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Search results 501 to 600 out of 735 for Nr4a1

0.161s
Type Details Score
Publication
First Author: Boddupalli CS
Year: 2016
Journal: J Clin Invest
Title: ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells.
Volume: 126
Issue: 10
Pages: 3905-3916
Other Genome Feature
Type: sequence_feature
Organism: mouse, laboratory
Allele
Name: nuclear receptor subfamily 4, group A, member 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Protein
Organism: Mus musculus/domesticus
Length: 222  
Fragment?: false
Publication
First Author: Chung HK
Year: 2003
Journal: J Biol Chem
Title: CR6-interacting factor 1 interacts with Gadd45 family proteins and modulates the cell cycle.
Volume: 278
Issue: 30
Pages: 28079-88
Protein Domain
Type: Family
Description: Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity []. They may be involved in the hormone-mediated regulation of NR4A1 transcriptional activity.
Protein Domain
Type: Homologous_superfamily
Description: This superfamily represents a domain found in proteins which act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity []. They may be involved in the hormone-mediated regulation of NR4A1 transcriptional activity.Structurally, this domain consists of 4 alpha helices.
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Allele
Name: nuclear receptor subfamily 4, group A, member 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: transgene insertion 2, Rodrigo Bravo
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion GY139, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: regulatory region 39; endonuclease-mediated mutation 1, Catherine Hedrick
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Publication
First Author: Moran AE
Year: 2011
Journal: J Exp Med
Title: T cell receptor signal strength in Treg and iNKT cell development demonstrated by a novel fluorescent reporter mouse.
Volume: 208
Issue: 6
Pages: 1279-89
Publication
First Author: Montgomery AB
Year: 2023
Journal: Cell Rep
Title: Tissue-resident, extravascular Ly6c(-) monocytes are critical for inflammation in the synovium.
Volume: 42
Issue: 5
Pages: 112513
Publication
First Author: Elliot TAE
Year: 2022
Journal: Discov Immunol
Title: Nur77-Tempo mice reveal T cell steady state antigen recognition.
Volume: 1
Issue: 1
Pages: kyac009
Publication
First Author: Davis MI
Year: 2011
Journal: PLoS One
Title: Nr4a1-eGFP is a marker of striosome-matrix architecture, development and activity in the extended striatum.
Volume: 6
Issue: 1
Pages: e16619
Strain
Attribute String: mutant stock, transgenic
Strain
Attribute String: congenic, mutant strain, transgenic
Strain
Attribute String: mutant strain, endonuclease-mediated mutation, coisogenic
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Allele
Name: transgene insertion 1, Alexander Y Rudensky
Allele Type: Transgenic
Attribute String: Reporter
Strain
Attribute String: coisogenic, mutant strain, transgenic
Genotype
Symbol: Rr39/Rr39
Background: C57BL/6-Rr39
Zygosity: hm
Has Mutant Allele: true
Genotype
Symbol: Rr39/Rr39
Background: C57BL/6-Rr39/J
Zygosity: hm
Has Mutant Allele: true
Publication
First Author: Ashouri JF
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Reporters of TCR signaling identify arthritogenic T cells in murine and human autoimmune arthritis.
Volume: 116
Issue: 37
Pages: 18517-18527
Publication
First Author: Prager EM
Year: 2020
Journal: Neuron
Title: Dopamine Oppositely Modulates State Transitions in Striosome and Matrix Direct Pathway Striatal Spiny Neurons.
Volume: 108
Issue: 6
Pages: 1091-1102.e5
Allele
Name: transposon insertion M4, Cyagen
Allele Type: Transposon induced
Attribute String: Reporter
Publication
First Author: Goldmann T
Year: 2016
Journal: Nat Immunol
Title: Origin, fate and dynamics of macrophages at central nervous system interfaces.
Volume: 17
Issue: 7
Pages: 797-805
Publication
First Author: Mildner A
Year: 2017
Journal: Immunity
Title: Genomic Characterization of Murine Monocytes Reveals C/EBPβ Transcription Factor Dependence of Ly6C- Cells.
Volume: 46
Issue: 5
Pages: 849-862.e7
Publication
First Author: Celen C
Year: 2022
Journal: Cell Rep
Title: Arid1a loss potentiates pancreatic β-cell regeneration through activation of EGF signaling.
Volume: 41
Issue: 5
Pages: 111581
Publication
First Author: Matzkin ME
Year: 2013
Journal: Mol Cell Endocrinol
Title: The ERK1/2 pathway regulates testosterone synthesis by coordinately regulating the expression of steroidogenic genes in Leydig cells.
Volume: 370
Issue: 1-2
Pages: 130-7
Publication
First Author: Chen C
Year: 2019
Journal: Cell Rep
Title: Spatial Genome Re-organization between Fetal and Adult Hematopoietic Stem Cells.
Volume: 29
Issue: 12
Pages: 4200-4211.e7
Publication
First Author: Pan J
Year: 2019
Journal: Sci Rep
Title: ALDH1A1 regulates postsynaptic μ-opioid receptor expression in dorsal striatal projection neurons and mitigates dyskinesia through transsynaptic retinoic acid signaling.
Volume: 9
Issue: 1
Pages: 3602
Publication
First Author: Weih F
Year: 1996
Journal: J Immunol
Title: Both multiorgan inflammation and myeloid hyperplasia in RelB-deficient mice are T cell dependent.
Volume: 157
Issue: 9
Pages: 3974-9
Publication
First Author: Avery L
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Tim-3 co-stimulation promotes short-lived effector T cells, restricts memory precursors, and is dispensable for T cell exhaustion.
Volume: 115
Issue: 10
Pages: 2455-2460
Publication
First Author: Myers DR
Year: 2019
Journal: Cell Rep
Title: Active Tonic mTORC1 Signals Shape Baseline Translation in Naive T Cells.
Volume: 27
Issue: 6
Pages: 1858-1874.e6
Publication
First Author: Gangarossa G
Year: 2019
Journal: J Neurochem
Title: Contrasting patterns of ERK activation in the tail of the striatum in response to aversive and rewarding signals.
Volume: 151
Issue: 2
Pages: 204-226
Publication    
First Author: Cirnaru MD
Year: 2021
Journal: Elife
Title: Unbiased identification of novel transcription factors in striatal compartmentation and striosome maturation.
Volume: 10
Allele
Name: transgene insertion 820, Kristin A Hogquist
Allele Type: Transgenic
Attribute String: Recombinase
Strain
Attribute String: mutant strain, transgenic
Publication
First Author: Sheng Y
Year: 2021
Journal: Blood
Title: Role of c-Myc haploinsufficiency in the maintenance of HSCs in mice.
Volume: 137
Issue: 5
Pages: 610-623
Publication  
First Author: Ren K
Year: 2022
Journal: J Autoimmun
Title: Notch signaling dependent monocyte conversion alleviates immune-mediated neuropathies by regulating RBP-J/NR4A1 axis.
Volume: 133
Pages: 102945
Publication
First Author: Chen J
Year: 2022
Journal: Adv Sci (Weinh)
Title: Single-cell RNA Sequencing Identified Novel Nr4a1(+) Ear2(+) Anti-Inflammatory Macrophage Phenotype under Myeloid-TLR4 Dependent Regulation in Anti-Glomerular Basement Membrane (GBM) Crescentic Glomerulonephritis (cGN).
Volume: 9
Issue: 18
Pages: e2200668
Publication
First Author: Hewitt SC
Year: 2010
Journal: FASEB J
Title: Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene.
Volume: 24
Issue: 12
Pages: 4660-7
Publication
First Author: Seong H
Year: 2024
Journal: Biochim Biophys Acta Mol Cell Biol Lipids
Title: Taste receptor type 1 member 3 regulates Western diet-induced male infertility.
Volume: 1869
Issue: 3
Pages: 159433
Publication
First Author: Shin JH
Year: 2020
Journal: FASEB J
Title: Transcriptional coactivator with PDZ-binding motif suppresses the expression of steroidogenic enzymes by nuclear receptor 4 A1 in Leydig cells.
Volume: 34
Issue: 4
Pages: 5332-5347
Publication      
First Author: Tripathi A
Year: 2024
Journal: Mol Psychiatry
Title: Microglial type I interferon signaling mediates chronic stress-induced synapse loss and social behavior deficits.
Publication
First Author: Di-Luoffo M
Year: 2015
Journal: Biol Reprod
Title: Novel Targets for the Transcription Factors MEF2 in MA-10 Leydig Cells.
Volume: 93
Issue: 1
Pages: 9
Publication
First Author: Hibino S
Year: 2018
Journal: Cancer Res
Title: Inhibition of Nr4a Receptors Enhances Antitumor Immunity by Breaking Treg-Mediated Immune Tolerance.
Volume: 78
Issue: 11
Pages: 3027-3040
Publication
First Author: Safe S
Year: 2021
Journal: Mol Cancer Res
Title: The Paradoxical Roles of Orphan Nuclear Receptor 4A (NR4A) in Cancer.
Volume: 19
Issue: 2
Pages: 180-191
Publication
First Author: Zhai X
Year: 2024
Journal: JHEP Rep
Title: Oxytocin alleviates liver fibrosis via hepatic macrophages.
Volume: 6
Issue: 6
Pages: 101032
Publication  
First Author: Liu XH
Year: 2022
Journal: Front Immunol
Title: Single-cell RNA sequencing reveals a novel inhibitory effect of ApoA4 on NAFL mediated by liver-specific subsets of myeloid cells.
Volume: 13
Pages: 1038401
Publication
First Author: Gallagher SJ
Year: 2013
Journal: Dev Biol
Title: Distinct requirements for Sin3a in perinatal male gonocytes and differentiating spermatogonia.
Volume: 373
Issue: 1
Pages: 83-94
Publication  
First Author: Yao Y
Year: 2021
Journal: Front Pharmacol
Title: Molecular Mechanisms of Epileptic Encephalopathy Caused by KCNMA1 Loss-of-Function Mutations.
Volume: 12
Pages: 775328
Publication
First Author: Wojciech L
Year: 2018
Journal: Sci Rep
Title: Non-canonicaly recruited TCRαβCD8αα IELs recognize microbial antigens.
Volume: 8
Issue: 1
Pages: 10848
Publication
First Author: Kimura T
Year: 2017
Journal: Am J Physiol Heart Circ Physiol
Title: Atheroprotective vaccination with MHC-II-restricted ApoB peptides induces peritoneal IL-10-producing CD4 T cells.
Volume: 312
Issue: 4
Pages: H781-H790
Publication  
First Author: Schad SE
Year: 2022
Journal: J Exp Med
Title: Tumor-induced double positive T cells display distinct lineage commitment mechanisms and functions.
Volume: 219
Issue: 6
Publication
First Author: Jones MC
Year: 2023
Journal: J Immunol
Title: CD4 Effector TCR Avidity for Peptide on APC Determines the Level of Memory Generated.
Volume: 210
Issue: 12
Pages: 1950-1961
Publication
First Author: Lee YJ
Year: 2015
Journal: Immunity
Title: Tissue-Specific Distribution of iNKT Cells Impacts Their Cytokine Response.
Volume: 43
Issue: 3
Pages: 566-78
Publication
First Author: Tsiantoulas D
Year: 2017
Journal: Sci Rep
Title: Secreted IgM deficiency leads to increased BCR signaling that results in abnormal splenic B cell development.
Volume: 7
Issue: 1
Pages: 3540
Publication  
First Author: Brioschi S
Year: 2021
Journal: Science
Title: Heterogeneity of meningeal B cells reveals a lymphopoietic niche at the CNS borders.
Volume: 373
Issue: 6553
Publication
First Author: Wells AC
Year: 2023
Journal: Nat Commun
Title: Let-7 enhances murine anti-tumor CD8 T cell responses by promoting memory and antagonizing terminal differentiation.
Volume: 14
Issue: 1
Pages: 5585
Publication
First Author: Bettini M
Year: 2014
Journal: J Immunol
Title: TCR affinity and tolerance mechanisms converge to shape T cell diabetogenic potential.
Volume: 193
Issue: 2
Pages: 571-9
Publication
First Author: Huang HI
Year: 2023
Journal: Cell Rep
Title: A binary module for microbiota-mediated regulation of γδ17 cells, hallmarked by microbiota-driven expression of programmed cell death protein 1.
Volume: 42
Issue: 8
Pages: 112951
Publication
First Author: Tsai K
Year: 2020
Journal: J Immunol
Title: Cutting Edge: Intestinal Mucus Limits the Clonal Deletion of Developing T Cells Specific for an Oral Antigen.
Volume: 205
Issue: 2
Pages: 329-334
Publication
First Author: Sgobio C
Year: 2017
Journal: Sci Rep
Title: Aldehyde dehydrogenase 1-positive nigrostriatal dopaminergic fibers exhibit distinct projection pattern and dopamine release dynamics at mouse dorsal striatum.
Volume: 7
Issue: 1
Pages: 5283
Publication
First Author: Sandu I
Year: 2020
Journal: Nat Commun
Title: Exhausted CD8+ T cells exhibit low and strongly inhibited TCR signaling during chronic LCMV infection.
Volume: 11
Issue: 1
Pages: 4454
Publication
First Author: Wencker M
Year: 2014
Journal: Nat Immunol
Title: Innate-like T cells straddle innate and adaptive immunity by altering antigen-receptor responsiveness.
Volume: 15
Issue: 1
Pages: 80-7
Publication  
First Author: Kupferschmidt DA
Year: 2015
Journal: Front Neuroanat
Title: Brain BLAQ: Post-hoc thick-section histochemistry for localizing optogenetic constructs in neurons and their distal terminals.
Volume: 9
Pages: 6
Publication
First Author: Hanna BS
Year: 2019
Journal: Leukemia
Title: PI3Kδ inhibition modulates regulatory and effector T-cell differentiation and function in chronic lymphocytic leukemia.
Volume: 33
Issue: 6
Pages: 1427-1438
Publication    
First Author: Jimeno R
Year: 2019
Journal: Elife
Title: Tissue-specific shaping of the TCR repertoire and antigen specificity of iNKT cells.
Volume: 8
Publication  
First Author: Whitesell JC
Year: 2022
Journal: Front Immunol
Title: Islet Lymphocytes Maintain a Stable Regulatory Phenotype Under Homeostatic Conditions and Metabolic Stress.
Volume: 13
Pages: 814203
Publication  
First Author: Mitra A
Year: 2020
Journal: Front Immunol
Title: CD28 Signaling Drives Notch Ligand Expression on CD4 T Cells.
Volume: 11
Pages: 735
Publication
First Author: Zemmour D
Year: 2018
Journal: Nat Immunol
Title: Single-cell gene expression reveals a landscape of regulatory T cell phenotypes shaped by the TCR.
Volume: 19
Issue: 3
Pages: 291-301
Publication
First Author: Hoffman D
Year: 2021
Journal: Immunity
Title: A non-classical monocyte-derived macrophage subset provides a splenic replication niche for intracellular Salmonella.
Volume: 54
Issue: 12
Pages: 2712-2723.e6
Strain
Attribute String: transgenic, mutant strain, coisogenic
Strain
Attribute String: congenic, mutant strain, transgenic
Strain
Attribute String: coisogenic, mutant strain, transgenic
Strain
Attribute String: congenic, mutant strain, transgenic
Publication    
First Author: Fast EM
Year: 2021
Journal: Elife
Title: External signals regulate continuous transcriptional states in hematopoietic stem cells.
Volume: 10
Publication
First Author: Sandu I
Year: 2020
Journal: Cell Rep
Title: Landscape of Exhausted Virus-Specific CD8 T Cells in Chronic LCMV Infection.
Volume: 32
Issue: 8
Pages: 108078
Publication
First Author: Finnigan JP
Year: 2024
Journal: Nat Commun
Title: Structural basis for self-discrimination by neoantigen-specific TCRs.
Volume: 15
Issue: 1
Pages: 2140
Publication  
First Author: Khorki ME
Year: 2023
Journal: Front Immunol
Title: Prior viral infection primes cross-reactive CD8+ T cells that respond to mouse heart allografts.
Volume: 14
Pages: 1287546
Publication  
First Author: Zhong MC
Year: 2021
Journal: J Exp Med
Title: SLAM family receptors control pro-survival effectors in germinal center B cells to promote humoral immunity.
Volume: 218
Issue: 3
Publication
First Author: Phong BL
Year: 2015
Journal: J Exp Med
Title: Tim-3 enhances FcεRI-proximal signaling to modulate mast cell activation.
Volume: 212
Issue: 13
Pages: 2289-304
Publication
First Author: Quintana JF
Year: 2023
Journal: PLoS Biol
Title: The murine meninges acquire lymphoid tissue properties and harbour autoreactive B cells during chronic Trypanosoma brucei infection.
Volume: 21
Issue: 11
Pages: e3002389
Publication  
First Author: Arkatkar T
Year: 2023
Journal: J Clin Invest
Title: Memory T cells possess an innate-like function in local protection from mucosal infection.
Volume: 133
Issue: 10
Publication
First Author: Copland A
Year: 2024
Journal: EMBO Mol Med
Title: Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity.
Volume: 16
Issue: 12
Pages: 3057-3088
Genotype
Symbol: Tg(Nr4a1-EGFP/cre)820Khog/?
Background: C57BL/6-Tg(Nr4a1-EGFP/cre)820Khog
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Cd4-BCL2*G101A*D102A*D103A)AWnt/? Tg(Nr4a1-EGFP/cre)820Khog/?
Background: involves: C57BL/6 * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Genotype
Symbol: Tg(LCKprBCL2)36Sjk/? Tg(Nr4a1-EGFP/cre)820Khog/?
Background: involves: C57BL/6 * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Bettini ML
Year: 2014
Journal: J Immunol
Title: Membrane association of the CD3ε signaling domain is required for optimal T cell development and function.
Volume: 193
Issue: 1
Pages: 258-67
Publication
First Author: St Leger AJ
Year: 2017
Journal: Immunity
Title: An Ocular Commensal Protects against Corneal Infection by Driving an Interleukin-17 Response from Mucosal γδ T Cells.
Volume: 47
Issue: 1
Pages: 148-158.e5
Publication
First Author: Luther N
Year: 2016
Journal: Circ Res
Title: Innate Effector-Memory T-Cell Activation Regulates Post-Thrombotic Vein Wall Inflammation and Thrombus Resolution.
Volume: 119
Issue: 12
Pages: 1286-1295
Publication
First Author: Vieth JA
Year: 2017
Journal: Nat Immunol
Title: TCRα-TCRβ pairing controls recognition of CD1d and directs the development of adipose NKT cells.
Volume: 18
Issue: 1
Pages: 36-44
Publication    
First Author: Marçais A
Year: 2017
Journal: Elife
Title: High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors.
Volume: 6
Publication
First Author: Bettini ML
Year: 2017
Journal: J Immunol
Title: Cutting Edge: CD3 ITAM Diversity Is Required for Optimal TCR Signaling and Thymocyte Development.
Volume: 199
Issue: 5
Pages: 1555-1560
Publication
First Author: Spence A
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Revealing the specificity of regulatory T cells in murine autoimmune diabetes.
Volume: 115
Issue: 20
Pages: 5265-5270
Publication
First Author: Sasaki K
Year: 2014
Journal: J Immunol
Title: Relapsing-remitting central nervous system autoimmunity mediated by GFAP-specific CD8 T cells.
Volume: 192
Issue: 7
Pages: 3029-42