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Search results 501 to 600 out of 723 for Sin3a

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Type Details Score
Allele
Sap130<Gt(OST461665)Lex> | MGI:4325159
 
Name: Sin3A associated protein; gene trap OST461665, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Sap130<Gt(OST461484)Lex> | MGI:4325097
 
Name: Sin3A associated protein; gene trap OST461484, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Sap130<Gt(W043F02)Wrst> | MGI:4333929
 
Name: Sin3A associated protein; gene trap W043F02, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Sap130<Gt(A20064)Wrst> | MGI:4335461
 
Name: Sin3A associated protein; gene trap A20064, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Sap130<Gt(A032C07)Wrst> | MGI:4335908
 
Name: Sin3A associated protein; gene trap A032C07, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Sin3a<Gt(RRU507)Byg> | MGI:4340725
 
Name: transcriptional regulator, SIN3A (yeast); gene trap RRU507, BayGenomics
Allele Type: Gene trapped
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Allele
Sap130<Gt(EUCJ0175h06)Hmgu> | MGI:4869860
 
Name: Sin3A associated protein; gene trap EUCJ0175h06, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Sap130<Gt(EUCJ0136b04)Hmgu> | MGI:4871455
 
Name: Sin3A associated protein; gene trap EUCJ0136b04, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Sap130<Tn(sb-Tyr)1799B.CA9Ove> | MGI:5300459
Name: Sin3A associated protein; transposon insertion 1799B.CA9, Paul A Overbeek
Allele Type: Transposon induced
Attribute String: Inserted expressed sequence
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Allele
Sin3a<tm1(KOMP)Vlcg> | MGI:5315988
Name: transcriptional regulator, SIN3A (yeast); targeted mutation 1, Velocigene
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Sap130<em1Clo> | MGI:5906303
Name: Sin3A associated protein; endonuclease-mediated mutation 1, Cecilia Lo
Allele Type: Endonuclease-mediated
Attribute String: Modified isoform(s)
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Allele
Sap130<em1Gpt> | MGI:7305756
Name: Sin3A associated protein; endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Sap130<em5Gpt> | MGI:7305757
Name: Sin3A associated protein; endonuclease-mediated mutation 5, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Sin3a<em1Gpt> | MGI:7377220
Name: transcriptional regulator, SIN3A (yeast); endonuclease-mediated mutation 1, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Sin3a<em2Gpt> | MGI:7377221
Name: transcriptional regulator, SIN3A (yeast); endonuclease-mediated mutation 2, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Sin3a<em2Cya> | MGI:7586516
Name: transcriptional regulator, SIN3A (yeast); endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Allele
Sin3a<Gt(BC0018)Wtsi> | MGI:3858147
 
Name: transcriptional regulator, SIN3A (yeast); gene trap BC0018, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Sin3a<Gt(CG0402)Wtsi> | MGI:3867228
 
Name: transcriptional regulator, SIN3A (yeast); gene trap CG0402, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Sin3a<Gt(D039F02)Wrst> | MGI:3875073
 
Name: transcriptional regulator, SIN3A (yeast); gene trap D039F02, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Sin3a<Gt(D187D01)Wrst> | MGI:3893311
 
Name: transcriptional regulator, SIN3A (yeast); gene trap D187D01, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Sin3a<Gt(H004G02)Wrst> | MGI:3897090
 
Name: transcriptional regulator, SIN3A (yeast); gene trap H004G02, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Sin3a<Gt(PST18644)Mfgc> | MGI:3902005
 
Name: transcriptional regulator, SIN3A (yeast); gene trap PST18644, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
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Allele
Sap130<Gt(IST12406A10)Tigm> | MGI:4075208
 
Name: Sin3A associated protein; gene trap IST12406A10, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sin3a<Gt(F011D04)Wrst> | MGI:4122857
 
Name: transcriptional regulator, SIN3A (yeast); gene trap F011D04, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Sin3a<Gt(EUCE0048e06)Hmgu> | MGI:4372421
 
Name: transcriptional regulator, SIN3A (yeast); gene trap EUCE0048e06, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Sin3a<Gt(EUCE0295h01)Hmgu> | MGI:4380924
 
Name: transcriptional regulator, SIN3A (yeast); gene trap EUCE0295h01, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Sin3a<Gt(EUCE0295h02)Hmgu> | MGI:4388056
 
Name: transcriptional regulator, SIN3A (yeast); gene trap EUCE0295h02, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Sin3a<Gt(EUCE0027b08)Hmgu> | MGI:4396718
 
Name: transcriptional regulator, SIN3A (yeast); gene trap EUCE0027b08, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Sin3a<tm1a(EUCOMM)Hmgu> | MGI:4455641
Name: transcriptional regulator, SIN3A (yeast); targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Sin3a<tm1e(EUCOMM)Hmgu> | MGI:4455882
Name: transcriptional regulator, SIN3A (yeast); targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Sap130<tm1e(KOMP)Mbp> | MGI:5141773
Name: Sin3A associated protein; targeted mutation 1e, Mouse Biology Program, UC Davis
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Sap130<tm1a(KOMP)Mbp> | MGI:5141821
Name: Sin3A associated protein; targeted mutation 1a, Mouse Biology Program, UC Davis
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Sin3a<Gt(IST10440F6)Tigm> | MGI:5143580
 
Name: transcriptional regulator, SIN3A (yeast); gene trap IST10440F6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sin3a<Gt(IST13157B5)Tigm> | MGI:5156131
 
Name: transcriptional regulator, SIN3A (yeast); gene trap IST13157B5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sin3a<Gt(IST13559A9)Tigm> | MGI:5177185
 
Name: transcriptional regulator, SIN3A (yeast); gene trap IST13559A9, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sin3a<Gt(IST14017F5)Tigm> | MGI:5205691
 
Name: transcriptional regulator, SIN3A (yeast); gene trap IST14017F5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sin3a<Gt(IST14149H2)Tigm> | MGI:5216381
 
Name: transcriptional regulator, SIN3A (yeast); gene trap IST14149H2, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sin3a<Gt(IST14439F4)Tigm> | MGI:5232327
 
Name: transcriptional regulator, SIN3A (yeast); gene trap IST14439F4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sin3a<Gt(IST14522B4)Tigm> | MGI:5242902
 
Name: transcriptional regulator, SIN3A (yeast); gene trap IST14522B4, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sap130<Gt(IST14652E1)Tigm> | MGI:5251881
 
Name: Sin3A associated protein; gene trap IST14652E1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sin3a<Gt(IST14755F7)Tigm> | MGI:5255795
 
Name: transcriptional regulator, SIN3A (yeast); gene trap IST14755F7, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sin3a<Gt(IST14988G6)Tigm> | MGI:5272105
 
Name: transcriptional regulator, SIN3A (yeast); gene trap IST14988G6, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sin3a<Gt(IST15059E5)Tigm> | MGI:5281943
 
Name: transcriptional regulator, SIN3A (yeast); gene trap IST15059E5, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sap130<b2b635.2Clo> | MGI:5906284
Name: Sin3A associated protein; Bench to Bassinet Program (B2B/CVDC), mutation 635.2 Cecilia Lo
Allele Type: Chemically induced (ENU)
Attribute String: Hypomorph, Modified isoform(s)
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Allele
Sin3a<em1(IMPC)Ccpcz> | MGI:6389083
Name: transcriptional regulator, SIN3A (yeast); endonuclease-mediated mutation 1, Institute of Molecular Genetics
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7382247 | C57BL/6JGpt-Sin3a<em1Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7382248 | C57BL/6JGpt-Sin3a<em2Gpt>/Gpt
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Strain
MGI:7588958 | C57BL/6J-Sin3a<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Sap130<tm1c(KOMP)Mbp> | MGI:7852339
Name: Sin3A associated protein; targeted mutation 1c, Mouse Biology Program, UC Davis
Allele Type: Targeted
Attribute String: Conditional ready
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Genotype
Genotype
Symbol: Sin3a/Sin3a
Background: involves: 129
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sin3a/Sin3a
Background: involves: 129 * C57BL/6 * SJL
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sap130/Sap130
Background: involves: FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sin3a/Sin3a
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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DO Term
DOID:0060395 | chromosome 15q24 deletion syndrome
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Publication
34556635 | J:331251
First Author: Lv LL
Year: 2021
Journal: Cell Death Dis
Title: SAP130 released by damaged tubule drives necroinflammation via miRNA-219c/Mincle signaling in acute kidney injury.
Volume: 12
Issue: 10
Pages: 866
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Publication
39774941 | J:360819
First Author: Gabriel GC
Year: 2025
Journal: Nat Commun
Title: Mitotic block and epigenetic repression underlie neurodevelopmental defects and neurobehavioral deficits in congenital heart disease.
Volume: 16
Issue: 1
Pages: 469
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Strain
MGI:5700699 | C57BL/6N-Sap130<tm1a(KOMP)Mbp>/Wtsi
Attribute String: coisogenic, targeted mutation
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Strain
MGI:6122338 | C57BL/6N-A<tm1Brd> Sap130<tm1a(KOMP)Mbp>/WtsiIeg
Attribute String: mutant strain, coisogenic, targeted mutation
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Strain
MGI:5907018 | C57BL/6J-Sap130<em1Clo> Pcdha9<em1Clo>/MurrJ
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Strain
MGI:5906295 | C57BL/6J-Sap130<b2b635.2Clo>
Attribute String: mutant strain, chemically induced mutation, coisogenic
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Strain
MGI:7853191 | C57BL/6NCrl-Sin3a<em1(IMPC)Ccpcz>/Ph
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Sap130/Sap130
Background: C57BL/6J-Sap130 Pcdha9
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pcdha9/Pcdha9 Sap130/Sap130
Background: C57BL/6J-Sap130 Pcdha9/MurrJ
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sap130/Sap130
Background: C57BL/6N-Sap130/Wtsi
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sap130/Sap130
Background: C57BL/6J-Sap130
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sap130/Sap130<+>
Background: C57BL/6N-Sap130/Wtsi
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sin3a/Sin3a<+>
Background: involves: 129 * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sap130/Sap130
Background: C57BL/6N-Sap130/Wtsi
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sin3a/Sin3a Tg(Ddx4-cre)1Dcas/?
Background: involves: 129 * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sin3a/Sin3a<+>
Background: involves: 129 * C57BL/6 * CD-1
Zygosity: ht
Has Mutant Allele: true
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Strain
MGI:5557318 | B6NTac;B6N-A<tm1Brd> Sap130<tm1a(KOMP)Mbp>/Wtsi
Attribute String: mutant strain, targeted mutation
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Publication
28530678 | J:242757
First Author: Liu X
Year: 2017
Journal: Nat Genet
Title: The complex genetics of hypoplastic left heart syndrome.
Volume: 49
Issue: 7
Pages: 1152-1159
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Publication
9139820 | -
First Author: Heinzel T
Year: 1997
Journal: Nature
Title: A complex containing N-CoR, mSin3 and histone deacetylase mediates transcriptional repression.
Volume: 387
Issue: 6628
Pages: 43-8
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Publication
12130660 | J:104339
First Author: Li X
Year: 2002
Journal: Science
Title: Tissue-specific regulation of retinal and pituitary precursor cell proliferation.
Volume: 297
Issue: 5584
Pages: 1180-3
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Publication
26124119 | -
First Author: Clark MD
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Structural insights into the assembly of the histone deacetylase-associated Sin3L/Rpd3L corepressor complex.
Volume: 112
Issue: 28
Pages: E3669-78
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Strain
MGI:5906292 | C57BL/6J-Sap130<b2b635.2Clo> Pcdha9<b2b635.1Clo>
Attribute String: chemically induced mutation, coisogenic, mutant strain
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Genotype
Genotype
Symbol: Sin3a/Sin3a<+> Trp53/Trp53
Background: involves: 129S2/SvPas * C57BL/6 * FVB
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sap130/Sap130
Background: involves: C57BL/6J * C57BL/6N
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sin3a/Sin3a<+> Tg(Ddx4-cre)1Dcas/?
Background: involves: 129 * FVB
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Sin3a/Sin3a Tg(Neurog3-cre)C1Able/?
Background: involves: 129 * C57BL/6 * CD-1
Zygosity: cn
Has Mutant Allele: true
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Protein Domain
IPR031693 | Sin3_C
Type: Domain
Description: This entry represents a domain found in the C-terminal of the transcriptional repressor Sin3.Budding yeast Sin3 is a component of both the Rpd3S and Rpd3L histone deacetylase complexes []. In mammals there are two Sin3 paraologues, Sin3A and Sin3B. They forms the larger Sin3L/Rpd3L and the smaller Sin3S/Rpd3S complexes, both complexes rely largely on HDAC (histone deacetylase) activity to affect transcriptional repression. Sin3A and Sin3B may partition into the Sin3L/Rpd3L and Sin3S/Rpd3S complexes, respectively [].
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Protein Domain
IPR013194 | HDAC_interact_dom
Type: Domain
Description: This domain is found in the transcriptional repressor Sin3. It forms interactions with histone deacetylases [].Budding yeast Sin3 is a component of both the Rpd3S and Rpd3L histone deacetylase complexes []. In mammals there are two Sin3 paraologues, Sin3A and Sin3B. They forms the larger Sin3L/Rpd3L and the smaller Sin3S/Rpd3S complexes, both complexes rely largely on HDAC (histone deacetylase) activity to affect transcriptional repression. Sin3A and Sin3B may partition into the Sin3L/Rpd3L and Sin3S/Rpd3S complexes, respectively [].
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Publication
29355515 | J:261106
First Author: Kim JW
Year: 2018
Journal: Am J Pathol
Title: Spliceosome-Associated Protein 130 Exacerbates Alcohol-Induced Liver Injury by Inducing NLRP3 Inflammasome-Mediated IL-1β in Mice.
Volume: 188
Issue: 4
Pages: 967-980
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Genotype
Genotype
Symbol: Pcdha9/Pcdha9 Sap130/Sap130<+>
Background: C57BL/6J-Sap130 Pcdha9
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Shh/Shh<+> Sin3a/Sin3a
Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Publication
21937600 | J:178818
First Author: Wang B
Year: 2011
Journal: Development
Title: Transposon mutagenesis with coat color genotyping identifies an essential role for Skor2 in sonic hedgehog signaling and cerebellum development.
Volume: 138
Issue: 20
Pages: 4487-97
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Publication
8617250 | -
First Author: Hurlin PJ
Year: 1996
Journal: EMBO J
Title: Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation.
Volume: 15
Issue: 8
Pages: 2030
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Publication
16314178 | -
First Author: Carrozza MJ
Year: 2005
Journal: Biochim Biophys Acta
Title: Stable incorporation of sequence specific repressors Ash1 and Ume6 into the Rpd3L complex.
Volume: 1731
Issue: 2
Pages: 77-87; discussion 75-6
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Protein Coding Gene
MGI:1919204 | Suds3
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
23487765 | J:210434
First Author: Wu RC
Year: 2013
Journal: Proc Natl Acad Sci U S A
Title: ARID4A and ARID4B regulate male fertility, a functional link to the AR and RB pathways.
Volume: 110
Issue: 12
Pages: 4616-21
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Protein
Q8BYB0
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: true
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Protein
Q8BXV6
Organism: Mus musculus/domesticus
Length: 398  
Fragment?: true
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Publication
22693453 | -
First Author: Winter SF
Year: 2012
Journal: PLoS Genet
Title: Allelic variation and differential expression of the mSIN3A histone deacetylase complex gene Arid4b promote mammary tumor growth and metastasis.
Volume: 8
Issue: 5
Pages: e1002735
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Protein Domain
IPR028853 | ARID4B
Type: Family
Description: AT-rich interactive domain-containing protein 4B (ARID4B) acts as a transcriptional repressor. It may function in the assembly and/or enzymatic activity of the Sin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes []. It may play an integral part in the AR (androgen receptor) and RB (retinoblastoma) regulatory pathways involved in the regulation of Sertoli cell function and male fertility []. It is linked to tumor growth and metastasis [].
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Protein Domain
IPR024145 | His_deAcase_SAP30/SAP30L
Type: Family
Description: Histone acetylation plays a key role in the regulation of gene expression. The chromatin structure and accessibility of genes to transcription factors isregulated by enzymes that acetylate and deacetylate histones. The Sin3A-histone deacetylase (HDAC) co-repressor complex consists of multiple proteins and regulates gene expression by deacetylating histones.This entry includes both Sin3-associated protein 30 (SAP30) and SAP30L, a close homologue of SAP30. Both are able to target Sin3A to the nucleolus [].
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Shh/Shh<+> Sin3a/Sin3a<+>
Background: involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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GO Term
GO:0070822 | Sin3-type complex
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Protein Domain
IPR028639 | ING2
Type: Family
Description: Members of the ING (inhibitor of growth protein) family of tumour suppressors regulate cell cycle progression, senescence, apoptosis, and DNA repair as important cofactors of p53. Inhibitorof growth protein 2 (ING2) seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53 []. It is also a component of a chromatin-modifying complex containing the transcriptional co-repressor SIN3A and HDAC1 (histone deacetylase 1), which is involved in deacetylation of nucleosomal histones [, ]. The stability of ING2 is regulated by nuclear phosphatidylinositol-5-phosphate at discrete chromatin targets in response to DNA damage [, ].
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Protein Domain
IPR042019 | ING2_PHD
Type: Domain
Description: This entry represents the PHD domain of ING2.Members of the ING (inhibitor of growth protein) family of tumour suppressors regulate cell cycle progression, senescence, apoptosis, and DNA repair as important cofactors of p53. Inhibitor of growth protein 2 (ING2) seems to be involved in p53/TP53 activation and p53/TP53-dependent apoptotic pathways, probably by enhancing acetylation of p53/TP53 []. It is also a component of a chromatin-modifying complex containing the transcriptional co-repressor SIN3A and HDAC1 (histone deacetylase 1), which is involved in deacetylation of nucleosomal histones [, ]. The stability of ING2 is regulated by nuclear phosphatidylinositol-5-phosphate at discrete chromatin targets in response to DNA damage [, ].
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Publication
29078390 | J:249035
First Author: Kannan M
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: WD40-repeat 47, a microtubule-associated protein, is essential for brain development and autophagy.
Volume: 114
Issue: 44
Pages: E9308-E9317
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