|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 501 to 550 out of 550 for Plcg2

<< First    < Previous  |  Next >    Last >>
0.07s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
- | J:72247
       
First Author: DDB, FB, MGI, GOA, ZFIN curators
Year: 2001
Title: Gene Ontology annotation through association of InterPro records with GO terms
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
•
•
•
•
•
Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
Publication
22236196 | -
First Author: Ombrello MJ
Year: 2012
Journal: N Engl J Med
Title: Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.
Volume: 366
Issue: 4
Pages: 330-8
•
•
•
•
•
Strain
MGI:5519924 | B10.Cg-Plcg2<tm1Jni> H2<d> Tg(BCL2)36Wehi Tg(Igh2<k>3-83)1Nemz/H
Attribute String: congenic, major histocompatibility congenic, mutant strain, targeted mutation, transgenic
•
•
•
•
•
HT Experiment
GSE180274 | PLCG2 regulates endocannabinoid and eicosanoid networks in innate immune cells
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
Allele
Plcg2<em1Smoc> | MGI:7291700
Name: phospholipase C, gamma 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
•
•
•
•
•
Strain
MGI:6429372 | C57BL/6JSmoc-Plcg2<em1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
•
•
•
•
•
DO Term
DOID:0090064 | familial cold autoinflammatory syndrome 3
•
•
•
•
•
DO Term
DOID:0070615 | autoinflammation, antibody deficiency, and immune dysregulation syndrome
•
•
•
•
•
Publication
11602179 | -
First Author: Wilde JI
Year: 2001
Journal: Cell Signal
Title: Regulation of phospholipase C gamma isoforms in haematopoietic cells: why one, not the other?
Volume: 13
Issue: 10
Pages: 691-701
•
•
•
•
•
Publication
20807769 | -
First Author: Gresset A
Year: 2010
Journal: J Biol Chem
Title: Mechanism of phosphorylation-induced activation of phospholipase C-gamma isozymes.
Volume: 285
Issue: 46
Pages: 35836-47
•
•
•
•
•
Publication
15194811 | -
First Author: Yin X
Year: 2004
Journal: Mol Biol Cell
Title: Inositol 1,4,5-trisphosphate signaling regulates rhythmic contractile activity of myoepithelial sheath cells in Caenorhabditis elegans.
Volume: 15
Issue: 8
Pages: 3938-49
•
•
•
•
•
Protein Domain
IPR016279 | PLC-gamma
Type: Family
Description: Phospholipase C gamma (PLCg), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, is a member of the family of phosphoinositide specific PLCs that convert phosphatidylinositol 4,5-bisphosphate into second messengers 1,2-diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), thereby initiating and propagating numerous cellular signaling events [].There are two forms of phospholipase C-gamma, PLCg1 and PLCg2. PLCg1 is widely distributed but the expression of PLCg2 is primarily limited to cells of haematopoietic lineage []. PLCg1 is critical in many cells, and in haematopoietic systems it is required for T cell and NK cell function, whereas PLCg2 is important in mast cells, NK cells, B cells, and platelets. A third form, plc-3, is known from Caenorhabditis elegans [].
•
•
•
•
•
Publication
23000145 | -
First Author: Zhou Q
Year: 2012
Journal: Am J Hum Genet
Title: A hypermorphic missense mutation in PLCG2, encoding phospholipase Cγ2, causes a dominantly inherited autoinflammatory disease with immunodeficiency.
Volume: 91
Issue: 4
Pages: 713-20
•
•
•
•
•
Protein Domain
IPR028381 | PLC-gamma2
Type: Family
Description: Phospholipase C gamma (PLCg), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, is a member of the family of phosphoinositide specific PLCs that convert phosphatidylinositol 4,5-bisphosphate into second messengers 1,2-diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), thereby initiating and propagating numerous cellular signaling events [].There are two forms of phospholipase C-gamma, PLCg1 and PLCg2. PLCg1 is widely distributed but the expression of PLCg2 is primarily limited to cells of haematopoietic lineage []. PLCg1 is critical in many cells, and in haematopoietic systems it is required for T cell and NK cell function, whereas PLCg2 is important in mast cells, NK cells, B cells, and platelets.This entry represents PLCg2. Mutations in PLCg2 gene cause familial cold autoinflammatory syndrome 3 (FCAS3), whcih is an autosomal dominant immune disorder charactersed by the development of cutaneous urticaria, erythema, and pruritis in response to cold exposure []. Mutations in PLCg2 gene also cause autoinflammation, antibody deficiency, and immune dysregulation PLCG2-associated (APLAID), which is an autosomal dominant systemic disorder characterised by recurrent blistering skin lesions with a dense inflammatory infiltrate and variable involvement of other tissues [].
•
•
•
•
•
Publication
17229814 | -
First Author: Wang Y
Year: 2007
Journal: Am J Physiol Cell Physiol
Title: Obligatory role for phospholipase C-gamma(1) in villin-induced epithelial cell migration.
Volume: 292
Issue: 5
Pages: C1775-86
•
•
•
•
•
Protein Domain
IPR028380 | PLC-gamma1
Type: Family
Description: Phospholipase C gamma (PLCg), also known as 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma, is a member of the family of phosphoinositide specific PLCs that convert phosphatidylinositol 4,5-bisphosphate into second messengers 1,2-diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3), thereby initiating and propagating numerous cellular signaling events [].There are two forms of phospholipase C-gamma, PLCg1 and PLCg2. PLCg1 is widely distributed but the expression of PLCg2 is primarily limited to cells of haematopoietic lineage []. PLCg1 is critical in many cells, and in haematopoietic systems it is required for T cell and NK cell function, whereas PLCg2 is important in mast cells, NK cells, B cells, and platelets.PLC-gamma-1 may have a role in actin reorganisation and cell migration [].
•
•
•
•
•
Protein
Q9Z2S5
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: false
•
•
•
•
•
Protein
Q3TUJ5
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
•
•
•
•
•
Publication
25329696 | J:217698
First Author: Li S
Year: 2014
Journal: J Clin Invest
Title: RBP-J imposes a requirement for ITAM-mediated costimulation of osteoclastogenesis.
Volume: 124
Issue: 11
Pages: 5057-73
•
•
•
•
•
Protein
G3V016
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: true
•
•
•
•
•
Protein
F6SLL0
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
•
•
•
•
•
Protein
Q8CIH5
Organism: Mus musculus/domesticus
Length: 1265  
Fragment?: false
•
•
•
•
•
Protein
G3UXP4
Organism: Mus musculus/domesticus
Length: 513  
Fragment?: false
•
•
•
•
•
Protein
Q62077
Organism: Mus musculus/domesticus
Length: 1302  
Fragment?: false
•
•
•
•
•
Protein
Q2M4I9
Organism: Mus musculus/domesticus
Length: 1178  
Fragment?: false
•
•
•
•
•
Protein
Q3UZ68
Organism: Mus musculus/domesticus
Length: 1178  
Fragment?: false
•
•
•
•
•
Protein
A2A4A6
Organism: Mus musculus/domesticus
Length: 1290  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom