|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 501 to 600 out of 645 for Ndc80

<< First    < Previous  |  Next >    Last >>
0.04s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Allele
Spc24<Gt(OST373151)Lex> | MGI:4298033
 
Name: SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae); gene trap OST373151, Lexicon Genetics
Allele Type: Gene trapped
•
•
•
•
•
Allele
Ndc80<Gt(XT0241)Wtsi> | MGI:4331925
 
Name: NDC80 kinetochore complex component; gene trap XT0241, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
•
•
•
•
•
Allele
Ndc80<Gt(EUCE312c06)Hmgu> | MGI:4373823
 
Name: NDC80 kinetochore complex component; gene trap EUCE312c06, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
•
•
•
•
•
Allele
Ndc80<Gt(EUCE316c06)Hmgu> | MGI:4376995
 
Name: NDC80 kinetochore complex component; gene trap EUCE316c06, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
•
•
•
•
•
Allele
Ndc80<Gt(EUCE307c06)Hmgu> | MGI:4385755
 
Name: NDC80 kinetochore complex component; gene trap EUCE307c06, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
•
•
•
•
•
Allele
Ndc80<tm1a(KOMP)Wtsi> | MGI:4454070
Name: NDC80 kinetochore complex component; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
•
•
•
•
•
Allele
Ndc80<tm1e(KOMP)Wtsi> | MGI:4454167
Name: NDC80 kinetochore complex component; targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
•
•
•
•
•
Allele
Nuf2<tm1a(EUCOMM)Wtsi> | MGI:4842500
Name: NUF2, NDC80 kinetochore complex component; targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
•
•
•
•
•
Allele
Ndc80<Gt(EUCJ0174h09)Hmgu> | MGI:4875681
 
Name: NDC80 kinetochore complex component; gene trap EUCJ0174h09, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
•
•
•
•
•
Allele
Nuf2<Gt(IST13526D1)Tigm> | MGI:5173128
 
Name: NUF2, NDC80 kinetochore complex component; gene trap IST13526D1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Allele
Ndc80<Gt(IST13404G2)Tigm> | MGI:5173898
 
Name: NDC80 kinetochore complex component; gene trap IST13404G2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Allele
Nuf2<Gt(IST14198E11)Tigm> | MGI:5212226
 
Name: NUF2, NDC80 kinetochore complex component; gene trap IST14198E11, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Allele
Spc24<tm1(KOMP)Vlcg> | MGI:5312547
Name: SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae); targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
•
•
•
•
•
Strain
MGI:6256534 | C57BL/6NJ-Ndc80<em1(IMPC)J>/Mmjax
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Allele
Spc25<em1(IMPC)J> | MGI:6259583
Name: SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae); endonuclease-mediated mutation 1, Jackson
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Allele
Spc25<em1Gpt> | MGI:7306702
Name: SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae); endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
•
•
•
•
•
Allele
Nuf2<em1(IMPC)Kmpc> | MGI:7377592
Name: NUF2, NDC80 kinetochore complex component; endonuclease-mediated mutation 1, Korea Mouse Phenotyping Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Strain
MGI:7835367 | C57BL/6N-Ndc80<em1Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Strain
MGI:7838320 | C57BL/6N-Ndc80<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Genotype
Genotype
Symbol: Ndc80/Ndc80
Background: C57BL/6NJ-Ndc80/Mmjax
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Protein
A2AUT3
Organism: Mus musculus/domesticus
Length: 167  
Fragment?: true
•
•
•
•
•
Protein Domain
IPR045143 | Spc25
Type: Family
Description: The Ndc80 complex is a conserved outer kinetochore protein complex consisting of Ndc80 (Hec1), Nuf2, Spc24 and Spc25. The Ndc80 complex is required for chromosome segregation and spindle checkpoint activity [, , ].
•
•
•
•
•
Protein
Q3UA16
Organism: Mus musculus/domesticus
Length: 226  
Fragment?: false
•
•
•
•
•
Protein
A2AUT1
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
•
•
•
•
•
Protein
A2AUT4
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true
•
•
•
•
•
Allele
Spc24<Gt(AG0164)Wtsi> | MGI:4344696
 
Name: SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae); gene trap AG0164, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
•
•
•
•
•
Allele
Spc24<tm1a(EUCOMM)Wtsi> | MGI:4820291
Name: SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae); targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
•
•
•
•
•
Allele
Spc24<tm1a(EUCOMM)Hmgu> | MGI:4841812
Name: SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae); targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
•
•
•
•
•
Allele
Spc25<tm1a(EUCOMM)Wtsi> | MGI:4944516
Name: SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae); targeted mutation 1a, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
•
•
•
•
•
Allele
Spc25<tm1e(EUCOMM)Wtsi> | MGI:4944533
Name: SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae); targeted mutation 1e, Wellcome Trust Sanger Institute
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
•
•
•
•
•
Allele
Spc24<Gt(271A1)Cmhd> | MGI:4960354
 
Name: SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae); gene trap 271A1, Centre for Modeling Human Disease
Allele Type: Gene trapped
•
•
•
•
•
Allele
Spc24<Gt(271G1)Cmhd> | MGI:4968255
 
Name: SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae); gene trap 271G1, Centre for Modeling Human Disease
Allele Type: Gene trapped
•
•
•
•
•
Allele
Spc24<Gt(IST10895D6)Tigm> | MGI:5145616
 
Name: SPC24, NDC80 kinetochore complex component, homolog (S. cerevisiae); gene trap IST10895D6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Allele
Spc25<Gt(IST14139A3)Tigm> | MGI:5213828
 
Name: SPC25, NDC80 kinetochore complex component, homolog (S. cerevisiae); gene trap IST14139A3, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
•
•
•
•
•
Strain
MGI:6259584 | C57BL/6NJ-Spc25<em1(IMPC)J>/Mmjax
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
•
•
•
•
•
Strain
MGI:7382641 | C57BL/6N-Nuf2<em1(IMPC)Kmpc>/Kmpc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
•
•
•
•
•
Genotype
Genotype
Symbol: Ndc80/Ndc80 Tg(Zp3-cre)3Mrt/?
Background: involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj * FVB/N
Zygosity: cn
Has Mutant Allele: true
•
•
•
•
•
Genotype
Genotype
Symbol: Spc25/Spc25
Background: C57BL/6NJ-Spc25/Mmjax
Zygosity: hm
Has Mutant Allele: true
•
•
•
•
•
Protein Domain
IPR013255 | Spc25_C
Type: Domain
Description: The Ndc80 complex is a conserved outer kinetochore protein complex consisting of Ndc80 (Hec1), Nuf2, Spc24 and Spc25. The Ndc80 complex is required for chromosome segregation and spindle checkpoint activity [, , ].This entry represents the C-terminal domain of Spc25 [].
•
•
•
•
•
Genotype
Genotype
Symbol: Spc25/Spc25<+>
Background: C57BL/6NJ-Spc25/Mmjax
Zygosity: ht
Has Mutant Allele: true
•
•
•
•
•
Protein Domain
IPR038275 | Nuf2_N_sf
Type: Homologous_superfamily
Description: This superfamily represents a domain found at the N terminus of the Kinetochore protein Nuf2, which is part of the Ndc80 complex. This domain fold as a CH domain consisting of a four-helix bundle containing the parallel helices alphaA, alphaC, alphaE, and alphaG, similar to that in Ndc80. These CH domains from Nuf2 and Ndc80 forms the globular rod at one end the complex [, ]. The ability of the Ndc80 complex to bind microtubules resides on the tightly packed CH domains from Nuf2 and Ndc80 []. This complex binds to the spindle and is required for chromosome segregation and spindle checkpoint activity [, , , , , , ].
•
•
•
•
•
Protein Domain
IPR005549 | Kinetochore_Nuf2_N
Type: Domain
Description: This entry represents the N-terminal domain of kinetochore protein Nuf2, which is part of the Ndc80 complex. This domain fold as a CH domain consisting of a four-helix bundle containing the parallel helices alphaA, alphaC, alphaE, and alphaG, similar to that in Ndc80. These CH domains from Nuf2 and Ndc80 forms the globular rod at one end the complex [, ]. The ability of the Ndc80 complex to bind microtubules resides on the tightly packed CH domains from Nuf2 and Ndc80 []. This complex binds to the spindle and is required for chromosome segregation and spindle checkpoint activity [, , , , , , ].
•
•
•
•
•
Protein
Q99P69
Organism: Mus musculus/domesticus
Length: 463  
Fragment?: false
•
•
•
•
•
Protein
A0A0A6YVY5
Organism: Mus musculus/domesticus
Length: 171  
Fragment?: true
•
•
•
•
•
Protein
A0A0A6YW74
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
•
•
•
•
•
Protein Domain
IPR040967 | DUF5595
Type: Domain
Description: This domain is found in Nude C 80 (Ndc80)proteins which can be found in species such as Homo sapiens. Ndc80 protein complexes are a core component of the end-on attachment sites for kinetochore microtubules. Ndc80 is also known as Hec1, for highly expressed in cancer 1 [].
•
•
•
•
•
Publication
17535814 | -
First Author: Liu D
Year: 2007
Journal: J Biol Chem
Title: Human NUF2 interacts with centromere-associated protein E and is essential for a stable spindle microtubule-kinetochore attachment.
Volume: 282
Issue: 29
Pages: 21415-24
•
•
•
•
•
Publication
12438418 | -
First Author: DeLuca JG
Year: 2002
Journal: J Cell Biol
Title: hNuf2 inhibition blocks stable kinetochore-microtubule attachment and induces mitotic cell death in HeLa cells.
Volume: 159
Issue: 4
Pages: 549-55
•
•
•
•
•
Publication
4654001 | -
First Author: Truswell AS
Year: 1972
Journal: S Afr Med J
Title: Thiamine deficiency in children with severe gastro-enteritis.
Volume: 46
Issue: 52
Pages: 2083-4
•
•
•
•
•
Publication
15062103 | -
First Author: Joseph J
Year: 2004
Journal: Curr Biol
Title: The RanGAP1-RanBP2 complex is essential for microtubule-kinetochore interactions in vivo.
Volume: 14
Issue: 7
Pages: 611-7
•
•
•
•
•
Publication
15235793 | -
First Author: Stucke VM
Year: 2004
Journal: Chromosoma
Title: Kinetochore localization and microtubule interaction of the human spindle checkpoint kinase Mps1.
Volume: 113
Issue: 1
Pages: 1-15
•
•
•
•
•
Publication
15239953 | -
First Author: Meraldi P
Year: 2004
Journal: Dev Cell
Title: Timing and checkpoints in the regulation of mitotic progression.
Volume: 7
Issue: 1
Pages: 45-60
•
•
•
•
•
Publication
15548592 | -
First Author: DeLuca JG
Year: 2005
Journal: Mol Biol Cell
Title: Hec1 and nuf2 are core components of the kinetochore outer plate essential for organizing microtubule attachment sites.
Volume: 16
Issue: 2
Pages: 519-31
•
•
•
•
•
Publication
16765893 | -
First Author: Wei RR
Year: 2006
Journal: Structure
Title: Structure of a central component of the yeast kinetochore: the Spc24p/Spc25p globular domain.
Volume: 14
Issue: 6
Pages: 1003-9
•
•
•
•
•
Protein Domain
IPR038066 | Spc24_Fungi_globular_sf
Type: Homologous_superfamily
Description: Spc24 is a component of the evolutionarily conserved kinetochore-associated Ndc80 complex, which is implicated in several essential outer kinetochore functions, including microtubule binding and control the spindle assembly checkpoint [, ].The Ndc80 complex appears to be a long rod with globular 'heads'. Ndc80 and Nuf2 contribute to one head and to the intervening shaft; Spc24 and Spc25 complete the shaft and contribute to the other head. Spc24 and Spc25 fold tightly together. TheC-terminal globular domains of Spc24 and Spc25 form the 'inner' head, which faces the centromere [].
•
•
•
•
•
Protein
Q9D083
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: false
•
•
•
•
•
Protein
A0A1L1SSK2
Organism: Mus musculus/domesticus
Length: 42  
Fragment?: true
•
•
•
•
•
Protein
Q14BA9
Organism: Mus musculus/domesticus
Length: 201  
Fragment?: false
•
•
•
•
•
Protein
A0A1L1SV84
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: false
•
•
•
•
•
Protein Domain
IPR013252 | Ndc80_Spc24
Type: Family
Description: Spc24 is a component of the evolutionarily conserved kinetochore-associated Ndc80 complex, which is implicated in several essential outer kinetochore functions, including microtubule binding and control the spindle assembly checkpoint [, ].
•
•
•
•
•
Publication
21633384 | J:320274
First Author: Lampert F
Year: 2011
Journal: Nat Rev Mol Cell Biol
Title: A blueprint for kinetochores - new insights into the molecular mechanics of cell division.
Volume: 12
Issue: 7
Pages: 407-12
•
•
•
•
•
Publication
34972250 | J:324155
First Author: Zhang J
Year: 2022
Journal: FASEB J
Title: BCAS2 is involved in alternative splicing and mouse oocyte development.
Volume: 36
Issue: 2
Pages: e22128
•
•
•
•
•
Protein Domain
IPR044951 | SPC24-like
Type: Family
Description: This entry includes SPC24 homologue, MUN (MERISTEM UNSTRUCTURED), from Arabidopsis. SPC24 is part of the outer kinetochore complex NDC80. In Arabidopsis, MUN interacts with components of the NDC80 complex and is required for chromosome segregation to ensure proper cell division [].
•
•
•
•
•
Publication
23878276 | J:201641
First Author: Park I
Year: 2013
Journal: J Cell Biol
Title: Loss of BubR1 acetylation causes defects in spindle assembly checkpoint signaling and promotes tumor formation.
Volume: 202
Issue: 2
Pages: 295-309
•
•
•
•
•
Publication
33660780 | J:304858
First Author: Olthof AM
Year: 2021
Journal: Nucleic Acids Res
Title: Disruption of exon-bridging interactions between the minor and major spliceosomes results in alternative splicing around minor introns.
Volume: 49
Issue: 6
Pages: 3524-3545
•
•
•
•
•
Protein
A3KGI6
Organism: Mus musculus/domesticus
Length: 91  
Fragment?: true
•
•
•
•
•
Publication
25601404 | -
First Author: Kim S
Year: 2015
Journal: J Cell Biol
Title: Multiple assembly mechanisms anchor the KMN spindle checkpoint platform at human mitotic kinetochores.
Volume: 208
Issue: 2
Pages: 181-96
•
•
•
•
•
Publication
17981135 | -
First Author: Kiyomitsu T
Year: 2007
Journal: Dev Cell
Title: Human Blinkin/AF15q14 is required for chromosome alignment and the mitotic checkpoint through direct interaction with Bub1 and BubR1.
Volume: 13
Issue: 5
Pages: 663-76
•
•
•
•
•
Publication
26675729 | -
First Author: Brunette TJ
Year: 2015
Journal: Nature
Title: Exploring the repeat protein universe through computational protein design.
Volume: 528
Issue: 7583
Pages: 580-4
•
•
•
•
•
Protein Domain
IPR041146 | IFT81_CH
Type: Domain
Description: This is the N-terminal domain found in IFT81 proteins. Crystal structure analysis revealed that IFT81-N adopts the fold of a calponin homology (CH) domain with structural similarity to the kinetochore complex component NDC80 with microtubule (MT)-binding properties. Functional analysis show that IFT74 and IFT81 form a tubulin-binding module required for ciliogenesis. It is suggested that IFT81-N binds the globular domain of tubulin to provide specificity, and IFT74-N recognizes the beta-tubulin tail to increase affinity [].
•
•
•
•
•
Protein Domain
IPR041112 | Nuf2_DHR10-like
Type: Domain
Description: This domain is found at the C-terminal region of Nuf2 proteins. This domain was identified as MazG related domain also designated as Designed helical repeat protein 10 (DHR10) []that actually adopts a coiled-coil structure []. Nuf2 is part of the Ndc80 complex, which complex binds to the spindle and is required for chromosome segregation and spindle checkpoint activity [, , , , , , ].
•
•
•
•
•
Protein Domain
IPR037388 | Blinkin
Type: Family
Description: The KMN network (for KNL1, MIS12 and NDC80 complexes) is a hub for signalling at the outer kinetochore []that acts as a receptor for both microtubules and checkpoint proteins []. Kinetochore scaffold 1, also known as Blinkin or KNL1, is a component of the KMN network. It is required to localize a subset of outer kinetochore proteins and is essential for chromosome segregation [, ].
•
•
•
•
•
Protein Domain
IPR043016 | IFT81_N_sf
Type: Homologous_superfamily
Description: This superfamily represents the N-terminal domain found in IFT81 (Intraflagellar transport protein 81) proteins. Crystal structure analysis revealed that IFT81-N adopts the fold of a calponin homology (CH) domain with structural similarity to the kinetochore complex component NDC80 with microtubule (MT)-binding properties. Functional analysis show that IFT74 and IFT81 form a tubulin-binding module required for ciliogenesis. It is suggested that IFT81-N binds the globular domain of tubulin to provide specificity, and IFT74-N recognizes the beta-tubulin tail to increase affinity [].
•
•
•
•
•
Publication
30093551 | J:266583
 
First Author: Baumgartner M
Year: 2018
Journal: Development
Title: Minor spliceosome inactivation causes microcephaly, owing to cell cycle defects and death of self-amplifying radial glial cells.
Volume: 145
Issue: 17
•
•
•
•
•
Protein
Q8C263
Organism: Mus musculus/domesticus
Length: 411  
Fragment?: false
•
•
•
•
•
Publication
19646878 | -
First Author: Daum JR
Year: 2009
Journal: Curr Biol
Title: Ska3 is required for spindle checkpoint silencing and the maintenance of chromosome cohesion in mitosis.
Volume: 19
Issue: 17
Pages: 1467-72
•
•
•
•
•
Publication
19360002 | -
First Author: Gaitanos TN
Year: 2009
Journal: EMBO J
Title: Stable kinetochore-microtubule interactions depend on the Ska complex and its new component Ska3/C13Orf3.
Volume: 28
Issue: 10
Pages: 1442-52
•
•
•
•
•
Protein Domain
IPR033341 | SKA3
Type: Family
Description: The Ska complex is an essential mitotic component required for accurate cell division in human cells. It is an important kinetochore component involved in the formation of kinetochore-microtubule interactions, and together with the Ndc80 complex couples chromosome movement to microtubule depolymerization []. The complex is composed of three subunits: Ska1, Ska2, and Ska3.Ska3 was the last subunit of the complex identified []. Ska3 accumulates on kinetochores in prometaphase after nuclear envelope breakdown. During mitosis, it is required for the maintenance of chromosome cohesion and may play an important role in silencing the spindle checkpoint [].
•
•
•
•
•
Publication
16420439 | J:105375
First Author: Ajioka I
Year: 2006
Journal: Eur J Neurosci
Title: Identification of ventricular-side-enriched molecules regulated in a stage-dependent manner during cerebral cortical development.
Volume: 23
Issue: 2
Pages: 296-308
•
•
•
•
•
Protein
O35594
Organism: Mus musculus/domesticus
Length: 676  
Fragment?: false
•
•
•
•
•
Protein
Q3TTH0
Organism: Mus musculus/domesticus
Length: 244  
Fragment?: false
•
•
•
•
•
Protein
A0A0G2JGC3
Organism: Mus musculus/domesticus
Length: 64  
Fragment?: false
•
•
•
•
•
Protein
D3Z5A8
Organism: Mus musculus/domesticus
Length: 217  
Fragment?: true
•
•
•
•
•
Protein
D6RHM7
Organism: Mus musculus/domesticus
Length: 59  
Fragment?: false
•
•
•
•
•
Protein
Q66JQ7
Organism: Mus musculus/domesticus
Length: 1612  
Fragment?: false
•
•
•
•
•
Protein
A0A1D5RMD0
Organism: Mus musculus/domesticus
Length: 43  
Fragment?: false
•
•
•
•
•
Protein
A3KGI5
Organism: Mus musculus/domesticus
Length: 484  
Fragment?: true
•
•
•
•
•
Protein
A0A1D5RM35
Organism: Mus musculus/domesticus
Length: 42  
Fragment?: false
•
•
•
•
•
Protein
A0A1D5RLB1
Organism: Mus musculus/domesticus
Length: 40  
Fragment?: false
•
•
•
•
•
Publication
17129783 | -
First Author: Cheeseman IM
Year: 2006
Journal: Cell
Title: The conserved KMN network constitutes the core microtubule-binding site of the kinetochore.
Volume: 127
Issue: 5
Pages: 983-97
•
•
•
•
•
Protein Domain
IPR032373 | CENP-T_N
Type: Domain
Description: Multiple proteins are assembled on centromeric DNA to form the kinetochore structure. CENP-T is a component of the constitutive centromere associated network (CCAN) of proteins that creates a platform for kinetochore formation. CENP-T associates directly with CENP-W. The N terminus of CENP-T proteins interacts directly with the Ndc80 complex in the outer kinetochore. Importantly, the CENP-T-W complex does not directly associate with CENP-A, but with histone H3 in the centromere region. CENP-T and -W form a hetero-tetramer with CENP-S and -X and bind to a ~100 bp region of nucleosome-free DNA forming a nucleosome-like structure. The DNA-CENP-T-W-S-X complex is likely to be associated with histone H3-containing nucleosomes rather than with CENP-nucleosomes [, , ]. This entry represents the N terminus of CENP-T.
•
•
•
•
•
Publication
23990561 | -
First Author: Bhogaraju S
Year: 2013
Journal: Science
Title: Molecular basis of tubulin transport within the cilium by IFT74 and IFT81.
Volume: 341
Issue: 6149
Pages: 1009-12
•
•
•
•
•
Publication
18270576 | J:154087
First Author: Trimarchi JM
Year: 2008
Journal: PLoS One
Title: Individual retinal progenitor cells display extensive heterogeneity of gene expression.
Volume: 3
Issue: 2
Pages: e1588
•
•
•
•
•
Publication
22391098 | -
First Author: Takeuchi K
Year: 2012
Journal: Exp Cell Res
Title: Molecular architecture of vertebrate kinetochores.
Volume: 318
Issue: 12
Pages: 1367-74
•
•
•
•
•
Publication
21464230 | -
First Author: Suzuki A
Year: 2011
Journal: J Cell Biol
Title: Spindle microtubules generate tension-dependent changes in the distribution of inner kinetochore proteins.
Volume: 193
Issue: 1
Pages: 125-40
•
•
•
•
•
Publication
29617656 | J:263646
First Author: Horiuchi K
Year: 2018
Journal: Cell Rep
Title: Impaired Spermatogenesis, Muscle, and Erythrocyte Function in U12 Intron Splicing-Defective Zrsr1 Mutant Mice.
Volume: 23
Issue: 1
Pages: 143-155
•
•
•
•
•
Protein
Q8K015
Organism: Mus musculus/domesticus
Length: 298  
Fragment?: false
•
•
•
•
•
Protein
A3KGI3
Organism: Mus musculus/domesticus
Length: 2119  
Fragment?: false
•
•
•
•
•
Protein
B8JK51
Organism: Mus musculus/domesticus
Length: 221  
Fragment?: true
•
•
•
•
•
Protein
Q8BI07
Organism: Mus musculus/domesticus
Length: 286  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom