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Search results 501 to 600 out of 655 for Pik3ca

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Type Details Score
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Gt(ROSA)26Sor<tm1(CAG-PIK3CA*H1047R,-EGFP)Balj> | MGI:5052133
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Mohamed Bentires-Alj
Allele Type: Targeted
Attribute String: Conditional ready, Humanized sequence, Inserted expressed sequence, Reporter, RMCE-ready
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Publication
30425131 | J:349080
First Author: Fricke SL
Year: 2019
Journal: Mol Cancer Ther
Title: MTORC1/2 Inhibition as a Therapeutic Strategy for PIK3CA Mutant Cancers.
Volume: 18
Issue: 2
Pages: 346-355
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Publication
37874915 | J:343415
First Author: Durham BH
Year: 2023
Journal: Blood Adv
Title: Mutant PIK3CA is a targetable driver alteration in histiocytic neoplasms.
Volume: 7
Issue: 23
Pages: 7319-7328
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Publication
32559461 | J:290420
First Author: Koundouros N
Year: 2020
Journal: Cell
Title: Metabolic Fingerprinting Links Oncogenic PIK3CA with Enhanced Arachidonic Acid-Derived Eicosanoids.
Volume: 181
Issue: 7
Pages: 1596-1611.e27
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Publication
21324922 | J:170898
First Author: Adams JR
Year: 2011
Journal: Cancer Res
Title: Cooperation between Pik3ca and p53 mutations in mouse mammary tumor formation.
Volume: 71
Issue: 7
Pages: 2706-17
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Publication
31996845 | J:293352
First Author: Yu K
Year: 2020
Journal: Nature
Title: PIK3CA variants selectively initiate brain hyperactivity during gliomagenesis.
Volume: 578
Issue: 7793
Pages: 166-171
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Publication
31112530 | J:337611
First Author: Sivaram N
Year: 2019
Journal: J Clin Invest
Title: Tumor-intrinsic PIK3CA represses tumor immunogenecity in a model of pancreatic cancer.
Volume: 129
Issue: 8
Pages: 3264-3276
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Publication
36353506 | J:330707
 
First Author: Marechal E
Year: 2022
Journal: Front Cell Dev Biol
Title: Multiple congenital malformations arise from somatic mosaicism for constitutively active Pik3ca signaling.
Volume: 10
Pages: 1013001
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Publication
36799863 | J:334877
First Author: Malik N
Year: 2023
Journal: Cancer Res
Title: Dysregulation of Mitochondrial Translation Caused by CBFB Deficiency Cooperates with Mutant PIK3CA and Is a Vulnerability in Breast Cancer.
Volume: 83
Issue: 8
Pages: 1280-1298
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Publication
24576621 | J:210526
First Author: Roper J
Year: 2014
Journal: Cancer Lett
Title: Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer.
Volume: 347
Issue: 2
Pages: 204-11
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Publication
28184015 | J:349078
First Author: Foley TM
Year: 2017
Journal: Mol Cancer Res
Title: Dual PI3K/mTOR Inhibition in Colorectal Cancers with APC and PIK3CA Mutations.
Volume: 15
Issue: 3
Pages: 317-327
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Publication
32112900 | J:286791
 
First Author: Niesen J
Year: 2020
Journal: Cancer Lett
Title: Pik3ca mutations significantly enhance the growth of SHH medulloblastoma and lead to metastatic tumour growth in a novel mouse model.
Volume: 477
Pages: 10-18
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Publication
39169259 | J:358047
First Author: Herms A
Year: 2024
Journal: Nat Genet
Title: Organismal metabolism regulates the expansion of oncogenic PIK3CA mutant clones in normal esophagus.
Volume: 56
Issue: 10
Pages: 2144-2157
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Publication
21482677 | J:173655
First Author: Meyer DS
Year: 2011
Journal: Cancer Res
Title: Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors.
Volume: 71
Issue: 13
Pages: 4344-51
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Publication
32436348 | J:339906
First Author: Tan MT
Year: 2020
Journal: Int J Exp Pathol
Title: A PIK3CA transgenic mouse model with chemical carcinogen exposure mimics human oral tongue tumorigenesis.
Volume: 101
Issue: 1-2
Pages: 45-54
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Publication
19029981 | J:142254
First Author: Engelman JA
Year: 2008
Journal: Nat Med
Title: Effective use of PI3K and MEK inhibitors to treat mutant Kras G12D and PIK3CA H1047R murine lung cancers.
Volume: 14
Issue: 12
Pages: 1351-6
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Publication
28442534 | J:246966
First Author: Riemer P
Year: 2017
Journal: J Cell Biol
Title: Oncogenic β-catenin and PIK3CA instruct network states and cancer phenotypes in intestinal organoids.
Volume: 216
Issue: 6
Pages: 1567-1577
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Publication
24080956 | J:361130
First Author: Meyer DS
Year: 2013
Journal: Oncogenesis
Title: Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047R.
Volume: 2
Issue: 9
Pages: e74
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Publication
30591517 | J:273211
First Author: Rodriguez-Laguna L
Year: 2019
Journal: J Exp Med
Title: Somatic activating mutations in PIK3CA cause generalized lymphatic anomaly.
Volume: 216
Issue: 2
Pages: 407-418
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DO Term
DOID:0081001 | Cowden syndrome 5
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Publication
29858226 | J:262549
First Author: Triscott J
Year: 2018
Journal: Cancer Discov
Title: Prostate Power Play: Does Pik3ca Accelerate Pten-Deficient Cancer Progression?
Volume: 8
Issue: 6
Pages: 682-685
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Allele
Pik3ca<tm1Smoc> | MGI:7786921
Name: phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Strain
MGI:7788765 | C57BL/6JSmoc-Pik3ca<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Protein
P42337
Organism: Mus musculus/domesticus
Length: 1068  
Fragment?: false
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Allele
Gt(ROSA)26Sor<tm7(Pik3ca*,EGFP)Rsky> | MGI:4430527
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 7, Klaus Rajewsky
Allele Type: Targeted
Attribute String: Conditional ready, Constitutively active, Inserted expressed sequence, Reporter
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(CAG-cre/Esr1*)5Amc/?
Background: B6.Cg-Gt(ROSA)26Sor Tg(CAG-cre/Esr1*)5Amc
Zygosity: cn
Has Mutant Allele: true
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DO Term
DOID:0080351 | CLOVES syndrome
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Allele
Gt(ROSA)26Sor<tm2(Pik3ca)Egan> | MGI:5000473
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Sean E Egan
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
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Allele
Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan> | MGI:5000472
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Sean E Egan
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
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Allele
Tg(tetO-PIK3CA*H1047R,-luc)2239Jjz | MGI:5526971
Name: transgene insertion 2239, Jean J Zhao
Allele Type: Transgenic
Attribute String: Humanized sequence, Inducible, Inserted expressed sequence, Reporter
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Publication
37272756 | J:339599
First Author: Cheng X
Year: 2023
Journal: Cancer Res
Title: Breast Cancer Mutations HER2V777L and PIK3CAH1047R Activate the p21-CDK4/6-Cyclin D1 Axis to Drive Tumorigenesis and Drug Resistance.
Volume: 83
Issue: 17
Pages: 2839-2857
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Publication
30753336 | J:288706
     
First Author: Ochiai M
Year: 2019
Journal: Carcinogenesis
Title: Kras-driven heterotopic tumor development from hepatobiliary organoids.
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Strain
MGI:5052137 | FVB.129S6-Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>/J
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:6147057 | FVB.129S6-Gt(ROSA)26Sor<tm1(Pik3ca*H1047R)Egan>
Attribute String: mutant strain, congenic, targeted mutation
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Publication
30297712 | J:267569
First Author: Wu S
Year: 2018
Journal: Nat Commun
Title: SWI/SNF catalytic subunits' switch drives resistance to EZH2 inhibitors in ARID1A-mutated cells.
Volume: 9
Issue: 1
Pages: 4116
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Allele
Gt(ROSA)26Sor<tm2(Pik3ca*)Dsa> | MGI:5510667
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Dieter Saur
Allele Type: Targeted
Attribute String: Conditional ready, Constitutively active, Inserted expressed sequence
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Allele
Col1a1<tm29(CAG-Pik3ca*E545K,-luc2)Nki> | MGI:7451118
Name: collagen, type I, alpha 1; targeted mutation 29, The Netherlands Cancer Institute
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Allele
Gt(ROSA)26Sor<tm3(Pik3ca*E545K)Egan> | MGI:7493251
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 3, Sean E Egan
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
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Allele
Gt(ROSA)26Sor<tm4(Pik3ca*E545K*H1047R)Egan> | MGI:7618564
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 4, Sean E Egan
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * CD-1
Zygosity: cn
Has Mutant Allele: true
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Publication
27292631 | J:238306
First Author: Spangle JM
Year: 2016
Journal: Cell Rep
Title: PI3K/AKT Signaling Regulates H3K4 Methylation in Breast Cancer.
Volume: 15
Issue: 12
Pages: 2692-704
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Publication
21822287 | J:175839
First Author: Liu P
Year: 2011
Journal: Nat Med
Title: Oncogenic PIK3CA-driven mammary tumors frequently recur via PI3K pathway-dependent and PI3K pathway-independent mechanisms.
Volume: 17
Issue: 9
Pages: 1116-20
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Publication
34941867 | J:317487
First Author: Reske JJ
Year: 2021
Journal: PLoS Genet
Title: Co-existing TP53 and ARID1A mutations promote aggressive endometrial tumorigenesis.
Volume: 17
Issue: 12
Pages: e1009986
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Publication
30003928 | J:264244
 
First Author: Liu XL
Year: 2018
Journal: Cancer Lett
Title: Decrease in phosphorylated ERK indicates the therapeutic efficacy of a clinical PI3Kα-selective inhibitor CYH33 in breast cancer.
Volume: 433
Pages: 273-282
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Publication
32464345 | J:303124
 
First Author: Wilson MR
Year: 2020
Journal: Stem Cell Res
Title: Lgr5-positive endothelial progenitor cells occupy a tumor and injury prone niche in the kidney vasa recta.
Volume: 46
Pages: 101849
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Publication
29281825 | J:277093
First Author: D'Gama AM
Year: 2017
Journal: Cell Rep
Title: Somatic Mutations Activating the mTOR Pathway in Dorsal Telencephalic Progenitors Cause a Continuum of Cortical Dysplasias.
Volume: 21
Issue: 13
Pages: 3754-3766
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Publication
33031100 | J:299982
 
First Author: Liu B
Year: 2021
Journal: J Clin Invest
Title: Mutant SF3B1 promotes AKT- and NF-κB-driven mammary tumorigenesis.
Volume: 131
Issue: 1
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Allele
Tg(Myh6-Pik3r1/PIK3CA)BSiz | MGI:3619920
Name: transgene insertion B, Seigo Izumo
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
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Allele
Tg(Myh6-Pik3ca)1Siz | MGI:3619921
Name: transgene insertion 1, Seigo Izumo
Allele Type: Transgenic
Attribute String: Dominant negative, Inserted expressed sequence
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Allele
Tg(Amhr2-Pik3ca*,-GFP)#Lzh | MGI:3832594
Name: transgene insertion, Lin Zhang
Allele Type: Transgenic
Attribute String: Constitutively active, Inserted expressed sequence
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Strain
MGI:6147058 | FVB.129S6-Gt(ROSA)26Sor<tm3(Pik3ca*E545K)Egan>
Attribute String: mutant strain, congenic, targeted mutation
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Genotype
Genotype
Symbol: Tg(Myh6-Pik3ca)1Siz/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Amhr2-Pik3ca*,-GFP)#Lzh/?
Background: involves: C3H * C57BL/6
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(MMTV-cre)#Tfln/?
Background: involves: 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Olig2/Olig2<+>
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
28396358 | J:242495
First Author: Hanker AB
Year: 2017
Journal: Cancer Res
Title: Extracellular Matrix/Integrin Signaling Promotes Resistance to Combined Inhibition of HER2 and PI3K in HER2+ Breast Cancer.
Volume: 77
Issue: 12
Pages: 3280-3292
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Publication
23028587 | J:191872
First Author: Li C
Year: 2012
Journal: PLoS One
Title: Activation of myocardial phosphoinositide-3-kinase p110α ameliorates cardiac dysfunction and improves survival in polymicrobial sepsis.
Volume: 7
Issue: 9
Pages: e44712
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Publication
20974681 | J:179541
First Author: Yang KC
Year: 2010
Journal: J Physiol
Title: Homeostatic regulation of electrical excitability in physiological cardiac hypertrophy.
Volume: 588
Issue: Pt 24
Pages: 5015-32
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Genotype
Genotype
Symbol: Tg(Myh6-Pik3r1/PIK3CA)BSiz/?
Background: involves: FVB/N
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(MMTV-cre)#Tfln/?
Background: involves: 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Ptf1a/Ptf1a<+>
Background: involves: 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Arid1a/Arid1a Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * CD-1
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Arid1a/Arid1a<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * CD-1
Zygosity: cn
Has Mutant Allele: true
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Publication
16627784 | J:122613
First Author: Sun H
Year: 2006
Journal: Circ Res
Title: Insulin-like growth factor-1 and PTEN deletion enhance cardiac L-type Ca2+ currents via increased PI3Kalpha/PKB signaling.
Volume: 98
Issue: 11
Pages: 1390-7
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Publication
34548333 | J:311807
First Author: Zundell JA
Year: 2021
Journal: Cancer Res
Title: Targeting the IRE1α/XBP1 Endoplasmic Reticulum Stress Response Pathway in ARID1A-Mutant Ovarian Cancers.
Volume: 81
Issue: 20
Pages: 5325-5335
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Publication
36963401 | J:334759
First Author: Zhou W
Year: 2023
Journal: Cancer Cell
Title: Targeting the mevalonate pathway suppresses ARID1A-inactivated cancers by promoting pyroptosis.
Volume: 41
Issue: 4
Pages: 740-756.e10
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Publication
31492885 | J:287759
First Author: Zhao B
Year: 2019
Journal: Nat Commun
Title: ARID1A promotes genomic stability through protecting telomere cohesion.
Volume: 10
Issue: 1
Pages: 4067
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Publication
28737768 | J:246354
First Author: Bitler BG
Year: 2017
Journal: Nat Cell Biol
Title: ARID1A-mutated ovarian cancers depend on HDAC6 activity.
Volume: 19
Issue: 8
Pages: 962-973
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Publication
29590609 | J:270936
First Author: Fukumoto T
Year: 2018
Journal: Cell Rep
Title: Repurposing Pan-HDAC Inhibitors for ARID1A-Mutated Ovarian Cancer.
Volume: 22
Issue: 13
Pages: 3393-3400
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Genotype
Genotype
Symbol: Tg(Myh6-IGF1R)7Jmcm/? Tg(Myh6-Pik3ca)1Siz/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-IGF1R)7Jmcm/? Tg(Myh6-Pik3r1/PIK3CA)BSiz/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Myh6-Akt1*T308D*S473D)1Siz/? Tg(Myh6-Pik3ca)1Siz/?
Background: involves: FVB/N
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Trp53/Trp53 Tg(MMTV-cre)#Tfln/?
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(MMTV-cre)#Tfln/? Trp53/Trp53<+>
Background: involves: 129P2/OlaHsd * 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Pdpk1/Pdpk1 Ptf1a/Ptf1a<+>
Background: involves: 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Tg(Cela1-cre/ERT)1Dam/?
Background: involves: 129S6/SvEvTac
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> H3c2/H3c2<+> Olig2/Olig2<+>
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Acvr1/Acvr1<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Olig2/Olig2<+>
Background: involves: 129 * C57BL/6 * FVB/N
Zygosity: cn
Has Mutant Allele: true
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Publication
21474066 | J:310528
First Author: Kennedy AL
Year: 2011
Journal: Mol Cell
Title: Activation of the PIK3CA/AKT pathway suppresses senescence induced by an activated RAS oncogene to promote tumorigenesis.
Volume: 42
Issue: 1
Pages: 36-49
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Publication
37172086 | J:335643
First Author: Bu W
Year: 2023
Journal: Sci Adv
Title: Efficient cancer modeling through CRISPR-Cas9/HDR-based somatic precision gene editing in mice.
Volume: 9
Issue: 19
Pages: eade0059
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Publication
25544637 | J:218823
First Author: Costa C
Year: 2015
Journal: Cancer Cell
Title: Measurement of PIP3 levels reveals an unexpected role for p110β in early adaptive responses to p110α-specific inhibitors in luminal breast cancer.
Volume: 27
Issue: 1
Pages: 97-108
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Publication
31551414 | J:279285
First Author: Wu RC
Year: 2019
Journal: Nat Commun
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