons in the pathophysiology of vein graft disease.
Volume: 121
Pages: 16-24
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Publication
15383179 | J:97145
First Author: Phaneuf D
Year: 2004
Journal: DNA Cell Biol
Title: Generation of a mouse expressing a conditional knockout of the hepatocyte growth factor gene: demonstration of impaired liver regeneration.
Volume: 23
Issue: 9
Pages: 592-603
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Publication
12529277 | J:83044
First Author: Schneider A
Year: 2003
Journal: Am J Physiol Renal Physiol
Title: Differential, inducible gene targeting in renal epithelia, vascular endothelium, and viscera of Mx1Cre mice.
Volume: 284
Issue: 2
Pages: F411-7
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Publication
24353186 | J:209067
First Author: Quah HS
Year: 2014
Journal: Diabetes
Title: Deficiency in type I interferon signaling prevents the early interferon-induced gene signature in pancreatic islets but not type 1 diabetes in NOD mice.
Volume: 63
Issue: 3
Pages: 1032-40
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Publication
33857803 | J:311079
 
First Author: Xia X
Year: 2021
Journal: Int Immunopharmacol
Title: SRC-3 deficiency protects host from Listeria monocytogenes infection through increasing ROS production and decreasing lymphocyte apoptosis.
Volume: 96
Pages: 107625
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Publication
11717426 | J:72930
First Author: Yang J
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Decreased lipid synthesis in livers of mice with disrupted Site-1 protease gene.
Volume: 98
Issue: 24
Pages: 13607-12
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Publication
33304351 | J:335604
 
First Author: Neupane B
Year: 2020
Journal: Front Immunol
Title: Interleukin-17A Facilitates Chikungunya Virus Infection by Inhibiting IFN-α2 Expression.
Volume: 11
Pages: 588382
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Publication
11044479 | J:86822
First Author: Sago H
Year: 2000
Journal: Pediatr Res
Title: Genetic dissection of region associated with behavioral abnormalities in mouse models for Down syndrome.
Volume: 48
Issue: 5
Pages: 606-13
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Publication
38648490 | J:349979
First Author: Mao T
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: Intranasal neomycin evokes broad-spectrum antiviral immunity in the upper respiratory tract.
Volume: 121
Issue: 18
Pages: e2319566121
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Publication
1578186 | J:38294
First Author: Müller M
Year: 1992
Journal: J Interferon Res
Title: Molecular cloning of porcine Mx cDNAs: new members of a family of interferon-inducible proteins with homology to GTP-binding proteins.
Volume: 12
Issue: 2
Pages: 119-29
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Publication
22262694 | J:185760
First Author: Wang T
Year: 2012
Journal: Biol Reprod
Title: Toll-like receptor 3-initiated antiviral responses in mouse male germ cells in vitro.
Volume: 86
Issue: 4
Pages: 106
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Publication
26588248 | J:244510
First Author: Duque-Afonso J
Year: 2015
Journal: PLoS One
Title: Conditional Expression of E2A-HLF Induces B-Cell Precursor Death and Myeloproliferative-Like Disease in Knock-In Mice.
Volume: 10
Issue: 11
Pages: e0143216
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Publication
32727902 | J:293808
First Author: He Y
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Lsh/HELLS is required for B lymphocyte development and immunoglobulin class switch recombination.
Volume: 117
Issue: 33
Pages: 20100-20108
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Publication
33077519 | J:300894
First Author: Sehgal PB
Year: 2020
Journal: J Biol Chem
Title: Murine GFP-Mx1 forms nuclear condensates and associates with cytoplasmic intermediate filaments: Novel antiviral activity against VSV.
Volume: 295
Issue: 52
Pages: 18023-18035
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Publication
33932778 | J:305609
 
First Author: Matsumoto T
Year: 2021
Journal: Biochem Biophys Res Commun
Title: Synoviolin is not a pathogenic factor for auto-inflammatory diseases.
Volume: 558
Pages: 183-188
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Publication
38367513 | J:345631
 
First Author: Wang Y
Year: 2024
Journal: Biochem Biophys Res Commun
Title: Tgfb1 deficiency impairs the self-renewal capacity of murine hematopoietic stem/progenitor cells in vivo.
Volume: 703
Pages: 149686
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Publication
17192398 | J:136594
First Author: Pondarre C
Year: 2007
Journal: Blood
Title: Abcb7, the gene responsible for X-linked sideroblastic anemia with ataxia, is essential for hematopoiesis.
Volume: 109
Issue: 8
Pages: 3567-9
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Publication
26816381 | J:245247
First Author: Masuda T
Year: 2016
Journal: Science
Title: Transcription factors LRF and BCL11A independently repress expression of fetal hemoglobin.
Volume: 351
Issue: 6270
Pages: 285-9
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Publication
23974957 | J:208223
First Author: Frelin C
Year: 2013
Journal: Nat Immunol
Title: GATA-3 regulates the self-renewal of long-term hematopoietic stem cells.
Volume: 14
Issue: 10
Pages: 1037-44
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Publication
25416277 | J:221203
First Author: Mayle A
Year: 2015
Journal: Blood
Title: Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation.
Volume: 125
Issue: 4
Pages: 629-38
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Publication
15998795 | J:100628
First Author: Kato Y
Year: 2005
Journal: J Exp Med
Title: Selective activation of STAT5 unveils its role in stem cell self-renewal in normal and leukemic hematopoiesis.
Volume: 202
Issue: 1
Pages: 169-79
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Publication
16288283 | J:104133
First Author: Kortylewski M
Year: 2005
Journal: Nat Med
Title: Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity.
Volume: 11
Issue: 12
Pages: 1314-21
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Publication
18776941 | J:141140
First Author: Kujawski M
Year: 2008
Journal: J Clin Invest
Title: Stat3 mediates myeloid cell-dependent tumor angiogenesis in mice.
Volume: 118
Issue: 10
Pages: 3367-77
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Publication
19258507 | J:146884
First Author: Kortylewski M
Year: 2009
Journal: Cancer Res
Title: Toll-like receptor 9 activation of signal transducer and activator of transcription 3 constrains its agonist-based immunotherapy.
Volume: 69
Issue: 6
Pages: 2497-505
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Publication
19345327 | J:147435
First Author: Lee H
Year: 2009
Journal: Cancer Cell
Title: Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors.
Volume: 15
Issue: 4
Pages: 283-93
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Publication
23548897 | J:198587
First Author: Xin H
Year: 2013
Journal: J Biol Chem
Title: G-protein-coupled receptor agonist BV8/prokineticin-2 and STAT3 protein form a feed-forward loop in both normal and malignant myeloid cells.
Volume: 288
Issue: 19
Pages: 13842-9
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Publication
28068330 | J:243149
First Author: Tsuruta-Kishino T
Year: 2017
Journal: Oncogene
Title: Loss of p53 induces leukemic transformation in a murine model of Jak2 V617F-driven polycythemia vera.
Volume: 36
Issue: 23
Pages: 3300-3311
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Publication
18682243 | J:149793
First Author: Larsson J
Year: 2008
Journal: Cell Stem Cell
Title: Nf2/merlin regulates hematopoietic stem cell behavior by altering microenvironmental architecture.
Volume: 3
Issue: 2
Pages: 221-7
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Publication
10021335 | J:52793
First Author: Gerber HP
Year: 1999
Journal: Development
Title: VEGF is required for growth and survival in neonatal mice.
Volume: 126
Issue: 6
Pages: 1149-59
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Publication
12087404 | J:77388
First Author: Gerber HP
Year: 2002
Journal: Nature
Title: VEGF regulates haematopoietic stem cell survival by an internal autocrine loop mechanism.
Volume: 417
Issue: 6892
Pages: 954-8
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Publication
15208295 | J:134576
First Author: Tang K
Year: 2004
Journal: J Appl Physiol (1985)
Title: Lung-targeted VEGF inactivation leads to an emphysema phenotype in mice.
Volume: 97
Issue: 4
Pages: 1559-66; discussion 1549
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Publication
18714032 | J:138939
First Author: Sander LE
Year: 2008
Journal: J Immunol
Title: Gp130 signaling promotes development of acute experimental colitis by facilitating early neutrophil/macrophage recruitment and activation.
Volume: 181
Issue: 5
Pages: 3586-94
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Publication
16250046 | J:191185
First Author: Wuestefeld T
Year: 2005
Journal: Hepatology
Title: Lack of gp130 expression results in more bacterial infection and higher mortality during chronic cholestasis in mice.
Volume: 42
Issue: 5
Pages: 1082-90
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Publication
22745821 | J:187931
First Author: Kroy DC
Year: 2012
Journal: PLoS One
Title: Differential role of gp130-dependent STAT and Ras signalling for haematopoiesis following bone-marrow transplantation.
Volume: 7
Issue: 6
Pages: e39728
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Publication
17666524 | J:128622
First Author: Li J
Year: 2007
Journal: Physiol Genomics
Title: Effect of deficiency in SREBP cleavage-activating protein on lipid metabolism during intermittent hypoxia.
Volume: 31
Issue: 2
Pages: 273-80
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Publication
10359843 | J:55718
First Author: Sjögren K
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Liver-derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice.
Volume: 96
Issue: 12
Pages: 7088-92
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Publication
18827067 | J:142809
First Author: Svensson J
Year: 2008
Journal: J Endocrinol
Title: Liver-derived IGF1 enhances the androgenic response in prostate.
Volume: 199
Issue: 3
Pages: 489-97
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Publication
27221117 | J:237390
First Author: Svensson J
Year: 2016
Journal: Am J Physiol Endocrinol Metab
Title: Liver-derived IGF-I regulates cortical bone mass but is dispensable for the osteogenic response to mechanical loading in female mice.
Volume: 311
Issue: 1
Pages: E138-44
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Publication
16731792 | J:109081
First Author: Svensson J
Year: 2006
Journal: J Endocrinol
Title: Endocrine, liver-derived IGF-I is of importance for spatial learning and memory in old mice.
Volume: 189
Issue: 3
Pages: 617-27
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Publication
21799924 | J:175763
First Author: Svensson J
Year: 2011
Journal: PLoS One
Title: Liver-derived IGF-I regulates mean life span in mice.
Volume: 6
Issue: 7
Pages: e22640
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Publication
16257281 | J:123447
First Author: Lindberg MK
Year: 2006
Journal: Bone
Title: Liver-derived IGF-I is permissive for ovariectomy-induced trabecular bone loss.
Volume: 38
Issue: 1
Pages: 85-92
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Publication
17535874 | J:121798
First Author: Svensson J
Year: 2007
Journal: J Endocrinol
Title: Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression.
Volume: 193
Issue: 3
Pages: 359-66
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Publication
25252870 | J:220215
First Author: Steger J
Year: 2015
Journal: Leukemia
Title: Insulin-like growth factor 1 is a direct HOXA9 target important for hematopoietic transformation.
Volume: 29
Issue: 4
Pages: 901-8
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Publication
31638855 | J:282938
First Author: Törnqvist AE
Year: 2019
Journal: Am J Physiol Endocrinol Metab
Title: Liver-derived IGF-I is not required for protection against osteoarthritis in male mice.
Volume: 317
Issue: 6
Pages: E1150-E1157
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•
•
•
Publication
11606442 | J:72793
First Author: Wallenius K
Year: 2001
Journal: Endocrinology
Title: Liver-derived IGF-I regulates GH secretion at the pituitary level in mice.
Volume: 142
Issue: 11
Pages: 4762-70
•
•
•
•
•
Publication
12399417 | J:80468
First Author: Tivesten A
Year: 2002
Journal: Endocrinology
Title: Liver-derived insulin-like growth factor-I is involved in the regulation of blood pressure in mice.
Volume: 143
Issue: 11
Pages: 4235-42
•
•
•
•
•
Publication
12412805 | J:111425
First Author: Sjögren K
Year: 2002
Journal: J Bone Miner Res
Title: Effects of liver-derived insulin-like growth factor I on bone metabolism in mice.
Volume: 17
Issue: 11
Pages: 1977-87
•
•
•
•
•
Publication
29534073 | J:261259
First Author: Botusan IR
Year: 2018
Journal: PLoS One
Title: Deficiency of liver-derived insulin-like growth factor-I (IGF-I) does not interfere with the skin wound healing rate.
Volume: 13
Issue: 3
Pages: e0193084
•
•
•
•
•
Publication
17582142 | J:125237
First Author: Anwar K
Year: 2007
Journal: J Lipid Res
Title: Mechanisms involved in vitamin E transport by primary enterocytes and in vivo absorption.
Volume: 48
Issue: 9
Pages: 2028-38
•
•
•
•
•
Publication
16710047 | J:112587
First Author: Minehira-Castelli K
Year: 2006
Journal: J Lipid Res
Title: Absence of VLDL secretion does not affect alpha-tocopherol content in peripheral tissues.
Volume: 47
Issue: 8
Pages: 1733-8
•
•
•
•
•
Publication
12588952 | J:83459
First Author: Liao W
Year: 2003
Journal: J Lipid Res
Title: Blocking microsomal triglyceride transfer protein interferes with apoB secretion without causing retention or stress in the ER.
Volume: 44
Issue: 5
Pages: 978-85
•
•
•
•
•
Publication
20864669 | J:183146
First Author: Miller JD
Year: 2010
Journal: Arterioscler Thromb Vasc Biol
Title: Evidence for active regulation of pro-osteogenic signaling in advanced aortic valve disease.
Volume: 30
Issue: 12
Pages: 2482-6
•
•
•
•
•
Strain
MGI:5294547 | B6.Cg-Cdkn1c<tm2.1Kei> Tg(Mx1-cre)1Cgn
Attribute String: congenic, mutant strain, targeted mutation, transgenic
•
•
•
•
•
Publication
16131565 | J:124057
First Author: Levéen P
Year: 2005
Journal: Blood
Title: TGF-beta type II receptor-deficient thymocytes develop normally but demonstrate increased CD8+ proliferation in vivo.
Volume: 106
Issue: 13
Pages: 4234-40
•
•
•
•
•
Publication
23103841 | J:193632
First Author: Nabinger SC
Year: 2013
Journal: Leukemia
Title: The protein tyrosine phosphatase, Shp2, positively contributes to FLT3-ITD-induced hematopoietic progenitor hyperproliferation and malignant disease in vivo.
Volume: 27
Issue: 2
Pages: 398-408
•
•
•
•
•
Publication
16247465 | J:105709
First Author: Putz G
Year: 2006
Journal: Oncogene
Title: AML1 deletion in adult mice causes splenomegaly and lymphomas.
Volume: 25
Issue: 6
Pages: 929-39
•
•
•
•
•
Publication
15050604 | J:146716
First Author: Alonzi T
Year: 2004
Journal: Cytokine
Title: Induced somatic inactivation of STAT3 in mice triggers the development of a fulminant form of enterocolitis.
Volume: 26
Issue: 2
Pages: 45-56
•
•
•
•
•
Publication
20501839 | J:160918
First Author: Wang YC
Year: 2010
Journal: Cancer Res
Title: Notch signaling determines the M1 versus M2 polarization of macrophages in antitumor immune responses.
Volume: 70
Issue: 12
Pages: 4840-9
•
•
•
•
•
Publication
12039915 | J:99747
First Author: Han H
Year: 2002
Journal: Int Immunol
Title: Inducible gene knockout of transcription factor recombination signal binding protein-J reveals its essential role in T versus B lineage decision.
Volume: 14
Issue: 6
Pages: 637-45
•
•
•
•
•
Publication
25201756 | J:230196
First Author: Hua C
Year: 2014
Journal: Exp Hematol
Title: Rictor/mammalian target of rapamycin 2 regulates the development of Notch1 induced murine T-cell acute lymphoblastic leukemia via forkhead box O3.
Volume: 42
Issue: 12
Pages: 1031-40.e1-4
•
•
•
•
•
Publication
25586960 | J:224027
First Author: Zeng Y
Year: 2015
Journal: Stem Cells
Title: Pak2 regulates hematopoietic progenitor cell proliferation, survival, and differentiation.
Volume: 33
Issue: 5
Pages: 1630-41
•
•
•
•
•
Publication
28111468 | J:241885
First Author: Jobe F
Year: 2017
Journal: Leukemia
Title: Deletion of Ptpn1 induces myeloproliferative neoplasm.
Volume: 31
Issue: 5
Pages: 1229-1234
•
•
•
•
•
Publication
16166091 | J:103822
First Author: Yang J
Year: 2005
Journal: J Biol Chem
Title: Metabolic response of mice to a postnatal ablation of CCAAT/enhancer-binding protein alpha.
Volume: 280
Issue: 46
Pages: 38689-99
•
•
•
•
•
Publication
12540851 | J:83215
First Author: Mikkola HK
Year: 2003
Journal: Nature
Title: Haematopoietic stem cells retain long-term repopulating activity and multipotency in the absence of stem-cell leukaemia SCL/tal-1 gene.
Volume: 421
Issue: 6922
Pages: 547-51
•
•
•
•
•
Publication
21474105 | J:171356
First Author: Kusy S
Year: 2011
Journal: Cell Stem Cell
Title: Adult hematopoiesis is regulated by TIF1γ, a repressor of TAL1 and PU.1 transcriptional activity.
Volume: 8
Issue: 4
Pages: 412-25
•
•
•
•
•
Publication
30297393 | J:266509
First Author: Das P
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Histone methylation regulator PTIP is required to maintain normal and leukemic bone marrow niches.
Volume: 115
Issue: 43
Pages: E10137-E10146
•
•
•
•
•
Publication
16432184 | J:105994
First Author: Metcalf D
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Inactivation of PU.1 in adult mice leads to the development of myeloid leukemia.
Volume: 103
Issue: 5
Pages: 1486-91
•
•
•
•
•
Publication
11157055 | J:93687
First Author: Jesenberger V
Year: 2001
Journal: J Exp Med
Title: Protective role of Raf-1 in Salmonella-induced macrophage apoptosis.
Volume: 193
Issue: 3
Pages: 353-64
•
•
•
•
•
Publication
31853216 | J:309150
First Author: Zhu L
Year: 2019
Journal: Int J Biol Sci
Title: Protein arginine methyltransferase 1 is required for maintenance of normal adult hematopoiesis.
Volume: 15
Issue: 13
Pages: 2763-2773
•
•
•
•
•
Publication
22072554 | J:181647
First Author: Bungartz G
Year: 2012
Journal: Blood
Title: NF-Y is necessary for hematopoietic stem cell proliferation and survival.
Volume: 119
Issue: 6
Pages: 1380-9
•
•
•
•
•
Publication
32024826 | J:286382
First Author: Zhao Y
Year: 2020
Journal: Nat Commun
Title: Liver governs adipose remodelling via extracellular vesicles in response to lipid overload.
Volume: 11
Issue: 1
Pages: 719
•
•
•
•
•
Publication
28202522 | J:242085
First Author: Valerio DG
Year: 2017
Journal: Cancer Res
Title: Histone Acetyltransferase Activity of MOF Is Required for MLL-AF9 Leukemogenesis.
Volume: 77
Issue: 7
Pages: 1753-1762
•
•
•
•
•
Publication
25670854 | J:278427
First Author: Nakajima T
Year: 2015
Journal: J Biol Chem
Title: Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of THR176 in GATA-binding protein 2.
Volume: 290
Issue: 16
Pages: 10368-81
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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