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Search results 501 to 593 out of 593 for Pdk1

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Type Details Score
Publication
19605683 | J:150710
First Author: Chalhoub N
Year: 2009
Journal: Genes Dev
Title: Cell type specificity of PI3K signaling in Pdk1- and Pten-deficient brains.
Volume: 23
Issue: 14
Pages: 1619-24
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Publication
22147265 | J:195605
First Author: Sperow M
Year: 2012
Journal: J Physiol
Title: Phosphatase and tensin homologue (PTEN) regulates synaptic plasticity independently of its effect on neuronal morphology and migration.
Volume: 590
Issue: 4
Pages: 777-92
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Publication
26401001 | J:269887
First Author: Zaru R
Year: 2015
Journal: J Immunol
Title: The PDK1-Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning.
Volume: 195
Issue: 9
Pages: 4264-72
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Genotype
Genotype
Symbol: Pdpk1/Pdpk1 Tg(Cd4-cre)1Cwi/?
Background: involves: 129P2/OlaHsd * BALB/c * C57BL/6 * DBA/2
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kras/Kras<+> Pdpk1/Pdpk1 Ptf1a/Ptf1a<+>
Background: involves: 129S4/SvJae * 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pdpk1/Pdpk1 Tnfrsf4/Tnfrsf4<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Protein
F2Z400
Organism: Mus musculus/domesticus
Length: 457  
Fragment?: false
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Protein
Q3UEW8
Organism: Mus musculus/domesticus
Length: 434  
Fragment?: true
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Protein
Q3UHZ0
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
Q8K3L3
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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Protein
Q3UGN6
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
F2Z3X6
Organism: Mus musculus/domesticus
Length: 532  
Fragment?: false
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Protein
Q810Z4
Organism: Mus musculus/domesticus
Length: 551  
Fragment?: true
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Protein
Q3TRL2
Organism: Mus musculus/domesticus
Length: 522  
Fragment?: false
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Publication
21059917 | J:166594
First Author: Liu J
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Three-amino-acid-loop-extension homeodomain factor Meis3 regulates cell survival via PDK1.
Volume: 107
Issue: 47
Pages: 20494-9
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Publication
10075713 | J:53564
First Author: Dong LQ
Year: 1999
Journal: J Biol Chem
Title: Primary structure, tissue distribution, and expression of mouse phosphoinositide-dependent protein kinase-1, a protein kinase that phosphorylates and activates protein kinase Czeta.
Volume: 274
Issue: 12
Pages: 8117-22
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Publication
22751929 | J:188803
First Author: Ijuin T
Year: 2012
Journal: Mol Cell Biol
Title: Regulation of insulin signaling by the phosphatidylinositol 3,4,5-triphosphate phosphatase SKIP through the scaffolding function of Pak1.
Volume: 32
Issue: 17
Pages: 3570-84
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Publication
16517406 | J:129656
First Author: Papandreou I
Year: 2006
Journal: Cell Metab
Title: HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption.
Volume: 3
Issue: 3
Pages: 187-97
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Publication
28137614 | J:249259
 
First Author: Lan ZJ
Year: 2017
Journal: Mol Cell Endocrinol
Title: Selective deletion of Pten in theca-interstitial cells leads to androgen excess and ovarian dysfunction in mice.
Volume: 444
Pages: 26-37
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Publication
24912186 | J:211709
First Author: Regan JN
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Up-regulation of glycolytic metabolism is required for HIF1α-driven bone formation.
Volume: 111
Issue: 23
Pages: 8673-8
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Publication
37216099 | J:338922
First Author: Reilly L
Year: 2023
Journal: iScience
Title: Loss of PI3k activity of inositol polyphosphate multikinase impairs PDK1-mediated AKT activation, cell migration, and intestinal homeostasis.
Volume: 26
Issue: 5
Pages: 106623
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Publication
17267763 | J:122117
First Author: Okamoto Y
Year: 2007
Journal: Diabetes
Title: Restoration of glucokinase expression in the liver normalizes postprandial glucose disposal in mice with hepatic deficiency of PDK1.
Volume: 56
Issue: 4
Pages: 1000-9
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Publication
31011187 | J:282639
First Author: Luo W
Year: 2019
Journal: Nat Immunol
Title: The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells.
Volume: 20
Issue: 6
Pages: 736-746
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Publication
21694754 | J:274061
First Author: Cao Y
Year: 2011
Journal: PLoS One
Title: PDK1-Foxo1 in agouti-related peptide neurons regulates energy homeostasis by modulating food intake and energy expenditure.
Volume: 6
Issue: 4
Pages: e18324
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Publication
39391719 | J:355219
First Author: Yılmaz S
Year: 2024
Journal: iScience
Title: Exploring temporal and sex-linked dysregulation in Alzheimer disease phosphoproteome.
Volume: 27
Issue: 10
Pages: 110941
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Publication
21145457 | J:168103
First Author: Chakraborty A
Year: 2010
Journal: Cell
Title: Inositol pyrophosphates inhibit Akt signaling, thereby regulating insulin sensitivity and weight gain.
Volume: 143
Issue: 6
Pages: 897-910
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Publication
17525368 | J:137808
First Author: Santini MP
Year: 2007
Journal: Circ Res
Title: Enhancing repair of the mammalian heart.
Volume: 100
Issue: 12
Pages: 1732-40
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Publication
26235620 | J:355661
First Author: Yang G
Year: 2015
Journal: Cell Rep
Title: A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation.
Volume: 12
Issue: 6
Pages: 937-43
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Publication
17434141 | J:122347
First Author: Dey D
Year: 2007
Journal: Biochem Biophys Res Commun
Title: Fatty acid represses insulin receptor gene expression by impairing HMGA1 through protein kinase Cepsilon.
Volume: 357
Issue: 2
Pages: 474-9
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Publication
17617409 | J:123728
First Author: Wood CD
Year: 2007
Journal: FEBS Lett
Title: Phosphoinositide-dependent protein kinase-1 (PDK1)-independent activation of the protein kinase C substrate, protein kinase D.
Volume: 581
Issue: 18
Pages: 3494-8
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Publication
18285454 | J:135677
First Author: Hao Y
Year: 2008
Journal: Mol Cell Biol
Title: RalGDS couples growth factor signaling to Akt activation.
Volume: 28
Issue: 9
Pages: 2851-9
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Publication
21329883 | J:170850
First Author: Ou YH
Year: 2011
Journal: Mol Cell
Title: TBK1 directly engages Akt/PKB survival signaling to support oncogenic transformation.
Volume: 41
Issue: 4
Pages: 458-70
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Publication
26338797 | J:226500
First Author: Wheeler DB
Year: 2015
Journal: Science
Title: Identification of an oncogenic RAB protein.
Volume: 350
Issue: 6257
Pages: 211-7
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Publication
26553931 | J:230746
First Author: Park H
Year: 2015
Journal: J Cell Biol
Title: AMIGO2, a novel membrane anchor of PDK1, controls cell survival and angiogenesis via Akt activation.
Volume: 211
Issue: 3
Pages: 619-37
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Publication
25742010 | J:248141
First Author: Bär S
Year: 2015
Journal: PLoS Pathog
Title: PKCη/Rdx-driven phosphorylation of PDK1: a novel mechanism promoting cancer cell survival and permissiveness for parvovirus-induced lysis.
Volume: 11
Issue: 3
Pages: e1004703
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Publication
26846144 | J:258528
First Author: Gómez-Suárez M
Year: 2016
Journal: Cell Death Differ
Title: 14-3-3 Proteins regulate Akt Thr308 phosphorylation in intestinal epithelial cells.
Volume: 23
Issue: 6
Pages: 1060-72
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Publication
35294873 | J:324905
First Author: Hu SH
Year: 2022
Journal: Cell Rep
Title: Methylene-bridge tryptophan fatty acylation regulates PI3K-AKT signaling and glucose uptake.
Volume: 38
Issue: 11
Pages: 110509
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Publication
36173858 | J:330274
First Author: Bou Sleiman M
Year: 2022
Journal: Science
Title: Sex- and age-dependent genetics of longevity in a heterogeneous mouse population.
Volume: 377
Issue: 6614
Pages: eabo3191
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Publication
21119626 | -
 
First Author: Gallego O
Year: 2010
Journal: Mol Syst Biol
Title: A systematic screen for protein-lipid interactions in Saccharomyces cerevisiae.
Volume: 6
Pages: 430
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Genotype
Genotype
Symbol: Pdpk1/Pdpk1 Rag2/Rag2 Tnfrsf4/Tnfrsf4<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S/SvEv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
17669420 | J:166353
First Author: Degenhardt T
Year: 2007
Journal: J Mol Biol
Title: Three members of the human pyruvate dehydrogenase kinase gene family are direct targets of the peroxisome proliferator-activated receptor beta/delta.
Volume: 372
Issue: 2
Pages: 341-55
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Publication
21865597 | J:183019
First Author: He P
Year: 2011
Journal: Mol Biol Cell
Title: Serum- and glucocorticoid-induced kinase 3 in recycling endosomes mediates acute activation of Na+/H+ exchanger NHE3 by glucocorticoids.
Volume: 22
Issue: 20
Pages: 3812-25
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Publication
21540297 | J:182940
First Author: Bekhite MM
Year: 2011
Journal: J Cell Sci
Title: VEGF-mediated PI3K class IA and PKC signaling in cardiomyogenesis and vasculogenesis of mouse embryonic stem cells.
Volume: 124
Issue: Pt 11
Pages: 1819-30
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Publication
16527821 | J:113737
First Author: Frey RS
Year: 2006
Journal: J Biol Chem
Title: Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells.
Volume: 281
Issue: 23
Pages: 16128-38
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Publication
19443706 | J:148919
First Author: Rodriguez OC
Year: 2009
Journal: Am J Pathol
Title: A reduction in Pten tumor suppressor activity promotes ErbB-2-induced mouse prostate adenocarcinoma formation through the activation of signaling cascades downstream of PDK1.
Volume: 174
Issue: 6
Pages: 2051-60
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Publication
22041125 | J:344713
 
First Author: Xifró X
Year: 2011
Journal: Mol Neurodegener
Title: Increased 90-kDa ribosomal S6 kinase (Rsk) activity is protective against mutant huntingtin toxicity.
Volume: 6
Pages: 74
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Publication
27795296 | J:242994
 
First Author: Guentsch A
Year: 2017
Journal: Mol Cell Biol
Title: PHD2 Is a Regulator for Glycolytic Reprogramming in Macrophages.
Volume: 37
Issue: 1
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Publication
22586579 | J:208461
First Author: Kawano Y
Year: 2012
Journal: Diabetes
Title: Loss of Pdk1-Foxo1 signaling in myeloid cells predisposes to adipose tissue inflammation and insulin resistance.
Volume: 61
Issue: 8
Pages: 1935-48
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Publication
38091840 | J:344742
 
First Author: Imamori M
Year: 2024
Journal: Biochem Biophys Res Commun
Title: Thrombospondin-1 promotes liver fibrosis by enhancing TGF-β action in hepatic stellate cells.
Volume: 693
Pages: 149369
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Publication
25084011 | J:218993
First Author: Zhang Y
Year: 2014
Journal: PLoS One
Title: Rictor is required for early B cell development in bone marrow.
Volume: 9
Issue: 8
Pages: e103970
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Publication
27644329 | J:243001
     
First Author: Cordón-Barris L
Year: 2016
Journal: Mol Cell Biol
Title: Mutation of the 3-phosphoinositide-dependent protein kinase-1 (PDK1) substrate-docking site in the developing brain causes microcephaly with abnormal brain morphogenesis independently of Akt, leading to impaired cognition and disruptive behaviors.
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Publication
20103739 | J:162892
First Author: Iskandar K
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: PDK-1/FoxO1 pathway in POMC neurons regulates Pomc expression and food intake.
Volume: 298
Issue: 4
Pages: E787-98
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Publication
19887597 | J:169947
First Author: Sajan MP
Year: 2010
Journal: Am J Physiol Endocrinol Metab
Title: AICAR and metformin, but not exercise, increase muscle glucose transport through AMPK-, ERK-, and PDK1-dependent activation of atypical PKC.
Volume: 298
Issue: 2
Pages: E179-92
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Publication
23071621 | J:192091
First Author: MacKay KB
Year: 2012
Journal: PLoS One
Title: Wortmannin reduces insulin signaling and death in seizure-prone Pcmt1-/- mice.
Volume: 7
Issue: 10
Pages: e46719
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Publication
24224061 | J:209318
First Author: Qin Z
Year: 2013
Journal: PLoS One
Title: Isoaspartate accumulation in mouse brain is associated with altered patterns of protein phosphorylation and acetylation, some of which are highly sex-dependent.
Volume: 8
Issue: 11
Pages: e80758
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Publication
22108800 | J:283469
First Author: Tawaramoto K
Year: 2012
Journal: Mol Endocrinol
Title: Ablation of 3-phosphoinositide-dependent protein kinase 1 (PDK1) in vascular endothelial cells enhances insulin sensitivity by reducing visceral fat and suppressing angiogenesis.
Volume: 26
Issue: 1
Pages: 95-109
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Publication
26795955 | J:250192
 
First Author: Qin Z
Year: 2016
Journal: Sci Rep
Title: Tsc1 deficiency impairs mammary development in mice by suppression of AKT, nuclear ERα, and cell-cycle-driving proteins.
Volume: 6
Pages: 19587
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Publication
28878342 | J:255538
First Author: Saurus P
Year: 2017
Journal: Sci Rep
Title: Inhibition of SHIP2 in CD2AP-deficient podocytes ameliorates reactive oxygen species generation but aggravates apoptosis.
Volume: 7
Issue: 1
Pages: 10731
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Publication
19703999 | J:153995
First Author: Waugh C
Year: 2009
Journal: Mol Cell Biol
Title: Phosphoinositide (3,4,5)-triphosphate binding to phosphoinositide-dependent kinase 1 regulates a protein kinase B/Akt signaling threshold that dictates T-cell migration, not proliferation.
Volume: 29
Issue: 21
Pages: 5952-62
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Publication
28462077 | J:271913
First Author: Sasanuma H
Year: 2017
Journal: Mol Metab
Title: PDK1-FoxO1 pathway in AgRP neurons of arcuate nucleus promotes bone formation via GHRH-GH-IGF1 axis.
Volume: 6
Issue: 5
Pages: 428-439
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Publication
12663261 | J:134746
First Author: Hopkins TA
Year: 2003
Journal: Am J Physiol Heart Circ Physiol
Title: Control of cardiac pyruvate dehydrogenase activity in peroxisome proliferator-activated receptor-alpha transgenic mice.
Volume: 285
Issue: 1
Pages: H270-6
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Publication
19703998 | J:153996
First Author: El-Naggar S
Year: 2009
Journal: Mol Cell Biol
Title: Mutation of the Rb1 pathway leads to overexpression of mTor, constitutive phosphorylation of Akt on serine 473, resistance to anoikis, and a block in c-Raf activation.
Volume: 29
Issue: 21
Pages: 5710-7
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Publication
32857910 | J:296937
First Author: Rao CV
Year: 2020
Journal: Aging Cell
Title: GSK3-ARC/Arg3.1 and GSK3-Wnt signaling axes trigger amyloid-β accumulation and neuroinflammation in middle-aged Shugoshin 1 mice.
Volume: 19
Issue: 10
Pages: e13221
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Publication
27119228 | J:311917
First Author: Qiu X
Year: 2016
Journal: Oncotarget
Title: NEDL2 regulates enteric nervous system and kidney development in its Nedd8 ligase activity-dependent manner.
Volume: 7
Issue: 21
Pages: 31440-53
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Publication
33850054 | J:355636
 
First Author: Baffi TR
Year: 2021
Journal: Sci Signal
Title: mTORC2 controls the activity of PKC and Akt by phosphorylating a conserved TOR interaction motif.
Volume: 14
Issue: 678
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Publication
15187024 | J:93757
First Author: Yamazaki T
Year: 2004
Journal: Blood
Title: Puromycin-insensitive leucyl-specific aminopeptidase (PILSAP) binds and catalyzes PDK1, allowing VEGF-stimulated activation of S6K for endothelial cell proliferation and angiogenesis.
Volume: 104
Issue: 8
Pages: 2345-52
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Publication
15867396 | J:98331
First Author: Yin Y
Year: 2005
Journal: Cancer Res
Title: Peroxisome proliferator-activated receptor delta and gamma agonists differentially alter tumor differentiation and progression during mammary carcinogenesis.
Volume: 65
Issue: 9
Pages: 3950-7
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Publication
16785309 | J:124408
First Author: Nirula A
Year: 2006
Journal: J Exp Med
Title: Phosphoinositide-dependent kinase 1 targets protein kinase A in a pathway that regulates interleukin 4.
Volume: 203
Issue: 7
Pages: 1733-44
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Publication
17562488 | J:134717
First Author: Sargeant AM
Year: 2007
Journal: Toxicol Pathol
Title: Chemopreventive and bioenergetic signaling effects of PDK1/Akt pathway inhibition in a transgenic mouse model of prostate cancer.
Volume: 35
Issue: 4
Pages: 549-61
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Publication
18426911 | J:137298
First Author: Hagan GN
Year: 2008
Journal: Mol Cell Biol
Title: A Rictor-Myo1c complex participates in dynamic cortical actin events in 3T3-L1 adipocytes.
Volume: 28
Issue: 13
Pages: 4215-26
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Publication
18514190 | J:138007
First Author: Tamgüney T
Year: 2008
Journal: Exp Cell Res
Title: Analysis of 3-phosphoinositide-dependent kinase-1 signaling and function in ES cells.
Volume: 314
Issue: 11-12
Pages: 2299-312
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Publication
25645675 | J:229644
First Author: Sturm EM
Year: 2015
Journal: Eur J Immunol
Title: Phosphoinositide-dependent protein kinase 1 (PDK1) mediates potent inhibitory effects on eosinophils.
Volume: 45
Issue: 5
Pages: 1548-59
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Publication
28596235 | J:255642
First Author: Hsu JY
Year: 2017
Journal: FASEB J
Title: Epidermal growth factor-induced pyruvate dehydrogenase kinase 1 expression enhances head and neck squamous cell carcinoma metastasis via up-regulation of fibronectin.
Volume: 31
Issue: 10
Pages: 4265-4276
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Publication
30092282 | J:275772
 
First Author: Pan H
Year: 2019
Journal: Matrix Biol
Title: RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells.
Volume: 77
Pages: 23-40
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Publication
34535769 | J:312446
First Author: Heltemes-Harris LM
Year: 2021
Journal: Oncogene
Title: Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia.
Volume: 40
Issue: 43
Pages: 6166-6179
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Publication
25670795 | J:238888
First Author: Luo W
Year: 2015
Journal: Development
Title: Akt1 signaling coordinates BMP signaling and β-catenin activity to regulate second heart field progenitor development.
Volume: 142
Issue: 4
Pages: 732-42
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Protein
F2Z3Z9
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Publication
34913989 | J:322738
First Author: Yang S
Year: 2022
Journal: Diabetologia
Title: MicroRNA-193b impairs muscle growth in mouse models of type 2 diabetes by targeting the PDK1/Akt signalling pathway.
Volume: 65
Issue: 3
Pages: 563-581
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Publication
15201286 | J:92558
First Author: Kondo T
Year: 2004
Journal: J Biol Chem
Title: Altered insulin signaling in retinal tissue in diabetic states.
Volume: 279
Issue: 36
Pages: 37997-8006
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Publication
17456009 | J:139422
First Author: Ford-Hutchinson AF
Year: 2007
Journal: J Bone Miner Res
Title: Inactivation of Pten in osteo-chondroprogenitor cells leads to epiphyseal growth plate abnormalities and skeletal overgrowth.
Volume: 22
Issue: 8
Pages: 1245-59
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Publication
29652518 | J:278995
First Author: Jia S
Year: 2018
Journal: Am J Respir Cell Mol Biol
Title: Discoidin Domain Receptor 2 Signaling Regulates Fibroblast Apoptosis through PDK1/Akt.
Volume: 59
Issue: 3
Pages: 295-305
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Publication
18591395 | J:141895
First Author: El Ouaamari A
Year: 2008
Journal: Diabetes
Title: miR-375 targets 3'-phosphoinositide-dependent protein kinase-1 and regulates glucose-induced biological responses in pancreatic beta-cells.
Volume: 57
Issue: 10
Pages: 2708-17
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Publication
32913213 | J:305622
First Author: Sun X
Year: 2020
Journal: Cell Death Dis
Title: miR-378-3p maintains the size of mouse primordial follicle pool by regulating cell autophagy and apoptosis.
Volume: 11
Issue: 9
Pages: 737
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Publication
34628272 | J:312367
 
First Author: Yuko AE
Year: 2021
Journal: Redox Biol
Title: LIN28a induced metabolic and redox regulation promotes cardiac cell survival in the heart after ischemic injury.
Volume: 47
Pages: 102162
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Publication
23453634 | J:194830
First Author: Schweighoffer E
Year: 2013
Journal: Immunity
Title: The BAFF receptor transduces survival signals by co-opting the B cell receptor signaling pathway.
Volume: 38
Issue: 3
Pages: 475-88
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Publication
21865646 | J:178240
First Author: Goertz MJ
Year: 2011
Journal: J Clin Invest
Title: Foxo1 is required in mouse spermatogonial stem cells for their maintenance and the initiation of spermatogenesis.
Volume: 121
Issue: 9
Pages: 3456-66
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Publication
21295499 | J:168979
First Author: Macintyre AN
Year: 2011
Journal: Immunity
Title: Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.
Volume: 34
Issue: 2
Pages: 224-36
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Title: Loss of Protein Kinase Novel 1 (PKN1) is associated with mild systolic and diastolic contractile dysfunction, increased phospholamban Thr17 phosphorylation, and exacerbated ischaemia-reperfusion injury.
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Title: Selective requirement of PI3K/PDK1 signaling for Kras oncogene-driven pancreatic cell plasticity and cancer.
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