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Search results 501 to 600 out of 2075 for Numb

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Hits by Strain

Type Details Score
Publication
21613258 | J:174870
First Author: de Andrés-Aguayo L
Year: 2011
Journal: Blood
Title: Musashi 2 is a regulator of the HSC compartment identified by a retroviral insertion screen and knockout mice.
Volume: 118
Issue: 3
Pages: 554-64
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Publication
20616797 | J:163322
First Author: Kharas MG
Year: 2010
Journal: Nat Med
Title: Musashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia.
Volume: 16
Issue: 8
Pages: 903-8
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Protein
Q6PEM6
Organism: Mus musculus/domesticus
Length: 445  
Fragment?: false
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Protein
Q8VCC6
Organism: Mus musculus/domesticus
Length: 481  
Fragment?: false
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Protein
Q3V3G7
Organism: Mus musculus/domesticus
Length: 320  
Fragment?: false
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Protein
E0CZH2
Organism: Mus musculus/domesticus
Length: 157  
Fragment?: false
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Protein
F7BJ98
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: true
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Protein
A4FUT6
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Protein
Q9D318
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: false
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Protein
Q8CAP5
Organism: Mus musculus/domesticus
Length: 334  
Fragment?: false
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Protein
Q5RJB9
Organism: Mus musculus/domesticus
Length: 194  
Fragment?: true
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Protein
D3YWU9
Organism: Mus musculus/domesticus
Length: 199  
Fragment?: true
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Protein
A0A087WPB6
Organism: Mus musculus/domesticus
Length: 224  
Fragment?: true
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Protein
A0A286YCN4
Organism: Mus musculus/domesticus
Length: 177  
Fragment?: true
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Protein
S4R1K4
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
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Protein
E0CYY2
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: false
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Protein
Q3TTJ8
Organism: Mus musculus/domesticus
Length: 323  
Fragment?: false
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Protein
F6X8K3
Organism: Mus musculus/domesticus
Length: 60  
Fragment?: true
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Protein
E0CZ84
Organism: Mus musculus/domesticus
Length: 113  
Fragment?: true
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Protein
A0A5F8MQ15
Organism: Mus musculus/domesticus
Length: 133  
Fragment?: true
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Protein
A0A571BF92
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: false
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Protein
A0A286YDC8
Organism: Mus musculus/domesticus
Length: 419  
Fragment?: true
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Protein
D3Z1T6
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: true
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Protein
A0A087WRK8
Organism: Mus musculus/domesticus
Length: 161  
Fragment?: true
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Protein
D3YVC0
Organism: Mus musculus/domesticus
Length: 245  
Fragment?: true
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Protein
A2ATH4
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein
Q3TAP6
Organism: Mus musculus/domesticus
Length: 412  
Fragment?: true
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Protein
S4R2M2
Organism: Mus musculus/domesticus
Length: 37  
Fragment?: true
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Protein
Q9D2W5
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Protein Domain
IPR034126 | MSI_RRM2
Type: Domain
Description: This entry represents the RNA recognition motif 2 (RRM2) of Musashi-1, which is a highly conserved RNA binding protein that was initially identified in Drosophila by its ability to regulate sensory organ development and asymmetric cell division []. Mammalian Musashi-1 has multiple functions in normal and abnormal processes by mediating different post-transcriptional processes. It has been implicated in the maintenance of the stem-cell state, differentiation, and tumorigenesis. It translationally regulates the expression of a mammalian numb gene by binding to the 3'-untranslated region of mRNA of Numb, encoding a membrane-associated inhibitor of Notch signaling, and further influences neural development []. Moreover, Musashi-1 represses translation by interacting with the poly(A)-binding protein and competes for binding of the eukaryotic initiation factor-4G (eIF-4G) [].Proteins containing this domain also includes Musashi-2, which has been identified as a regulator of the hematopoietic stem cell (HSC) compartment and of leukemic stem cells after transplantation of cells with loss and gain of function of the gene []. It influences proliferation and differentiation of HSCs and myeloid progenitors, and further modulates normal hematopoiesis and promotes aggressive myeloid leukemia [, ]. Musashi-1 and Musashi-2 contain two conserved N-terminal tandem RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), along with other domains of unknown function
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Protein Domain
IPR034130 | MSI_RRM1
Type: Domain
Description: This entry represents the RNA recognition motif 1 (RRM1) of Musashi-1, which is a highly conserved RNA binding protein that was initially identified in Drosophila by its ability toregulate sensory organ development and asymmetric cell division []. Mammalian Musashi-1 has multiple functions in normal and abnormal processes by mediating different post-transcriptional processes. It has been implicated in the maintenance of the stem-cell state, differentiation, and tumorigenesis. It translationally regulates the expression of a mammalian numb gene by binding to the 3'-untranslated region of mRNA of Numb, encoding a membrane-associated inhibitor of Notch signaling, and further influences neural development []. Moreover, Musashi-1 represses translation by interacting with the poly(A)-binding protein and competes for binding of the eukaryotic initiation factor-4G (eIF-4G) [].Proteins containing this domain also includes Musashi-2, which has been identified as a regulator of the hematopoietic stem cell (HSC) compartment and of leukemic stem cells after transplantation of cells with loss and gain of function of the gene []. It influences proliferation and differentiation of HSCs and myeloid progenitors, and further modulates normal hematopoiesis and promotes aggressive myeloid leukemia [, ]. Musashi-1 and Musashi-2 contain two conserved N-terminal tandem RNA recognition motifs (RRMs), also termed RBDs (RNA binding domains) or RNPs (ribonucleoprotein domains), along with other domains of unknown function.
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Protein
Q9CZQ9
Organism: Mus musculus/domesticus
Length: 341  
Fragment?: false
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Protein
Q8CB44
Organism: Mus musculus/domesticus
Length: 633  
Fragment?: false
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Protein
Q3V0Y1
Organism: Mus musculus/domesticus
Length: 813  
Fragment?: false
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Protein
Q91YD3
Organism: Mus musculus/domesticus
Length: 602  
Fragment?: false
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Protein
Q3U564
Organism: Mus musculus/domesticus
Length: 578  
Fragment?: false
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Protein
Q8R570
Organism: Mus musculus/domesticus
Length: 413  
Fragment?: false
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Protein
Q5U4C7
Organism: Mus musculus/domesticus
Length: 681  
Fragment?: true
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Protein
E9Q481
Organism: Mus musculus/domesticus
Length: 833  
Fragment?: false
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Protein
B9EIX0
Organism: Mus musculus/domesticus
Length: 578  
Fragment?: false
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Protein
B2RX57
Organism: Mus musculus/domesticus
Length: 801  
Fragment?: false
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Protein
F7AVU1
Organism: Mus musculus/domesticus
Length: 389  
Fragment?: false
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Protein
Q3TM53
Organism: Mus musculus/domesticus
Length: 333  
Fragment?: true
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Protein
D3YUE7
Organism: Mus musculus/domesticus
Length: 627  
Fragment?: false
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Protein
A2AR15
Organism: Mus musculus/domesticus
Length: 306  
Fragment?: true
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Protein
A0A2I3BRA2
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
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Protein
A0A571BDK9
Organism: Mus musculus/domesticus
Length: 564  
Fragment?: false
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Protein
A2ADI4
Organism: Mus musculus/domesticus
Length: 785  
Fragment?: false
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Protein
I7HFU4
Organism: Mus musculus/domesticus
Length: 183  
Fragment?: true
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Protein
E9PZ95
Organism: Mus musculus/domesticus
Length: 52  
Fragment?: true
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Protein
B2FDF6
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Protein
A0A0U1RQ60
Organism: Mus musculus/domesticus
Length: 190  
Fragment?: false
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Protein
J3QMH1
Organism: Mus musculus/domesticus
Length: 92  
Fragment?: true
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Protein
I7HPB1
Organism: Mus musculus/domesticus
Length: 181  
Fragment?: true
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Protein
A0A2I3BPR2
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Protein
D3YWI5
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
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Protein
E9Q4H6
Organism: Mus musculus/domesticus
Length: 57  
Fragment?: true
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Protein
Q3TQ81
Organism: Mus musculus/domesticus
Length: 254  
Fragment?: true
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Protein
Q3THY1
Organism: Mus musculus/domesticus
Length: 225  
Fragment?: false
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Publication
10078529 | -
First Author: Vetter IR
Year: 1999
Journal: Nature
Title: Structure of a Ran-binding domain complexed with Ran bound to a GTP analogue: implications for nuclear transport.
Volume: 398
Issue: 6722
Pages: 39-46
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Publication
12694559 | -
First Author: Lemmon MA
Year: 2003
Journal: Traffic
Title: Phosphoinositide recognition domains.
Volume: 4
Issue: 4
Pages: 201-13
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Publication
15710406 | -
First Author: Harmer NJ
Year: 2005
Journal: FEBS Lett
Title: 1.15 A crystal structure of the X. tropicalis Spred1 EVH1 domain suggests a fourth distinct peptide-binding mechanism within the EVH1 family.
Volume: 579
Issue: 5
Pages: 1161-6
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Protein
Q8CI52
Organism: Mus musculus/domesticus
Length: 662  
Fragment?: false
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Protein
Q8C142
Organism: Mus musculus/domesticus
Length: 308  
Fragment?: false
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Protein
Q8VEF1
Organism: Mus musculus/domesticus
Length: 722  
Fragment?: false
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Protein
Q80TI0
Organism: Mus musculus/domesticus
Length: 738  
Fragment?: false
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Protein
Q9CT10
Organism: Mus musculus/domesticus
Length: 491  
Fragment?: false
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Protein
P34022
Organism: Mus musculus/domesticus
Length: 203  
Fragment?: false
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Protein
Q8K2A1
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: false
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Protein
Q9D3A8
Organism: Mus musculus/domesticus
Length: 503  
Fragment?: false
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Protein
Q03173
Organism: Mus musculus/domesticus
Length: 802  
Fragment?: false
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Protein
P97318
Organism: Mus musculus/domesticus
Length: 588  
Fragment?: false
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Protein
P98078
Organism: Mus musculus/domesticus
Length: 766  
Fragment?: false
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Protein
Q8BKH7
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Protein
Q6PDH4
Organism: Mus musculus/domesticus
Length: 491  
Fragment?: false
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Protein
Q80VP0
Organism: Mus musculus/domesticus
Length: 1166  
Fragment?: false
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Protein
Q9CR95
Organism: Mus musculus/domesticus
Length: 275  
Fragment?: false
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Protein
Q9D1J1
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
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Protein
Q9DCE6
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: false
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Protein
Q3TRB6
Organism: Mus musculus/domesticus
Length: 271  
Fragment?: false
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Protein
Q3TRE6
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
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Protein
Q0PNF0
Organism: Mus musculus/domesticus
Length: 304  
Fragment?: false
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Protein
E0CZ53
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
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Protein
Q3TN55
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
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Protein
A0A2I3BQU7
Organism: Mus musculus/domesticus
Length: 354  
Fragment?: true
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Protein
A0A0A6YXC8
Organism: Mus musculus/domesticus
Length: 524  
Fragment?: false
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Protein
F6VRL0
Organism: Mus musculus/domesticus
Length: 214  
Fragment?: true
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Protein
A0A140LHR9
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
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Protein
E9QL31
Organism: Mus musculus/domesticus
Length: 745  
Fragment?: false
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Protein
A0A1L1SQ42
Organism: Mus musculus/domesticus
Length: 734  
Fragment?: false
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Protein
H7BX22
Organism: Mus musculus/domesticus
Length: 153  
Fragment?: false
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Protein
Q3TMQ2
Organism: Mus musculus/domesticus
Length: 548  
Fragment?: false
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Protein
B7ZNH1
Organism: Mus musculus/domesticus
Length: 383  
Fragment?: true
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Protein
A2AWA7
Organism: Mus musculus/domesticus
Length: 455  
Fragment?: true
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Protein
A0A3B2WCL5
Organism: Mus musculus/domesticus
Length: 558  
Fragment?: false
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Protein
E0CXC5
Organism: Mus musculus/domesticus
Length: 299  
Fragment?: false
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Protein
A2AWB0
Organism: Mus musculus/domesticus
Length: 147  
Fragment?: true
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Protein
Q9CUY3
Organism: Mus musculus/domesticus
Length: 59  
Fragment?: true
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Protein
Q8CBR4
Organism: Mus musculus/domesticus
Length: 484  
Fragment?: true
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Protein
D3YWR0
Organism: Mus musculus/domesticus
Length: 761  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom