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Genomics |
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Genetic mapping of mouse tumor necrosis factor-alpha converting enzyme (TACE) to chromosome 12. |
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Dash-Wagh S |
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Mol Cell Neurosci |
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The survival promoting peptide Y-P30 promotes cellular migration. |
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Vielkind U |
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Acta Anat (Basel) |
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Changing patterns of cell adhesion molecules during mouse pelage hair follicle development. 2. Follicle morphogenesis in the hair mutants, Tabby and downy. |
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157 |
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Iwabuchi T |
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2006 |
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Mech Dev |
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Syndecan-4 dependent FGF stimulation of mouse vibrissae growth. |
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Grisanti L |
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2013 |
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J Invest Dermatol |
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Enpp2/Autotaxin in dermal papilla precursors is dispensable for hair follicle morphogenesis. |
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Jasuja R |
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2004 |
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J Biol Chem |
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Cell-surface heparan sulfate proteoglycans potentiate chordin antagonism of bone morphogenetic protein signaling and are necessary for cellular uptake of chordin. |
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Thesleff I |
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Ford-Perriss M |
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Dev Dyn |
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Localisation of specific heparan sulfate proteoglycans during the proliferative phase of brain development. |
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van Rossum AM |
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Infect Immun |
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Host and bacterial factors contributing to the clearance of colonization by Streptococcus pneumoniae in a murine model. |
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Shimokawa K |
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2011 |
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Dev Cell |
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Cell surface heparan sulfate chains regulate local reception of FGF signaling in the mouse embryo. |
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2 |
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Development |
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Msx1 controls inductive signaling in mammalian tooth morphogenesis. |
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Zhao X |
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2000 |
| Journal: |
Mech Dev |
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Transgenically ectopic expression of Bmp4 to the Msx1 mutant dental mesenchyme restores downstream gene expression but represses Shh and Bmp2 in the enamel knot of wild type tooth germ. |
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1-2 |
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Richardson GD |
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2009 |
| Journal: |
Development |
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KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin. |
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136 |
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13 |
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Wishart TFL |
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Genomics |
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Anat Embryol (Berl) |
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Comparison of expression patterns between CREB family transcription factor OASIS and proteoglycan core protein genes during murine tooth development. |
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Dev Cell |
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Sox2 in the dermal papilla niche controls hair growth by fine-tuning BMP signaling in differentiating hair shaft progenitors. |
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Grisanti L |
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2013 |
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J Invest Dermatol |
| Title: |
Tbx18 targets dermal condensates for labeling, isolation, and gene ablation during embryonic hair follicle formation. |
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133 |
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Ormestad M |
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2006 |
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Development |
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Foxf1 and Foxf2 control murine gut development by limiting mesenchymal Wnt signaling and promoting extracellular matrix production. |
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DeRouen MC |
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2010 |
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BMC Dev Biol |
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Laminin-511 and integrin beta-1 in hair follicle development and basal cell carcinoma formation. |
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10 |
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Fantauzzo KA |
| Year: |
2012 |
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Development |
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Trps1 activates a network of secreted Wnt inhibitors and transcription factors crucial to vibrissa follicle morphogenesis. |
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Matrix Biol |
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Altered heparan sulfate structure in Glce(-/-) mice leads to increased Hedgehog signaling in endochondral bones. |
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Lathia JD |
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J Comp Neurol |
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Patterns of laminins and integrins in the embryonic ventricular zone of the CNS. |
| Volume: |
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Genome Res |
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Natale DR |
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2009 |
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Dev Biol |
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Activin promotes differentiation of cultured mouse trophoblast stem cells towards a labyrinth cell fate. |
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PLoS Genet |
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A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development. |
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Activin is an essential early mesenchymal signal in tooth development that is required for patterning of the murine dentition. |
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Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate. |
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Mol Biol Cell |
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CASK deletion in intestinal epithelia causes mislocalization of LIN7C and the DLG1/Scrib polarity complex without affecting cell polarity. |
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Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation. |
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Abnormal hair development and apparent follicular transformation to mammary gland in the absence of hedgehog signaling. |
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| Allele |
| Name: |
syndecan 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Humanized sequence, Inserted expressed sequence |
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•
•
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•
•
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| Allele |
| Name: |
syndecan 1; endonuclease-mediated mutation 2, Shanghai Model Organisms Center |
| Allele Type: |
Endonuclease-mediated |
| Attribute String: |
Null/knockout |
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•
•
•
•
•
|
| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
|
•
•
•
•
•
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| Strain |
| Attribute String: |
coisogenic, mutant strain, endonuclease-mediated mutation |
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•
•
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| Strain |
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coisogenic, endonuclease-mediated mutation, mutant strain |
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Neuroscience |
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Nerve injury induces the expression of syndecan-1 heparan sulfate proteoglycan in primary sensory neurons. |
| Volume: |
300 |
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| Pages: |
338-50 |
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| Publication |
| First Author: |
Stepp MA |
| Year: |
2015 |
| Journal: |
Adv Wound Care (New Rochelle) |
| Title: |
Syndecan-1 and Its Expanding List of Contacts. |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
235-249 |
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•
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| Publication |
| First Author: |
Worapamorn W |
| Year: |
2002 |
| Journal: |
J Periodontal Res |
| Title: |
Differential expression and distribution of syndecan-1 and -2 in periodontal wound healing of the rat. |
| Volume: |
37 |
| Issue: |
4 |
| Pages: |
293-9 |
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| Protein Domain |
| Type: |
Family |
| Description: |
Four members of the syndecan family of transmembrane heparan sulfate proteoglycans are expressed in mammals, Sdc1-4 [, ]. Syndecan 1 (Sdc1) plays an important role in regulating key events during wound healing, including cell adhesion, cell migration and fibrosis [, , ]. Sdc1 is expressed in injured primary sensory neurons and may have a role in nerve regeneration and synaptic plasticity []. |
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| Publication |
| First Author: |
Hughes CM |
| Year: |
2004 |
| Journal: |
Mol Cell |
| Title: |
Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus. |
| Volume: |
13 |
| Issue: |
4 |
| Pages: |
587-97 |
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•
•
•
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| Publication |
| First Author: |
Xu Z |
| Year: |
2009 |
| Journal: |
J Cell Biol |
| Title: |
A role of histone H3 lysine 4 methyltransferase components in endosomal trafficking. |
| Volume: |
186 |
| Issue: |
3 |
| Pages: |
343-53 |
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•
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•
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| Protein Domain |
| Type: |
Family |
| Description: |
This entry includes Sdc1 from yeasts, and its homologues, Dpy-30, from animals. Protein dpy-30 homologue (DPY30) is a component of the MLL1/MLL complex which trimethylates histone H3 at 'Lys-4' as a specific tag for epigenetic transcriptional activation []. DPY30 is also a component in MLL2/3 and MLL4/WBP7 methyltransferase-containing complexes [, ]and the SET1 complex []. DPY30 is found in the nucleus and the trans-Golgi network where it interacts with ARFGEF1 implying a role in endosomal trafficking []. This entry also includes C. elegans dpy-30, which is an essential component of the C. elegans dosage compensation machinery that reduces X chromosome transcript levels in hermaphrodites (XX) [].The SET1 complex is a methyltransferase that that produces trimethylated histone H3 at Lys(4). It is composed of at least the catalytic subunit (SETD1A or SETD1B), WDR5, WDR82, RBBP5, ASH2L/ASH2, CXXC1/CFP1, HCFC1 and DPY30 []. In yeast there is only one SET1 complex, but in mammals there are additional H3K4 methylases []. |
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| Publication |
| First Author: |
Sabouri Z |
| Year: |
2016 |
| Journal: |
Nat Commun |
| Title: |
IgD attenuates the IgM-induced anergy response in transitional and mature B cells. |
| Volume: |
7 |
|
| Pages: |
13381 |
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•
•
•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
206
 |
| Fragment?: |
true |
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•
•
•
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| Publication |
| First Author: |
Choi Y |
| Year: |
2011 |
| Journal: |
Matrix Biol |
| Title: |
Syndecans as cell surface receptors: Unique structure equates with functional diversity. |
| Volume: |
30 |
| Issue: |
2 |
| Pages: |
93-9 |
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•
•
•
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| Publication |
| First Author: |
Cho YW |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex. |
| Volume: |
282 |
| Issue: |
28 |
| Pages: |
20395-406 |
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•
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| Publication |
| First Author: |
Tirronen A |
| Year: |
2018 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
Deletion of Lymphangiogenic and Angiogenic Growth Factor VEGF-D Leads to Severe Hyperlipidemia and Delayed Clearance of Chylomicron Remnants. |
| Volume: |
38 |
| Issue: |
10 |
| Pages: |
2327-2337 |
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•
•
•
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| Publication |
| First Author: |
Conway KL |
| Year: |
2013 |
| Journal: |
Autophagy |
| Title: |
ATG5 regulates plasma cell differentiation. |
| Volume: |
9 |
| Issue: |
4 |
| Pages: |
528-37 |
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•
•
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| Publication |
| First Author: |
Manchanda K |
| Year: |
2018 |
| Journal: |
Arterioscler Thromb Vasc Biol |
| Title: |
MPO (Myeloperoxidase) Reduces Endothelial Glycocalyx Thickness Dependent on Its Cationic Charge. |
| Volume: |
38 |
| Issue: |
8 |
| Pages: |
1859-1867 |
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•
•
•
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| Publication |
| First Author: |
Ma M |
| Year: |
2022 |
| Journal: |
Cells |
| Title: |
The Ash2l SDI Domain Is Required to Maintain the Stability and Binding of DPY30. |
| Volume: |
11 |
| Issue: |
9 |
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•
•
•
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| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
175
 |
| Fragment?: |
false |
|
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•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
99
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
139
 |
| Fragment?: |
false |
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•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
177
 |
| Fragment?: |
false |
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•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
99
 |
| Fragment?: |
false |
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•
•
•
|
| Publication |
| First Author: |
Hsu DR |
| Year: |
1995 |
| Journal: |
Development |
| Title: |
DPY-30, a nuclear protein essential early in embryogenesis for Caenorhabditis elegans dosage compensation. |
| Volume: |
121 |
| Issue: |
10 |
| Pages: |
3323-34 |
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•
•
•
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| Publication |
| First Author: |
Patel A |
| Year: |
2009 |
| Journal: |
J Biol Chem |
| Title: |
On the mechanism of multiple lysine methylation by the human mixed lineage leukemia protein-1 (MLL1) core complex. |
| Volume: |
284 |
| Issue: |
36 |
| Pages: |
24242-56 |
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•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
311
 |
| Fragment?: |
false |
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•
•
•
•
|
| Publication |
| First Author: |
Lee JH |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex. |
| Volume: |
282 |
| Issue: |
18 |
| Pages: |
13419-28 |
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•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
311
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
311
 |
| Fragment?: |
false |
|
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•
•
•
•
|