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Search results 501 to 600 out of 616 for Ryr2

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Type Details Score
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
25844899 | J:222412
First Author: Santulli G
Year: 2015
Journal: J Clin Invest
Title: Calcium release channel RyR2 regulates insulin release and glucose homeostasis.
Volume: 125
Issue: 5
Pages: 1968-78
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Publication
17355963 | J:122552
First Author: Huang G
Year: 2007
Journal: J Biol Chem
Title: Ca2+ signaling in microdomains: Homer1 mediates the interaction between RyR2 and Cav1.2 to regulate excitation-contraction coupling.
Volume: 282
Issue: 19
Pages: 14283-90
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Publication
32122157 | J:304346
First Author: Wang Y
Year: 2020
Journal: Circulation
Title: Integrin β1D Deficiency-Mediated RyR2 Dysfunction Contributes to Catecholamine-Sensitive Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy.
Volume: 141
Issue: 18
Pages: 1477-1493
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Publication
23973696 | J:308141
First Author: Beavers DL
Year: 2013
Journal: J Am Coll Cardiol
Title: Mutation E169K in junctophilin-2 causes atrial fibrillation due to impaired RyR2 stabilization.
Volume: 62
Issue: 21
Pages: 2010-9
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Protein
E9Q401
Organism: Mus musculus/domesticus
Length: 4966  
Fragment?: false
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Allele
Ryr2<tm1Sgp> | MGI:3641338
Name: ryanodine receptor 2, cardiac; targeted mutation 1, Silvia G Priori
Allele Type: Targeted
Attribute String: Humanized sequence, Modified isoform(s)
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Allele
Ryr2<tm1Slh> | MGI:3665257
 
Name: ryanodine receptor 2, cardiac; targeted mutation 1, Susan L Hamilton
Allele Type: Targeted
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Allele
Ryr2<tm2Amks> | MGI:3802940
Name: ryanodine receptor 2, cardiac; targeted mutation 2, Andrew R Marks
Allele Type: Targeted
Attribute String: Humanized sequence
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Allele
Ryr2<tm1.1Clhh> | MGI:5432111
Name: ryanodine receptor 2, cardiac; targeted mutation 1.1, Christopher Huang
Allele Type: Targeted
Attribute String: Humanized sequence
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Allele
Ryr2<tm3.1Amks> | MGI:5582510
Name: ryanodine receptor 2, cardiac; targeted mutation 3.1, Andrew R Marks
Allele Type: Targeted
Attribute String: Humanized sequence
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Allele
Ryr2<tm4.1Amks> | MGI:5582511
 
Name: ryanodine receptor 2, cardiac; targeted mutation 4.1, Andrew R Marks
Allele Type: Targeted
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Allele
Ryr2<tm2Hhv> | MGI:5583980
Name: ryanodine receptor 2, cardiac; targeted mutation 2, Hector H Valdivia
Allele Type: Targeted
Attribute String: Humanized sequence, Null/knockout
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Allele
Ryr2<tm3.1Hhv> | MGI:5750602
Name: ryanodine receptor 2, cardiac; targeted mutation 3.1, Hector H Valdivia
Allele Type: Targeted
Attribute String: Hypomorph
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Genotype
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: 129/Sv * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ryr2/Ryr2<+>
Background: C57BL/6J-Ryr2
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ryr2/Ryr2
Background: 129S/SvEv-Ryr2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: 129 * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: 129 * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: ht
Has Mutant Allele: true
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DO Term
DOID:0060675 | catecholaminergic polymorphic ventricular tachycardia 1
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Genotype
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: 129S7/SvEvBrd * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: 129S7/SvEvBrd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Publication
15916532 | -
First Author: Dulhunty AF
Year: 2005
Journal: Biochem J
Title: A recently identified member of the glutathione transferase structural family modifies cardiac RyR2 substate activity, coupled gating and activation by Ca2+ and ATP.
Volume: 390
Issue: Pt 1
Pages: 333-43
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Allele
Ryr2<m2Btlr> | MGI:6268710
Name: ryanodine receptor 2, cardiac; mutation 2, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Allele
Ryr2<m3Btlr> | MGI:6268714
Name: ryanodine receptor 2, cardiac; mutation 3, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Allele
Ryr2<em1Swch> | MGI:6682022
Name: ryanodine receptor 2, cardiac; endonuclease-mediated mutation 1, S R Wayne Chen
Allele Type: Endonuclease-mediated
Attribute String: Humanized sequence
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Allele
Tg(Myh6/tetO-Sypl2)1Jmol | MGI:5897324
Name: transgene insertion 1, Jeffery Molkentin
Allele Type: Transgenic
Attribute String: Inducible, Inserted expressed sequence
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Publication
27332123 | -
First Author: Cabra V
Year: 2016
Journal: Biophys J
Title: Ultrastructural Analysis of Self-Associated RyR2s.
Volume: 110
Issue: 12
Pages: 2651-2662
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Protein Domain
IPR035761 | SPRY1_RyR
Type: Domain
Description: This SPRY domain is the first of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR) []. There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3 []. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs []. The first domain may be involved in RyR2 dimerization [].
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Publication
28706255 | J:252890
First Author: Correll RN
Year: 2017
Journal: Sci Rep
Title: Mitsugumin 29 regulates t-tubule architecture in the failing heart.
Volume: 7
Issue: 1
Pages: 5328
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Strain
MGI:5897327 | FVB-Tg(Myh6/tetO-Sypl2)1Jmol/J
Attribute String: coisogenic, mutant strain, transgenic
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Allele
Ryr2<M1Btlr> | MGI:6268706
Name: ryanodine receptor 2, cardiac; mutation 1, Bruce Beutler
Allele Type: Chemically induced (ENU)
Attribute String: Not Specified
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Strain
MGI:6268707 | C57BL/6J-Ryr2<M1Btlr>
Attribute String: chemically induced mutation, coisogenic, mutant strain
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Strain
MGI:6268711 | C57BL/6J-Ryr2<m2Btlr>
Attribute String: mutant strain, chemically induced mutation, coisogenic
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Strain
MGI:6268715 | C57BL/6J-Ryr2<m3Btlr>
Attribute String: chemically induced mutation, coisogenic, mutant strain
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Genotype
Genotype
Symbol: Ryr2/Ryr2
Background: C57BL/6J-Ryr2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ryr2/Ryr2
Background: C57BL/6J-Ryr2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ryr2/Ryr2
Background: C57BL/6J-Ryr2
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ryr2/Ryr2
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ryr2/Ryr2<+>
Background: involves: 129 * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Publication
20961976 | -
First Author: Lanner JT
Year: 2010
Journal: Cold Spring Harb Perspect Biol
Title: Ryanodine receptors: structure, expression, molecular details, and function in calcium release.
Volume: 2
Issue: 11
Pages: a003996
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Publication
19399493 | -
First Author: Tae H
Year: 2009
Journal: Eur Biophys J
Title: Ubiquitous SPRY domains and their role in the skeletal type ryanodine receptor.
Volume: 39
Issue: 1
Pages: 51-9
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Publication
19076161 | -
First Author: Tae HS
Year: 2009
Journal: Clin Exp Pharmacol Physiol
Title: Molecular recognition of the disordered dihydropyridine receptor II-III loop by a conserved spry domain of the type 1 ryanodine receptor.
Volume: 36
Issue: 3
Pages: 346-9
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Publication
21239886 | -
First Author: Tae H
Year: 2011
Journal: Channels (Austin)
Title: The elusive role of the SPRY2 domain in RyR1.
Volume: 5
Issue: 2
Pages: 148-60
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Protein Domain
IPR035762 | SPRY3_RyR
Type: Domain
Description: This SPRY domain is the third of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR) []. There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3 []. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, but no specific function has been found for this third SPRY domain of the RyRs [].
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Protein Domain
IPR035764 | SPRY2_RyR
Type: Domain
Description: This SPRY domain (SPRY2) is the second of three structural repeats in all three isoforms of the ryanodine receptor (RyR), which are the major Ca2+ release channels in the membranes of sarcoplasmic reticulum (SR). There are three RyR genes in mammals; the skeletal RyR1, the cardiac RyR2 and the brain RyR3. The three SPRY domains are located in the N-terminal part of the cytoplasmic region of the RyRs, The SPRY2 domain has been shown to bind to the dihydropryidine receptor (DHPR) II-III loop and the ASI region of RyR1 [, ].
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HT Experiment
GSE201018 | I536T variant of RBM20 affects splicing of cardiac structural proteins that are causative for developing dilated cardiomyopathy
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
18650434 | J:142324
First Author: Wright NT
Year: 2008
Journal: J Biol Chem
Title: S100A1 and calmodulin compete for the same binding site on ryanodine receptor.
Volume: 283
Issue: 39
Pages: 26676-83
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Publication
25598495 | J:219724
 
First Author: Aschar-Sobbi R
Year: 2015
Journal: Nat Commun
Title: Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα.
Volume: 6
Pages: 6018
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Publication
32151269 | J:301890
First Author: Han RW
Year: 2020
Journal: Mol Brain
Title: Role of lateral amygdala calstabin2 in regulation of fear memory.
Volume: 13
Issue: 1
Pages: 35
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Publication
19381018 | J:149675
First Author: Ling H
Year: 2009
Journal: J Clin Invest
Title: Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice.
Volume: 119
Issue: 5
Pages: 1230-40
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Publication
28740084 | J:262362
First Author: Benson MA
Year: 2017
Journal: Sci Rep
Title: Ryanodine receptors are part of the myospryn complex in cardiac muscle.
Volume: 7
Issue: 1
Pages: 6312
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Publication
17607358 | J:124211
First Author: Song L
Year: 2007
Journal: J Clin Invest
Title: Calsequestrin 2 (CASQ2) mutations increase expression of calreticulin and ryanodine receptors, causing catecholaminergic polymorphic ventricular tachycardia.
Volume: 117
Issue: 7
Pages: 1814-23
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Publication
22422768 | J:184462
First Author: Roux-Buisson N
Year: 2012
Journal: Hum Mol Genet
Title: Absence of triadin, a protein of the calcium release complex, is responsible for cardiac arrhythmia with sudden death in human.
Volume: 21
Issue: 12
Pages: 2759-67
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Publication
37468098 | J:339705
First Author: Zhang IX
Year: 2023
Journal: J Biol Chem
Title: ER stress increases expression of intracellular calcium channel RyR1 to modify Ca(2+) homeostasis in pancreatic beta cells.
Volume: 299
Issue: 8
Pages: 105065
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Publication
18313230 | J:135635
First Author: Sawada K
Year: 2008
Journal: Neuroscience
Title: Differential alterations in expressions of ryanodine receptor subtypes in cerebellar cortical neurons of an ataxic mutant, rolling mouse Nagoya.
Volume: 152
Issue: 3
Pages: 609-17
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Publication
20530114 | J:176763
First Author: Wang H
Year: 2010
Journal: J Physiol
Title: Regulation of myocyte contraction via neuronal nitric oxide synthase: role of ryanodine receptor S-nitrosylation.
Volume: 588
Issue: Pt 15
Pages: 2905-17
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Publication
19641109 | J:151323
First Author: Chakroborty S
Year: 2009
Journal: J Neurosci
Title: Deviant ryanodine receptor-mediated calcium release resets synaptic homeostasis in presymptomatic 3xTg-AD mice.
Volume: 29
Issue: 30
Pages: 9458-70
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Publication
19959778 | J:170053
First Author: Zhang T
Year: 2010
Journal: Circ Res
Title: Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice.
Volume: 106
Issue: 2
Pages: 354-62
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Publication
23135969 | J:211451
First Author: Kalyanasundaram A
Year: 2013
Journal: Cardiovasc Res
Title: Up-regulation of sarcoplasmic reticulum Ca(2+) uptake leads to cardiac hypertrophy, contractile dysfunction and early mortality in mice deficient in CASQ2.
Volume: 98
Issue: 2
Pages: 297-306
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Publication
29352041 | J:312218
First Author: Yan J
Year: 2018
Journal: Circ Res
Title: Stress Signaling JNK2 Crosstalk With CaMKII Underlies Enhanced Atrial Arrhythmogenesis.
Volume: 122
Issue: 6
Pages: 821-835
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Publication
22087651 | J:198903
First Author: Liu Y
Year: 2011
Journal: Assay Drug Dev Technol
Title: Transgenic analysis of the role of FKBP12.6 in cardiac function and intracellular calcium release.
Volume: 9
Issue: 6
Pages: 620-7
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Publication
29537866 | J:263191
First Author: Matsuki K
Year: 2018
Journal: Am J Physiol Cell Physiol
Title: Negative regulation of cellular Ca2+ mobilization by ryanodine receptor type 3 in mouse mesenteric artery smooth muscle.
Volume: 315
Issue: 1
Pages: C1-C9
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Publication
33199609 | J:297677
First Author: Griffin CS
Year: 2020
Journal: Proc Natl Acad Sci U S A
Title: The intracellular Ca2+ release channel TRPML1 regulates lower urinary tract smooth muscle contractility.
Volume: 117
Issue: 48
Pages: 30775-30786
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Publication
24091324 | J:203982
First Author: Okada H
Year: 2013
Journal: J Clin Invest
Title: Integrins protect cardiomyocytes from ischemia/reperfusion injury.
Volume: 123
Issue: 10
Pages: 4294-308
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Publication
18378612 | J:153299
First Author: Gellen B
Year: 2008
Journal: Circulation
Title: Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation-contraction coupling.
Volume: 117
Issue: 14
Pages: 1778-86
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Publication
25824149 | J:251253
First Author: Delgado C
Year: 2015
Journal: Cardiovasc Res
Title: NOD1, a new player in cardiac function and calcium handling.
Volume: 106
Issue: 3
Pages: 375-86
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Publication
31217359 | J:294248
 
First Author: Brandenburg S
Year: 2019
Journal: JCI Insight
Title: Junctophilin-2 expression rescues atrial dysfunction through polyadic junctional membrane complex biogenesis.
Volume: 4
Issue: 12
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Publication
36821382 | J:353320
 
First Author: Tarasov M
Year: 2023
Journal: J Clin Invest
Title: NaV1.6 dysregulation within myocardial T-tubules by D96V calmodulin enhances proarrhythmic sodium and calcium mishandling.
Volume: 133
Issue: 7
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Publication
30792355 | J:273161
First Author: Batiste SM
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: Unnatural verticilide enantiomer inhibits type 2 ryanodine receptor-mediated calcium leak and is antiarrhythmic.
Volume: 116
Issue: 11
Pages: 4810-4815
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Publication
25538156 | J:256752
First Author: Radwański PB
Year: 2015
Journal: Cardiovasc Res
Title: Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release.
Volume: 106
Issue: 1
Pages: 143-52
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Publication
34990403 | J:333174
 
First Author: Blackwell DJ
Year: 2022
Journal: JCI Insight
Title: The Purkinje-myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT.
Volume: 7
Issue: 3
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Publication
17925380 | J:128454
First Author: Fritz N
Year: 2007
Journal: J Cell Sci
Title: RyR1-specific requirement for depolarization-induced Ca2+ sparks in urinary bladder smooth muscle.
Volume: 120
Issue: Pt 21
Pages: 3784-91
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Publication
28740174 | J:247755
First Author: Cerrone M
Year: 2017
Journal: Nat Commun
Title: Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm.
Volume: 8
Issue: 1
Pages: 106
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Publication
34625584 | J:359938
First Author: Federico M
Year: 2021
Journal: Sci Rep
Title: CaMKII activation in early diabetic hearts induces altered sarcoplasmic reticulum-mitochondria signaling.
Volume: 11
Issue: 1
Pages: 20025
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Publication
26198358 | J:250859
First Author: Little SC
Year: 2015
Journal: Sci Signal
Title: Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart.
Volume: 8
Issue: 386
Pages: ra72
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Publication
36198914 | J:335127
First Author: Yamamoto T
Year: 2022
Journal: J Mol Med (Berl)
Title: I536T variant of RBM20 affects splicing of cardiac structural proteins that are causative for developing dilated cardiomyopathy.
Volume: 100
Issue: 12
Pages: 1741-1754
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Publication
20042427 | J:184957
First Author: Valdivia CR
Year: 2010
Journal: Cardiovasc Res
Title: Loss-of-function mutation of the SCN3B-encoded sodium channel {beta}3 subunit associated with a case of idiopathic ventricular fibrillation.
Volume: 86
Issue: 3
Pages: 392-400
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Publication
20797399 | J:171027
First Author: Seidler T
Year: 2011
Journal: J Mol Cell Cardiol
Title: Limitations of FKBP12.6-directed treatment strategies for maladaptive cardiac remodeling and heart failure.
Volume: 50
Issue: 1
Pages: 33-42
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Publication
22328519 | J:197296
First Author: Zissimopoulos S
Year: 2012
Journal: J Cell Sci
Title: Disparities in the association of the ryanodine receptor and the FK506-binding proteins in mammalian heart.
Volume: 125
Issue: Pt 7
Pages: 1759-69
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Publication
25012845 | J:221826
First Author: Lewarchik CM
Year: 2014
Journal: Am J Physiol Gastrointest Liver Physiol
Title: The ryanodine receptor is expressed in human pancreatic acinar cells and contributes to acinar cell injury.
Volume: 307
Issue: 5
Pages: G574-81
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Publication
28587810 | J:253741
 
First Author: Yuen GK
Year: 2017
Journal: J Mol Cell Cardiol
Title: Subcellular localization of Na/K-ATPase isoforms in ventricular myocytes.
Volume: 108
Pages: 158-169
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Publication
32260593 | J:299859
 
First Author: Liu B
Year: 2020
Journal: Int J Mol Sci
Title: Conditional Up-Regulation of SERCA2a Exacerbates RyR2-Dependent Ventricular and Atrial Arrhythmias.
Volume: 21
Issue: 7
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Publication
33388782 | J:304460
First Author: Dridi H
Year: 2021
Journal: Hum Mol Genet
Title: Ryanodine receptor remodeling in cardiomyopathy and muscular dystrophy caused by lamin A/C gene mutation.
Volume: 29
Issue: 24
Pages: 3919-3934
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Protein
E9PZQ0
Organism: Mus musculus/domesticus
Length: 5035  
Fragment?: false
•
•
•
•
•
Protein
A2AGL3
Organism: Mus musculus/domesticus
Length: 4863  
Fragment?: false
•
•
•
•
•
Protein
A0A140LJK7
Organism: Mus musculus/domesticus
Length: 4868  
Fragment?: false
•
•
•
•
•
Protein
F6U7V1
Organism: Mus musculus/domesticus
Length: 4966  
Fragment?: false
•
•
•
•
•
Protein
K3W4M2
Organism: Mus musculus/domesticus
Length: 5033  
Fragment?: false
•
•
•
•
•
Protein
A0A140LJF7
Organism: Mus musculus/domesticus
Length: 4858  
Fragment?: false
•
•
•
•
•
Protein
A0A1L1SQG7
Organism: Mus musculus/domesticus
Length: 5061  
Fragment?: false
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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