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Search results 501 to 600 out of 8636 for Pml

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Hits by Pathway

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Hits by Strain

Type Details Score
Genotype
Genotype
Symbol: Mleu3/Mleu3 Tg(CTSG-PML/RARA)135Ley/?
Background: involves: C3H/HeJ * C57BL/6J * SWR/J
Zygosity: cx
Has Mutant Allele: true
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Publication
30862451 | J:274773
 
First Author: Barefield DY
Year: 2019
Journal: J Mol Cell Cardiol
Title: Ablation of the calpain-targeted site in cardiac myosin binding protein-C is cardioprotective during ischemia-reperfusion injury.
Volume: 129
Pages: 236-246
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Protein Coding Gene
MGI:2444855 | Klhl20
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1197527 | Top3a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915751 | Nsmce2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914120 | Serbp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1352465 | Nr2c1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2183446 | Agap3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1921382 | Rnf6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88548 | Csnk2b
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Tg(CTSG-PML/RARA)6179Ppp | MGI:3573865
Name: transgene insertion 6179, Pier Paolo Pandolfi
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
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Protein Coding Gene
MGI:1336201 | Sumo3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1860606 | Akap8l
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1928377 | Elf4
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
21498514 | J:173222
First Author: Ahmady E
Year: 2011
Journal: J Biol Chem
Title: Identification of a novel muscle A-type lamin-interacting protein (MLIP).
Volume: 286
Issue: 22
Pages: 19702-13
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Protein Coding Gene
MGI:1861447 | Ankrd2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17008533 | J:139857
First Author: Walter MJ
Year: 2007
Journal: Blood
Title: Expression of a bcr-1 isoform of RARalpha-PML does not affect the penetrance of acute promyelocytic leukemia or the acquisition of an interstitial deletion on mouse chromosome 2.
Volume: 109
Issue: 3
Pages: 1237-40
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Protein Coding Gene
MGI:1917600 | Basp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1928895 | Isg20
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2384584 | Rfwd3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1934919 | Rnf111
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1929612 | Ikbke
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108247 | Tdg
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2385088 | Smc5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1339939 | Rpa2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1921004 | Thap1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1891713 | Habp4
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
30143619 | J:266248
First Author: Peterson JM
Year: 2018
Journal: Nat Commun
Title: NF-κB inhibition rescues cardiac function by remodeling calcium genes in a Duchenne muscular dystrophy model.
Volume: 9
Issue: 1
Pages: 3431
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Publication
31064843 | J:281018
First Author: Lubbers ER
Year: 2019
Journal: J Biol Chem
Title: Defining new mechanistic roles for αII spectrin in cardiac function.
Volume: 294
Issue: 24
Pages: 9576-9591
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Publication
34587386 | J:341542
First Author: Chai G
Year: 2021
Journal: N Engl J Med
Title: A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion.
Volume: 385
Issue: 14
Pages: 1292-1301
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Publication
35203314 | J:321611
 
First Author: El Refaey M
Year: 2022
Journal: Cells
Title: Altered Expression of Zonula occludens-1 Affects Cardiac Na+ Channels and Increases Susceptibility to Ventricular Arrhythmias.
Volume: 11
Issue: 4
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Publication
33781820 | J:308888
 
First Author: Lynch TL 4th
Year: 2021
Journal: J Mol Cell Cardiol
Title: Amino terminus of cardiac myosin binding protein-C regulates cardiac contractility.
Volume: 156
Pages: 33-44
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Protein Coding Gene
MGI:1345184 | Tenm2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1344395 | Chd3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2683486 | Rere
Type: protein_coding_gene
Organism: mouse, laboratory
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Allele
Tg(CTSG-PML/RARA)#Ppp | MGI:3040508
Name: transgene insertion, Pier Paolo Pandolfi
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
16331271 | J:107263
First Author: Rego EM
Year: 2006
Journal: Oncogene
Title: Leukemia with distinct phenotypes in transgenic mice expressing PML/RAR alpha, PLZF/RAR alpha or NPM/RAR alpha.
Volume: 25
Issue: 13
Pages: 1974-9
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Publication
16648899 | J:114907
First Author: Santana BA
Year: 2006
Journal: Braz J Med Biol Res
Title: Asynchronous expression of myeloid antigens in leukemic cells in a PML/RARalpha transgenic mouse model.
Volume: 39
Issue: 5
Pages: 615-20
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Allele
Pml<tm1(PML/RARA)Ley> | MGI:5014059
Name: promyelocytic leukemia; targeted mutation 1, Timothy J Ley
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence, Null/knockout
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Genotype
Genotype
Symbol: Tg(CTSG-PML/RARA)6179Ppp/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Protein Coding Gene
MGI:1314882 | Hipk3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2158813 | Sumo2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2445066 | Hmbox1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:99257 | Eif3e
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1923076 | Senp2
Type: protein_coding_gene
Organism: mouse, laboratory
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GO Term
GO:0016606 | LYSP100-associated nuclear domain
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Protein
Q8BSJ6
Organism: Mus musculus/domesticus
Length: 543  
Fragment?: true
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Protein Domain
IPR021978 | DUF3583
Type: Family
Description: This domain is found in eukaryotes, and is typically between 302 and 338 amino acids in length. It is found in association with and . Most members are promyelocytic leukemia proteins, and this family lies towards the C terminus. Proteins containing this domain include PML protein from mammals. PML (promyelocytic leukaemia) functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms [].
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Protein Coding Gene
MGI:1921453 | Eif4enif1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1914491 | Smc6
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:109372 | Cbx5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1913125 | Pias1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:103067 | Atrx
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97308 | Nfe2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1096566 | Pias2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
9462740 | J:78201
First Author: He LZ
Year: 1998
Journal: Nat Genet
Title: Distinct interactions of PML-RARalpha and PLZF-RARalpha with co-repressors determine differential responses to RA in APL.
Volume: 18
Issue: 2
Pages: 126-35
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Protein Coding Gene
MGI:2182061 | Usp7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:105084 | Satb1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1933302 | Trim8
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1926609 | Trp53inp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1203520 | Dapk3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1100512 | Mre11a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108445 | Ciita
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
21869839 | J:181530
First Author: dos Santos GA
Year: 2012
Journal: Leukemia
Title: (+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo.
Volume: 26
Issue: 3
Pages: 451-60
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Publication
22517898 | J:188662
First Author: Jácomo RH
Year: 2012
Journal: Blood
Title: Methionine-induced hyperhomocysteinemia reverts fibrinolytic pathway activation in a murine model of acute promyelocytic leukemia.
Volume: 120
Issue: 1
Pages: 207-13
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Allele
Tg(CTSG-RARA/PML)#Ley | MGI:4353264
Name: transgene insertion, Timothy Ley
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Allele
Tg(CTSG-RARA/PML)2544Ley | MGI:4353271
Name: transgene insertion 2544, Timothy Ley
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:5317168 | C57BL/6-Pml<tm1(PML/RARA)Ley>/J
Attribute String: targeted mutation, mutant strain, coisogenic
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Genotype
Genotype
Symbol: Pml/Pml<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(CTSG-PML/RARA)#Ppp/?
Background: Not Specified
Zygosity: ot
Has Mutant Allele: true
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Protein Coding Gene
MGI:1915525 | Rpa1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2146189 | Topors
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12419228 | J:84904
First Author: Best JL
Year: 2002
Journal: Mol Cell
Title: SUMO-1 protease-1 regulates gene transcription through PML.
Volume: 10
Issue: 4
Pages: 843-55
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Protein Coding Gene
MGI:1197015 | Daxx
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:88543 | Csnk2a1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1351625 | Nbn
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1314873 | Hipk1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
18552208 | J:139159
First Author: Funk RK
Year: 2008
Journal: Blood
Title: Quantitative trait loci associated with susceptibility to therapy-related acute murine promyelocytic leukemia in hCG-PML/RARA transgenic mice.
Volume: 112
Issue: 4
Pages: 1434-42
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Protein Coding Gene
MGI:109561 | Sp100
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:2136940 | Pias4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:96921 | Max
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:107365 | Ube2i
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:106203 | Skil
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1201691 | Rnf4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:98384 | Spn
Type: protein_coding_gene
Organism: mouse, laboratory
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Genotype
Genotype
Symbol: Pml/Pml<+> Lyz2/Lyz2<+>
Background: involves: 129P2/OlaHsd * BALB/cJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pml/Pml<+> Tg(CMV-cre)1Cgn/?
Background: involves: BALB/cJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Protein Coding Gene
MGI:894279 | Mknk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1346347 | Mapk7
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:97904 | Trim27
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1859709 | Rgs14
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1890574 | Sptbn4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1920018 | Topbp1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1355321 | Chek2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
17245429 | J:196105
First Author: Milovic-Holm K
Year: 2007
Journal: EMBO J
Title: FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies.
Volume: 26
Issue: 2
Pages: 391-401
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Protein Domain
IPR038368 | Mastadenovirus_E4/Orf3_sf
Type: Homologous_superfamily
Description: This superfamily consists of several Mastadenovirus E4 ORF3 proteins. Early proteins E4 ORF3 and E4 ORF6 have complementary functions during viral infection. Both proteins facilitate efficient viral DNA replication, late protein expression, and prevention of concatenation of viral genomes. A unique function of E4 ORF3 is the reorganisation of nuclear structures known as PML oncogenic domains (PODs). This domain is annotated as pleiotropic. It is relevant to highlight that early proteins E4 ORF3 and E4 ORF6 have complementary functions during viral infection which include efficient viral DNA replication, late protein expression, and prevention of concatenation of viral genomes. However, characterisation of E4 ORF3 has revealed several unique functions such as the reorganisation of nuclear structures known as PML oncogenic domains (PODs), which are nuclear structures whose function still remains unclear although these have been implicated in several critical cellular processes such as, regulation of transcription, apoptosis, transformation, and response to interferon [].
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Protein
Q5FW52
Organism: Mus musculus/domesticus
Length: 269  
Fragment?: false
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Protein
V9GXX2
Organism: Mus musculus/domesticus
Length: 836  
Fragment?: false
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Protein
V9GXK2
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: true
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Protein
V9GXA0
Organism: Mus musculus/domesticus
Length: 775  
Fragment?: false
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom