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Search results 501 to 600 out of 666 for Rala

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Type Details Score
Protein
Q9CXY0
Organism: Mus musculus/domesticus
Length: 206  
Fragment?: false
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Publication
9438849 | -
First Author: Nimnual AS
Year: 1998
Journal: Science
Title: Coupling of Ras and Rac guanosine triphosphatases through the Ras exchanger Sos.
Volume: 279
Issue: 5350
Pages: 560-3
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Protein
A0A1W2P7Y4
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: true
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Protein Domain
IPR036964 | RASGEF_cat_dom_sf
Type: Homologous_superfamily
Description: Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP []in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. The balance between the GTP bound (active) and GDP bound (inactive) states is regulated by the opposite action of proteins activating the GTPase activity and that of proteins which promote the loss of bound GDP and the uptake of fresh GTP [, ]. The latter proteins are known as guanine-nucleotide exchange (or releasing) factors (GEFs or GRFs) (or also as guanine-nucleotide dissociation stimulators (GDSs)). GEFs catalyze thedissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors [, ].The crystal structure of the GEF region of human Sos1 complexes with Ras has been solved []. The structure consists of two distinct alpha helical structural domains: the N-terminal domain which seems to have a purely structural role and the C-terminal domain which is sufficient for catalytic activity and contains all residues that interact with Ras. A main feature of the catalytic domain is the protrusion of a helical hairpin important for the nucleotide-exchange mechanism. The N-terminal domain is likely to be important for the stability and correct placement of the hairpin structure.Some proteins known to contain a Ras-GEF domain are listed below:Cdc25 from yeast.Scd25 from yeast.Ste6 from fission yeast.Son of sevenless (gene sos) from Drosophila and mammals.p140-RAS GRF (cdc25Mm) from mammals. This protein possesses both a domain belonging to the CDC25 family and one belonging to the CDC24 family.Bud5 from yeast, that may interact with the ras-like protein RSR1/BUD1.Lte1 from yeast, whose target protein is not yet known.ralGDS from mammals, which interacts with the ras-like proteins ralA and ralB [].This entry represents the C-terminal catalytic domain of the Ras guanine-nucleotide exchange factors.
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Protein Domain
IPR001895 | RASGEF_cat_dom
Type: Domain
Description: Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP []in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. The balance between the GTP bound (active) and GDP bound (inactive) states is regulated by the opposite action of proteins activating the GTPase activity and that of proteins which promote the loss of bound GDP and the uptake of fresh GTP [, ]. The latter proteins are known as guanine-nucleotide exchange (or releasing) factors (GEFs or GRFs) (or also as guanine-nucleotide dissociation stimulators (GDSs)). GEFs catalyze the dissociation of GDP from the inactive GTP-binding proteins. GTP can then bind and induce structural changes that allow interaction with effectors [, ].The crystal structure of the GEF region of human Sos1 complexes with Ras has been solved []. The structure consists of two distinct alpha helical structural domains: the N-terminal domain which seems to have a purely structural role and the C-terminal domain which is sufficient for catalytic activity and contains all residues that interact with Ras. A main feature of the catalytic domain is the protrusion of a helical hairpin important for the nucleotide-exchange mechanism. The N-terminal domain is likely to be important for the stability and correct placement of the hairpin structure.Some proteins known to contain a Ras-GEF domain are listed below:Cdc25 from yeast.Scd25 from yeast.Ste6 from fission yeast.Son of sevenless (gene sos) from Drosophila and mammals.p140-RAS GRF (cdc25Mm) from mammals. This protein possesses both a domain belonging to the CDC25 family and one belonging to the CDC24 family.Bud5 from yeast, that may interact with the ras-like protein RSR1/BUD1.Lte1 from yeast, whose target protein is not yet known.ralGDS from mammals, which interacts with the ras-like proteins ralA and ralB [].This entry represents the catalytic domain of the Ras guanine-nucleotide exchange factors.
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Protein
A0A087WPL3
Organism: Mus musculus/domesticus
Length: 128  
Fragment?: true
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Protein
A0A087WQU0
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
A0A087WQ61
Organism: Mus musculus/domesticus
Length: 463  
Fragment?: false
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Protein
Q8C134
Organism: Mus musculus/domesticus
Length: 523  
Fragment?: false
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Protein
A0A1W2P6Q0
Organism: Mus musculus/domesticus
Length: 49  
Fragment?: true
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Protein
A0A0A6YXI6
Organism: Mus musculus/domesticus
Length: 78  
Fragment?: false
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Protein
A0A0G2JFC0
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: true
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Protein
A0A1W2P7P2
Organism: Mus musculus/domesticus
Length: 111  
Fragment?: true
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Protein
Q925J1
Organism: Mus musculus/domesticus
Length: 149  
Fragment?: true
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Publication
15340059 | -
First Author: Li Y
Year: 2004
Journal: Mol Cell Biol
Title: Biochemical and functional characterizations of small GTPase Rheb and TSC2 GAP activity.
Volume: 24
Issue: 18
Pages: 7965-75
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Publication
12271141 | -
First Author: Tee AR
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
Volume: 99
Issue: 21
Pages: 13571-6
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Protein
Q68EF8
Organism: Mus musculus/domesticus
Length: 662  
Fragment?: false
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Protein
Q3TYC0
Organism: Mus musculus/domesticus
Length: 344  
Fragment?: false
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Publication
7786285 | J:25630
First Author: Quilliam LA
Year: 1995
Journal: Bioessays
Title: Guanine nucleotide exchange factors: activators of the Ras superfamily of proteins.
Volume: 17
Issue: 5
Pages: 395-404
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Publication
15335949 | -
First Author: Downward J
Year: 1992
Journal: Curr Biol
Title: Ras regulation: putting back the GTP.
Volume: 2
Issue: 6
Pages: 329-31
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Protein
Q8BQZ4
Organism: Mus musculus/domesticus
Length: 1484  
Fragment?: false
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Protein
B2RRF1
Organism: Mus musculus/domesticus
Length: 1507  
Fragment?: false
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Protein
F8WHN4
Organism: Mus musculus/domesticus
Length: 1491  
Fragment?: false
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Protein
Q3TP98
Organism: Mus musculus/domesticus
Length: 207  
Fragment?: true
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Protein
E9Q0J2
Organism: Mus musculus/domesticus
Length: 1507  
Fragment?: false
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Protein
A2ACC6
Organism: Mus musculus/domesticus
Length: 1495  
Fragment?: false
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Protein
A0A0G2JGV2
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: true
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Protein
A2ACC7
Organism: Mus musculus/domesticus
Length: 1173  
Fragment?: true
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Protein
Q3TQ10
Organism: Mus musculus/domesticus
Length: 237  
Fragment?: true
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Publication
10760592 | -
First Author: Sood R
Year: 2000
Journal: Biochim Biophys Acta
Title: The human RGL (RalGDS-like) gene: cloning, expression analysis and genomic organization.
Volume: 1491
Issue: 1-3
Pages: 285-8
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Publication
20478380 | -
First Author: Ferro E
Year: 2010
Journal: Cell Signal
Title: RalGDS family members couple Ras to Ral signalling and that's not all.
Volume: 22
Issue: 12
Pages: 1804-10
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Publication
9099691 | -
First Author: Murai H
Year: 1997
Journal: J Biol Chem
Title: Characterization of Ral GDP dissociation stimulator-like (RGL) activities to regulate c-fos promoter and the GDP/GTP exchange of Ral.
Volume: 272
Issue: 16
Pages: 10483-90
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Protein
Q0KK55
Organism: Mus musculus/domesticus
Length: 1742  
Fragment?: false
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Protein
A6H650
Organism: Mus musculus/domesticus
Length: 481  
Fragment?: false
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Protein
Q562E3
Organism: Mus musculus/domesticus
Length: 504  
Fragment?: true
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Protein
G3UZ21
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: true
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Protein
B1ATE5
Organism: Mus musculus/domesticus
Length: 425  
Fragment?: false
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Protein
E0CX54
Organism: Mus musculus/domesticus
Length: 429  
Fragment?: true
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Protein
B7ZNG9
Organism: Mus musculus/domesticus
Length: 490  
Fragment?: false
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Protein
Q9QYS6
Organism: Mus musculus/domesticus
Length: 537  
Fragment?: true
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Protein
E9Q813
Organism: Mus musculus/domesticus
Length: 431  
Fragment?: false
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Protein
H3BKA8
Organism: Mus musculus/domesticus
Length: 216  
Fragment?: false
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Protein
E9QKB7
Organism: Mus musculus/domesticus
Length: 679  
Fragment?: false
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Protein
A0A0N4SVR5
Organism: Mus musculus/domesticus
Length: 498  
Fragment?: false
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Protein
D3Z2F9
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
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Protein
B2RX11
Organism: Mus musculus/domesticus
Length: 1742  
Fragment?: false
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Protein
Q8R3E5
Organism: Mus musculus/domesticus
Length: 834  
Fragment?: true
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Protein
A0A0N4SVF2
Organism: Mus musculus/domesticus
Length: 489  
Fragment?: false
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Protein
Q3TSK1
Organism: Mus musculus/domesticus
Length: 260  
Fragment?: true
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Publication
9371744 | J:44483
First Author: Brady KP
Year: 1997
Journal: Genome Res
Title: Genetic mapping of 262 loci derived from expressed sequences in a murine interspecific cross using single-strand conformational polymorphism analysis.
Volume: 7
Issue: 11
Pages: 1085-93
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Protein
Q61193
Organism: Mus musculus/domesticus
Length: 778  
Fragment?: false
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Protein
A0A068BD34
Organism: Mus musculus/domesticus
Length: 778  
Fragment?: false
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Protein
Q60695
Organism: Mus musculus/domesticus
Length: 768  
Fragment?: false
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Protein
Q9QZK2
Organism: Mus musculus/domesticus
Length: 820  
Fragment?: false
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Protein
Q03385
Organism: Mus musculus/domesticus
Length: 852  
Fragment?: false
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Protein
Q8BTM9
Organism: Mus musculus/domesticus
Length: 673  
Fragment?: false
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Protein
Q9QUG9
Organism: Mus musculus/domesticus
Length: 608  
Fragment?: false
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Protein
Q9QZS8
Organism: Mus musculus/domesticus
Length: 854  
Fragment?: false
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Protein
Q8JZL7
Organism: Mus musculus/domesticus
Length: 473  
Fragment?: false
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Protein
Q9D300
Organism: Mus musculus/domesticus
Length: 466  
Fragment?: false
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Protein
Q3UYI5
Organism: Mus musculus/domesticus
Length: 709  
Fragment?: false
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Protein
Q3TWC1
Organism: Mus musculus/domesticus
Length: 907  
Fragment?: false
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Protein
Q9QYS7
Organism: Mus musculus/domesticus
Length: 536  
Fragment?: true
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Protein
E9Q8N0
Organism: Mus musculus/domesticus
Length: 766  
Fragment?: false
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Protein
Q3UHC1
Organism: Mus musculus/domesticus
Length: 1224  
Fragment?: false
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Protein
G3UZQ7
Organism: Mus musculus/domesticus
Length: 546  
Fragment?: false
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Protein
Q5DTR1
Organism: Mus musculus/domesticus
Length: 1046  
Fragment?: true
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Protein
A0A0N4SVV6
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
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Protein
Q3UY04
Organism: Mus musculus/domesticus
Length: 461  
Fragment?: true
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Protein
Q6ZPU1
Organism: Mus musculus/domesticus
Length: 924  
Fragment?: true
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Protein
A0A0N4SUQ3
Organism: Mus musculus/domesticus
Length: 639  
Fragment?: false
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Protein
A0A571BEH0
Organism: Mus musculus/domesticus
Length: 869  
Fragment?: false
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Protein
F7B9R2
Organism: Mus musculus/domesticus
Length: 588  
Fragment?: true
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Protein
Q8C5V7
Organism: Mus musculus/domesticus
Length: 642  
Fragment?: true
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Protein
A2AK33
Organism: Mus musculus/domesticus
Length: 895  
Fragment?: false
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Protein
A0A5F8MPT3
Organism: Mus musculus/domesticus
Length: 1267  
Fragment?: false
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Protein
Q3UEA9
Organism: Mus musculus/domesticus
Length: 555  
Fragment?: true
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Protein
A0A5F8MPI9
Organism: Mus musculus/domesticus
Length: 1087  
Fragment?: false
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Protein
A0A0N4SUN7
Organism: Mus musculus/domesticus
Length: 604  
Fragment?: false
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Protein
Q9QYS5
Organism: Mus musculus/domesticus
Length: 248  
Fragment?: true
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Protein
Q3TXZ3
Organism: Mus musculus/domesticus
Length: 895  
Fragment?: false
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Protein
A0A1B0GSM5
Organism: Mus musculus/domesticus
Length: 559  
Fragment?: false
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Protein
A0A0A0MQE4
Organism: Mus musculus/domesticus
Length: 557  
Fragment?: false
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Protein
E9Q8M9
Organism: Mus musculus/domesticus
Length: 803  
Fragment?: false
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Protein
E0CZ06
Organism: Mus musculus/domesticus
Length: 659  
Fragment?: false
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Protein
G3UYP5
Organism: Mus musculus/domesticus
Length: 481  
Fragment?: false
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Protein
Q3UPQ2
Organism: Mus musculus/domesticus
Length: 1131  
Fragment?: true
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Protein
F6ZDE5
Organism: Mus musculus/domesticus
Length: 643  
Fragment?: true
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Protein
Q3UQY9
Organism: Mus musculus/domesticus
Length: 840  
Fragment?: false
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Protein
A0A0N4SW33
Organism: Mus musculus/domesticus
Length: 581  
Fragment?: false
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Protein
A1L338
Organism: Mus musculus/domesticus
Length: 1185  
Fragment?: false
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Protein
Q91ZZ2
Organism: Mus musculus/domesticus
Length: 1086  
Fragment?: false
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Protein
Q3UGX8
Organism: Mus musculus/domesticus
Length: 1218  
Fragment?: false
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Publication
8259209 | J:16033
First Author: Boguski MS
Year: 1993
Journal: Nature
Title: Proteins regulating Ras and its relatives.
Volume: 366
Issue: 6456
Pages: 643-54
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Publication
- | J:82809
     
First Author: European Mouse Mutant Archive
Year: 2003
Journal: Unpublished
Title: Information obtained from the European Mouse Mutant Archive (EMMA)
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Protein
Q6GYP7
Organism: Mus musculus/domesticus
Length: 2035  
Fragment?: false
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Protein
A3KGS3
Organism: Mus musculus/domesticus
Length: 1872  
Fragment?: false
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Protein
A0A2I3BRX9
Organism: Mus musculus/domesticus
Length: 2538  
Fragment?: false
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Protein
Q3UI96
Organism: Mus musculus/domesticus
Length: 621  
Fragment?: false
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Protein
A0A2I3BPE9
Organism: Mus musculus/domesticus
Length: 1359  
Fragment?: true
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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Cambridge CB2 3EH, United Kingdom