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Search results 501 to 519 out of 519 for Pdxk

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0.016s

Type

Details

Score

Publication

34440389 | J:351600

First Author:	Li Y
Year:	2021
Journal:	Genes (Basel)
Title:	Coat Color-Facilitated Efficient Generation and Analysis of a Mouse Model of Down Syndrome Triplicated for All Human Chromosome 21 Orthologous Regions.
Volume:	12
Issue:	8

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Publication

20442137 | J:161325

First Author:	Yu T
Year:	2010
Journal:	Hum Mol Genet
Title:	A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions.
Volume:	19
Issue:	14
Pages:	2780-91

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Publication

31086297 | J:278677

First Author:	Granno S
Year:	2019
Journal:	Sci Rep
Title:	Downregulated Wnt/β-catenin signalling in the Down syndrome hippocampus.
Volume:	9
Issue:	1
Pages:	7322

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Publication

33707583 | J:304829

First Author:	Tosh JL
Year:	2021
Journal:	Sci Rep
Title:	Genetic dissection of down syndrome-associated alterations in APP/amyloid-β biology using mouse models.
Volume:	11
Issue:	1
Pages:	5736

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Publication

36818290 | J:341136

First Author:	Muza PM
Year:	2023
Journal:	iScience
Title:	Cognitive impairments in a Down syndrome model with abnormal hippocampal and prefrontal dynamics and cytoarchitecture.
Volume:	26
Issue:	2
Pages:	106073

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Genotype

Symbol:	Dp(10Prmt2-Pdxk)2Yey/? Dp(16Lipi-Zbtb21)1Yey/? Dp(17Abcg1-Rrp1b)3Yey/?
Background:	B6.129S7-Dp(10Prmt2-Pdxk)2Yey Dp(16Lipi-Zbtb21)1Yey Dp(17Abcg1-Rrp1b)3Yey
Zygosity:	cx
Has Mutant Allele:	true

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Publication

9537380 | -

First Author:	Yang Y
Year:	1998
Journal:	J Bacteriol
Title:	Identification and function of the pdxY gene, which encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis in Escherichia coli K-12.
Volume:	180
Issue:	7
Pages:	1814-21

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Protein

Q8K183

Organism:	Mus musculus/domesticus
Length:	312
Fragment?:	false

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Publication

15249053 | -

First Author:	di Salvo ML
Year:	2004
Journal:	Protein Expr Purif
Title:	Expression, purification, and kinetic constants for human and Escherichia coli pyridoxal kinases.
Volume:	36
Issue:	2
Pages:	300-6

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Protein Domain

IPR023685 | Pyridoxal_kinase_PdxY

Type:

Family

Description:

Pyridoxal phosphate is the active form of vitamin B6 (pyridoxine or pyridoxal). Pyridoxal 5'-phosphate (PLP) is a versatile catalyst, acting as a coenzyme in a multitude of reactions, including decarboxylation, deamination and transamination [, , ]. PLP-dependent enzymes are primarily involved in the biosynthesis of amino acids and amino acid-derived metabolites, but they are also found in the biosynthetic pathways of amino sugars and in the synthesis or catabolism of neurotransmitters; pyridoxal phosphate can also inhibit DNA polymerases and several steroid receptors []. Inadequate levels of pyridoxal phosphate in the brain can cause neurological dysfunction, particularly epilepsy [].PLP enzymes exist in their resting state as a Schiff base, the aldehyde group of PLP forming a linkage with the ε-amino group of an active site lysine residue on the enzyme. The α-amino group of the substrate displaces the lysine ε-amino group, in the process forming a new aldimine with the substrate. This aldimine is the common central intermediate for all PLP-catalysed reactions, enzymatic and non-enzymatic [].Pyridoxal kinase PdxY (Escherichia coli pyridoxal kinase 2 or ePL kinase 2) phosphorylates B6 vitamers. PdxY acts in the salvage pathway of pyridoxal 5'-phosphate biosynthesis []. It has been shown to have some pyridoxal (PL) kinase activity, but at a greatly reduced level compared tothe enzyme expressed by the pdxK gene (ePL kinase 1) [].

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Publication

31995755 | J:287679

First Author:	Chang P
Year:	2020
Journal:	Cell Rep
Title:	Altered Hippocampal-Prefrontal Neural Dynamics in Mouse Models of Down Syndrome.
Volume:	30
Issue:	4
Pages:	1152-1163.e4

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Publication

24041763 | J:204610

First Author:	Zhang L
Year:	2014
Journal:	Hum Mol Genet
Title:	Human chromosome 21 orthologous region on mouse chromosome 17 is a major determinant of Down syndrome-related developmental cognitive deficits.
Volume:	23
Issue:	3
Pages:	578-89

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Publication

29435140 | J:257058

First Author:	Liu C
Year:	2018
Journal:	Oncotarget
Title:	Triplications of human chromosome 21 orthologous regions in mice result in expansion of megakaryocyte-erythroid progenitors and reduction of granulocyte-macrophage progenitors.
Volume:	9
Issue:	4
Pages:	4773-4786

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Publication

37580797 | J:351211

First Author:	Wu Y
Year:	2023
Journal:	Acta Neuropathol Commun
Title:	Cathepsin B abundance, activity and microglial localisation in Alzheimer's disease-Down syndrome and early onset Alzheimer's disease; the role of elevated cystatin B.
Volume:	11
Issue:	1
Pages:	132

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Publication

24068166 | J:201811

First Author:	Bhutta MF
Year:	2013
Journal:	Mamm Genome
Title:	Surveying the Down syndrome mouse model resource identifies critical regions responsible for chronic otitis media.
Volume:	24
Issue:	11-12
Pages:	439-45

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Publication

29746474 | J:262380

First Author:	Watson-Scales S
Year:	2018
Journal:	PLoS Genet
Title:	Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration.
Volume:	14
Issue:	5
Pages:	e1007383

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Publication

- | J:361105

First Author:	Tateossian H
Year:	2025
Journal:	Elife
Title:	DYRK1A kinase triplication is the major cause of Otitis Media in Down Syndrome.

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Publication

27538963 | J:242664

First Author:	Gupta M
Year:	2016
Journal:	Mamm Genome
Title:	Mouse models of Down syndrome: gene content and consequences.
Volume:	27
Issue:	11-12
Pages:	538-555

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Publication

22126738 | J:196862

First Author:	Zhang L
Year:	2012
Journal:	Bioeng Bugs
Title:	Genetic analysis of Down syndrome facilitated by mouse chromosome engineering.
Volume:	3
Issue:	1
Pages:	8-12

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