| Type |
Details |
Score |
| Genotype |
| Symbol: |
Tg(RP11-209M4*)#Gglo/Tg(RP11-209M4*)#Gglo |
| Background: |
FVB-Tg(RP11-209M4*)#Gglo |
| Zygosity: |
hm |
| Has Mutant Allele: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
206
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aobulikasimu A |
| Year: |
2023 |
| Journal: |
Sci Rep |
| Title: |
SIRT6-PAI-1 axis is a promising therapeutic target in aging-related bone metabolic disruption. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
7991 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kaneko K |
| Year: |
2014 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Integrin αv in the mechanical response of osteoblast lineage cells. |
| Volume: |
447 |
| Issue: |
2 |
| Pages: |
352-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Song D |
| Year: |
2021 |
| Journal: |
Sci Rep |
| Title: |
Functional interaction between Wnt and Bmp signaling in periosteal bone growth. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
10782 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sato T |
| Year: |
2020 |
| Journal: |
Nat Commun |
| Title: |
A FAK/HDAC5 signaling axis controls osteocyte mechanotransduction. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
3282 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yambe S |
| Year: |
2024 |
| Journal: |
Front Cell Dev Biol |
| Title: |
Sclerostin modulates mineralization degree and stiffness profile in the fibrocartilaginous enthesis for mechanical tissue integrity. |
| Volume: |
12 |
|
| Pages: |
1360041 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sebastian A |
| Year: |
2018 |
| Journal: |
Metabolism |
| Title: |
Genetics of Sost/SOST in sclerosteosis and van Buchem disease animal models. |
| Volume: |
80 |
|
| Pages: |
38-47 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu H |
| Year: |
2022 |
| Journal: |
Nat Commun |
| Title: |
Osteocyte CIITA aggravates osteolytic bone lesions in myeloma. |
| Volume: |
13 |
| Issue: |
1 |
| Pages: |
3684 |
|
•
•
•
•
•
|
| HT Experiment |
| Series Id: |
GSE14242 |
| Experiment Type: |
transcription profiling by array |
| Study Type: |
WT vs. Mutant |
| Source: |
ArrayExpress |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Delgado-Calle J |
| Year: |
2022 |
| Journal: |
FASEB J |
| Title: |
The Notch pathway regulates the bone gain induced by PTH anabolic signaling. |
| Volume: |
36 |
| Issue: |
3 |
| Pages: |
e22196 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Powell WF Jr |
| Year: |
2011 |
| Journal: |
J Endocrinol |
| Title: |
Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses. |
| Volume: |
209 |
| Issue: |
1 |
| Pages: |
21-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Martineau C |
| Year: |
2014 |
| Journal: |
Physiol Rep |
| Title: |
Scavenger receptor class B, type I (Scarb1) deficiency promotes osteoblastogenesis but stunts terminal osteocyte differentiation. |
| Volume: |
2 |
| Issue: |
10 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lau KH |
| Year: |
2013 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
Osteocyte-derived insulin-like growth factor I is essential for determining bone mechanosensitivity. |
| Volume: |
305 |
| Issue: |
2 |
| Pages: |
E271-81 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kaneko K |
| Year: |
2011 |
| Journal: |
J Bone Miner Res |
| Title: |
Physiological function of the angiotensin AT1a receptor in bone remodeling. |
| Volume: |
26 |
| Issue: |
12 |
| Pages: |
2959-66 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meury T |
| Year: |
2010 |
| Journal: |
Mol Cell Biol |
| Title: |
Nuclear alpha NAC influences bone matrix mineralization and osteoblast maturation in vivo. |
| Volume: |
30 |
| Issue: |
1 |
| Pages: |
43-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Movérare-Skrtic S |
| Year: |
2023 |
| Journal: |
EBioMedicine |
| Title: |
B4GALNT3 regulates glycosylation of sclerostin and bone mass. |
| Volume: |
91 |
|
| Pages: |
104546 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Morse A |
| Year: |
2020 |
| Journal: |
Bone |
| Title: |
Increased anabolic bone response in Dkk1 KO mice following tibial compressive loading. |
| Volume: |
131 |
|
| Pages: |
115054 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xu C |
| Year: |
2021 |
| Journal: |
Front Physiol |
| Title: |
TGF-Beta Receptor II Is Critical for Osteogenic Progenitor Cell Proliferation and Differentiation During Postnatal Alveolar Bone Formation. |
| Volume: |
12 |
|
| Pages: |
721775 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kondoh S |
| Year: |
2014 |
| Journal: |
Bone |
| Title: |
Estrogen receptor α in osteocytes regulates trabecular bone formation in female mice. |
| Volume: |
60 |
|
| Pages: |
68-77 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Reppe S |
| Year: |
2024 |
| Journal: |
Int J Mol Sci |
| Title: |
The DLEU2-miR-15a-16-1 Cluster Is a Determinant of Bone Microarchitecture and Strength in Postmenopausal Women and Mice. |
| Volume: |
25 |
| Issue: |
23 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Staines KA |
| Year: |
2020 |
| Journal: |
Biosci Rep |
| Title: |
Conditional deletion of E11/Podoplanin in bone protects against ovariectomy-induced increases in osteoclast formation and activity. |
| Volume: |
40 |
| Issue: |
1 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Grimston SK |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
Enhanced periosteal and endocortical responses to axial tibial compression loading in conditional connexin43 deficient mice. |
| Volume: |
7 |
| Issue: |
9 |
| Pages: |
e44222 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Baroi S |
| Year: |
2021 |
| Journal: |
Bone |
| Title: |
PPARG in osteocytes controls sclerostin expression, bone mass, marrow adiposity and mediates TZD-induced bone loss. |
| Volume: |
147 |
|
| Pages: |
115913 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Canalis E |
| Year: |
2016 |
| Journal: |
Am J Physiol Endocrinol Metab |
| Title: |
Canonical Notch activation in osteocytes causes osteopetrosis. |
| Volume: |
310 |
| Issue: |
2 |
| Pages: |
E171-82 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gerbaix M |
| Year: |
2015 |
| Journal: |
Bone |
| Title: |
Periostin expression contributes to cortical bone loss during unloading. |
| Volume: |
71 |
|
| Pages: |
94-100 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shiraki M |
| Year: |
2019 |
| Journal: |
FASEB J |
| Title: |
Deficiency of stress-associated gene Nupr1 increases bone volume by attenuating differentiation of osteoclasts and enhancing differentiation of osteoblasts. |
| Volume: |
33 |
| Issue: |
8 |
| Pages: |
8836-8852 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Maridas DE |
| Year: |
2017 |
| Journal: |
J Endocrinol |
| Title: |
IGFBP-4 regulates adult skeletal growth in a sex-specific manner. |
| Volume: |
233 |
| Issue: |
1 |
| Pages: |
131-144 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Homer-Bouthiette C |
| Year: |
2014 |
| Journal: |
J Biol Chem |
| Title: |
Knockout of nuclear high molecular weight FGF2 isoforms in mice modulates bone and phosphate homeostasis. |
| Volume: |
289 |
| Issue: |
52 |
| Pages: |
36303-14 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Maeda A |
| Year: |
2015 |
| Journal: |
J Biol Chem |
| Title: |
WNT1-induced Secreted Protein-1 (WISP1), a Novel Regulator of Bone Turnover and Wnt Signaling. |
| Volume: |
290 |
| Issue: |
22 |
| Pages: |
14004-18 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zanotti S |
| Year: |
2017 |
| Journal: |
Bone |
| Title: |
Parathyroid hormone inhibits Notch signaling in osteoblasts and osteocytes. |
| Volume: |
103 |
|
| Pages: |
159-167 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rhee Y |
| Year: |
2013 |
| Journal: |
J Biol Chem |
| Title: |
Resorption controls bone anabolism driven by parathyroid hormone (PTH) receptor signaling in osteocytes. |
| Volume: |
288 |
| Issue: |
41 |
| Pages: |
29809-20 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rahman S |
| Year: |
2013 |
| Journal: |
Endocrinology |
| Title: |
Inducible brown adipose tissue, or beige fat, is anabolic for the skeleton. |
| Volume: |
154 |
| Issue: |
8 |
| Pages: |
2687-701 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
You L |
| Year: |
2015 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Zinc finger protein 467 regulates Wnt signaling by modulating the expression of sclerostin in adipose derived stem cells. |
| Volume: |
456 |
| Issue: |
2 |
| Pages: |
598-604 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Remoli C |
| Year: |
2015 |
| Journal: |
J Bone Miner Res |
| Title: |
Osteoblast-specific expression of the fibrous dysplasia (FD)-causing mutation Gsα(R201C) produces a high bone mass phenotype but does not reproduce FD in the mouse. |
| Volume: |
30 |
| Issue: |
6 |
| Pages: |
1030-43 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chan WCW |
| Year: |
2017 |
| Journal: |
Hum Mol Genet |
| Title: |
Activating the unfolded protein response in osteocytes causes hyperostosis consistent with craniodiaphyseal dysplasia. |
| Volume: |
26 |
| Issue: |
23 |
| Pages: |
4572-4587 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Sun N |
| Year: |
2019 |
| Journal: |
J Biol Chem |
| Title: |
Effects of histone deacetylase inhibitor Scriptaid and parathyroid hormone on osteocyte functions and metabolism. |
| Volume: |
294 |
| Issue: |
25 |
| Pages: |
9722-9733 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Castro-Mollo M |
| Year: |
2021 |
| Journal: |
Elife |
| Title: |
The hepcidin regulator erythroferrone is a new member of the erythropoiesis-iron-bone circuitry. |
| Volume: |
10 |
|
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ohori F |
| Year: |
2019 |
| Journal: |
J Immunol Res |
| Title: |
Effect of TNF-α-Induced Sclerostin on Osteocytes during Orthodontic Tooth Movement. |
| Volume: |
2019 |
|
| Pages: |
9716758 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xiong J |
| Year: |
2015 |
| Journal: |
PLoS One |
| Title: |
Osteocytes, not Osteoblasts or Lining Cells, are the Main Source of the RANKL Required for Osteoclast Formation in Remodeling Bone. |
| Volume: |
10 |
| Issue: |
9 |
| Pages: |
e0138189 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lau KW |
| Year: |
2016 |
| Journal: |
Bone |
| Title: |
Conditional deletion of IGF-I in osteocytes unexpectedly accelerates bony union of the fracture gap in mice. |
| Volume: |
92 |
|
| Pages: |
18-28 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lloyd SA |
| Year: |
2013 |
| Journal: |
Bone |
| Title: |
Connexin 43 deficiency desensitizes bone to the effects of mechanical unloading through modulation of both arms of bone remodeling. |
| Volume: |
57 |
| Issue: |
1 |
| Pages: |
76-83 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhao G |
| Year: |
2020 |
| Journal: |
J Bone Miner Res |
| Title: |
CCN1/Cyr61 Is Required in Osteoblasts for Responsiveness to the Anabolic Activity of PTH. |
| Volume: |
35 |
| Issue: |
11 |
| Pages: |
2289-2300 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Collins JN |
| Year: |
2013 |
| Journal: |
Endocrinology |
| Title: |
Lactating Ctcgrp nulls lose twice the normal bone mineral content due to fewer osteoblasts and more osteoclasts, whereas bone mass is fully restored after weaning in association with up-regulation of Wnt signaling and other novel genes. |
| Volume: |
154 |
| Issue: |
4 |
| Pages: |
1400-13 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nakatani T |
| Year: |
2018 |
| Journal: |
J Bone Miner Res |
| Title: |
The Deletion of Hdac4 in Mouse Osteoblasts Influences Both Catabolic and Anabolic Effects in Bone. |
| Volume: |
33 |
| Issue: |
7 |
| Pages: |
1362-1375 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kramer I |
| Year: |
2012 |
| Journal: |
J Bone Miner Res |
| Title: |
Mef2c deletion in osteocytes results in increased bone mass. |
| Volume: |
27 |
| Issue: |
2 |
| Pages: |
360-73 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ben-awadh AN |
| Year: |
2014 |
| Journal: |
Endocrinology |
| Title: |
Parathyroid hormone receptor signaling induces bone resorption in the adult skeleton by directly regulating the RANKL gene in osteocytes. |
| Volume: |
155 |
| Issue: |
8 |
| Pages: |
2797-809 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Boudin E |
| Year: |
2013 |
| Journal: |
Bone |
| Title: |
Mutations in sFRP1 or sFRP4 are not a common cause of craniotubular hyperostosis. |
| Volume: |
52 |
| Issue: |
1 |
| Pages: |
292-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Buck HV |
| Year: |
2024 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Nitric oxide contributes to rapid sclerostin protein loss following mechanical load. |
| Volume: |
727 |
|
| Pages: |
150315 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kao RS |
| Year: |
2013 |
| Journal: |
Bone |
| Title: |
Constitutive protein kinase A activity in osteocytes and late osteoblasts produces an anabolic effect on bone. |
| Volume: |
55 |
| Issue: |
2 |
| Pages: |
277-87 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
MGD Nomenclature Committee |
| Year: |
1995 |
|
| Title: |
Nomenclature Committee Use |
|
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•
•
•
•
•
|