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Search results 501 to 600 out of 868 for Plk1

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Type Details Score
Publication
22753416 | -
First Author: Ikeda M
Year: 2012
Journal: J Biol Chem
Title: Furry protein promotes aurora A-mediated Polo-like kinase 1 activation.
Volume: 287
Issue: 33
Pages: 27670-81
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Interaction Experiment
Liu XS (2012)
Description: Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment.
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UniProt Feature
UniProt Feature
Begin: 1
Description: Mitotic interactor and substrate of PLK1
Type: chain
End: 648
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Publication
21601650 | -
First Author: McInnes C
Year: 2011
Journal: Drug Discov Today
Title: PLK1 as an oncology target: current status and future potential.
Volume: 16
Issue: 13-14
Pages: 619-25
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Allele
Mplkipl1<+> | MGI:3661176
 
Name: M-phase specific PLK1 intereacting protein like 1; wild type
Allele Type: Not Specified
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Allele
Mplkip<Gt(OST127512)Lex> | MGI:4195920
 
Name: M-phase specific PLK1 intereacting protein; gene trap OST127512, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Mplkip<Gt(OST140370)Lex> | MGI:4201790
 
Name: M-phase specific PLK1 intereacting protein; gene trap OST140370, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Mplkip<Gt(OST253082)Lex> | MGI:4252412
 
Name: M-phase specific PLK1 intereacting protein; gene trap OST253082, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Mplkip<Gt(OST265128)Lex> | MGI:4256697
 
Name: M-phase specific PLK1 intereacting protein; gene trap OST265128, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Mplkip<Gt(OST306708)Lex> | MGI:4273398
 
Name: M-phase specific PLK1 intereacting protein; gene trap OST306708, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Mplkip<Gt(OST396479)Lex> | MGI:4305018
 
Name: M-phase specific PLK1 intereacting protein; gene trap OST396479, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Mplkip<Gt(OST469199)Lex> | MGI:4327711
 
Name: M-phase specific PLK1 intereacting protein; gene trap OST469199, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Mplkip<tm1(KOMP)Vlcg> | MGI:4453014
Name: M-phase specific PLK1 intereacting protein; targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Mplkip<tm1.1(KOMP)Vlcg> | MGI:5569045
Name: M-phase specific PLK1 intereacting protein; targeted mutation 1.1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Mplkip<em1Nimo> | MGI:7518886
Name: M-phase specific PLK1 intereacting protein; endonuclease-mediated mutation 1, Nima Mosammaparast
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
Mplkip<em2Nimo> | MGI:7518887
Name: M-phase specific PLK1 intereacting protein; endonuclease-mediated mutation 2, Nima Mosammaparast
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Publication
21654194 | -
First Author: de Cárcer G
Year: 2011
Journal: Cell Cycle
Title: From Plk1 to Plk5: functional evolution of polo-like kinases.
Volume: 10
Issue: 14
Pages: 2255-62
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Publication
11829489 | J:74613
First Author: Nakabayashi K
Year: 2002
Journal: Genomics
Title: Molecular genetic studies of human chromosome 7 in Russell-Silver syndrome.
Volume: 79
Issue: 2
Pages: 186-96
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Publication
19503101 | -
First Author: Izumi H
Year: 2009
Journal: Oncogene
Title: BubR1 localizes to centrosomes and suppresses centrosome amplification via regulating Plk1 activity in interphase cells.
Volume: 28
Issue: 31
Pages: 2806-20
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Allele
Mplkip<Gt(D106E11)Wrst> | MGI:3890835
 
Name: M-phase specific PLK1 intereacting protein; gene trap D106E11, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Mplkip<Gt(D175H08)Wrst> | MGI:3892948
 
Name: M-phase specific PLK1 intereacting protein; gene trap D175H08, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Mplkip<Gt(E264E03)Wrst> | MGI:3920980
 
Name: M-phase specific PLK1 intereacting protein; gene trap E264E03, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Mplkip<Gt(EUCE0093e03)Hmgu> | MGI:4384088
 
Name: M-phase specific PLK1 intereacting protein; gene trap EUCE0093e03, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Mplkip<Gt(EUCE0082c08)Hmgu> | MGI:4387571
 
Name: M-phase specific PLK1 intereacting protein; gene trap EUCE0082c08, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Mplkip<Gt(EUCE00149h03)Hmgu> | MGI:4392701
 
Name: M-phase specific PLK1 intereacting protein; gene trap EUCE00149h03, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Mplkip<Gt(EUCE0247a02)Hmgu> | MGI:4395955
 
Name: M-phase specific PLK1 intereacting protein; gene trap EUCE0247a02, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Strain
MGI:6346630 | C57BL/6N-Mplkip<tm1(KOMP)Vlcg>/MbpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Allele
Mplkip<Gt(EUCJ0015e06)Hmgu> | MGI:4869844
 
Name: M-phase specific PLK1 intereacting protein; gene trap EUCJ0015e06, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Mplkip<Gt(348G7)Cmhd> | MGI:4951328
 
Name: M-phase specific PLK1 intereacting protein; gene trap 348G7, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Mplkip<Gt(476H6)Cmhd> | MGI:4954215
 
Name: M-phase specific PLK1 intereacting protein; gene trap 476H6, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Mplkip<Gt(IST13717H9)Tigm> | MGI:5192182
 
Name: M-phase specific PLK1 intereacting protein; gene trap IST13717H9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Mplkip<Gt(IST14427E5)Tigm> | MGI:5236819
 
Name: M-phase specific PLK1 intereacting protein; gene trap IST14427E5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Mplkip<tm1a(EUCOMM)Hmgu> | MGI:5523852
Name: M-phase specific PLK1 intereacting protein; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Strain
MGI:5756295 | C57BL/6N-Mplkip<tm1.1(KOMP)Vlcg>/Ucd
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6346629 | C57BL/6N-Mplkip<tm1.1(KOMP)Vlcg>/MbpMmucd
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:7519034 | C57BL/6-Mplkip<em1Nimo>
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:7519036 | C57BL/6-Mplkip<em2Nimo>
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Mplkip/Mplkip
Background: C57BL/6-Mplkip
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mplkip/Mplkip
Background: C57BL/6-Mplkip
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Mplkip/Mplkip
Background: C57BL/6N-Mplkip/Ucd
Zygosity: hm
Has Mutant Allele: true
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Pathway
R-MMU-2565942 | Regulation of PLK1 Activity at G2/M Transition
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Allele
Plk1<tm1Smoc> | MGI:7291717
Name: polo like kinase 1; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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Publication
16980960 | -
First Author: Oshimori N
Year: 2006
Journal: Nat Cell Biol
Title: The Plk1 target Kizuna stabilizes mitotic centrosomes to ensure spindle bipolarity.
Volume: 8
Issue: 10
Pages: 1095-101
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Publication
23509069 | -
First Author: Zhu M
Year: 2013
Journal: J Cell Biol
Title: MISP is a novel Plk1 substrate required for proper spindle orientation and mitotic progression.
Volume: 200
Issue: 6
Pages: 773-87
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Publication
22869522 | -
First Author: Liu XS
Year: 2012
Journal: Mol Cell Biol
Title: Plk1 phosphorylates Sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment.
Volume: 32
Issue: 19
Pages: 4053-67
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Genotype
Genotype
Symbol: Mplkip/Mplkip<+>
Background: C57BL/6N-Mplkip/Ucd
Zygosity: ht
Has Mutant Allele: true
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Protein Coding Gene
MGI:1924994 | Bora
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q8BS90
Organism: Mus musculus/domesticus
Length: 525  
Fragment?: false
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Publication
9438855 | J:45570
First Author: Echard A
Year: 1998
Journal: Science
Title: Interaction of a Golgi-associated kinesin-like protein with Rab6.
Volume: 279
Issue: 5350
Pages: 580-5
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Publication
12939256 | -
First Author: Neef R
Year: 2003
Journal: J Cell Biol
Title: Phosphorylation of mitotic kinesin-like protein 2 by polo-like kinase 1 is required for cytokinesis.
Volume: 162
Issue: 5
Pages: 863-75
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Protein Domain
IPR027326 | KIF20A
Type: Family
Description: Kinesin-like protein KIF20A was first identified as a binding partner for the rab6 GTPase involved in protein transport at the Golgi apparatus []. It was later found to be a mitotic kinesin required for chromosome passenger complex (CPC)-mediated cytokinesis. It is phosphorylated by PLK1 at Ser-528 during mitosis, creating a docking site for PLK1 and recruiting PLK1 at central spindle. It contains a kinesin-motor domain and has a microtubule plus end-directed motility [].
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Protein
Q5F2C3
Organism: Mus musculus/domesticus
Length: 434  
Fragment?: false
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Protein
C6EQJ0
Organism: Mus musculus/domesticus
Length: 332  
Fragment?: false
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Protein
Q9D5P1
Organism: Mus musculus/domesticus
Length: 259  
Fragment?: false
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Protein Domain
IPR034545 | Meikin
Type: Family
Description: The meiosis-specific kinetochore factor Meikin plays a crucial role in both mono-orientation and centromeric cohesion protection during meiosis I, partly by stabilizing the localization of the cohesin protector shugoshin, and also by recruiting Polo-like kinase PLK1 to the kinetochores. PLK1 is required for mono-orientation and the protection of centromeric cohesion [].
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Allele
Foxm1<em1Pra> | MGI:7331325
Name: forkhead box M1; endonuclease-mediated mutation 1, Pradip Raychaudhuri
Allele Type: Endonuclease-mediated
Attribute String: Modified regulatory region
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Protein Domain
IPR045842 | Fry_C
Type: Domain
Description: This entry represents the C-terminal domain of protein furry (Fry). Fry plays a crucial role in the structural integrity of mitotic centrosomes and in the maintenance of spindle bipolarity. This domain binds to polo-like kinase 1 (Plk1) through the polo-box domain (PBD) of Plk1 in a manner dependent on the cyclin-dependent kinase 1-mediated Fry phosphorylation, promoting Plk1 activity during early mitosis. Fry also binds to Aurora A and may function as a scaffold promoting the interaction between AURKA and PLK1, thereby enhancing AURKA-mediated PLK1 phosphorylation [].
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Publication
29370175 | J:256989
First Author: King R
Year: 2018
Journal: PLoS Genet
Title: Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma.
Volume: 14
Issue: 1
Pages: e1007145
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Protein Domain
IPR032921 | PRC1
Type: Family
Description: PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone []. It is a key regulator of cytokinesis that cross-links antiparallel microtubules at an average distance of 35 nM [, ]. PRC1 is also required for KIF14 (a kinesin-3 family motor protein) localisation to the central spindle and midbody [, , ]and is required to recruit PLK1 to the spindle. It stimulates PLK1 phosphorylation of RACGAP1/HsCyk-4 to allow recruitment of ECT2 to the central spindle [].
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Protein Coding Gene
MGI:1341886 | Ajuba
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q91XC0
Organism: Mus musculus/domesticus
Length: 547  
Fragment?: false
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Protein
Q99KZ2
Organism: Mus musculus/domesticus
Length: 295  
Fragment?: true
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Protein
A0A0J9YTT8
Organism: Mus musculus/domesticus
Length: 653  
Fragment?: true
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Protein
Q8BIX6
Organism: Mus musculus/domesticus
Length: 567  
Fragment?: false
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Protein
A0A0J9YU33
Organism: Mus musculus/domesticus
Length: 331  
Fragment?: true
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Protein
Q80UX7
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: false
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Protein
Q9CS05
Organism: Mus musculus/domesticus
Length: 514  
Fragment?: true
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Publication
9497389 | J:46555
First Author: Dong F
Year: 1998
Journal: J Biol Chem
Title: Molecular characterization of a cDNA that encodes six isoforms of a novel murine A kinase anchor protein.
Volume: 273
Issue: 11
Pages: 6533-41
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Protein
Q99K43
Organism: Mus musculus/domesticus
Length: 603  
Fragment?: false
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Protein
G3UXB1
Organism: Mus musculus/domesticus
Length: 151  
Fragment?: true
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Protein
G3UW86
Organism: Mus musculus/domesticus
Length: 606  
Fragment?: false
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Protein
G3XA79
Organism: Mus musculus/domesticus
Length: 525  
Fragment?: false
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Protein
G3UY19
Organism: Mus musculus/domesticus
Length: 566  
Fragment?: false
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Protein
Q91ZQ9
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: true
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Protein
G3UXT4
Organism: Mus musculus/domesticus
Length: 235  
Fragment?: true
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Protein
G3UYX6
Organism: Mus musculus/domesticus
Length: 249  
Fragment?: true
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Protein
G3UWQ7
Organism: Mus musculus/domesticus
Length: 620  
Fragment?: false
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Publication
9885575 | -
First Author: Jiang W
Year: 1998
Journal: Mol Cell
Title: PRC1: a human mitotic spindle-associated CDK substrate protein required for cytokinesis.
Volume: 2
Issue: 6
Pages: 877-85
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Publication
12082078 | -
First Author: Mollinari C
Year: 2002
Journal: J Cell Biol
Title: PRC1 is a microtubule binding and bundling protein essential to maintain the mitotic spindle midzone.
Volume: 157
Issue: 7
Pages: 1175-86
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Publication
15297875 | -
First Author: Kurasawa Y
Year: 2004
Journal: EMBO J
Title: Essential roles of KIF4 and its binding partner PRC1 in organized central spindle midzone formation.
Volume: 23
Issue: 16
Pages: 3237-48
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Publication
15625105 | -
First Author: Zhu C
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Cell cycle-dependent translocation of PRC1 on the spindle by Kif4 is essential for midzone formation and cytokinesis.
Volume: 102
Issue: 2
Pages: 343-8
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Publication
16431929 | -
First Author: Gruneberg U
Year: 2006
Journal: J Cell Biol
Title: KIF14 and citron kinase act together to promote efficient cytokinesis.
Volume: 172
Issue: 3
Pages: 363-72
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Publication
20691902 | -
First Author: Subramanian R
Year: 2010
Journal: Cell
Title: Insights into antiparallel microtubule crosslinking by PRC1, a conserved nonmotor microtubule binding protein.
Volume: 142
Issue: 3
Pages: 433-43
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Publication
19468300 | -
First Author: Wolfe BA
Year: 2009
Journal: PLoS Biol
Title: Polo-like kinase 1 directs assembly of the HsCyk-4 RhoGAP/Ect2 RhoGEF complex to initiate cleavage furrow formation.
Volume: 7
Issue: 5
Pages: e1000110
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Protein Domain
IPR029304 | AKAP2_C
Type: Domain
Description: This domain is found at the C terminus of A-kinase anchor protein 2 (AKAP2). It includes the site where the regulatory subunits (RII) of protein kinase AII binds [].Besides AKAP2, proteins containing this domain include mitotic interactor and substrate of PLK1 (Misp) []and uncharacterised protein LOC113230.
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Protein Coding Gene
MGI:1916417 | Ppp1r12b
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1309528 | Ppp1r12a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:104871 | Ppp1cb
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P62141
Organism: Mus musculus/domesticus
Length: 327  
Fragment?: false
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Protein
Q9DBR7
Organism: Mus musculus/domesticus
Length: 1029  
Fragment?: false
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Protein
Q8BG95
Organism: Mus musculus/domesticus
Length: 976  
Fragment?: false
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Publication
19020301 | J:145878
First Author: Greenbaum MP
Year: 2009
Journal: Biol Reprod
Title: Mouse TEX14 is required for embryonic germ cell intercellular bridges but not female fertility.
Volume: 80
Issue: 3
Pages: 449-57
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Publication
16549803 | J:107660
First Author: Greenbaum MP
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: TEX14 is essential for intercellular bridges and fertility in male mice.
Volume: 103
Issue: 13
Pages: 4982-7
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Publication
20176808 | J:161709
First Author: Iwamori T
Year: 2010
Journal: Mol Cell Biol
Title: TEX14 interacts with CEP55 to block cell abscission.
Volume: 30
Issue: 9
Pages: 2280-92
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Publication
12591913 | -
First Author: Schuyler SC
Year: 2003
Journal: J Cell Biol
Title: The molecular function of Ase1p: evidence for a MAP-dependent midzone-specific spindle matrix. Microtubule-associated proteins.
Volume: 160
Issue: 4
Pages: 517-28
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Publication
16014384 | -
First Author: Chang HY
Year: 2005
Journal: J Cell Sci
Title: Dynamic interaction of NtMAP65-1a with microtubules in vivo.
Volume: 118
Issue: Pt 14
Pages: 3195-201
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Publication
15908607 | -
First Author: Mao T
Year: 2005
Journal: Plant Physiol
Title: Two microtubule-associated proteins of the Arabidopsis MAP65 family function differently on microtubules.
Volume: 138
Issue: 2
Pages: 654-62
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Publication
16098102 | -
First Author: Mao G
Year: 2005
Journal: Plant J
Title: Modulated targeting of GFP-AtMAP65-1 to central spindle microtubules during division.
Volume: 43
Issue: 4
Pages: 469-78
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Publication
17011227 | -
First Author: Sasabe M
Year: 2006
Journal: Curr Opin Plant Biol
Title: MAP65: a bridge linking a MAP kinase to microtubule turnover.
Volume: 9
Issue: 6
Pages: 563-70
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Publication
16847052 | -
First Author: Smertenko AP
Year: 2006
Journal: J Cell Sci
Title: Control of the AtMAP65-1 interaction with microtubules through the cell cycle.
Volume: 119
Issue: Pt 15
Pages: 3227-37
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