Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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•
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Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
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Title: |
Annotation inferences using phylogenetic trees |
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•
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Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
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Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
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Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
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Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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•
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Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
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Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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•
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•
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Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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HT Experiment |
Series Id: |
GSE40439 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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•
•
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•
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HT Experiment |
Series Id: |
GSE54192 |
Experiment Type: |
transcription profiling by array |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
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Interaction Experiment |
Description: |
NCoR1 regulates thyroid hormone receptor isoform-dependent adipogenesis. |
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•
•
•
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Publication |
First Author: |
Zhu XG |
Year: |
2011 |
Journal: |
J Mol Endocrinol |
Title: |
NCoR1 regulates thyroid hormone receptor isoform-dependent adipogenesis. |
Volume: |
46 |
Issue: |
3 |
Pages: |
233-44 |
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•
•
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•
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Publication |
First Author: |
Ramamoorthy S |
Year: |
2013 |
Journal: |
Mol Cell Biol |
Title: |
Ligand-induced repression of the glucocorticoid receptor gene is mediated by an NCoR1 repression complex formed by long-range chromatin interactions with intragenic glucocorticoid response elements. |
Volume: |
33 |
Issue: |
9 |
Pages: |
1711-22 |
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•
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Allele |
Name: |
nuclear receptor co-repressor 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
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•
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Protein |
Organism: |
Mus musculus/domesticus |
Length: |
291
 |
Fragment?: |
false |
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•
•
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•
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Protein Domain |
Type: |
Domain |
Description: |
The G-protein pathway suppressor 2 (GPS2)-interacting domain is found in NCoR (nuclear receptor corepressor) proteins. NCoR1 and NCoR2 (also known as SMRT) are related corepressors that mediate transcriptional repression by unliganded nuclear receptors and other classes of transcriptional repressors. GPS2 is a stoichiometric subunit of the N-CoR-HDAC3 complex. GPS2 links the complex to membrane receptor-related intracellular JNK (c-Jun amino-terminal kinase) signalling pathways []. |
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Allele |
Name: |
nuclear receptor co-repressor 1; targeted mutation 1, Mitchell A Lazar |
Allele Type: |
Targeted |
Attribute String: |
Hypomorph, Inserted expressed sequence |
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•
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Strain |
Attribute String: |
coisogenic, targeted mutation |
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•
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Genotype |
Symbol: |
Ncor1/Ncor1 |
Background: |
C57BL/6-Ncor1 |
Zygosity: |
hm |
Has Mutant Allele: |
true |
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•
•
•
•
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Publication |
First Author: |
Zhang J |
Year: |
2002 |
Journal: |
Mol Cell |
Title: |
The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. |
Volume: |
9 |
Issue: |
3 |
Pages: |
611-23 |
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•
•
•
|
Publication |
First Author: |
Jeon YG |
Year: |
2024 |
Journal: |
Nat Commun |
Title: |
Ubiquitin ligase RNF20 coordinates sequential adipose thermogenesis with brown and beige fat-specific substrates. |
Volume: |
15 |
Issue: |
1 |
Pages: |
940 |
|
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•
•
•
•
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Publication |
First Author: |
Takahashi SS |
Year: |
2020 |
Journal: |
Life Sci Alliance |
Title: |
Loss of autophagy impairs physiological steatosis by accumulation of NCoR1. |
Volume: |
3 |
Issue: |
1 |
|
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•
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•
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Publication |
First Author: |
Bhaskara S |
Year: |
2010 |
Journal: |
Cancer Cell |
Title: |
Hdac3 is essential for the maintenance of chromatin structure and genome stability. |
Volume: |
18 |
Issue: |
5 |
Pages: |
436-47 |
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•
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Publication |
First Author: |
Thiagarajan D |
Year: |
2016 |
Journal: |
Cell Rep |
Title: |
Aldose Reductase Acts as a Selective Derepressor of PPARγ and the Retinoic Acid Receptor. |
Volume: |
15 |
Issue: |
1 |
Pages: |
181-96 |
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•
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•
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Publication |
First Author: |
Chen Z |
Year: |
2021 |
Journal: |
J Exp Med |
Title: |
Nuclear DEK preserves hematopoietic stem cells potential via NCoR1/HDAC3-Akt1/2-mTOR axis. |
Volume: |
218 |
Issue: |
5 |
|
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•
•
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•
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Strain |
Attribute String: |
targeted mutation, mutant strain |
|
•
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•
|
Genotype |
Symbol: |
Ncor1/Ncor1 Ncor2/Ncor2 |
Background: |
B6(FVB)-Ncor2 Ncor1 |
Zygosity: |
cx |
Has Mutant Allele: |
true |
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•
•
•
•
•
|
Publication |
First Author: |
Xie X |
Year: |
2015 |
Journal: |
Biochim Biophys Acta |
Title: |
L312, a novel PPARγ ligand with potent anti-diabetic activity by selective regulation. |
Volume: |
1850 |
Issue: |
1 |
Pages: |
62-72 |
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•
•
•
•
•
|
Publication |
First Author: |
Pasricha SR |
Year: |
2017 |
Journal: |
Nat Commun |
Title: |
Hepcidin is regulated by promoter-associated histone acetylation and HDAC3. |
Volume: |
8 |
Issue: |
1 |
Pages: |
403 |
|
•
•
•
•
•
|
Publication |
First Author: |
Kyle SM |
Year: |
2016 |
Journal: |
Hum Mol Genet |
Title: |
MeCP2 co-ordinates liver lipid metabolism with the NCoR1/HDAC3 corepressor complex. |
Volume: |
25 |
Issue: |
14 |
Pages: |
3029-3041 |
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•
•
•
•
•
|
Publication |
First Author: |
Koerner MV |
Year: |
2018 |
Journal: |
Genes Dev |
Title: |
Toxicity of overexpressed MeCP2 is independent of HDAC3 activity. |
Volume: |
32 |
Issue: |
23-24 |
Pages: |
1514-1524 |
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•
•
•
•
•
|
Publication |
First Author: |
Tanaka H |
Year: |
2016 |
Journal: |
J Biol Chem |
Title: |
Epigenetic Regulation of the Blimp-1 Gene (Prdm1) in B Cells Involves Bach2 and Histone Deacetylase 3. |
Volume: |
291 |
Issue: |
12 |
Pages: |
6316-30 |
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•
•
•
•
•
|
Publication |
First Author: |
Sengupta S |
Year: |
2010 |
Journal: |
Nature |
Title: |
mTORC1 controls fasting-induced ketogenesis and its modulation by ageing. |
Volume: |
468 |
Issue: |
7327 |
Pages: |
1100-4 |
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•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2453
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2472
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2473
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2386
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
791
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
541
 |
Fragment?: |
true |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2332
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2468
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2507
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2454
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Gerhard DS |
Year: |
2004 |
Journal: |
Genome Res |
Title: |
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |
Volume: |
14 |
Issue: |
10B |
Pages: |
2121-7 |
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•
•
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•
|