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Search results 501 to 596 out of 596 for Pcsk9

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Type Details Score
Publication      
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
Publication      
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
Publication      
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
Publication        
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Publication
First Author: Frank-Kamenetsky M
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates.
Volume: 105
Issue: 33
Pages: 11915-20
Publication
First Author: Luo Y
Year: 2009
Journal: J Lipid Res
Title: Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice.
Volume: 50
Issue: 8
Pages: 1581-8
Publication
First Author: Carreras A
Year: 2019
Journal: BMC Biol
Title: In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model.
Volume: 17
Issue: 1
Pages: 4
Publication
First Author: Liu X
Year: 2020
Journal: Nature
Title: Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer.
Volume: 588
Issue: 7839
Pages: 693-698
Publication
First Author: Fan D
Year: 2008
Journal: Biochemistry
Title: Self-association of human PCSK9 correlates with its LDLR-degrading activity.
Volume: 47
Issue: 6
Pages: 1631-9
Publication      
First Author: Rogers MA
Year: 2021
Journal: Cardiovasc Res
Title: Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion.
Publication
First Author: Qian YW
Year: 2007
Journal: J Lipid Res
Title: Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis.
Volume: 48
Issue: 7
Pages: 1488-98
Publication  
First Author: Xu X
Year: 2021
Journal: Metabolism
Title: MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice.
Volume: 119
Pages: 154768
Publication
First Author: Ason B
Year: 2014
Journal: J Lipid Res
Title: PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE.
Volume: 55
Issue: 11
Pages: 2370-9
Publication
First Author: Herbert B
Year: 2010
Journal: Arterioscler Thromb Vasc Biol
Title: Increased secretion of lipoproteins in transgenic mice expressing human D374Y PCSK9 under physiological genetic control.
Volume: 30
Issue: 7
Pages: 1333-9
Publication
First Author: Luan C
Year: 2023
Journal: J Biol Chem
Title: PCSK9 inhibition interrupts the cross-talk between keratinocytes and macrophages and prevents UVB-induced skin damage.
Volume: 299
Issue: 7
Pages: 104895
Publication
First Author: Hampton EN
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain.
Volume: 104
Issue: 37
Pages: 14604-9
Publication
First Author: Schroeder CI
Year: 2014
Journal: Chem Biol
Title: Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro.
Volume: 21
Issue: 2
Pages: 284-94
Publication  
First Author: Goettsch C
Year: 2016
Journal: Atherosclerosis
Title: A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification.
Volume: 251
Pages: 109-118
Publication
First Author: Guo WJ
Year: 2021
Journal: Reproduction
Title: Contribution of high-fat diet-induced PCSK9 upregulation to a mouse model of PCOS is mediated partly by SREBP2.
Volume: 162
Issue: 6
Pages: 397-410
Publication
First Author: Qi Z
Year: 2021
Journal: Circulation
Title: PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Enhances Platelet Activation, Thrombosis, and Myocardial Infarct Expansion by Binding to Platelet CD36.
Volume: 143
Issue: 1
Pages: 45-61
Publication
First Author: Burdick DJ
Year: 2020
Journal: ACS Chem Biol
Title: Design of Organo-Peptides As Bipartite PCSK9 Antagonists.
Volume: 15
Issue: 2
Pages: 425-436
Publication
First Author: Dixon DL
Year: 2016
Journal: J Clin Lipidol
Title: A review of PCSK9 inhibition and its effects beyond LDL receptors.
Volume: 10
Issue: 5
Pages: 1073-80
GO Term
Allele
Name: proprotein convertase subtilisin/kexin type 9; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence, Inserted expressed sequence
Allele
Name: proprotein convertase subtilisin/kexin type 9; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
Strain
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
Strain
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
Protein Domain
Type: Domain
Description: This entry represents the second subdomain found in the C-terminal cysteine/histidine-rich domain (CRD) of PCSK9 (also known as neural apoptosis-regulated convertase, NARC-1) []. PCSK9 has been shown to regulate circulating LDL-R levels by controlling LDL-R degradation. Furthermore, numerous mutations in the PCSK9 gene have been identified and associated with hypercholesterolemia (gain of function) or hypocholesterolemia (loss of function) []. The fully folded CRD, shows structural similarity to the resistin homotrimer, a small cytokine associated with obesity and diabetes. The C-terminal domain from PCSK9 consists of three, three-stranded β-subdomains arranged in a pseudo threefold, and each of the subdomains in the CRD of PCSK9 consists of three structurally conserved disulfide bonds [].
Protein Domain
Type: Domain
Description: This entry represents the third subdomain found in the C-terminal cysteine/histidine-rich domain (CRD) of PCSK9 (also known as neural apoptosis-regulated convertase, NARC-1) []. PCSK9 has been shown to regulate circulating LDL-R levels by controlling LDL-R degradation. Furthermore, numerous mutations in the PCSK9 gene have been identified and associated with hypercholesterolemia (gain of function) or hypocholesterolemia (loss of function) []. The fully folded CRD, shows structural similarity to the resistin homotrimer, a small cytokine associated with obesity and diabetes. The C-terminal domain from PCSK9 consists of three, three-stranded β-subdomains arranged in a pseudo threefold, and each of the subdomains in the CRD of PCSK9 consists of three structurally conserved disulfide bonds [].
Protein Domain
Type: Domain
Description: This entry represents the first subdomain found in the C-terminal cysteine/histidine-rich domain (CRD) of PCSK9 (also known as neural apoptosis-regulated convertase, NARC-1) []. PCSK9 has been shown to regulate circulating LDL-R levels by controlling LDL-R degradation. Furthermore, numerous mutations in the PCSK9 gene have been identified and associated with hypercholesterolemia (gain of function) or hypocholesterolemia (loss of function) []. The fully folded CRD, shows structural similarity to the resistin homotrimer, a small cytokine associated with obesity and diabetes. The C-terminal domain from PCSK9 consists of three, three-stranded β-subdomains arranged in a pseudo threefold, and each of the subdomains in the CRD of PCSK9 consists of three structurally conserved disulfide bonds [].
Publication
First Author: Zhang Y
Year: 2017
Journal: Nat Struct Mol Biol
Title: Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists.
Volume: 24
Issue: 10
Pages: 848-856
Publication
First Author: Ultsch M
Year: 2019
Journal: J Mol Biol
Title: Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain.
Volume: 431
Issue: 5
Pages: 885-903
Allele
Name: transgene insertion 1, Jay D Horton
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: proprotein convertase subtilisin/kexin type 9; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
Allele
Name: proprotein convertase subtilisin/kexin type 9; targeted mutation 1, Cyagen Biosciences
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
Publication
First Author: Dewpura T
Year: 2008
Journal: FEBS J
Title: PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans.
Volume: 275
Issue: 13
Pages: 3480-93
Allele
Name: transgene insertion, Annik Prat
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 2, Annik Prat
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 3, Annik Prat
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 4, Annik Prat
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Allele
Name: transgene insertion 1, Annik Prat
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Strain
Attribute String: coisogenic, targeted mutation, mutant strain
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
GO Term
Allele
Name: transgene insertion FU119, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
Allele
Name: transgene insertion, Annik Prat
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
Genotype
Symbol: Tg(APOE-PCSK9)1Jdh/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Tg(Apoe-Pcsk9*H229A)#Prat/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
Strain
Attribute String: mutant stock, transgenic
Allele
Name: transgene insertion A, Jeffrey Stock
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
Strain
Attribute String: coisogenic, mutant strain, transgenic
Allele
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Mohammad Bohlooly-Y
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
Genotype
Symbol: Tg(Apoe-Pcsk9)#Prat/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: C57BL/6 * C57BL/6N
Zygosity: ht
Has Mutant Allele: true
HT Experiment  
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
Protein
Organism: Mus musculus/domesticus
Length: 694  
Fragment?: false
Publication  
First Author: Samal B
Year: 1996
Journal: Adv Exp Med Biol
Title: Cloning and expression of the gene encoding a novel proteinase from Tritirachium album limber.
Volume: 379
Pages: 95-104
Publication
First Author: Ebeling W
Year: 1974
Journal: Eur J Biochem
Title: Proteinase K from Tritirachium album Limber.
Volume: 47
Issue: 1
Pages: 91-7
Publication
First Author: Liu SQ
Year: 2011
Journal: J Mol Model
Title: The effect of calciums on molecular motions of proteinase K.
Volume: 17
Issue: 2
Pages: 289-300
Protein Domain
Type: Domain
Description: This domain is found in some members of peptidase family S8 (subtilisins) [], such as PCSK9 (proprotein convertase subtilisin/kexin type 9; MEROPS identifier S08.039), proteinase K (S08.054), proteinase T (S08.061) from the fungus Tritirachium albumLimber [], and other subtilisin-like serine endopeptidases. PCSK9 post-translationally regulates hepatic low-density lipoprotein receptors (LDLRs) by binding to LDLRs on the cell surface, leading to their degradation, and is a target for drugs for hypercholesterolaemia. The binding site of PCSK9 has been localized to the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR []. Characterized proteinases K are secreted endopeptidases that are not substrate-specific and function in a wide variety of species in different pathways. It can hydrolyze keratin and other proteins with subtilisin-like specificity []. The number of calcium-binding motifs found in these differ []. The subtilisin family is one of the largest serine peptidase families characterised to date. Over 200 subtilises are presently known, more than 170 of which with their complete amino acid sequence []. It is widespread, being found in eubacteria, archaebacteria, eukaryotes and viruses []. The vast majority of the family are endopeptidases, although there is an exopeptidase, tripeptidyl peptidase [, ]. Structures have been determined for several members of the subtilisin family: they exploit the same catalytic triad as the chymotrypsins, although the residues occur in a different order (HDS in chymotrypsin and DHS in subtilisin), but the structures show no other similarity [, ]. Some subtilisins are mosaic proteins, while others contain N- and C-terminal extensions that show no sequence similarity to any other known protein [].
Publication
First Author: Emmer BT
Year: 2020
Journal: PLoS One
Title: Murine Surf4 is essential for early embryonic development.
Volume: 15
Issue: 1
Pages: e0227450
Publication
First Author: Stomberski CT
Year: 2022
Journal: Cell Rep
Title: A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis.
Volume: 41
Issue: 4
Pages: 111538
Publication
First Author: Levine JA
Year: 2021
Journal: Sci Rep
Title: Role of PAI-1 in hepatic steatosis and dyslipidemia.
Volume: 11
Issue: 1
Pages: 430
Publication
First Author: Benedicto I
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells.
Volume: 121
Issue: 18
Pages: e2400752121
Publication
First Author: Scotti E
Year: 2011
Journal: Mol Cell Biol
Title: Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists.
Volume: 31
Issue: 9
Pages: 1885-93
Publication
First Author: Yu P
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering.
Volume: 38
Issue: 1
Pages: 26-39
Publication
First Author: Topchiy E
Year: 2016
Journal: PLoS One
Title: Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor.
Volume: 11
Issue: 5
Pages: e0155030
Publication
First Author: HÃ¥versen L
Year: 2018
Journal: Sci Rep
Title: Vimentin deficiency in macrophages induces increased oxidative stress and vascular inflammation but attenuates atherosclerosis in mice.
Volume: 8
Issue: 1
Pages: 16973
Publication
First Author: Jarrett KE
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: Somatic Editing of Ldlr With Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis Research.
Volume: 38
Issue: 9
Pages: 1997-2006
Publication
First Author: Armstrong SM
Year: 2015
Journal: Cardiovasc Res
Title: A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis.
Volume: 108
Issue: 2
Pages: 268-77
Publication
First Author: LeBlond ND
Year: 2020
Journal: J Lipid Res
Title: Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice.
Volume: 61
Issue: 12
Pages: 1697-1706
Publication
First Author: Liu M
Year: 2016
Journal: Biochem Biophys Res Commun
Title: Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice.
Volume: 469
Issue: 3
Pages: 456-62
Publication    
First Author: Tang VT
Year: 2022
Journal: Elife
Title: Hepatic inactivation of murine <i>Surf4</i> results in marked reduction in plasma cholesterol.
Volume: 11
Publication  
First Author: Dong YT
Year: 2023
Journal: Neuroscience
Title: Resveratrol Attenuates the Disruption of Lipid Metabolism Observed in Amyloid Precursor Protein/Presenilin 1 Mouse Brains and Cultured Primary Neurons Exposed to Aβ.
Volume: 521
Pages: 134-147
Publication
First Author: Scotti E
Year: 2013
Journal: Mol Cell Biol
Title: IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor.
Volume: 33
Issue: 8
Pages: 1503-14
Publication
First Author: Cansby E
Year: 2018
Journal: Arterioscler Thromb Vasc Biol
Title: STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia.
Volume: 38
Issue: 8
Pages: 1723-1737
Publication
First Author: Hosseini Z
Year: 2021
Journal: Arterioscler Thromb Vasc Biol
Title: Resolvin D1 Enhances Necroptotic Cell Clearance Through Promoting Macrophage Fatty Acid Oxidation and Oxidative Phosphorylation.
Volume: 41
Issue: 3
Pages: 1062-1075
Publication
First Author: Yang L
Year: 2019
Journal: J Lipid Res
Title: LPA receptor 4 deficiency attenuates experimental atherosclerosis.
Volume: 60
Issue: 5
Pages: 972-980
Publication
First Author: Yntema T
Year: 2025
Journal: Sci Rep
Title: The impact of a humanized bile acid composition on atherosclerosis development in hypercholesterolaemic Cyp2c70 knockout mice.
Volume: 15
Issue: 1
Pages: 2100
Publication
First Author: Silvestro M
Year: 2022
Journal: Arterioscler Thromb Vasc Biol
Title: The Nonproteolytic Intracellular Domain of Membrane-Type 1 Matrix Metalloproteinase Coordinately Modulates Abdominal Aortic Aneurysm and Atherosclerosis in Mice-Brief Report.
Volume: 42
Issue: 10
Pages: 1244-1253
Publication
First Author: Susan-Resiga D
Year: 2017
Journal: J Biol Chem
Title: The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA.
Volume: 292
Issue: 5
Pages: 1573-1590
Publication
First Author: Vozenilek AE
Year: 2018
Journal: J Vasc Res
Title: Absence of Nicotinamide Nucleotide Transhydrogenase in C57BL/6J Mice Exacerbates Experimental Atherosclerosis.
Volume: 55
Issue: 2
Pages: 98-110
Publication  
First Author: Xu YX
Year: 2018
Journal: Atherosclerosis
Title: Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol.
Volume: 268
Pages: 196-206
Publication  
First Author: Cheng X
Year: 2024
Journal: Atherosclerosis
Title: Multifaceted roles of Meg3 in cellular senescence and atherosclerosis.
Volume: 392
Pages: 117506
Publication
First Author: Vos DY
Year: 2023
Journal: Arterioscler Thromb Vasc Biol
Title: Cargo-Specific Role for Retriever Subunit VPS26C in Hepatocyte Lipoprotein Receptor Recycling to Control Postprandial Triglyceride-Rich Lipoproteins.
Volume: 43
Issue: 1
Pages: e29-e45
Publication  
First Author: van der Vorst EPC
Year: 2023
Journal: Front Cardiovasc Med
Title: Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice.
Volume: 10
Pages: 974918
Publication
First Author: Rautureau Y
Year: 2018
Journal: Circulation
Title: ADCY9 (Adenylate Cyclase Type 9) Inactivation Protects From Atherosclerosis Only in the Absence of CETP (Cholesteryl Ester Transfer Protein).
Volume: 138
Issue: 16
Pages: 1677-1692
Publication  
First Author: Davel AP
Year: 2018
Journal: J Am Heart Assoc
Title: Sex-Specific Mechanisms of Resistance Vessel Endothelial Dysfunction Induced by Cardiometabolic Risk Factors.
Volume: 7
Issue: 4
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication
First Author: Siezen RJ
Year: 1997
Journal: Protein Sci
Title: Subtilases: the superfamily of subtilisin-like serine proteases.
Volume: 6
Issue: 3
Pages: 501-23
Publication  
First Author: Rawlings ND
Year: 1994
Journal: Methods Enzymol
Title: Families of serine peptidases.
Volume: 244
Pages: 19-61
Publication  
First Author: Rawlings ND
Year: 1993
Journal: Biochem J
Title: Evolutionary families of peptidases.
Volume: 290 ( Pt 1)
Pages: 205-18
Publication      
First Author: The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY)
Year: 2005
Journal: Database Download
Title: MGI download of GENSAT transgene data