Type |
Details |
Score |
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Frank-Kamenetsky M |
Year: |
2008 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates. |
Volume: |
105 |
Issue: |
33 |
Pages: |
11915-20 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luo Y |
Year: |
2009 |
Journal: |
J Lipid Res |
Title: |
Function and distribution of circulating human PCSK9 expressed extrahepatically in transgenic mice. |
Volume: |
50 |
Issue: |
8 |
Pages: |
1581-8 |
|
•
•
•
•
•
|
Publication |
First Author: |
Carreras A |
Year: |
2019 |
Journal: |
BMC Biol |
Title: |
In vivo genome and base editing of a human PCSK9 knock-in hypercholesterolemic mouse model. |
Volume: |
17 |
Issue: |
1 |
Pages: |
4 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu X |
Year: |
2020 |
Journal: |
Nature |
Title: |
Inhibition of PCSK9 potentiates immune checkpoint therapy for cancer. |
Volume: |
588 |
Issue: |
7839 |
Pages: |
693-698 |
|
•
•
•
•
•
|
Publication |
First Author: |
Fan D |
Year: |
2008 |
Journal: |
Biochemistry |
Title: |
Self-association of human PCSK9 correlates with its LDLR-degrading activity. |
Volume: |
47 |
Issue: |
6 |
Pages: |
1631-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Rogers MA |
Year: |
2021 |
Journal: |
Cardiovasc Res |
Title: |
Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Qian YW |
Year: |
2007 |
Journal: |
J Lipid Res |
Title: |
Secreted PCSK9 downregulates low density lipoprotein receptor through receptor-mediated endocytosis. |
Volume: |
48 |
Issue: |
7 |
Pages: |
1488-98 |
|
•
•
•
•
•
|
Publication |
First Author: |
Xu X |
Year: |
2021 |
Journal: |
Metabolism |
Title: |
MiR-337-3p lowers serum LDL-C level through targeting PCSK9 in hyperlipidemic mice. |
Volume: |
119 |
|
Pages: |
154768 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ason B |
Year: |
2014 |
Journal: |
J Lipid Res |
Title: |
PCSK9 inhibition fails to alter hepatic LDLR, circulating cholesterol, and atherosclerosis in the absence of ApoE. |
Volume: |
55 |
Issue: |
11 |
Pages: |
2370-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Herbert B |
Year: |
2010 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Increased secretion of lipoproteins in transgenic mice expressing human D374Y PCSK9 under physiological genetic control. |
Volume: |
30 |
Issue: |
7 |
Pages: |
1333-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Luan C |
Year: |
2023 |
Journal: |
J Biol Chem |
Title: |
PCSK9 inhibition interrupts the cross-talk between keratinocytes and macrophages and prevents UVB-induced skin damage. |
Volume: |
299 |
Issue: |
7 |
Pages: |
104895 |
|
•
•
•
•
•
|
Publication |
First Author: |
Hampton EN |
Year: |
2007 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
The self-inhibited structure of full-length PCSK9 at 1.9 A reveals structural homology with resistin within the C-terminal domain. |
Volume: |
104 |
Issue: |
37 |
Pages: |
14604-9 |
|
•
•
•
•
•
|
Publication |
First Author: |
Schroeder CI |
Year: |
2014 |
Journal: |
Chem Biol |
Title: |
Design and synthesis of truncated EGF-A peptides that restore LDL-R recycling in the presence of PCSK9 in vitro. |
Volume: |
21 |
Issue: |
2 |
Pages: |
284-94 |
|
•
•
•
•
•
|
Publication |
First Author: |
Goettsch C |
Year: |
2016 |
Journal: |
Atherosclerosis |
Title: |
A single injection of gain-of-function mutant PCSK9 adeno-associated virus vector induces cardiovascular calcification in mice with no genetic modification. |
Volume: |
251 |
|
Pages: |
109-118 |
|
•
•
•
•
•
|
Publication |
First Author: |
Guo WJ |
Year: |
2021 |
Journal: |
Reproduction |
Title: |
Contribution of high-fat diet-induced PCSK9 upregulation to a mouse model of PCOS is mediated partly by SREBP2. |
Volume: |
162 |
Issue: |
6 |
Pages: |
397-410 |
|
•
•
•
•
•
|
Publication |
First Author: |
Qi Z |
Year: |
2021 |
Journal: |
Circulation |
Title: |
PCSK9 (Proprotein Convertase Subtilisin/Kexin 9) Enhances Platelet Activation, Thrombosis, and Myocardial Infarct Expansion by Binding to Platelet CD36. |
Volume: |
143 |
Issue: |
1 |
Pages: |
45-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Burdick DJ |
Year: |
2020 |
Journal: |
ACS Chem Biol |
Title: |
Design of Organo-Peptides As Bipartite PCSK9 Antagonists. |
Volume: |
15 |
Issue: |
2 |
Pages: |
425-436 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dixon DL |
Year: |
2016 |
Journal: |
J Clin Lipidol |
Title: |
A review of PCSK9 inhibition and its effects beyond LDL receptors. |
Volume: |
10 |
Issue: |
5 |
Pages: |
1073-80 |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Allele |
Name: |
proprotein convertase subtilisin/kexin type 9; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
proprotein convertase subtilisin/kexin type 9; endonuclease-mediated mutation 3, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Null/knockout |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, endonuclease-mediated mutation, mutant strain |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the second subdomain found in the C-terminal cysteine/histidine-rich domain (CRD) of PCSK9 (also known as neural apoptosis-regulated convertase, NARC-1) []. PCSK9 has been shown to regulate circulating LDL-R levels by controlling LDL-R degradation. Furthermore, numerous mutations in the PCSK9 gene have been identified and associated with hypercholesterolemia (gain of function) or hypocholesterolemia (loss of function) []. The fully folded CRD, shows structural similarity to the resistin homotrimer, a small cytokine associated with obesity and diabetes. The C-terminal domain from PCSK9 consists of three, three-stranded β-subdomains arranged in a pseudo threefold, and each of the subdomains in the CRD of PCSK9 consists of three structurally conserved disulfide bonds []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the third subdomain found in the C-terminal cysteine/histidine-rich domain (CRD) of PCSK9 (also known as neural apoptosis-regulated convertase, NARC-1) []. PCSK9 has been shown to regulate circulating LDL-R levels by controlling LDL-R degradation. Furthermore, numerous mutations in the PCSK9 gene have been identified and associated with hypercholesterolemia (gain of function) or hypocholesterolemia (loss of function) []. The fully folded CRD, shows structural similarity to the resistin homotrimer, a small cytokine associated with obesity and diabetes. The C-terminal domain from PCSK9 consists of three, three-stranded β-subdomains arranged in a pseudo threefold, and each of the subdomains in the CRD of PCSK9 consists of three structurally conserved disulfide bonds []. |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This entry represents the first subdomain found in the C-terminal cysteine/histidine-rich domain (CRD) of PCSK9 (also known as neural apoptosis-regulated convertase, NARC-1) []. PCSK9 has been shown to regulate circulating LDL-R levels by controlling LDL-R degradation. Furthermore, numerous mutations in the PCSK9 gene have been identified and associated with hypercholesterolemia (gain of function) or hypocholesterolemia (loss of function) []. The fully folded CRD, shows structural similarity to the resistin homotrimer, a small cytokine associated with obesity and diabetes. The C-terminal domain from PCSK9 consists of three, three-stranded β-subdomains arranged in a pseudo threefold, and each of the subdomains in the CRD of PCSK9 consists of three structurally conserved disulfide bonds []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Zhang Y |
Year: |
2017 |
Journal: |
Nat Struct Mol Biol |
Title: |
Discovery of a cryptic peptide-binding site on PCSK9 and design of antagonists. |
Volume: |
24 |
Issue: |
10 |
Pages: |
848-856 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ultsch M |
Year: |
2019 |
Journal: |
J Mol Biol |
Title: |
Identification of a Helical Segment within the Intrinsically Disordered Region of the PCSK9 Prodomain. |
Volume: |
431 |
Issue: |
5 |
Pages: |
885-903 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Jay D Horton |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
proprotein convertase subtilisin/kexin type 9; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Endonuclease-mediated |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Allele |
Name: |
proprotein convertase subtilisin/kexin type 9; targeted mutation 1, Cyagen Biosciences |
Allele Type: |
Targeted |
Attribute String: |
Inserted expressed sequence, Null/knockout |
|
•
•
•
•
•
|
Publication |
First Author: |
Dewpura T |
Year: |
2008 |
Journal: |
FEBS J |
Title: |
PCSK9 is phosphorylated by a Golgi casein kinase-like kinase ex vivo and circulates as a phosphoprotein in humans. |
Volume: |
275 |
Issue: |
13 |
Pages: |
3480-93 |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Annik Prat |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 2, Annik Prat |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 3, Annik Prat |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 4, Annik Prat |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion 1, Annik Prat |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, targeted mutation, mutant strain |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
GO Term |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion FU119, GENSAT Project at Rockefeller University |
Allele Type: |
Transgenic |
Attribute String: |
Reporter |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion, Annik Prat |
Allele Type: |
Transgenic |
Attribute String: |
Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(APOE-PCSK9)1Jdh/? |
Background: |
Not Specified |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Apoe-Pcsk9*H229A)#Prat/? |
Background: |
involves: C3H * C57BL/6 |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Strain |
Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
Allele |
Name: |
transgene insertion A, Jeffrey Stock |
Allele Type: |
Transgenic |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Strain |
Attribute String: |
coisogenic, mutant strain, transgenic |
|
•
•
•
•
•
|
Allele |
Name: |
gene trap ROSA 26, Philippe Soriano; targeted mutation 1.1, Mohammad Bohlooly-Y |
Allele Type: |
Targeted |
Attribute String: |
Humanized sequence, Inserted expressed sequence |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Tg(Apoe-Pcsk9)#Prat/? |
Background: |
involves: C3H * C57BL/6 |
Zygosity: |
ot |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
Genotype |
Symbol: |
Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> |
Background: |
involves: C57BL/6 * C57BL/6N |
Zygosity: |
ht |
Has Mutant Allele: |
true |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
694
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Publication |
First Author: |
Samal B |
Year: |
1996 |
Journal: |
Adv Exp Med Biol |
Title: |
Cloning and expression of the gene encoding a novel proteinase from Tritirachium album limber. |
Volume: |
379 |
|
Pages: |
95-104 |
|
•
•
•
•
•
|
Publication |
First Author: |
Ebeling W |
Year: |
1974 |
Journal: |
Eur J Biochem |
Title: |
Proteinase K from Tritirachium album Limber. |
Volume: |
47 |
Issue: |
1 |
Pages: |
91-7 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu SQ |
Year: |
2011 |
Journal: |
J Mol Model |
Title: |
The effect of calciums on molecular motions of proteinase K. |
Volume: |
17 |
Issue: |
2 |
Pages: |
289-300 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Domain |
Description: |
This domain is found in some members of peptidase family S8 (subtilisins) [], such as PCSK9 (proprotein convertase subtilisin/kexin type 9; MEROPS identifier S08.039), proteinase K (S08.054), proteinase T (S08.061) from the fungus Tritirachium albumLimber [], and other subtilisin-like serine endopeptidases. PCSK9 post-translationally regulates hepatic low-density lipoprotein receptors (LDLRs) by binding to LDLRs on the cell surface, leading to their degradation, and is a target for drugs for hypercholesterolaemia. The binding site of PCSK9 has been localized to the epidermal growth factor-like repeat A (EGF-A) domain of the LDLR []. Characterized proteinases K are secreted endopeptidases that are not substrate-specific and function in a wide variety of species in different pathways. It can hydrolyze keratin and other proteins with subtilisin-like specificity []. The number of calcium-binding motifs found in these differ []. The subtilisin family is one of the largest serine peptidase families characterised to date. Over 200 subtilises are presently known, more than 170 of which with their complete amino acid sequence []. It is widespread, being found in eubacteria, archaebacteria, eukaryotes and viruses []. The vast majority of the family are endopeptidases, although there is an exopeptidase, tripeptidyl peptidase [, ]. Structures have been determined for several members of the subtilisin family: they exploit the same catalytic triad as the chymotrypsins, although the residues occur in a different order (HDS in chymotrypsin and DHS in subtilisin), but the structures show no other similarity [, ]. Some subtilisins are mosaic proteins, while others contain N- and C-terminal extensions that show no sequence similarity to any other known protein []. |
|
•
•
•
•
•
|
Publication |
First Author: |
Emmer BT |
Year: |
2020 |
Journal: |
PLoS One |
Title: |
Murine Surf4 is essential for early embryonic development. |
Volume: |
15 |
Issue: |
1 |
Pages: |
e0227450 |
|
•
•
•
•
•
|
Publication |
First Author: |
Stomberski CT |
Year: |
2022 |
Journal: |
Cell Rep |
Title: |
A multienzyme S-nitrosylation cascade regulates cholesterol homeostasis. |
Volume: |
41 |
Issue: |
4 |
Pages: |
111538 |
|
•
•
•
•
•
|
Publication |
First Author: |
Levine JA |
Year: |
2021 |
Journal: |
Sci Rep |
Title: |
Role of PAI-1 in hepatic steatosis and dyslipidemia. |
Volume: |
11 |
Issue: |
1 |
Pages: |
430 |
|
•
•
•
•
•
|
Publication |
First Author: |
Benedicto I |
Year: |
2024 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells. |
Volume: |
121 |
Issue: |
18 |
Pages: |
e2400752121 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scotti E |
Year: |
2011 |
Journal: |
Mol Cell Biol |
Title: |
Targeted disruption of the idol gene alters cellular regulation of the low-density lipoprotein receptor by sterols and liver x receptor agonists. |
Volume: |
31 |
Issue: |
9 |
Pages: |
1885-93 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu P |
Year: |
2018 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Rosuvastatin Reduces Aortic Sinus and Coronary Artery Atherosclerosis in SR-B1 (Scavenger Receptor Class B Type 1)/ApoE (Apolipoprotein E) Double Knockout Mice Independently of Plasma Cholesterol Lowering. |
Volume: |
38 |
Issue: |
1 |
Pages: |
26-39 |
|
•
•
•
•
•
|
Publication |
First Author: |
Topchiy E |
Year: |
2016 |
Journal: |
PLoS One |
Title: |
Lipopolysaccharide Is Cleared from the Circulation by Hepatocytes via the Low Density Lipoprotein Receptor. |
Volume: |
11 |
Issue: |
5 |
Pages: |
e0155030 |
|
•
•
•
•
•
|
Publication |
First Author: |
HÃ¥versen L |
Year: |
2018 |
Journal: |
Sci Rep |
Title: |
Vimentin deficiency in macrophages induces increased oxidative stress and vascular inflammation but attenuates atherosclerosis in mice. |
Volume: |
8 |
Issue: |
1 |
Pages: |
16973 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jarrett KE |
Year: |
2018 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Somatic Editing of Ldlr With Adeno-Associated Viral-CRISPR Is an Efficient Tool for Atherosclerosis Research. |
Volume: |
38 |
Issue: |
9 |
Pages: |
1997-2006 |
|
•
•
•
•
•
|
Publication |
First Author: |
Armstrong SM |
Year: |
2015 |
Journal: |
Cardiovasc Res |
Title: |
A novel assay uncovers an unexpected role for SR-BI in LDL transcytosis. |
Volume: |
108 |
Issue: |
2 |
Pages: |
268-77 |
|
•
•
•
•
•
|
Publication |
First Author: |
LeBlond ND |
Year: |
2020 |
Journal: |
J Lipid Res |
Title: |
Myeloid deletion and therapeutic activation of AMPK do not alter atherosclerosis in male or female mice. |
Volume: |
61 |
Issue: |
12 |
Pages: |
1697-1706 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu M |
Year: |
2016 |
Journal: |
Biochem Biophys Res Commun |
Title: |
Impact of age and sex on the development of atherosclerosis and expression of the related genes in apoE deficient mice. |
Volume: |
469 |
Issue: |
3 |
Pages: |
456-62 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tang VT |
Year: |
2022 |
Journal: |
Elife |
Title: |
Hepatic inactivation of murine <i>Surf4</i> results in marked reduction in plasma cholesterol. |
Volume: |
11 |
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Dong YT |
Year: |
2023 |
Journal: |
Neuroscience |
Title: |
Resveratrol Attenuates the Disruption of Lipid Metabolism Observed in Amyloid Precursor Protein/Presenilin 1 Mouse Brains and Cultured Primary Neurons Exposed to Aβ. |
Volume: |
521 |
|
Pages: |
134-147 |
|
•
•
•
•
•
|
Publication |
First Author: |
Scotti E |
Year: |
2013 |
Journal: |
Mol Cell Biol |
Title: |
IDOL stimulates clathrin-independent endocytosis and multivesicular body-mediated lysosomal degradation of the low-density lipoprotein receptor. |
Volume: |
33 |
Issue: |
8 |
Pages: |
1503-14 |
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Publication |
First Author: |
Cansby E |
Year: |
2018 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
STK25 Regulates Cardiovascular Disease Progression in a Mouse Model of Hypercholesterolemia. |
Volume: |
38 |
Issue: |
8 |
Pages: |
1723-1737 |
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Publication |
First Author: |
Hosseini Z |
Year: |
2021 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Resolvin D1 Enhances Necroptotic Cell Clearance Through Promoting Macrophage Fatty Acid Oxidation and Oxidative Phosphorylation. |
Volume: |
41 |
Issue: |
3 |
Pages: |
1062-1075 |
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Publication |
First Author: |
Yang L |
Year: |
2019 |
Journal: |
J Lipid Res |
Title: |
LPA receptor 4 deficiency attenuates experimental atherosclerosis. |
Volume: |
60 |
Issue: |
5 |
Pages: |
972-980 |
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Publication |
First Author: |
Yntema T |
Year: |
2025 |
Journal: |
Sci Rep |
Title: |
The impact of a humanized bile acid composition on atherosclerosis development in hypercholesterolaemic Cyp2c70 knockout mice. |
Volume: |
15 |
Issue: |
1 |
Pages: |
2100 |
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Publication |
First Author: |
Silvestro M |
Year: |
2022 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
The Nonproteolytic Intracellular Domain of Membrane-Type 1 Matrix Metalloproteinase Coordinately Modulates Abdominal Aortic Aneurysm and Atherosclerosis in Mice-Brief Report. |
Volume: |
42 |
Issue: |
10 |
Pages: |
1244-1253 |
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Publication |
First Author: |
Susan-Resiga D |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
The Proprotein Convertase Subtilisin/Kexin Type 9-resistant R410S Low Density Lipoprotein Receptor Mutation: A NOVEL MECHANISM CAUSING FAMILIAL HYPERCHOLESTEROLEMIA. |
Volume: |
292 |
Issue: |
5 |
Pages: |
1573-1590 |
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Publication |
First Author: |
Vozenilek AE |
Year: |
2018 |
Journal: |
J Vasc Res |
Title: |
Absence of Nicotinamide Nucleotide Transhydrogenase in C57BL/6J Mice Exacerbates Experimental Atherosclerosis. |
Volume: |
55 |
Issue: |
2 |
Pages: |
98-110 |
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Publication |
First Author: |
Xu YX |
Year: |
2018 |
Journal: |
Atherosclerosis |
Title: |
Role of angiopoietin-like 3 (ANGPTL3) in regulating plasma level of low-density lipoprotein cholesterol. |
Volume: |
268 |
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Pages: |
196-206 |
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Publication |
First Author: |
Cheng X |
Year: |
2024 |
Journal: |
Atherosclerosis |
Title: |
Multifaceted roles of Meg3 in cellular senescence and atherosclerosis. |
Volume: |
392 |
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Pages: |
117506 |
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Publication |
First Author: |
Vos DY |
Year: |
2023 |
Journal: |
Arterioscler Thromb Vasc Biol |
Title: |
Cargo-Specific Role for Retriever Subunit VPS26C in Hepatocyte Lipoprotein Receptor Recycling to Control Postprandial Triglyceride-Rich Lipoproteins. |
Volume: |
43 |
Issue: |
1 |
Pages: |
e29-e45 |
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Publication |
First Author: |
van der Vorst EPC |
Year: |
2023 |
Journal: |
Front Cardiovasc Med |
Title: |
Endothelial ADAM10 controls cellular response to oxLDL and its deficiency exacerbates atherosclerosis with intraplaque hemorrhage and neovascularization in mice. |
Volume: |
10 |
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Pages: |
974918 |
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Publication |
First Author: |
Rautureau Y |
Year: |
2018 |
Journal: |
Circulation |
Title: |
ADCY9 (Adenylate Cyclase Type 9) Inactivation Protects From Atherosclerosis Only in the Absence of CETP (Cholesteryl Ester Transfer Protein). |
Volume: |
138 |
Issue: |
16 |
Pages: |
1677-1692 |
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Publication |
First Author: |
Davel AP |
Year: |
2018 |
Journal: |
J Am Heart Assoc |
Title: |
Sex-Specific Mechanisms of Resistance Vessel Endothelial Dysfunction Induced by Cardiometabolic Risk Factors. |
Volume: |
7 |
Issue: |
4 |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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Protein Coding Gene |
Type: |
protein_coding_gene |
Organism: |
mouse, laboratory |
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First Author: |
Siezen RJ |
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1997 |
Journal: |
Protein Sci |
Title: |
Subtilases: the superfamily of subtilisin-like serine proteases. |
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6 |
Issue: |
3 |
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501-23 |
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Rawlings ND |
Year: |
1994 |
Journal: |
Methods Enzymol |
Title: |
Families of serine peptidases. |
Volume: |
244 |
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Pages: |
19-61 |
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Rawlings ND |
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1993 |
Journal: |
Biochem J |
Title: |
Evolutionary families of peptidases. |
Volume: |
290 ( Pt 1) |
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Pages: |
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First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
Year: |
2005 |
Journal: |
Database Download |
Title: |
MGI download of GENSAT transgene data |
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