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Search results 501 to 600 out of 844 for Pam

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Hits by Pathway

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Hits by Strain

Type Details Score
Allele
Cthrc1<em1(cre/ERT2)Rph> | MGI:7712823
Name: collagen triple helix repeat containing 1; endonuclease-mediated mutation 1, Richard P Harvey
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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Allele
Kcnq2<em5Lutzy> | MGI:7714664
Name: potassium voltage-gated channel, subfamily Q, member 2; endonuclease-mediated mutation 5, Cathy Lutz
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7780117 | C57BL/6N-Alas2<em1Mdf>/Mmjax
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7780129 | C57BL/6N-Alas2<em7Mdf>/Mmjax
Attribute String: Not specified
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Strain
MGI:7783543 | B6129S1-Hdac8<em1Lutzy>/Mmjax
Attribute String: mutant stock, endonuclease-mediated mutation
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Genotype
Genotype
Symbol: Arc/Arc
Background: involves: C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gabrg1/Gabrg1
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mmut/Mmut
Background: involves: 129S/SvEv * C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Slc17a8/Slc17a8
Background: involves: C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Atxn1/Atxn1<+>
Background: B6(129S7)-Atxn1
Zygosity: ht
Has Mutant Allele: true
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Publication
20156452 | -
First Author: Sampathkumar P
Year: 2010
Journal: J Mol Biol
Title: Structures of PHR domains from Mus musculus Phr1 (Mycbp2) explain the loss-of-function mutation (Gly1092-->Glu) of the C. elegans ortholog RPM-1.
Volume: 397
Issue: 4
Pages: 883-92
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Protein
Q0P614
Organism: Mus musculus/domesticus
Length: 74  
Fragment?: false
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Protein
Q6IS59
Organism: Mus musculus/domesticus
Length: 209  
Fragment?: true
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Protein
Q91YK4
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: true
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Publication
12878161 | J:180485
First Author: Xu L
Year: 2003
Journal: Exp Cell Res
Title: BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta.
Volume: 288
Issue: 1
Pages: 84-93
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Publication
36768419 | J:336281
 
First Author: Loers G
Year: 2023
Journal: Int J Mol Sci
Title: The Interactions of the 70 kDa Fragment of Cell Adhesion Molecule L1 with Topoisomerase 1, Peroxisome Proliferator-Activated Receptor γ and NADH Dehydrogenase (Ubiquinone) Flavoprotein 2 Are Involved in Gene Expression and Neuronal L1-Dependent Functions.
Volume: 24
Issue: 3
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Strain
MGI:6334651 | C57BL/6N-Polr3a<em1Tcp>/1
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6334662 | C57BL/6N-Polr3a<em1Tcp>/2
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Cdkn2a<em2Cjs> | MGI:6113939
Name: cyclin dependent kinase inhibitor 2A; endonuclease-mediated mutation 2, Charles J Sherr
Allele Type: Endonuclease-mediated
Attribute String: Modified isoform(s)
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Strain
MGI:6866455 | C57BL/6NCrl-Hsd17b4<em1(IMPC)Tcp>/TcpMmucd
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6260772 | C57BL/6NCrl-Hsd17b4<em1(IMPC)Tcp>/Tcp
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6334816 | C57BL/6N-Hsd17b4<em1(IMPC)Tcp>
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:6384880 | B6(Cg)-Tnni3k<em1Hsv>/J
Attribute String: mutant strain, endonuclease-mediated mutation
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Strain
MGI:6501718 | B6.Cg-Atxn1<em2Hzo>/J
Attribute String: mutant strain, endonuclease-mediated mutation, congenic
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Allele
Gt(ROSA)26Sor<em4(CAG-ZsGreen1)Jahe> | MGI:6864088
Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 4, Jason Heaney
Allele Type: Endonuclease-mediated
Attribute String: Reporter
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Strain
MGI:7316638 | C57BL/6J-Fxn<em10Lutzy>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
35038030 | J:326677
First Author: Medina-Carbonero M
Year: 2022
Journal: Cell Mol Life Sci
Title: Mice harboring the FXN I151F pathological point mutation present decreased frataxin levels, a Friedreich ataxia-like phenotype, and mitochondrial alterations.
Volume: 79
Issue: 2
Pages: 74
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Publication
39243573 | J:359342
 
First Author: Sanz-Alcázar A
Year: 2024
Journal: Redox Biol
Title: Deciphering the ferroptosis pathways in dorsal root ganglia of Friedreich ataxia models. The role of LKB1/AMPK, KEAP1, and GSK3β in the impairment of the NRF2 response.
Volume: 76
Pages: 103339
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Strain
MGI:7505616 | B6.Cg-Flrt2<em1Jnk>/J
Attribute String: congenic, endonuclease-mediated mutation, mutant strain
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Allele
Kcnn3<em1Lutzy> | MGI:7526139
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; endonuclease-mediated mutation 1, Cathy Lutz
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, Humanized sequence, Null/knockout
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Allele
Kcnn3<em1.1Lutzy> | MGI:7526160
Name: potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3; endonuclease-mediated mutation 1.1, Cathy Lutz
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Strain
MGI:7607379 | C57BL/6NCrl-Hapln1<em2Mbp>/Mmucd
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Gt(ROSA)26Sor<em1(CAG-cas12a*)Sidi> | MGI:7662591
Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Sidi Chen
Allele Type: Endonuclease-mediated
Attribute String: Inserted expressed sequence
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Allele
Gt(ROSA)26Sor<em1.1(CAG-cas12a*)Sidi> | MGI:7662592
Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1.1, Sidi Chen
Allele Type: Endonuclease-mediated
Attribute String: Endonuclease
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Strain
MGI:7712825 | C57BL/6J-Cthrc1<em1(cre/ERT2)Rph>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
38857329 | J:353336
First Author: Janbandhu V
Year: 2024
Journal: Circulation
Title: Novel Mouse Model for Selective Tagging, Purification, and Manipulation of Cardiac Myofibroblasts.
Volume: 149
Issue: 24
Pages: 1931-1934
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Allele
Kcnq2<em4Lutzy> | MGI:7714662
Name: potassium voltage-gated channel, subfamily Q, member 2; endonuclease-mediated mutation 4, Cathy Lutz
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Publication
38954486 | J:361327
 
First Author: Heruye SH
Year: 2024
Journal: J Clin Invest
Title: Inflammation primes the murine kidney for recovery by activating AZIN1 adenosine-to-inosine editing.
Volume: 134
Issue: 17
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Genotype
Genotype
Symbol: Mrtfb/Mrtfb<+> Myh7/Myh7<+>
Background: involves: C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sar1b/Sar1b
Background: C57BL/6N-Sar1b
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sar1b/Sar1b<+>
Background: C57BL/6N-Sar1b
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sar1b/Sar1b
Background: involves: 129 * C57BL/6N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hsd17b4/Hsd17b4<+>
Background: C57BL/6NCrl-Hsd17b4/Tcp
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hsd17b4/Hsd17b4
Background: C57BL/6NCrl-Hsd17b4/Tcp
Zygosity: hm
Has Mutant Allele: true
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Publication
8288234 | J:15566
First Author: Ouafik LH
Year: 1993
Journal: Genomics
Title: Localization of the gene encoding peptidylglycine alpha-amidating monooxygenase (PAM) to human chromosome 5q14-5q21.
Volume: 18
Issue: 2
Pages: 319-21
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Publication
22745249 | -
First Author: Jinek M
Year: 2012
Journal: Science
Title: A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity.
Volume: 337
Issue: 6096
Pages: 816-21
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Publication
23563642 | -
First Author: Chylinski K
Year: 2013
Journal: RNA Biol
Title: The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems.
Volume: 10
Issue: 5
Pages: 726-37
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Protein Domain
IPR028629 | Cas9
Type: Family
Description: CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA) to guide the silencing of invading nucleic acids. In type II CRISPR systems, correct processing of pre-crRNA requires a trans-encoded small RNA (tracrRNA), endogenous ribonuclease 3 (rnc) and this protein, Cas9 (Csn1) []. The tracrRNA serves as a guide for ribonuclease 3-aided processing of pre-crRNA. Subsequently Cas9/crRNA/tracrRNA endonucleolytically cleaves linear or circular dsDNA target complementary to the spacer []. Cas9 probably recognises a short motif in the CRISPR repeat sequences (the PAM or protospacer adjacent motif) to help distinguish self versus nonself.
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Protein Domain
IPR038648 | PHR_sf
Type: Homologous_superfamily
Description: This domain is called PHR as it was originally found in the E3 ubiquitin-protein ligase proteins PAM (), highwire () and RPM-1 () [].PHR proteins are conserved, large multi-domain E3 ubiquitin ligases with modular architecture. PHR proteins presynaptically control synaptic growth and axon guidance and postsynaptically regulate endocytosis of glutamate receptors. Dysfunction of neuronal ubiquitin-mediated proteasomal degradation is implicated in various neurodegenerative diseases. PHR proteins are characterised by the presence of two PHR domains near the N terminus, which are essential for proper localisation and function. The domain has a β-sandwich fold composed of 11 anti-parallel β-strands [].The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils [].
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Protein Domain
IPR012983 | PHR
Type: Domain
Description: This domain is called PHR as it was originally found in the E3 ubiquitin-protein ligase proteins PAM (), highwire () and RPM-1 () [].PHR proteins are conserved, large multi-domain E3 ubiquitin ligases with modular architecture. PHR proteins presynaptically control synaptic growth and axon guidance and postsynaptically regulate endocytosis of glutamate receptors. Dysfunction of neuronal ubiquitin-mediated proteasomal degradation is implicated in various neurodegenerative diseases. PHR proteins are characterised by the presence of two PHR domains near the N terminus, which are essential for proper localisation and function. The domain has a β-sandwich fold composed of 11 anti-parallel β-strands [].The C-terminal region of the protein BTBD1 includes the PHR domain and is known to interact with Topoisomerase I, an enzyme which relaxes DNA supercoils [].
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Protein
O35857
Organism: Mus musculus/domesticus
Length: 452  
Fragment?: false
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Protein
Q8R3X4
Organism: Mus musculus/domesticus
Length: 450  
Fragment?: true
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Publication
33964306 | J:319817
 
First Author: Auclair N
Year: 2021
Journal: J Lipid Res
Title: Sar1b mutant mice recapitulate gastrointestinal abnormalities associated with chylomicron retention disease.
Volume: 62
Pages: 100085
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Publication
31147515 | J:277399
First Author: Gifford CA
Year: 2019
Journal: Science
Title: Oligogenic inheritance of a human heart disease involving a genetic modifier.
Volume: 364
Issue: 6443
Pages: 865-870
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Publication
33132203 | J:296318
 
First Author: Hawkins NA
Year: 2021
Journal: Neurobiol Dis
Title: Epilepsy and neurobehavioral abnormalities in mice with a dominant-negative KCNB1 pathogenic variant.
Volume: 147
Pages: 105141
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Strain
MGI:6114770 | C57BL/6-Cdkn2a<em2Cjs>
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:6194256 | C57BL/6-Cdkn2a<em2Cjs>/J
Attribute String: mutant strain, endonuclease-mediated mutation, coisogenic
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Strain
MGI:7616381 | B6.Cg-Gt(ROSA)26Sor<em4(CAG-ZsGreen1)Jahe>/Mmjax
Attribute String: congenic, mutant strain, endonuclease-mediated mutation
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Publication
32986867 | J:308569
First Author: Kleene R
Year: 2021
Journal: J Neurochem
Title: Revisiting the proteolytic processing of cell adhesion molecule L1.
Volume: 157
Issue: 4
Pages: 1102-1117
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Publication
37558128 | J:341219
First Author: Auclair N
Year: 2023
Journal: J Lipid Res
Title: High-fat diet reveals the impact of Sar1b defects on lipid and lipoprotein profile and cholesterol metabolism.
Volume: 64
Issue: 9
Pages: 100423
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Strain
MGI:7366911 | STOCK Dmrt1<em1Zark>/J
Attribute String: endonuclease-mediated mutation, mutant stock
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Publication
34901307 | J:332892
 
First Author: Schneller JL
Year: 2021
Journal: Mol Ther Methods Clin Dev
Title: In vivo genome editing at the albumin locus to treat methylmalonic acidemia.
Volume: 23
Pages: 619-632
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Strain
MGI:7526141 | C57BL/6J-Kcnn3<em1Lutzy>/Mmjax
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7526161 | B6J(CBA)-Kcnn3<em1.1Lutzy>/Mmjax
Attribute String: endonuclease-mediated mutation, mutant strain
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Strain
MGI:7662595 | C57BL/6-Gt(ROSA)26Sor<em1(CAG-cas12a*)Sidi>/J
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7662596 | B6(C)-Gt(ROSA)26Sor<em1.1(CAG-cas12a*)Sidi>/J
Attribute String: endonuclease-mediated mutation, mutant strain
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Strain
MGI:7714663 | C57BL/6J-Kcnq2<em4Lutzy>/Mmjax
Attribute String: endonuclease-mediated mutation, mutant strain, coisogenic
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Strain
MGI:7714665 | C57BL/6J-Kcnq2<em5Lutzy>/Mmjax
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Cdkn2a/Cdkn2a
Background: C57BL/6-Cdkn2a
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mrtfb/Mrtfb<+> Myh7/Myh7<+> Nkx2-5/Nkx2-5<+>
Background: involves: C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Dmrt1/Dmrt1<+>
Background: involves: 129 * C57BL/6J * FVB/NJ
Zygosity: ht
Has Mutant Allele: true
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Protein Coding Gene
MGP_CAROLIEiJ_G0020403 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0022466 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0022428 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0022405 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0022433 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0022200 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_1913699 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0022882 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0021726 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0022169 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0022300 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0022275 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0022368 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0022297 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0022894 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0021466 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0021775 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016111 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0021297 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
20719856 | J:165671
First Author: Tagliati F
Year: 2010
Journal: Endocrinology
Title: Magmas, a gene newly identified as overexpressed in human and mouse ACTH-secreting pituitary adenomas, protects pituitary cells from apoptotic stimuli.
Volume: 151
Issue: 10
Pages: 4635-42
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GXD Expression
GXD Expression
   
Probe: MGI:5691695
Assay Type: Immunohistochemistry
Annotation Date: 2015-10-16
Strength: Trace
Sex: Not Specified
Emaps: EMAPS:1876728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5691702
Age: postnatal adult
Specimen Label: not shown
Detected: true
Specimen Num: 27
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GXD Expression
GXD Expression
     
Probe: MGI:5691695
Assay Type: Immunohistochemistry
Annotation Date: 2015-10-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1737322
Stage: TS22
Assay Id: MGI:5691702
Age: embryonic day 14.5
Specimen Label: Table - 14.5d
Detected: false
Specimen Num: 4
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GXD Expression
GXD Expression
   
Probe: MGI:5691695
Assay Type: Immunohistochemistry
Annotation Date: 2015-10-16
Strength: Weak
Sex: Not Specified
Emaps: EMAPS:1737323
Pattern: Not Specified
Stage: TS23
Assay Id: MGI:5691702
Age: embryonic day 15.5
Specimen Label: Table - 15.5d
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
   
Probe: MGI:5691695
Assay Type: Immunohistochemistry
Annotation Date: 2015-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1737326
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:5691702
Age: embryonic day 18.0
Specimen Label: Table - 18d
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
   
Probe: MGI:5691695
Assay Type: Immunohistochemistry
Annotation Date: 2015-10-16
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:3266228
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5691702
Age: postnatal adult
Specimen Label: 4E
Detected: true
Specimen Num: 26
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GXD Expression
GXD Expression
   
Probe: MGI:5691695
Assay Type: Immunohistochemistry
Annotation Date: 2015-10-16
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2828128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5691702
Age: postnatal adult
Specimen Label: 3D
Detected: true
Specimen Num: 19
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GXD Expression
GXD Expression
   
Probe: MGI:5691695
Assay Type: Immunohistochemistry
Annotation Date: 2015-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:2828128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5691702
Age: postnatal adult
Specimen Label: 3E
Detected: true
Specimen Num: 20
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•
•
•
•
GXD Expression
GXD Expression
     
Probe: MGI:5691695
Assay Type: Immunohistochemistry
Annotation Date: 2015-10-16
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:3555728
Stage: TS28
Assay Id: MGI:5691702
Age: postnatal adult
Specimen Label: 3D
Detected: false
Specimen Num: 19
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•
•
•
•
GXD Expression
GXD Expression
   
Probe: MGI:5691695
Assay Type: Immunohistochemistry
Annotation Date: 2015-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160699
Pattern: Not Specified
Stage: TS09
Assay Id: MGI:5691702
Age: embryonic day 6.5
Specimen Label: Table - 6.5d
Detected: true
Specimen Num: 1
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•
•
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