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Search results 501 to 600 out of 1155 for Rrm2

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Hits by Strain

Type Details Score
Publication
8413212 | -
First Author: Anderson JT
Year: 1993
Journal: Mol Cell Biol
Title: PUB1 is a major nuclear and cytoplasmic polyadenylated RNA-binding protein in Saccharomyces cerevisiae.
Volume: 13
Issue: 10
Pages: 6102-13
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Protein
Q9Z0H4
Organism: Mus musculus/domesticus
Length: 508  
Fragment?: false
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Protein
P52912
Organism: Mus musculus/domesticus
Length: 386  
Fragment?: false
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Protein
D3Z4H6
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: false
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Protein
Q564E7
Organism: Mus musculus/domesticus
Length: 386  
Fragment?: false
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Protein Coding Gene
MGI:2387629 | Tardbp
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CAROLIEiJ_G0026805 | -
Type: protein_coding_gene
Organism: Mus caroli
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Protein Coding Gene
MGP_129S1SvImJ_G0029129 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AJ_G0029094 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_AKRJ_G0029042 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_BALBcJ_G0029110 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C3HHeJ_G0028831 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI_C57BL6J_2387629 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_C57BL6NJ_G0029559 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CASTEiJ_G0028244 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0028793 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0028942 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0028906 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0029032 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0028933 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NZOHlLtJ_G0029591 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0027964 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0028324 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0029153 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0027798 | -
Type: protein_coding_gene
Organism: Mus spretus
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Publication
23449777 | J:324570
First Author: Iguchi Y
Year: 2013
Journal: Brain
Title: Loss of TDP-43 causes age-dependent progressive motor neuron degeneration.
Volume: 136
Issue: Pt 5
Pages: 1371-82
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Publication
31964415 | J:285792
First Author: Huang SL
Year: 2020
Journal: Acta Neuropathol Commun
Title: A robust TDP-43 knock-in mouse model of ALS.
Volume: 8
Issue: 1
Pages: 3
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Publication
20014337 | J:155958
First Author: Wu LS
Year: 2010
Journal: Genesis
Title: TDP-43, a neuro-pathosignature factor, is essential for early mouse embryogenesis.
Volume: 48
Issue: 1
Pages: 56-62
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Publication
31953403 | J:285640
First Author: Zhao L
Year: 2020
Journal: Nat Commun
Title: TDP-43 facilitates milk lipid secretion by post-transcriptional regulation of Btn1a1 and Xdh.
Volume: 11
Issue: 1
Pages: 341
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Publication
24616503 | J:207750
First Author: Yang C
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Partial loss of TDP-43 function causes phenotypes of amyotrophic lateral sclerosis.
Volume: 111
Issue: 12
Pages: E1121-9
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Publication
30625319 | J:283769
First Author: Ebstein SY
Year: 2019
Journal: Cell Rep
Title: Mutant TDP-43 Causes Early-Stage Dose-Dependent Motor Neuron Degeneration in a TARDBP Knockin Mouse Model of ALS.
Volume: 26
Issue: 2
Pages: 364-373.e4
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Publication
30692134 | J:278313
 
First Author: Tann JY
Year: 2019
Journal: EMBO J
Title: Abnormal TDP-43 function impairs activity-dependent BDNF secretion, synaptic plasticity, and cognitive behavior through altered Sortilin splicing.
Volume: 38
Issue: 5
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Publication
30922385 | J:290614
First Author: Wu LS
Year: 2019
Journal: Acta Neuropathol Commun
Title: Transcriptomopathies of pre- and post-symptomatic frontotemporal dementia-like mice with TDP-43 depletion in forebrain neurons.
Volume: 7
Issue: 1
Pages: 50
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Publication
22539017 | J:265381
First Author: Cannon A
Year: 2012
Journal: Acta Neuropathol
Title: Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction.
Volume: 123
Issue: 6
Pages: 807-23
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Publication
25392493 | J:217404
First Author: Alfieri JA
Year: 2014
Journal: J Neurosci
Title: Reversible behavioral phenotypes in a conditional mouse model of TDP-43 proteinopathies.
Volume: 34
Issue: 46
Pages: 15244-59
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Publication
21206091 | J:170756
First Author: Igaz LM
Year: 2011
Journal: J Clin Invest
Title: Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice.
Volume: 121
Issue: 2
Pages: 726-38
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Publication
28416393 | J:259472
 
First Author: Davis SA
Year: 2017
Journal: Neurobiol Dis
Title: TDP-43 expression influences amyloidβ plaque deposition and tau aggregation.
Volume: 103
Pages: 154-162
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Publication
36536457 | J:338954
First Author: Kim DW
Year: 2022
Journal: Mol Neurodegener
Title: Amyloid-beta and tau pathologies act synergistically to induce novel disease stage-specific microglia subtypes.
Volume: 17
Issue: 1
Pages: 83
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Publication
25213598 | J:357703
First Author: Cai M
Year: 2015
Journal: Neurol Res
Title: TDP-43 modification in the hSOD1(G93A) amyotrophic lateral sclerosis mouse model.
Volume: 37
Issue: 3
Pages: 253-62
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Publication
20198480 | J:158641
First Author: Kraemer BC
Year: 2010
Journal: Acta Neuropathol
Title: Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis.
Volume: 119
Issue: 4
Pages: 409-19
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Publication
26672899 | J:231836
 
First Author: Hasegawa M
Year: 2016
Journal: Neurosci Res
Title: Analysis of RNA metabolism in peripheral WBCs of TDP-43 KI mice identifies novel biomarkers of ALS.
Volume: 106
Pages: 12-22
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Publication
24465814 | J:211620
First Author: Ricketts T
Year: 2014
Journal: PLoS One
Title: A nonsense mutation in mouse Tardbp affects TDP43 alternative splicing activity and causes limb-clasping and body tone defects.
Volume: 9
Issue: 1
Pages: e85962
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Publication
29556029 | J:261673
First Author: White MA
Year: 2018
Journal: Nat Neurosci
Title: TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD.
Volume: 21
Issue: 4
Pages: 552-563
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Publication
35986894 | J:340897
First Author: Zomer HD
Year: 2022
Journal: Biol Reprod
Title: Sertoli cells require TDP-43 to support spermatogenesis†.
Volume: 107
Issue: 5
Pages: 1345-1359
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Publication
23967244 | J:206353
First Author: Stallings NR
Year: 2013
Journal: PLoS One
Title: TDP-43, an ALS linked protein, regulates fat deposition and glucose homeostasis.
Volume: 8
Issue: 8
Pages: e71793
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Publication
33127758 | J:299676
First Author: Peng AYT
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: Loss of TDP-43 in astrocytes leads to motor deficits by triggering A1-like reactive phenotype and triglial dysfunction.
Volume: 117
Issue: 46
Pages: 29101-29112
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Publication
27496536 | J:263195
First Author: Handley EE
Year: 2017
Journal: Cereb Cortex
Title: Synapse Dysfunction of Layer V Pyramidal Neurons Precedes Neurodegeneration in a Mouse Model of TDP-43 Proteinopathies.
Volume: 27
Issue: 7
Pages: 3630-3647
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Publication
27785573 | J:319578
First Author: LaClair KD
Year: 2016
Journal: Acta Neuropathol
Title: Depletion of TDP-43 decreases fibril and plaque β-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model.
Volume: 132
Issue: 6
Pages: 859-873
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Publication
33230138 | J:299821
First Author: Shih YH
Year: 2020
Journal: Nat Commun
Title: TDP-43 interacts with amyloid-β, inhibits fibrillization, and worsens pathology in a model of Alzheimer's disease.
Volume: 11
Issue: 1
Pages: 5950
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Publication
31678156 | J:282311
First Author: Gao J
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: TDP-43 inhibitory peptide alleviates neurodegeneration and memory loss in an APP transgenic mouse model for Alzheimer's disease.
Volume: 1866
Issue: 1
Pages: 165580
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Publication
20736350 | J:164382
First Author: Shan X
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Altered distributions of Gemini of coiled bodies and mitochondria in motor neurons of TDP-43 transgenic mice.
Volume: 107
Issue: 37
Pages: 16325-30
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Publication
27466204 | J:238566
First Author: Perera ND
Year: 2016
Journal: Hum Mol Genet
Title: Enhancing survival motor neuron expression extends lifespan and attenuates neurodegeneration in mutant TDP-43 mice.
Volume: 25
Issue: 18
Pages: 4080-4093
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Publication
34599968 | J:324061
First Author: Campbell KM
Year: 2021
Journal: J Biol Chem
Title: Loss of TDP-43 in male germ cells causes meiotic failure and impairs fertility in mice.
Volume: 297
Issue: 5
Pages: 101231
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Publication
38300714 | J:361146
 
First Author: Arribas V
Year: 2024
Journal: JCI Insight
Title: Endothelial TDP-43 controls sprouting angiogenesis and vascular barrier integrity, and its deletion triggers neuroinflammation.
Volume: 9
Issue: 5
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Publication
32157143 | J:293888
First Author: Martínez-González L
Year: 2020
Journal: Sci Rep
Title: Motor neuron preservation and decrease of in vivo TDP-43 phosphorylation by protein CK-1δ kinase inhibitor treatment.
Volume: 10
Issue: 1
Pages: 4449
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Publication
27348499 | J:240141
First Author: Wang W
Year: 2016
Journal: Nat Med
Title: The inhibition of TDP-43 mitochondrial localization blocks its neuronal toxicity.
Volume: 22
Issue: 8
Pages: 869-78
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Publication
35277554 | J:322539
First Author: Gautam M
Year: 2022
Journal: Sci Rep
Title: Mitochondrial dysregulation occurs early in ALS motor cortex with TDP-43 pathology and suggests maintaining NAD+ balance as a therapeutic strategy.
Volume: 12
Issue: 1
Pages: 4287
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Publication
24938805 | J:210295
 
First Author: Herdewyn S
Year: 2014
Journal: Mol Neurodegener
Title: Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice.
Volume: 9
Pages: 24
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Publication
23954172 | J:211978
First Author: Medina DX
Year: 2014
Journal: Neurobiol Aging
Title: Accumulation of C-terminal fragments of transactive response DNA-binding protein 43 leads to synaptic loss and cognitive deficits in human TDP-43 transgenic mice.
Volume: 35
Issue: 1
Pages: 79-87
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Publication
30450515 | J:309239
First Author: Gautam M
Year: 2019
Journal: Acta Neuropathol
Title: Mitochondria, ER, and nuclear membrane defects reveal early mechanisms for upper motor neuron vulnerability with respect to TDP-43 pathology.
Volume: 137
Issue: 1
Pages: 47-69
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Publication
20660618 | J:163612
First Author: Tsai KJ
Year: 2010
Journal: J Exp Med
Title: Elevated expression of TDP-43 in the forebrain of mice is sufficient to cause neurological and pathological phenotypes mimicking FTLD-U.
Volume: 207
Issue: 8
Pages: 1661-73
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Publication
22932872 | J:190027
First Author: Wang IF
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Autophagy activators rescue and alleviate pathogenesis of a mouse model with proteinopathies of the TAR DNA-binding protein 43.
Volume: 109
Issue: 37
Pages: 15024-9
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Publication
29118263 | J:249958
 
First Author: Ito D
Year: 2017
Journal: Sci Transl Med
Title: RNA binding proteins and the pathological cascade in ALS/FTD neurodegeneration.
Volume: 9
Issue: 415
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Publication
32558887 | J:291709
First Author: Grønning AGB
Year: 2020
Journal: Nucleic Acids Res
Title: DeepCLIP: predicting the effect of mutations on protein-RNA binding with deep learning.
Volume: 48
Issue: 13
Pages: 7099-7118
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Publication
23922830 | J:203274
First Author: Xu YF
Year: 2013
Journal: PLoS One
Title: The pathological phenotypes of human TDP-43 transgenic mouse models are independent of downregulation of mouse Tdp-43.
Volume: 8
Issue: 7
Pages: e69864
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Publication
28129109 | J:277514
First Author: Wang W
Year: 2017
Journal: Mol Ther
Title: Motor-Coordinative and Cognitive Dysfunction Caused by Mutant TDP-43 Could Be Reversed by Inhibiting Its Mitochondrial Localization.
Volume: 25
Issue: 1
Pages: 127-139
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Publication
23382207 | J:191785
First Author: Arnold ES
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43.
Volume: 110
Issue: 8
Pages: E736-45
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Publication
29295857 | J:274292
First Author: Chand KK
Year: 2018
Journal: FASEB J
Title: Defects in synaptic transmission at the neuromuscular junction precede motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis.
Volume: 32
Issue: 5
Pages: 2676-2689
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Publication
22084410 | J:178611
First Author: Swarup V
Year: 2011
Journal: J Exp Med
Title: Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB-mediated pathogenic pathways.
Volume: 208
Issue: 12
Pages: 2429-47
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Publication
23747512 | J:199083
First Author: Rodriguez-Ortiz CJ
Year: 2013
Journal: Am J Pathol
Title: Neuronal-specific overexpression of a mutant valosin-containing protein associated with IBMPFD promotes aberrant ubiquitin and TDP-43 accumulation and cognitive dysfunction in transgenic mice.
Volume: 183
Issue: 2
Pages: 504-15
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Publication
27897242 | J:315853
 
First Author: Fogarty MJ
Year: 2016
Journal: Sci Rep
Title: Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis.
Volume: 6
Pages: 37968
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Publication
32371051 | J:294557
First Author: Chan G
Year: 2020
Journal: Am J Pathol
Title: Neurodegeneration and Motor Deficits in the Absence of Astrogliosis upon Transgenic Mutant TDP-43 Expression in Mature Mice.
Volume: 190
Issue: 8
Pages: 1713-1722
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Publication
29577934 | J:264748
First Author: van Hummel A
Year: 2018
Journal: Am J Pathol
Title: Selective Spatiotemporal Vulnerability of Central Nervous System Neurons to Pathologic TAR DNA-Binding Protein 43 in Aged Transgenic Mice.
Volume: 188
Issue: 6
Pages: 1447-1456
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Publication
33149110 | J:306979
First Author: Kim E
Year: 2020
Journal: Transl Psychiatry
Title: Coexistence of perseveration and apathy in the TDP-43Q331K knock-in mouse model of ALS-FTD.
Volume: 10
Issue: 1
Pages: 377
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Publication
33154447 | J:299991
First Author: Watkins J
Year: 2020
Journal: Sci Rep
Title: Female sex mitigates motor and behavioural phenotypes in TDP-43Q331K knock-in mice.
Volume: 10
Issue: 1
Pages: 19220
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Publication
30130494 | J:269757
 
First Author: Tawara N
Year: 2018
Journal: Exp Neurol
Title: Muscle-dominant wild-type TDP-43 expression induces myopathological changes featuring tubular aggregates and TDP-43-positive inclusions.
Volume: 309
Pages: 169-180
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Publication
31959210 | J:285477
First Author: Watanabe S
Year: 2020
Journal: Mol Brain
Title: ALS-linked TDP-43M337V knock-in mice exhibit splicing deregulation without neurodegeneration.
Volume: 13
Issue: 1
Pages: 8
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Publication
31345270 | J:283597
First Author: Nishino K
Year: 2019
Journal: Acta Neuropathol Commun
Title: Mice deficient in the C-terminal domain of TAR DNA-binding protein 43 develop age-dependent motor dysfunction associated with impaired Notch1-Akt signaling pathway.
Volume: 7
Issue: 1
Pages: 118
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Publication
37819053 | J:348301
   
First Author: Necarsulmer JC
Year: 2023
Journal: Elife
Title: RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy.
Volume: 12
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Publication
34427634 | J:337808
 
First Author: Gao J
Year: 2021
Journal: J Cell Biol
Title: Translational regulation in the brain by TDP-43 phase separation.
Volume: 220
Issue: 10
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Publication
37474791 | J:340113
First Author: Li D
Year: 2023
Journal: Nat Aging
Title: LONRF2 is a protein quality control ubiquitin ligase whose deficiency causes late-onset neurological deficits.
Volume: 3
Issue: 8
Pages: 1001-1019
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Publication
14667816 | J:87849
First Author: Wang HY
Year: 2004
Journal: Genomics
Title: Structural diversity and functional implications of the eukaryotic TDP gene family.
Volume: 83
Issue: 1
Pages: 130-9
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Publication
17932037 | J:129028
First Author: Abhyankar MM
Year: 2007
Journal: J Biol Chem
Title: A novel CpG-free vertebrate insulator silences the testis-specific SP-10 gene in somatic tissues: role for TDP-43 in insulator function.
Volume: 282
Issue: 50
Pages: 36143-54
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Publication
18305110 | J:137092
First Author: Winton MJ
Year: 2008
Journal: J Biol Chem
Title: Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation.
Volume: 283
Issue: 19
Pages: 13302-9
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Publication
18703504 | J:142560
First Author: Bose JK
Year: 2008
Journal: J Biol Chem
Title: TDP-43 overexpression enhances exon 7 inclusion during the survival of motor neuron pre-mRNA splicing.
Volume: 283
Issue: 43
Pages: 28852-9
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Publication
18957508 | J:145775
First Author: Ayala YM
Year: 2008
Journal: J Cell Sci
Title: Structural determinants of the cellular localization and shuttling of TDP-43.
Volume: 121
Issue: Pt 22
Pages: 3778-85
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Publication
19535326 | J:153454
First Author: Iguchi Y
Year: 2009
Journal: J Biol Chem
Title: TDP-43 depletion induces neuronal cell damage through dysregulation of Rho family GTPases.
Volume: 284
Issue: 33
Pages: 22059-66
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Publication
19782731 | J:156639
First Author: Sato T
Year: 2009
Journal: Neuroscience
Title: Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons.
Volume: 164
Issue: 4
Pages: 1565-78
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Publication
21252238 | J:170608
First Author: Lalmansingh AS
Year: 2011
Journal: J Biol Chem
Title: TDP-43 is a transcriptional repressor: the testis-specific mouse acrv1 gene is a TDP-43 target in vivo.
Volume: 286
Issue: 13
Pages: 10970-82
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Publication
21358643 | J:172305
First Author: Polymenidou M
Year: 2011
Journal: Nat Neurosci
Title: Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43.
Volume: 14
Issue: 4
Pages: 459-68
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Publication
22193716 | J:181968
First Author: Cohen TJ
Year: 2012
Journal: EMBO J
Title: Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking.
Volume: 31
Issue: 5
Pages: 1241-52
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Publication
22323604 | J:181992
First Author: Kawahara Y
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes.
Volume: 109
Issue: 9
Pages: 3347-52
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Publication
22855830 | J:185946
First Author: Avendaño-Vázquez SE
Year: 2012
Journal: Genes Dev
Title: Autoregulation of TDP-43 mRNA levels involves interplay between transcription, splicing, and alternative polyA site selection.
Volume: 26
Issue: 15
Pages: 1679-84
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Publication
23575225 | J:198525
First Author: Zhang YJ
Year: 2013
Journal: Hum Mol Genet
Title: The dual functions of the extreme N-terminus of TDP-43 in regulating its biological activity and inclusion formation.
Volume: 22
Issue: 15
Pages: 3112-22
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Publication
23827948 | J:202253
First Author: Wang W
Year: 2013
Journal: Hum Mol Genet
Title: The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons.
Volume: 22
Issue: 23
Pages: 4706-19
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24381309 | J:209163
First Author: Yan S
Year: 2014
Journal: Hum Mol Genet
Title: TDP-43 causes differential pathology in neuronal versus glial cells in the mouse brain.
Volume: 23
Issue: 10
Pages: 2678-93
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Publication
24466128 | J:212560
First Author: D'Alton S
Year: 2014
Journal: PLoS One
Title: Divergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling.
Volume: 9
Issue: 1
Pages: e86513
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Publication
25557830 | J:219752
 
First Author: Lee S
Year: 2015
Journal: Nat Commun
Title: Identification of a subnuclear body involved in sequence-specific cytokine RNA processing.
Volume: 6
Pages: 5791
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Publication
29125873 | J:250916
First Author: Yahara M
Year: 2017
Journal: PLoS One
Title: U6 snRNA expression prevents toxicity in TDP-43-knockdown cells.
Volume: 12
Issue: 11
Pages: e0187813
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29142232 | J:256947
First Author: Herzog JJ
Year: 2017
Journal: Sci Rep
Title: TDP-43 misexpression causes defects in dendritic growth.
Volume: 7
Issue: 1
Pages: 15656
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