|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 501 to 600 out of 715 for Rrm1

<< First    < Previous  |  Next >    Last >>
0.029s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
GXD Expression
GXD Expression
 
Probe: MGI:4416810
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827816
Age: embryonic day 14.5
Image: euxassay_012459_12
Specimen Label: euxassay_012459_12
Detected: true
Specimen Num: 12
•
•
•
•
•
GXD Expression
GXD Expression
 
Probe: MGI:4416810
Assay Type: RNA in situ
Annotation Date: 2010-09-14
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1791823
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:4827816
Age: embryonic day 14.5
Image: euxassay_012459_13
Specimen Label: euxassay_012459_13
Detected: true
Specimen Num: 13
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:3724983
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421634
Age: embryonic day 14.5
Image: MH1636; Specimen C1769
Note: Expression was strong in whisker follicle.
Specimen Label: MH1636; Specimen C1769
Detected: true
Specimen Num: 1
•
•
•
•
•
GXD Expression
GXD Expression
Probe: MGI:4416810
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5421909
Age: embryonic day 14.5
Image: ES2018; Specimen S757
Note: Expression was strong in whisker follicle.
Specimen Label: ES2018; Specimen S757
Detected: true
Specimen Num: 1
•
•
•
•
•
Publication
3025593 | J:8537
First Author: Thelander L
Year: 1986
Journal: Mol Cell Biol
Title: Isolation and characterization of expressible cDNA clones encoding the M1 and M2 subunits of mouse ribonucleotide reductase.
Volume: 6
Issue: 10
Pages: 3433-42
•
•
•
•
•
Publication
16861739 | J:116926
First Author: Rofougaran R
Year: 2006
Journal: J Biol Chem
Title: Enzymatically active mammalian ribonucleotide reductase exists primarily as an alpha6beta2 octamer.
Volume: 281
Issue: 38
Pages: 27705-11
•
•
•
•
•
Publication
16829694 | J:116942
First Author: Narváez AJ
Year: 2006
Journal: J Biol Chem
Title: The involvement of Arg265 of mouse ribonucleotide reductase R2 protein in proton transfer and catalysis.
Volume: 281
Issue: 36
Pages: 26022-8
•
•
•
•
•
Publication
8130196 | J:240730
First Author: Lycksell PO
Year: 1994
Journal: Biochemistry
Title: 1H NMR studies of mouse ribonucleotide reductase: the R2 protein carboxyl-terminal tail, essential for subunit interaction, is highly flexible but becomes rigid in the presence of protein R1.
Volume: 33
Issue: 10
Pages: 2838-42
•
•
•
•
•
Publication
12578384 | J:314099
First Author: Kashlan OB
Year: 2003
Journal: Biochemistry
Title: Comprehensive model for allosteric regulation of mammalian ribonucleotide reductase: refinements and consequences.
Volume: 42
Issue: 6
Pages: 1696-706
•
•
•
•
•
Publication
9021149 | J:38240
First Author: Klinga-Levan K
Year: 1997
Journal: Mamm Genome
Title: Mapping of the ribonucleotide reductase genes (Rrm1, Rrm2) in the rat.
Volume: 8
Issue: 1
Pages: 47-9
•
•
•
•
•
Publication
23530224 | J:196187
First Author: Nowakowski SG
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Transgenic overexpression of ribonucleotide reductase improves cardiac performance.
Volume: 110
Issue: 15
Pages: 6187-92
•
•
•
•
•
Publication
19176520 | J:148731
First Author: Zahedi Avval F
Year: 2009
Journal: J Biol Chem
Title: Molecular mechanisms of thioredoxin and glutaredoxin as hydrogen donors for Mammalian s phase ribonucleotide reductase.
Volume: 284
Issue: 13
Pages: 8233-40
•
•
•
•
•
Publication
17486094 | J:122389
First Author: Bourdon A
Year: 2007
Journal: Nat Genet
Title: Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion.
Volume: 39
Issue: 6
Pages: 776-80
•
•
•
•
•
Publication
10716435 | J:320121
First Author: Tanaka H
Year: 2000
Journal: Nature
Title: A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint for DNA damage.
Volume: 404
Issue: 6773
Pages: 42-9
•
•
•
•
•
Publication
11517226 | J:72397
First Author: Guittet O
Year: 2001
Journal: J Biol Chem
Title: Mammalian p53R2 protein forms an active ribonucleotide reductase in vitro with the R1 protein, which is expressed both in resting cells in response to DNA damage and in proliferating cells.
Volume: 276
Issue: 44
Pages: 40647-51
•
•
•
•
•
Publication
19114063 | J:145763
First Author: Kawakami Y
Year: 2009
Journal: Neurosci Res
Title: Impaired neurogenesis in embryonic spinal cord of Phgdh knockout mice, a serine deficiency disorder model.
Volume: 63
Issue: 3
Pages: 184-93
•
•
•
•
•
Publication
31693903 | J:300611
First Author: Carper MB
Year: 2019
Journal: Cell Rep
Title: An Immunocompetent Mouse Model of HPV16(+) Head and Neck Squamous Cell Carcinoma.
Volume: 29
Issue: 6
Pages: 1660-1674.e7
•
•
•
•
•
Publication
3146546 | J:9576
First Author: Barton DE
Year: 1988
Journal: Genomics
Title: Human tyrosinase gene, mapped to chromosome 11 (q14----q21), defines second region of homology with mouse chromosome 7.
Volume: 3
Issue: 1
Pages: 17-24
•
•
•
•
•
Publication
15890332 | J:99698
First Author: Abramova N
Year: 2005
Journal: Dev Biol
Title: Stage-specific changes in gene expression in acutely isolated mouse CNS progenitor cells.
Volume: 283
Issue: 2
Pages: 269-81
•
•
•
•
•
Publication
26178733 | J:316183
 
First Author: Cai Y
Year: 2015
Journal: BMC Pulm Med
Title: Transgenically-expressed secretoglobin 3A2 accelerates resolution of bleomycin-induced pulmonary fibrosis in mice.
Volume: 15
Pages: 72
•
•
•
•
•
Publication
11389549 | J:69146
First Author: Hwang SY
Year: 2001
Journal: Mol Reprod Dev
Title: Expression of genes involved in mammalian meiosis during the transition from egg to embryo.
Volume: 59
Issue: 2
Pages: 144-58
•
•
•
•
•
Publication
30389914 | J:267889
First Author: Moon S
Year: 2018
Journal: Cell Death Dis
Title: Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis.
Volume: 9
Issue: 11
Pages: 1118
•
•
•
•
•
Publication
16420439 | J:105375
First Author: Ajioka I
Year: 2006
Journal: Eur J Neurosci
Title: Identification of ventricular-side-enriched molecules regulated in a stage-dependent manner during cerebral cortical development.
Volume: 23
Issue: 2
Pages: 296-308
•
•
•
•
•
Publication
15031102 | J:92177
First Author: Powles N
Year: 2004
Journal: Dev Biol
Title: Identification and analysis of genes from the mouse otic vesicle and their association with developmental subprocesses through in situ hybridization.
Volume: 268
Issue: 1
Pages: 24-38
•
•
•
•
•
Publication
24154525 | J:205051
First Author: Miller JA
Year: 2013
Journal: Development
Title: Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates.
Volume: 140
Issue: 22
Pages: 4633-44
•
•
•
•
•
Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
•
•
•
•
•
Publication
18554416 | J:139177
First Author: Hoffman BG
Year: 2008
Journal: Genome Biol
Title: Identification of transcripts with enriched expression in the developing and adult pancreas.
Volume: 9
Issue: 6
Pages: R99
•
•
•
•
•
Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
•
•
•
•
•
Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
•
•
•
•
•
Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
•
•
•
•
•
Publication
24194600 | J:228563
First Author: Koscielny G
Year: 2014
Journal: Nucleic Acids Res
Title: The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data.
Volume: 42
Issue: Database issue
Pages: D802-9
•
•
•
•
•
Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
•
•
•
•
•
Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
•
•
•
•
•
Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
•
•
•
•
•
Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
•
•
•
•
•
Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
•
•
•
•
•
Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
•
•
•
•
•
Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 561
Description: Important for the positionning of RRM1 relative to RRM2
Type: site
End: 561
•
•
•
•
•
UniProt Feature
UniProt Feature
Begin: 410
Description: Important for the positionning of RRM1 relative to RRM2
Type: site
End: 410
•
•
•
•
•
Allele
Tg(CAG-Rrm1)#Rsw | MGI:5488605
Name: transgene insertion, Robert S Weiss
Allele Type: Transgenic
Attribute String: Inserted expressed sequence
•
•
•
•
•
Publication
11149944 | -
First Author: Eichmuller S
Year: 2001
Journal: Proc Natl Acad Sci U S A
Title: Serological detection of cutaneous T-cell lymphoma-associated antigens.
Volume: 98
Issue: 2
Pages: 629-34
•
•
•
•
•
Protein Domain
IPR034451 | RBM27_RRM
Type: Domain
Description: This entry represents the RNA recognition motif (RRM) of RBM27. Although the specific function of the RRM in RBM27 remains unclear, it shows high sequence similarity with RRM1 of RBM26, which functions as a cutaneous lymphoma (CL)-associated antigen [].
•
•
•
•
•
Protein Domain
IPR026520 | THAP3
Type: Family
Description: The THAP domain is a C2CH module with zinc-dependent sequence-specific DNA-binding activity []. Several THAP domain-containing proteins have been described. THAP3 is a component of a THAP1/THAP3-HCFC1-OGT complex that is required for the regulation of the transcriptional activity of the cell cycle-specific gene RRM1 [].
•
•
•
•
•
Publication
22730302 | J:199697
First Author: Chao HW
Year: 2012
Journal: Nucleic Acids Res
Title: NMDAR signaling facilitates the IPO5-mediated nuclear import of CPEB3.
Volume: 40
Issue: 17
Pages: 8484-98
•
•
•
•
•
Publication
10858537 | -
First Author: Honoré B
Year: 2000
Journal: Biochim Biophys Acta
Title: The hnRNP 2H9 gene, which is involved in the splicing reaction, is a multiply spliced gene.
Volume: 1492
Issue: 1
Pages: 108-19
•
•
•
•
•
Publication
11571276 | -
First Author: Caputi M
Year: 2001
Journal: J Biol Chem
Title: Determination of the RNA binding specificity of the heterogeneous nuclear ribonucleoprotein (hnRNP) H/H'/F/2H9 family.
Volume: 276
Issue: 47
Pages: 43850-9
•
•
•
•
•
Publication
8999868 | -
First Author: Mahé D
Year: 1997
Journal: J Biol Chem
Title: Cloning of human 2H9 heterogeneous nuclear ribonucleoproteins. Relation with splicing and early heat shock-induced splicing arrest.
Volume: 272
Issue: 3
Pages: 1827-36
•
•
•
•
•
Publication
16096647 | -
First Author: Benecke H
Year: 2005
Journal: EMBO J
Title: The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein.
Volume: 24
Issue: 17
Pages: 3057-69
•
•
•
•
•
Publication
19447915 | -
First Author: Netter C
Year: 2009
Journal: RNA
Title: Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion.
Volume: 15
Issue: 7
Pages: 1305-13
•
•
•
•
•
Protein Domain
IPR034147 | RBM40_RRM1
Type: Domain
Description: This entry represents the RNA recognition motif 1 (RRM1) of RBM40 (also known as U11/U12-65K). RBM40 serves as a bridging factor between the U11 and U12 snRNPs []. It contains two repeats of an RNA recognition motif (RRM), connected by a linker that includes a proline-rich region. It binds to the U11-associated 59K protein via its RRM1 and employs the RRM2 to bind hairpin III of the U12 small nuclear RNA (snRNA). The proline-rich region might be involved in protein-protein interactions [].
•
•
•
•
•
Protein Domain
IPR045164 | RBM41/RNPC3
Type: Family
Description: RNPC3 serves as a bridging factor between the U11 and U12 snRNPs. It contains two RNA recognition motifs (RRMs), connected by a linker that includes a proline-rich region. It binds to the U11-associated 59K protein via its RRM1 and employs the RRM2 to bind hairpin III of the U12 small nuclear RNA (snRNA). The proline-rich region might be involved in protein-protein interactions [, ]. RBM41 contains only one RRM. Its biological function remains unclear.
•
•
•
•
•
Protein Domain
IPR034969 | hnRNPH3_RRM3
Type: Domain
Description: This entry represents the RNA recognition motif 3 (RRM3) of heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3). hnRNP H3 (also termed hnRNP 2H9) is a nuclear RNA binding protein that belongs to the hnRNP H protein family that also includes hnRNP H, hnRNP H2, and hnRNP F. This family is involved in mRNA processing and exhibit extensive sequence homology. Little is known about the functions of hnRNP H3 except for its role in the splicing arrest induced by heat shock [, ]. The typical hnRNP H proteins contain contain three RNA recognition motifs (RRMs), except for hnRNP H3, in which the RRM1 is absent. RRM1 and RRM2 are responsible for the binding to the RNA at DGGGD motifs, and they play an important role in efficiently silencing the exon. Members in this family can regulate the alternative splicing of the fibroblast growth factor receptor 2 (FGFR2) transcripts, and function as silencers of FGFR2 exon IIIc through an interaction with the exonic GGG motifs. The lack of RRM1 could account for the reduced silencing activity within hnRNP H3. In addition, like other hnRNP H protein family members, hnRNP H3 has an extensive glycine-rich region near the C terminus, which may allow it to homo- or heterodimerize [].
•
•
•
•
•
Protein Domain
IPR034970 | hnRNPH3_RRM2
Type: Domain
Description: This entry represents the RNA recognition motif 2 (RRM2) of heterogeneous nuclear ribonucleoprotein H3 (hnRNP H3).hnRNP H3 (also termed hnRNP 2H9) is a nuclear RNA binding protein that belongs to the hnRNP H protein family that also includes hnRNP H, hnRNP H2, and hnRNP F. This family is involved in mRNA processing and exhibit extensive sequence homology. Little is known about the functions of hnRNP H3 except for its role in the splicing arrest induced by heat shock [, ]. The typical hnRNP H proteins contain contain three RNA recognition motifs (RRMs), except for hnRNP H3, in which the RRM1 is absent. RRM1 and RRM2 are responsible for the binding to the RNA at DGGGD motifs, and they play an important role in efficiently silencing the exon. Members in this family can regulate the alternative splicing of the fibroblast growth factor receptor 2 (FGFR2) transcripts, and function as silencers of FGFR2 exon IIIc through an interaction with the exonic GGG motifs. The lack of RRM1 could account for the reduced silencing activity within hnRNP H3. In addition, like other hnRNP H protein family members, hnRNP H3 has an extensive glycine-rich region near the C terminus, which may allow it to homo- or heterodimerize [].
•
•
•
•
•
Publication
18413732 | J:133963
First Author: Xu X
Year: 2008
Journal: Cancer Res
Title: Broad overexpression of ribonucleotide reductase genes in mice specifically induces lung neoplasms.
Volume: 68
Issue: 8
Pages: 2652-60
•
•
•
•
•
Publication
11158314 | J:67386
First Author: Ladd AN
Year: 2001
Journal: Mol Cell Biol
Title: The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing.
Volume: 21
Issue: 4
Pages: 1285-96
•
•
•
•
•
Publication
9016658 | J:37552
First Author: Abe R
Year: 1996
Journal: Nucleic Acids Res
Title: Two different RNA binding activities for the AU-rich element and the poly(A) sequence of the mouse neuronal protein mHuC.
Volume: 24
Issue: 24
Pages: 4895-901
•
•
•
•
•
Publication
23247071 | -
 
First Author: Ladd AN
Year: 2013
Journal: Mol Cell Neurosci
Title: CUG-BP, Elav-like family (CELF)-mediated alternative splicing regulation in the brain during health and disease.
Volume: 56
Pages: 456-64
•
•
•
•
•
Publication
14973222 | -
First Author: Singh G
Year: 2004
Journal: Nucleic Acids Res
Title: ETR-3 and CELF4 protein domains required for RNA binding and splicing activity in vivo.
Volume: 32
Issue: 3
Pages: 1232-41
•
•
•
•
•
Publication
22180311 | -
First Author: Dasgupta T
Year: 2012
Journal: Wiley Interdiscip Rev RNA
Title: The importance of CELF control: molecular and biological roles of the CUG-BP, Elav-like family of RNA-binding proteins.
Volume: 3
Issue: 1
Pages: 104-21
•
•
•
•
•
Publication
10449789 | -
First Author: Akamatsu W
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Mammalian ELAV-like neuronal RNA-binding proteins HuB and HuC promote neuronal development in both the central and the peripheral nervous systems.
Volume: 96
Issue: 17
Pages: 9885-90
•
•
•
•
•
Protein Domain
IPR034648 | CELF3/4/5/6_RRM1
Type: Domain
Description: This entry represents the RNA recognition motif 1 (RRM1) of CELF-3, CELF-4, CELF-5, CELF-6, all of which belong to the CUGBP1 and ETR-3-like factors (CELF) or BRUNOL (Bruno-like) family of RNA-binding proteins [, ]. The CELF family members have three RRMs []. It has been shown that either RRM1 or RRM2 of CELF-4 are necessary and sufficient for muscle-specific splicing enhancer (MSE) RNA binding []. The human CELF family has six members, which can be divided into two subfamilies based on their phylogeny: CELF1-2 and CELF3-6. They all possess alternative splicing activity in the nucleus and all have cytoplasmic roles, including regulating mRNA adenylation status, stability, and translation in various cell types [].
•
•
•
•
•
Protein Domain
IPR034914 | HuB_RRM3
Type: Domain
Description: This entry represents the RNA recognition motif 3 (RRM3) of HuB. HuB (also known as ELAV-like protein 2 or Hel-N1) is one of the neuronal members of the Hu family []. The neuronal Hu proteins play important roles in neuronal differentiation, plasticity and memory. HuB is also expressed in gonads. It is up-regulated during neuronal differentiation of embryonic carcinoma P19 cells []. Like other Hu proteins, HuB contains three RNA recognition motifs (RRMs). RRM1 and RRM2 may cooperate in binding to an AU-rich RNA element (ARE). RRM3 may help to maintain the stability of the RNA-protein complex, and might also bind to poly(A) tails or be involved in protein-protein interactions [].
•
•
•
•
•
Protein Domain
IPR034915 | HuC_RRM3
Type: Domain
Description: This entry represents the RNA recognition motif 3 (RRM3) of HuC (also known as ELAV-like protein 3), one of the neuronal members of the Hu family. The neuronal Hu proteins play important roles in neuronal differentiation, plasticity and memory []. Like other Hu proteins, HuC contains three RNA recognition motifs (RRMs). RRM1 and RRM2 may cooperate in binding to an AU-rich RNA element (ARE) []. The AU-rich element binding of HuC can be inhibited by flavonoids. RRM3 may help to maintain the stability of the RNA-protein complex, and might also bind to poly(A) tails or be involved in protein-protein interactions [].
•
•
•
•
•
Protein Domain
IPR034999 | HuB_RRM2
Type: Domain
Description: This entry represents the RNA recognition motif 2 (RRM2) of HuB. HuB (also known as ELAV-like protein 2 or Hel-N1) is one of the neuronal members of the Hu family []. The neuronal Hu proteins play important roles in neuronal differentiation, plasticity and memory. HuB is also expressed in gonads. It is up-regulated during neuronal differentiation of embryonic carcinoma P19 cells []. Like other Hu proteins, HuB contains three RNA recognition motifs (RRMs). RRM1 and RRM2 may cooperate in binding to an AU-rich RNA element (ARE). RRM3 may help to maintain the stability of the RNA-protein complex, and might also bind to poly(A) tails or be involved in protein-protein interactions [].
•
•
•
•
•
Publication
7959009 | J:21628
First Author: Ehrenman K
Year: 1994
Journal: Gene
Title: Characterization of cDNAs encoding the murine A+U-rich RNA-binding protein AUF1.
Volume: 149
Issue: 2
Pages: 315-9
•
•
•
•
•
Publication
25940628 | J:306204
First Author: Tan LY
Year: 2015
Journal: Nucleic Acids Res
Title: Generation of functionally distinct isoforms of PTBP3 by alternative splicing and translation initiation.
Volume: 43
Issue: 11
Pages: 5586-600
•
•
•
•
•
Publication
16818620 | J:110566
First Author: Gautam A
Year: 2006
Journal: Cancer Res
Title: Suppression of lung tumor formation by the regulatory subunit of ribonucleotide reductase.
Volume: 66
Issue: 13
Pages: 6497-502
•
•
•
•
•
Publication
21252238 | J:170608
First Author: Lalmansingh AS
Year: 2011
Journal: J Biol Chem
Title: TDP-43 is a transcriptional repressor: the testis-specific mouse acrv1 gene is a TDP-43 target in vivo.
Volume: 286
Issue: 13
Pages: 10970-82
•
•
•
•
•
Publication
26657638 | J:234677
First Author: Marnef A
Year: 2016
Journal: Nucleic Acids Res
Title: Human polypyrimidine tract-binding protein interacts with mitochondrial tRNA(Thr) in the cytosol.
Volume: 44
Issue: 3
Pages: 1342-53
•
•
•
•
•
Publication
23533276 | J:196179
First Author: Tang JZ
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: Transposon mutagenesis reveals cooperation of ETS family transcription factors with signaling pathways in erythro-megakaryocytic leukemia.
Volume: 110
Issue: 15
Pages: 6091-6
•
•
•
•
•
Publication
8907704 | -
 
First Author: Gao FB
Year: 1996
Journal: J Cell Sci
Title: Hel-N1/Hel-N2 proteins are bound to poly(A)+ mRNA in granular RNP structures and are implicated in neuronal differentiation.
Volume: 109 ( Pt 3)
Pages: 579-89
•
•
•
•
•
Publication
18581050 | -
First Author: Hinman MN
Year: 2008
Journal: Cell Mol Life Sci
Title: Diverse molecular functions of Hu proteins.
Volume: 65
Issue: 20
Pages: 3168-81
•
•
•
•
•
Publication
7753842 | J:25196
First Author: Good PJ
Year: 1995
Journal: Proc Natl Acad Sci U S A
Title: A conserved family of elav-like genes in vertebrates.
Volume: 92
Issue: 10
Pages: 4557-61
•
•
•
•
•
Protein
Q8BJ25
Organism: Mus musculus/domesticus
Length: 218  
Fragment?: false
•
•
•
•
•
Protein
A2A8D4
Organism: Mus musculus/domesticus
Length: 184  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom