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Search results 501 to 567 out of 567 for Pou1f1

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Type Details Score
Publication
28807898 | J:245758
First Author: Carreno G
Year: 2017
Journal: Development
Title: Hypothalamic sonic hedgehog is required for cell specification and proliferation of LHX3/LHX4 pituitary embryonic precursors.
Volume: 144
Issue: 18
Pages: 3289-3302
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Publication
23674600 | J:198684
First Author: Trowe MO
Year: 2013
Journal: Development
Title: Inhibition of Sox2-dependent activation of Shh in the ventral diencephalon by Tbx3 is required for formation of the neurohypophysis.
Volume: 140
Issue: 11
Pages: 2299-309
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Publication
7873877 | J:21510
First Author: Johnson KR
Year: 1994
Journal: Mamm Genome
Title: Identification and genetic mapping of 151 dispersed members of 16 ribosomal protein multigene families in the mouse.
Volume: 5
Issue: 11
Pages: 670-87
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Publication
20932939 | J:168654
First Author: Chung YC
Year: 2011
Journal: Gene Expr Patterns
Title: Screening large numbers of expression patterns of transcription factors in late stages of the mouse thymus.
Volume: 11
Issue: 1-2
Pages: 84-92
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Publication
- | J:15839
       
First Author: International Committee on Standardized Genetic Nomenclature for Mice
Year: 1993
Title: Nomenclature rule change to delete hyphens and parentheses from mouse locus symbols
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Publication
20059953 | J:156017
First Author: Yokoyama S
Year: 2009
Journal: Dev Cell
Title: A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58.
Volume: 17
Issue: 6
Pages: 836-48
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
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Publication
15618518 | J:91257
First Author: Gray PA
Year: 2004
Journal: Science
Title: Mouse brain organization revealed through direct genome-scale TF expression analysis.
Volume: 306
Issue: 5705
Pages: 2255-7
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
- | J:136110
     
First Author: Velocigene
Year: 2008
Journal: MGI Direct Data Submission
Title: Alleles produced for the KOMP project by Velocigene (Regeneron Pharmaceuticals)
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Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:78475
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database
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Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Allele
Pou1f1<em1(cre)Xidw> | MGI:7767880
Name: POU domain, class 1, transcription factor 1; endonuclease-mediated mutation 1, Xiaodong Wang
Allele Type: Endonuclease-mediated
Attribute String: Recombinase
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DO Term
DOID:0061019 | combined or isolated pituitary hormone deficiency 1
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Publication
37616545 | J:342821
 
First Author: Gonigam RL
Year: 2023
Journal: Endocrinology
Title: Characterization of Somatotrope Cell Expansion in Response to GHRH in the Neonatal Mouse Pituitary.
Volume: 164
Issue: 10
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Publication
36683433 | J:335569
 
First Author: Winningham AH
Year: 2023
Journal: Endocrinology
Title: Pituitary Stem Cell Regulation by Zeb2 and BMP Signaling.
Volume: 164
Issue: 3
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Publication
26812162 | J:233898
First Author: Davis SW
Year: 2016
Journal: Endocrinology
Title: All Hormone-Producing Cell Types of the Pituitary Intermediate and Anterior Lobes Derive From Prop1-Expressing Progenitors.
Volume: 157
Issue: 4
Pages: 1385-96
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Publication
21964592 | J:197591
First Author: Castinetti F
Year: 2011
Journal: Mol Endocrinol
Title: PITX2 AND PITX1 regulate thyrotroph function and response to hypothyroidism.
Volume: 25
Issue: 11
Pages: 1950-60
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Publication
33837405 | J:305948
     
First Author: Daly AZ
Year: 2021
Journal: Endocrinology
Title: Pituitary tumors and immortalized cell lines generated by cre-inducible expression of SV40 T antigen.
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Publication
31650157 | J:290388
 
First Author: Joustra SD
Year: 2020
Journal: J Clin Endocrinol Metab
Title: IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction.
Volume: 105
Issue: 3
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Publication
22890843 | J:189254
First Author: Romero CJ
Year: 2012
Journal: Mol Cell Biol
Title: Insulin-like growth factor 1 mediates negative feedback to somatotroph GH expression via POU1F1/CREB binding protein interactions.
Volume: 32
Issue: 21
Pages: 4258-69
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Publication
32188976 | J:295321
 
First Author: Peel MT
Year: 2020
Journal: Endocrinology
Title: The Transcription Factor NR4A2 Plays an Essential Role in Driving Prolactin Expression in Female Pituitary Lactotropes.
Volume: 161
Issue: 5
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Publication
20181723 | J:158763
First Author: Carvalho LR
Year: 2010
Journal: Mol Endocrinol
Title: Corepressors TLE1 and TLE3 interact with HESX1 and PROP1.
Volume: 24
Issue: 4
Pages: 754-65
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Publication
9462743 | J:45911
First Author: Wu W
Year: 1998
Journal: Nat Genet
Title: Mutations in PROP1 cause familial combined pituitary hormone deficiency.
Volume: 18
Issue: 2
Pages: 147-9
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Publication
20025935 | J:160034
First Author: Davis SW
Year: 2010
Journal: Mol Cell Endocrinol
Title: Molecular mechanisms of pituitary organogenesis: In search of novel regulatory genes.
Volume: 323
Issue: 1
Pages: 4-19
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Publication
30247555 | J:268615
First Author: Peel MT
Year: 2018
Journal: Endocrinology
Title: Transcriptome Analyses of Female Somatotropes and Lactotropes Reveal Novel Regulators of Cell Identity in the Pituitary.
Volume: 159
Issue: 12
Pages: 3965-3980
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Publication
24284820 | J:211885
First Author: Avtanski D
Year: 2014
Journal: Mol Endocrinol
Title: Both estrogen receptor α and β stimulate pituitary GH gene expression.
Volume: 28
Issue: 1
Pages: 40-52
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Protein Domain
IPR015586 | Pit_1
Type: Family
Description: POU proteins are eukaryotic transcription factors containing a bipartite DNA-binding domain referred to as the POU domain. The acronym POU (pronounced 'pow') is named after the pituitary-specific Pit-1, octamer-binding proteins Oct-1 and Oct-2, and the neural Unc-86 from Caenorhabditis elegans. The POU domain is a 70 to 75 amino-acid region found upstream of a homeobox domain in some transcription factors. POU domain genes have been described in organisms as divergent as C. elegans, Drosophila melanogaster (Fruit fly), Xenopus laevis (African clawed frog), Danio rerio (Zebrafish) (Brachydanio rerio) and Homo sapiens (Human) but have not been yet identified in plants and fungi. The various members of the POU family have a wide variety of functions, all of which are related to the development of an organism [].The POU domain is a bipartite domain composed of two subunits separated by a non-conserved region of 15-55 amino acids. The N-terminal subunit is known as POU-specific (POUs) domain () and a C-terminal homeodomain. Both subdomains contain the structural motif 'helix-turn-helix', which directly associates with the two components of bipartite DNA-binding sites. The 3-D structure of the POU-domain has been determined by multidimensional NMR []and X-ray crystallography to 3.0 A resolution []. The subdomains are connected by a flexible linker [, , ]. Despite of the lack of sequence homology, 3D structure of POUs is similar to 3D structure of bacteriophage lambda repressor and other members of HTH_3 family [, ].POU domain containing proteins bind to specific DNA sequences to cause temporal and spatial regulation of genes. Including genes: involved in the regulation of neuronal development in the central nervous system of mammals []; immunoglobulin light and heavy chains (Oct-2) []; and those for prolactin and growth hormone (Pit-1). Both elements of the POU-domain are required for high affinity sequence-specific DNA-binding. The domain may also be involved in protein-protein interactions [].Pituitary-specific positive transcription factor 1 (PIT1) is required for the appearance of hormone specific cell types in the anterior pituitary, including: lactotrophs, which secrete prolactin (PRL); thyrotrophs, which secrete thyroid stimulating hormone (TSH); somatotrophs, which secrete growth hormone (GH), and corticotrophs, which secrete adrenocorticotropic hormone (ACTH) []. PIT1-deficient Pit1dw mutant mouse shows that PIT1 autoregulation is not needed for initial activation or continued expression during critical phases of PIT1 target gene activation, but is necessary for subsequent maintenance of Pit1 gene expression after birth. Homozygous Pit1dw mice are about one-fourth to one-third normal size and are sterile. The small size is due to a defective anterior pituitary in which there is a great deficiency of GH-producing, PRL-producing, and TSH-producing cells. The human homologue POU1F1 gene has been shown to be mutated in some forms of human dwarfism caused by a lack of pituitary hormones [].
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Protein
Q62089
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: true
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Publication
1628619 | -
First Author: Mathis JM
Year: 1992
Journal: EMBO J
Title: Brain 4: a novel mammalian POU domain transcription factor exhibiting restricted brain-specific expression.
Volume: 11
Issue: 7
Pages: 2551-61
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Publication
1967821 | -
First Author: Johnson WA
Year: 1990
Journal: Nature
Title: Binding of a Drosophila POU-domain protein to a sequence element regulating gene expression in specific dopaminergic neurons.
Volume: 343
Issue: 6257
Pages: 467-70
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Publication
1967834 | -
First Author: Petryniak B
Year: 1990
Journal: Proc Natl Acad Sci U S A
Title: Characterization of chicken octamer-binding proteins demonstrates that POU domain-containing homeobox transcription factors have been highly conserved during vertebrate evolution.
Volume: 87
Issue: 3
Pages: 1099-103
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Publication
8462099 | -
First Author: Assa-Munt N
Year: 1993
Journal: Cell
Title: The solution structure of the Oct-1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain.
Volume: 73
Issue: 1
Pages: 193-205
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Publication
8156594 | -
First Author: Klemm JD
Year: 1994
Journal: Cell
Title: Crystal structure of the Oct-1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules.
Volume: 77
Issue: 1
Pages: 21-32
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Publication
11159814 | -
First Author: Andersen B
Year: 2001
Journal: Endocr Rev
Title: POU domain factors in the neuroendocrine system: lessons from developmental biology provide insights into human disease.
Volume: 22
Issue: 1
Pages: 2-35
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Publication
11183772 | -
First Author: Phillips K
Year: 2000
Journal: J Mol Biol
Title: The virtuoso of versatility: POU proteins that flex to fit.
Volume: 302
Issue: 5
Pages: 1023-39
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Publication
9009203 | -
First Author: Jacobson EM
Year: 1997
Journal: Genes Dev
Title: Structure of Pit-1 POU domain bound to DNA as a dimer: unexpected arrangement and flexibility.
Volume: 11
Issue: 2
Pages: 198-212
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Protein
Q00286
Organism: Mus musculus/domesticus
Length: 291  
Fragment?: false
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Protein
F8WGJ8
Organism: Mus musculus/domesticus
Length: 317  
Fragment?: false
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Protein
F1T2M3
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
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