| Type |
Details |
Score |
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| First Author: |
Lee H |
| Year: |
2015 |
| Journal: |
Exp Neurol |
| Title: |
Slit and Semaphorin signaling governed by Islet transcription factors positions motor neuron somata within the neural tube. |
| Volume: |
269 |
|
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17-27 |
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| First Author: |
Li L |
| Year: |
2019 |
| Journal: |
Cell Rep |
| Title: |
The COMPASS Family Protein ASH2L Mediates Corticogenesis via Transcriptional Regulation of Wnt Signaling. |
| Volume: |
28 |
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3 |
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698-711.e5 |
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| First Author: |
Arlotta P |
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2008 |
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J Neurosci |
| Title: |
Ctip2 controls the differentiation of medium spiny neurons and the establishment of the cellular architecture of the striatum. |
| Volume: |
28 |
| Issue: |
3 |
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622-32 |
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| First Author: |
Padget RL |
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2019 |
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Mech Dev |
| Title: |
Hemodynamic force is required for vascular smooth muscle cell recruitment to blood vessels during mouse embryonic development. |
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156 |
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8-19 |
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| First Author: |
Joza S |
| Year: |
2012 |
| Journal: |
Am J Pathol |
| Title: |
Loss of semaphorin-neuropilin-1 signaling causes dysmorphic vascularization reminiscent of alveolar capillary dysplasia. |
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181 |
| Issue: |
6 |
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2003-17 |
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| First Author: |
Tang K |
| Year: |
2012 |
| Journal: |
Development |
| Title: |
COUP-TFII controls amygdala patterning by regulating neuropilin expression. |
| Volume: |
139 |
| Issue: |
9 |
| Pages: |
1630-9 |
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•
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| First Author: |
Yang Y |
| Year: |
2017 |
| Journal: |
Cereb Cortex |
| Title: |
Impaired Interneuron Development after Foxg1 Disruption. |
| Volume: |
27 |
| Issue: |
1 |
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793-808 |
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| First Author: |
Cohen S |
| Year: |
2005 |
| Journal: |
Eur J Neurosci |
| Title: |
A semaphorin code defines subpopulations of spinal motor neurons during mouse development. |
| Volume: |
21 |
| Issue: |
7 |
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1767-76 |
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| First Author: |
Xu C |
| Year: |
2008 |
| Journal: |
Gene Expr Patterns |
| Title: |
Expression of Robo/Slit and Semaphorin/Plexin/Neuropilin family members in the developing hypothalamic paraventricular and supraoptic nuclei. |
| Volume: |
8 |
| Issue: |
7-8 |
| Pages: |
502-7 |
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| First Author: |
Wu H |
| Year: |
2012 |
| Journal: |
Development |
| Title: |
β-Catenin gain of function in muscles impairs neuromuscular junction formation. |
| Volume: |
139 |
| Issue: |
13 |
| Pages: |
2392-404 |
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| First Author: |
Meadows SM |
| Year: |
2012 |
| Journal: |
Circ Res |
| Title: |
Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. |
| Volume: |
110 |
| Issue: |
1 |
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34-46 |
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| First Author: |
Yan K |
| Year: |
2023 |
| Journal: |
Cereb Cortex |
| Title: |
TrkB-dependent EphrinA reverse signaling regulates callosal axon fasciculate growth downstream of Neurod2/6. |
| Volume: |
33 |
| Issue: |
5 |
| Pages: |
1752-1767 |
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| First Author: |
Bibollet-Bahena O |
| Year: |
2017 |
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PLoS One |
| Title: |
A dual-strategy expression screen for candidate connectivity labels in the developing thalamus. |
| Volume: |
12 |
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5 |
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| First Author: |
Puelles L |
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2023 |
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Int J Mol Sci |
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The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic Organizer. |
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24 |
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11 |
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| First Author: |
Yoshida Y |
| Year: |
2006 |
| Journal: |
Neuron |
| Title: |
PlexinA1 signaling directs the segregation of proprioceptive sensory axons in the developing spinal cord. |
| Volume: |
52 |
| Issue: |
5 |
| Pages: |
775-88 |
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•
•
•
•
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| Publication |
| First Author: |
Chen B |
| Year: |
2005 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. |
| Volume: |
102 |
| Issue: |
47 |
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17184-9 |
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| First Author: |
Abonnenc M |
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2013 |
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Circ Res |
| Title: |
Extracellular matrix secretion by cardiac fibroblasts: role of microRNA-29b and microRNA-30c. |
| Volume: |
113 |
| Issue: |
10 |
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1138-47 |
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| First Author: |
NIH Mouse Knockout Inventory |
| Year: |
2004 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Information obtained from the NIH Mouse Knockout Inventory |
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| First Author: |
Blackshaw S |
| Year: |
2004 |
| Journal: |
PLoS Biol |
| Title: |
Genomic analysis of mouse retinal development. |
| Volume: |
2 |
| Issue: |
9 |
| Pages: |
E247 |
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| First Author: |
Dickinson ME |
| Year: |
2016 |
| Journal: |
Nature |
| Title: |
High-throughput discovery of novel developmental phenotypes. |
| Volume: |
537 |
| Issue: |
7621 |
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508-514 |
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| First Author: |
Thompson CL |
| Year: |
2014 |
| Journal: |
Neuron |
| Title: |
A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain. |
| Volume: |
83 |
| Issue: |
2 |
| Pages: |
309-323 |
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| First Author: |
Koscielny G |
| Year: |
2014 |
| Journal: |
Nucleic Acids Res |
| Title: |
The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. |
| Volume: |
42 |
| Issue: |
Database issue |
| Pages: |
D802-9 |
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| First Author: |
Bedogni F |
| Year: |
2021 |
| Journal: |
Front Mol Neurosci |
| Title: |
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. |
| Volume: |
14 |
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| Pages: |
686034 |
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•
•
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| Publication |
| First Author: |
International Knockout Mouse Consortium |
| Year: |
2014 |
| Journal: |
Database Download |
| Title: |
MGI download of modified allele data from IKMC and creation of new knockout alleles |
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| Publication |
| First Author: |
International Mouse Strain Resource |
| Year: |
2014 |
| Journal: |
Database Download |
| Title: |
MGI download of germline transmission data for alleles from IMSR strain data |
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| First Author: |
GUDMAP Consortium |
| Year: |
2004 |
| Journal: |
www.gudmap.org |
| Title: |
GUDMAP: the GenitoUrinary Development Molecular Anatomy Project |
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| First Author: |
Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC) |
| Year: |
2014 |
| Journal: |
Database Release |
| Title: |
Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database |
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| First Author: |
Hansen GM |
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2008 |
| Journal: |
Genome Res |
| Title: |
Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. |
| Volume: |
18 |
| Issue: |
10 |
| Pages: |
1670-9 |
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| First Author: |
Helmholtz Zentrum Muenchen GmbH |
| Year: |
2010 |
| Journal: |
MGI Direct Data Submission |
| Title: |
Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu) |
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| First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
| Year: |
2001 |
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| Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
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Magdaleno S |
| Year: |
2006 |
| Journal: |
PLoS Biol |
| Title: |
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. |
| Volume: |
4 |
| Issue: |
4 |
| Pages: |
e86 |
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•
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
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| Title: |
Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database |
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Carninci P |
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2005 |
| Journal: |
Science |
| Title: |
The transcriptional landscape of the mammalian genome. |
| Volume: |
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| Issue: |
5740 |
| Pages: |
1559-63 |
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Adams DJ |
| Year: |
2024 |
| Journal: |
Nature |
| Title: |
Genetic determinants of micronucleus formation in vivo. |
| Volume: |
627 |
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8002 |
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MGD Nomenclature Committee |
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1995 |
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Nomenclature Committee Use |
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GemPharmatech |
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2020 |
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GemPharmatech Website. |
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| First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
| Year: |
2008 |
| Journal: |
Database Download |
| Title: |
Mouse Gene Trap Data Load from dbGSS |
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| First Author: |
Diez-Roux G |
| Year: |
2011 |
| Journal: |
PLoS Biol |
| Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
| Volume: |
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Mouse Genome Informatics Scientific Curators |
| Year: |
2002 |
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| Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
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| First Author: |
MGI Genome Annotation Group and UniGene Staff |
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2015 |
| Journal: |
Database Download |
| Title: |
MGI-UniGene Interconnection Effort |
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| First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
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2010 |
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Annotation inferences using phylogenetic trees |
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| First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
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2000 |
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Database Release |
| Title: |
Entrez Gene Load |
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| First Author: |
Allen Institute for Brain Science |
| Year: |
2004 |
| Journal: |
Allen Institute |
| Title: |
Allen Brain Atlas: mouse riboprobes |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
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2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
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| First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
| Year: |
2010 |
| Journal: |
Database Download |
| Title: |
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| First Author: |
Mouse Genome Informatics Group |
| Year: |
2003 |
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Database Procedure |
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Automatic Encodes (AutoE) Reference |
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| First Author: |
Bairoch A |
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1999 |
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Database Release |
| Title: |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
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| First Author: |
Mouse Genome Informatics |
| Year: |
2010 |
| Journal: |
Database Release |
| Title: |
Protein Ontology Association Load. |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2005 |
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| Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
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| First Author: |
Mouse Genome Informatics Scientific Curators |
| Year: |
2009 |
| Journal: |
Database Download |
| Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
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•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion IN103, GENSAT Project at Rockefeller University |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
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| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen H |
| Year: |
2000 |
| Journal: |
Neuron |
| Title: |
Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections. |
| Volume: |
25 |
| Issue: |
1 |
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43-56 |
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•
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| First Author: |
Bagri A |
| Year: |
2003 |
| Journal: |
Cell |
| Title: |
Stereotyped pruning of long hippocampal axon branches triggered by retraction inducers of the semaphorin family. |
| Volume: |
113 |
| Issue: |
3 |
| Pages: |
285-99 |
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•
•
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| First Author: |
Yaron A |
| Year: |
2005 |
| Journal: |
Neuron |
| Title: |
Differential requirement for Plexin-A3 and -A4 in mediating responses of sensory and sympathetic neurons to distinct class 3 Semaphorins. |
| Volume: |
45 |
| Issue: |
4 |
| Pages: |
513-23 |
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•
•
•
•
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| Publication |
| First Author: |
Takahashi T |
| Year: |
1999 |
| Journal: |
Cell |
| Title: |
Plexin-neuropilin-1 complexes form functional semaphorin-3A receptors. |
| Volume: |
99 |
| Issue: |
1 |
| Pages: |
59-69 |
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•
•
•
•
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| Publication |
| First Author: |
Goshima Y |
| Year: |
2002 |
| Journal: |
J Clin Invest |
| Title: |
Semaphorins as signals for cell repulsion and invasion. |
| Volume: |
109 |
| Issue: |
8 |
| Pages: |
993-8 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nakamura F |
| Year: |
2000 |
| Journal: |
J Neurobiol |
| Title: |
Molecular basis of semaphorin-mediated axon guidance. |
| Volume: |
44 |
| Issue: |
2 |
| Pages: |
219-29 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lindholm T |
| Year: |
2004 |
| Journal: |
Neuroreport |
| Title: |
Semaphorin and neuropilin expression in motoneurons after intraspinal motoneuron axotomy. |
| Volume: |
15 |
| Issue: |
4 |
| Pages: |
649-54 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Steinbach K |
| Year: |
2002 |
| Journal: |
Exp Cell Res |
| Title: |
Semaphorin 3E/collapsin-5 inhibits growing retinal axons. |
| Volume: |
279 |
| Issue: |
1 |
| Pages: |
52-61 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Semaphorins were first cloned as recognised mediators of cellular guidance, and consist of a large family of phylogenetically conserved secreted and transmembrane signalling proteins. Among the best-characterised vertebrate Semaphorins are the five secreted Class 3 members that contain an approximately 500 amino acid N-terminal Semaphorin domain, a C2 type immunoglobulin domain, and a highly basic C-terminal tail []. Two receptor families have been implicated in mediating the actions of class 3 semaphorins: the Neuropilins and Plexins. The nine known vertebrate Plexins are divided into four subfamilies (A through D) based on structure []. Several Plexins have been shown to interact directly with some class 4, 7 and V Semaphorins, but class 3 Semaphorins, however, do not appear to bind Plexins directly. Rather, the functional receptors for these Semaphorins are complexes of Neuropilins and A-type Plexins, with the former serving as the ligand-binding moiety and the latter the signal-transducing component [, ]. There are two Neuropilins (NP-1 and NP-2) that bind the five class 3 Semaphorins preferentially. In particular, Sema3A binds NP-1, whereas Sema3F utilises NP-2, while NP-1 and NP-2 heterodimers are thought to serve as functional receptors for Sema3C [].Semaphorin 4F may be involved in the injury response of intramedullary axotomized motoneurons []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Semaphorins were first cloned as recognised mediators of cellular guidance, and consist of a large family of phylogenetically conserved secreted and transmembrane signalling proteins. Among the best-characterised vertebrate Semaphorins are the five secreted Class 3 members that contain an approximately 500 amino acid N-terminal Semaphorin domain, a C2 type immunoglobulin domain, and a highly basic C-terminal tail []. Two receptor families have been implicated in mediating the actions of class 3 semaphorins: the Neuropilins and Plexins. The nine known vertebrate Plexins are divided into four subfamilies (A through D) based on structure []. Several Plexins have been shown to interact directly with some class 4, 7 and V Semaphorins, but class 3 Semaphorins, however, do not appear to bind Plexins directly. Rather, the functional receptors for these Semaphorins are complexes of Neuropilins and A-type Plexins, with the former serving as the ligand-binding moiety and the latter the signal-transducing component [, ]. There are two Neuropilins (NP-1 and NP-2), which bind the five class 3 Semaphorins preferentially. In particular, Sema3A binds NP-1, whereas Sema3F utilises NP-2, while NP-1 and NP-2 heterodimers are thought to serve as functional receptors for Sema3C [].Recent work suggests a possible role of Gallus gallus (Chicken) Sema3E/collapsin-5 in restricting growth of retinal ganglion cell axons to the optic fibre layer []. |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Family |
| Description: |
Semaphorins were first cloned as recognised mediators of cellular guidance, and consist of a large family of phylogenetically conserved secreted and transmembrane signalling proteins. Among the best-characterised vertebrate Semaphorins are the five secreted Class 3 members that contain an approximately 500 amino acid N-terminal Semaphorin domain, a C2 type immunoglobulin domain, and a highly basic C-terminal tail []. Two receptor families have been implicated in mediating the actions of class 3 semaphorins: the Neuropilins and Plexins. The nine known vertebrate Plexins are divided into four subfamilies (A through D) based on structure []. Several Plexins have been shown to interact directly with some class 4, 7 and V Semaphorins, but class 3 Semaphorins, however, do not appear to bind Plexins directly. Rather, the functional receptors for these Semaphorins are complexes of Neuropilins and A-type Plexins, with the former serving as the ligand-binding moiety and the latter the signal-transducing component [, ]. There are two Neuropilins (NP-1 and NP-2) that bind the five class 3 Semaphorins preferentially. In particular, Sema3A binds NP-1, whereas Sema3F utilises NP-2, while NP-1 and NP-2 heterodimers are thought to serve as functional receptors for Sema3C [].Recent microarray studies have suggested a role for Sema 6C in dental mesenchyme-induced neurite repulsion []. |
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•
•
•
•
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| Publication |
| First Author: |
Low LK |
| Year: |
2008 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Plexin signaling selectively regulates the stereotyped pruning of corticospinal axons from visual cortex. |
| Volume: |
105 |
| Issue: |
23 |
| Pages: |
8136-41 |
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•
•
•
•
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| Publication |
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Yamauchi K |
| Year: |
2009 |
| Journal: |
J Neurosci |
| Title: |
FGF8 signaling regulates growth of midbrain dopaminergic axons by inducing semaphorin 3F. |
| Volume: |
29 |
| Issue: |
13 |
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4044-55 |
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•
•
•
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| Publication |
| First Author: |
Pozas E |
| Year: |
2001 |
| Journal: |
Mol Cell Neurosci |
| Title: |
Age-dependent effects of secreted Semaphorins 3A, 3F, and 3E on developing hippocampal axons: in vitro effects and phenotype of Semaphorin 3A (-/-) mice. |
| Volume: |
18 |
| Issue: |
1 |
| Pages: |
26-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Mohan V |
| Year: |
2018 |
| Journal: |
Front Cell Neurosci |
| Title: |
Neurocan Inhibits Semaphorin 3F Induced Dendritic Spine Remodeling Through NrCAM in Cortical Neurons. |
| Volume: |
12 |
|
| Pages: |
346 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reuer T |
| Year: |
2018 |
| Journal: |
Invest Ophthalmol Vis Sci |
| Title: |
Semaphorin 3F Modulates Corneal Lymphangiogenesis and Promotes Corneal Graft Survival. |
| Volume: |
59 |
| Issue: |
12 |
| Pages: |
5277-5284 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ziak J |
| Year: |
2020 |
| Journal: |
EMBO Rep |
| Title: |
CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling. |
| Volume: |
21 |
| Issue: |
3 |
| Pages: |
e48512 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
80
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tamagnone L |
| Year: |
1999 |
| Journal: |
Cell |
| Title: |
Plexins are a large family of receptors for transmembrane, secreted, and GPI-anchored semaphorins in vertebrates. |
| Volume: |
99 |
| Issue: |
1 |
| Pages: |
71-80 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
124
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
931
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
963
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
774
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
61
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
923
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
923
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
963
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
777
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
777
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
722
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
775
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
574
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
| Year: |
2005 |
| Journal: |
Database Download |
| Title: |
MGI download of GENSAT transgene data |
|
|
|
|
•
•
•
•
•
|