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Search results 501 to 538 out of 538 for Rec8

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Type Details Score
Publication
14730319 | J:88148
First Author: Kitajima TS
Year: 2004
Journal: Nature
Title: The conserved kinetochore protein shugoshin protects centromeric cohesion during meiosis.
Volume: 427
Issue: 6974
Pages: 510-7
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GO Term
GO:0008278 | cohesin complex
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Protein Domain
IPR006909 | Rad21/Rec8_C_eu
Type: Domain
Description: This domain represents a conserved C-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Rad21/Rec8 like proteins mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex []. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation [].
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Protein Domain
IPR006910 | Rad21_Rec8_N
Type: Domain
Description: This domain represents a conserved N-terminal region found in eukaryotic cohesins of the Rad21, Rec8 and Scc1 families. Rad21/Rec8 like proteins mediate sister chromatid cohesion during mitosis and meiosis, as part of the cohesin complex []. Cohesion is necessary for homologous recombination (including double-strand break repair) and correct chromatid segregation. These proteins may also be involved in chromosome condensation. Dissociation at the metaphase to anaphase transition causes loss of cohesion and chromatid segregation [].
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Publication
11687503 | -
 
First Author: Lee JY
Year: 2001
Journal: Annu Rev Cell Dev Biol
Title: The molecular basis of sister-chromatid cohesion.
Volume: 17
Pages: 753-77
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Protein
A0A2I3BS25
Organism: Mus musculus/domesticus
Length: 160  
Fragment?: true
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Publication
17205076 | J:159144
First Author: Gómez R
Year: 2007
Journal: EMBO Rep
Title: Mammalian SGO2 appears at the inner centromere domain and redistributes depending on tension across centromeres during meiosis II and mitosis.
Volume: 8
Issue: 2
Pages: 173-80
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Publication
32284991 | J:326154
First Author: Zhou C
Year: 2020
Journal: Sci Adv
Title: The cohesin release factor Wapl interacts with Bub3 to govern SAC activity in female meiosis I.
Volume: 6
Issue: 15
Pages: eaax3969
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Protein
A2AU37
Organism: Mus musculus/domesticus
Length: 552  
Fragment?: false
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Protein
Q61550
Organism: Mus musculus/domesticus
Length: 635  
Fragment?: false
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Protein
Q3TG35
Organism: Mus musculus/domesticus
Length: 635  
Fragment?: false
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Protein
A1L366
Organism: Mus musculus/domesticus
Length: 635  
Fragment?: false
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Protein
Q3UTE4
Organism: Mus musculus/domesticus
Length: 601  
Fragment?: true
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Protein
A1L367
Organism: Mus musculus/domesticus
Length: 635  
Fragment?: false
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Protein
R4GML2
Organism: Mus musculus/domesticus
Length: 549  
Fragment?: false
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Publication
18987869 | -
First Author: Rivera T
Year: 2009
Journal: Chromosoma
Title: Shugoshin regulates cohesion by driving relocalization of PP2A in Xenopus extracts.
Volume: 118
Issue: 2
Pages: 223-33
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Publication
16687935 | -
First Author: Suzuki H
Year: 2006
Journal: Cell Cycle
Title: Human Shugoshin mediates kinetochore-driven formation of kinetochore microtubules.
Volume: 5
Issue: 10
Pages: 1094-101
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Publication
17322402 | -
First Author: Kawashima SA
Year: 2007
Journal: Genes Dev
Title: Shugoshin enables tension-generating attachment of kinetochores by loading Aurora to centromeres.
Volume: 21
Issue: 4
Pages: 420-35
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Protein Domain
IPR011515 | Shugoshin_C
Type: Domain
Description: This entry represents the C-terminal domain of Shugoshin (Sgo1) kinetochore-attachment proteins. Shugoshin has a conserved coiled-coil N-terminal domain and a highly conserved C-terminal basic region (). Shugoshin is a crucial target of Bub1 kinase that plays a central role in chromosome cohesion during mitosis and meiosis divisions by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms [, ]. Shugoshin is thought to act by protecting Rec8 and Rad21 at the centromeres from separase degradation during anaphase I (during meiosis) so that sister chromatids remain tethered []. Shugoshin also acts as a spindle checkpoint component required for sensing tension between sister chromatids during mitosis, its degradation when they separate preventing cell cycle arrest and chromosome loss in anaphase, a time when sister chromatids are no longer under tension. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly []. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process [].
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Protein Domain
IPR011516 | Shugoshin_N
Type: Domain
Description: This entry represents the N-terminal domain of Shugoshin (Sgo1) kinetochore-attachment proteins. Shugoshin has this conserved coiled-coil N-terminal domain and a highly conserved C-terminal basic region ().Shugoshin is a crucial target of Bub1 kinase that plays a central role in chromosome cohesion during mitosis and meiosis divisions by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms [, ]. Shugoshin is thought to act by protecting Rec8 and Rad21 at the centromeres from separase degradation during anaphase I (during meiosis) so that sister chromatids remain tethered []. Shugoshin also acts as a spindle checkpoint component required for sensing tension between sister chromatids during mitosis, its degradation when they separate preventing cell cycle arrest and chromosome loss in anaphase, a time when sister chromatids are no longer under tension. Human shugoshin is diffusible and mediates kinetochore-driven formation of kinetochore-microtubules during bipolar spindle assembly []. Further, the primary role of shugoshin is to ensure bipolar attachment of kinetochores, and its role in protecting cohesion has co-developed to facilitate this process [].
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Publication
21527826 | J:173689
First Author: Gutiérrez-Caballero C
Year: 2011
Journal: Cell Cycle
Title: Identification and molecular characterization of the mammalian α-kleisin RAD21L.
Volume: 10
Issue: 9
Pages: 1477-87
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Publication
32931493 | J:296548
First Author: Fujiwara Y
Year: 2020
Journal: PLoS Genet
Title: Meiotic cohesins mediate initial loading of HORMAD1 to the chromosomes and coordinate SC formation during meiotic prophase.
Volume: 16
Issue: 9
Pages: e1009048
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Publication
35536551 | J:334012
First Author: Cheng J
Year: 2022
Journal: Cell Cycle
Title: Knockout of cyclin B1 in granulosa cells causes female subfertility.
Volume: 21
Issue: 17
Pages: 1867-1878
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Publication
18753610 | J:145799
First Author: Hupalowska A
Year: 2008
Journal: Biol Reprod
Title: Metaphase I arrest in LT/Sv mouse oocytes involves the spindle assembly checkpoint.
Volume: 79
Issue: 6
Pages: 1102-10
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Publication
23434280 | J:199734
First Author: Chambon JP
Year: 2013
Journal: Curr Biol
Title: The PP2A inhibitor I2PP2A is essential for sister chromatid segregation in oocyte meiosis II.
Volume: 23
Issue: 6
Pages: 485-90
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Publication
25123474 | J:216178
First Author: Yuan YF
Year: 2014
Journal: Mol Reprod Dev
Title: SUMO-1 plays crucial roles for spindle organization, chromosome congression, and chromosome segregation during mouse oocyte meiotic maturation.
Volume: 81
Issue: 8
Pages: 712-24
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Publication
33721419 | J:307638
First Author: Han F
Year: 2021
Journal: Aging Cell
Title: Identification of SRY-box 30 as an age-related essential gatekeeper for male germ-cell meiosis and differentiation.
Volume: 20
Issue: 5
Pages: e13343
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Protein
Q9CXH7
Organism: Mus musculus/domesticus
Length: 517  
Fragment?: false
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Protein Coding Gene
MGI:1098658 | Stag1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q6ZQJ6
Organism: Mus musculus/domesticus
Length: 426  
Fragment?: true
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Publication
34599968 | J:324061
First Author: Campbell KM
Year: 2021
Journal: J Biol Chem
Title: Loss of TDP-43 in male germ cells causes meiotic failure and impairs fertility in mice.
Volume: 297
Issue: 5
Pages: 101231
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Publication
23444375 | J:200659
First Author: Qi ST
Year: 2013
Journal: J Cell Sci
Title: Overexpression of SETβ, a protein localizing to centromeres, causes precocious separation of chromatids during the first meiosis of mouse oocytes.
Volume: 126
Issue: Pt 7
Pages: 1595-603
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Protein Coding Gene
MGI:1339795 | Smc3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1098583 | Stag2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1344345 | Smc1a
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:108016 | Rad21
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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