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Search results 501 to 569 out of 569 for Myo5a

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Hits by Pathway

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Hits by Strain

Type Details Score
Strain
MGI:3808914 | D2;B6-Rgsc779/Rbrc
Attribute String: mutant stock, chemically induced mutation
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Strain
MGI:3808988 | D2;B6-Rgsc780/Rbrc
Attribute String: chemically induced mutation, mutant stock
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Genotype
Genotype
Symbol: Rgsc779/?
Background: involves: C57BL/6JJcl * DBA/2JJcl
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Rgsc780/?
Background: involves: C57BL/6JJcl * DBA/2JJcl
Zygosity: ot
Has Mutant Allele: true
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Strain
MGI:2160119 | C57BL/6J-Myo5a<d-l20J>
Attribute String: mutant strain
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Allele
Myo5a<flr> | MGI:1858520
 
Name: myosin VA; flailer
Allele Type: Spontaneous
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Allele
Gnb5<flr> | MGI:1858521
 
Name: guanine nucleotide binding protein (G protein), beta 5; flailer
Allele Type: Spontaneous
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Strain
MGI:3799148 | D2;B6-Myo5a<rgsc229>/Rbrc
Attribute String: chemically induced mutation, mutant stock
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: C57BL/6J * DBA/2J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: C57BL/6JJcl * DBA/2JJcl
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: d-100H/d-100H
Background: involves: C3H/HeH
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: d-58H/d-58H
Background: involves: 101/H * C3H/HeH
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: 101/H * C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: 101/H * C3H/HeH
Zygosity: hm
Has Mutant Allele: true
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Publication
28357189 | -
First Author: Minocha P
Year: 2017
Journal: Intractable Rare Dis Res
Title: Griscelli syndrome subtype 2 with hemophagocytic lympho-histiocytosis: A case report and review of literature.
Volume: 6
Issue: 1
Pages: 76-79
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Protein Domain
IPR037988 | Myo5a_CBD
Type: Domain
Description: Class V myosins are well studied unconventional myosins, represented by three paralogs (Myo5a,b,c) in vertebrates. Their C-terminal cargo binding domains (CBDs) are important for the binding of a diverse set of cargos, including membrane vesicles, organelles, proteins and mRNA. They interact with several adaptor proteins, in case of Myo5a-CBD, melanophilin (MLPH), Rab interacting lysosomal protein-like 2 (RILPL2), and granuphilin []. Mutations in human Myo5a (many of which map to the cargo binding domain) lead to Griscelli syndrome, a severe neurological disease [].
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Strain
MGI:3664465 | DLB/Oda
Attribute String: spontaneous mutation, mutant stock
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Strain
MGI:2162640 | DLS/LeJ
Attribute String: inbred strain, spontaneous mutation
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Allele
Rgsc80 | MGI:3798687
 
Name: RIKEN Genomic Sciences Center, 80
Allele Type: Chemically induced (ENU)
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: 101/H * C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: 101/H * C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: 101/H * C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: 101/H * C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: 101/H * C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: 101/H * C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: 101/H * C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: 101/H * C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: 101/H * C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: 101/H
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: 101/H * C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/? d-100H/?
Background: involves: C3H/HeH * C57BL/Gr
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: 101/H * C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: 101/H * C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Strain
MGI:3798692 | D2;B6-Rgsc80/Rbrc
Attribute String: chemically induced mutation, mutant stock
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Genotype
Genotype
Symbol: Rgsc80/Rgsc80
Background: involves: C57BL/6JJcl * DBA/2JJcl
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: d-100H/d-100H<+> Myo5a/Myo5a<+>
Background: involves: C3H/HeH
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: d-58H/d-58H<+> Myo5a/Myo5a<+>
Background: involves: 101/H * C3H/HeH
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Myo5a/Myo5a
Background: involves: 101/H * C3H/HeH
Zygosity: ht
Has Mutant Allele: true
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Publication
29509981 | J:326866
First Author: Liakath-Ali K
Year: 2019
Journal: Exp Dermatol
Title: Myosin 10 is involved in murine pigmentation.
Volume: 28
Issue: 4
Pages: 391-394
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Strain
MGI:2162888 | B6 x B6CBCa A<w-J>/A-Myo5a<flr> Gnb5<flr>/J
Attribute String: mutant stock
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Strain
MGI:5652641 | STOCK Gnb5<flr> or STOCK Myo5a<flr>
Attribute String: mutant stock
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Genotype
Genotype
Symbol: Mreg/Mreg Myo5a/Myo5a
Background: involves: C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gnb5/Gnb5 Myo5a/Myo5a
Background: involves: C57BL/6J * C57BL/10J * CBA/Ca
Zygosity: cx
Has Mutant Allele: true
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Publication
26286357 | J:317665
First Author: Hegan PS
Year: 2015
Journal: Cytoskeleton (Hoboken)
Title: Restoration of cytoskeletal and membrane tethering defects but not defects in membrane trafficking in the intestinal brush border of mice lacking both myosin Ia and myosin VI.
Volume: 72
Issue: 9
Pages: 455-76
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Publication
19741097 | J:164477
First Author: Jacobs DT
Year: 2009
Journal: Mol Biol Cell
Title: Myosin Vc is a molecular motor that functions in secretory granule trafficking.
Volume: 20
Issue: 21
Pages: 4471-88
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Publication
24126843 | J:206063
First Author: Lewis CJ
Year: 2014
Journal: J Invest Dermatol
Title: Bone morphogenetic protein signaling suppresses wound-induced skin repair by inhibiting keratinocyte proliferation and migration.
Volume: 134
Issue: 3
Pages: 827-837
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Protein
F6TDE5
Organism: Mus musculus/domesticus
Length: 585  
Fragment?: true
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Publication
14508494 | -
First Author: Coureux PD
Year: 2003
Journal: Nature
Title: A structural state of the myosin V motor without bound nucleotide.
Volume: 425
Issue: 6956
Pages: 419-23
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Publication
11112691 | -
First Author: Win TZ
Year: 2001
Journal: J Cell Sci
Title: Two type V myosins with non-overlapping functions in the fission yeast Schizosaccharomyces pombe: Myo52 is concerned with growth polarity and cytokinesis, Myo51 is a component of the cytokinetic actin ring.
Volume: 114
Issue: Pt 1
Pages: 69-79
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Publication
9288973 | -
First Author: Takizawa PA
Year: 1997
Journal: Nature
Title: Actin-dependent localization of an RNA encoding a cell-fate determinant in yeast.
Volume: 389
Issue: 6646
Pages: 90-3
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Publication
11212351 | -
First Author: Provance DW
Year: 1999
Journal: Cell Mol Life Sci
Title: Myosin-V: head to tail.
Volume: 56
Issue: 3-4
Pages: 233-42
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Publication
14610051 | -
First Author: Vale RD
Year: 2003
Journal: J Cell Biol
Title: Myosin V motor proteins: marching stepwise towards a mechanism.
Volume: 163
Issue: 3
Pages: 445-50
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Publication
23990471 | -
First Author: Hammer JA 3rd
Year: 2013
Journal: J Biol Chem
Title: Functions of class V myosins in neurons.
Volume: 288
Issue: 40
Pages: 28428-34
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Publication
11980908 | -
First Author: Strom M
Year: 2002
Journal: J Biol Chem
Title: A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport.
Volume: 277
Issue: 28
Pages: 25423-30
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Protein Domain
IPR036103 | MYSc_Myo5
Type: Domain
Description: Class V myosins have been shown to play a role in both membrane trafficking and RNA transport []. There are two type V myosins in yeast, which appear to have nonoverlapping functions. In Schizosaccharomyces pombe Myo52 is involved in growth polarity and cytokinesis, whereas Myo51 is a component of the cytokinetic actin ring []. Similarly, Saccharomyces cerevisiae Myo2 is essential for polarized growth, most likely through transport of secretory vesicles to the developing bud [], while Myo4 has been proposed to transport a mRNA needed to repress mating type switching in daughter cells []. Mice and humans possess three class V myosins (Myo5A, Myo5B, and Myo5C). Possible cargoes for myosin-V in mammals include melanosomes, synaptic vesicles [, , ]and organelles in neurons []. Mutations in myo5A cause Griscelli syndrome type-1 (GS1) and neuroectodermal melanolysosomal disease, or Elejalde disease [].This entry represents the motor (head) domain of class V myosins []. The motor domain has ATPase activity and belongs to the larger group of P-loop NTPases.
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Genotype
Genotype
Symbol: Myo5a/Myo5a<+> Rgsc80/Rgsc80<+>
Background: involves: C57BL/6JJcl * DBA/2JJcl
Zygosity: cx
Has Mutant Allele: true
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Publication
10444380 | J:57716
 
First Author: Tsakraklides V
Year: 1999
Journal: J Cell Sci
Title: Subcellular localization of GFP-myosin-V in live mouse melanocytes.
Volume: 112 ( Pt 17)
Pages: 2853-65
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Publication
10931864 | -
First Author: Catlett NL
Year: 2000
Journal: J Cell Biol
Title: Two distinct regions in a yeast myosin-V tail domain are required for the movement of different cargoes.
Volume: 150
Issue: 3
Pages: 513-26
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Publication
21976956 | J:179648
 
First Author: Lu H
Year: 2011
Journal: Mol Vis
Title: Complex interactions of Tyrp1 in the eye.
Volume: 17
Pages: 2455-68
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Protein
Q99104
Organism: Mus musculus/domesticus
Length: 1853  
Fragment?: false
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Protein
D3Z4J3
Organism: Mus musculus/domesticus
Length: 1855  
Fragment?: false
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Protein
D3YZ62
Organism: Mus musculus/domesticus
Length: 1828  
Fragment?: false
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Protein
P21271
Organism: Mus musculus/domesticus
Length: 1818  
Fragment?: false
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Protein
Q8BWY8
Organism: Mus musculus/domesticus
Length: 986  
Fragment?: true
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Protein
G5E8G6
Organism: Mus musculus/domesticus
Length: 1818  
Fragment?: false
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Protein
E9Q1F5
Organism: Mus musculus/domesticus
Length: 1742  
Fragment?: false
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Protein
G3X9Y9
Organism: Mus musculus/domesticus
Length: 1844  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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