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Search results 501 to 600 out of 686 for Sumo1

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Type Details Score
Allele
Sae1<Gt(OST407337)Lex> | MGI:4307934
 
Name: SUMO1 activating enzyme subunit 1; gene trap OST407337, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Sae1<Gt(OST420783)Lex> | MGI:4311666
 
Name: SUMO1 activating enzyme subunit 1; gene trap OST420783, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Sae1<Gt(OST423990)Lex> | MGI:4312423
 
Name: SUMO1 activating enzyme subunit 1; gene trap OST423990, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Sae1<Gt(OST426408)Lex> | MGI:4313207
 
Name: SUMO1 activating enzyme subunit 1; gene trap OST426408, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Sae1<Gt(OST432802)Lex> | MGI:4315315
 
Name: SUMO1 activating enzyme subunit 1; gene trap OST432802, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Sae1<Gt(OST440600)Lex> | MGI:4318112
 
Name: SUMO1 activating enzyme subunit 1; gene trap OST440600, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Sae1<Gt(OST454838)Lex> | MGI:4323266
 
Name: SUMO1 activating enzyme subunit 1; gene trap OST454838, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Sae1<Gt(OST454844)Lex> | MGI:4323268
 
Name: SUMO1 activating enzyme subunit 1; gene trap OST454844, Lexicon Genetics
Allele Type: Gene trapped
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Allele
Sae1<Gt(37v-34)Yais> | MGI:4831306
 
Name: SUMO1 activating enzyme subunit 1; gene trap 37v-34, Yasumasa Ishida
Allele Type: Gene trapped
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Allele
Sae1<em1(IMPC)J> | MGI:6860670
Name: SUMO1 activating enzyme subunit 1; endonuclease-mediated mutation 1, Jackson
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Allele
Sae1<em2Cya> | MGI:7795943
Name: SUMO1 activating enzyme subunit 1; endonuclease-mediated mutation 2, Cyagen Biosciences
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Publication
30703554 | -
 
First Author: Yao Y
Year: 2019
Journal: Pulm Pharmacol Ther
Title: SUMOylation of Vps34 by SUMO1 promotes phenotypic switching of vascular smooth muscle cells by activating autophagy in pulmonary arterial hypertension.
Volume: 55
Pages: 38-49
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Publication
17644626 | -
First Author: Saracco SA
Year: 2007
Journal: Plant Physiol
Title: Genetic analysis of SUMOylation in Arabidopsis: conjugation of SUMO1 and SUMO2 to nuclear proteins is essential.
Volume: 145
Issue: 1
Pages: 119-34
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Allele
Sae1<Gt(M093B03)Wrst> | MGI:3866330
 
Name: SUMO1 activating enzyme subunit 1; gene trap M093B03, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Sae1<Gt(M093B02)Wrst> | MGI:3866337
 
Name: SUMO1 activating enzyme subunit 1; gene trap M093B02, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Sae1<Gt(M093F01)Wrst> | MGI:3866344
 
Name: SUMO1 activating enzyme subunit 1; gene trap M093F01, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Sae1<Gt(M093C02)Wrst> | MGI:3866345
 
Name: SUMO1 activating enzyme subunit 1; gene trap M093C02, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Sae1<Gt(CB0367)Wtsi> | MGI:3871838
 
Name: SUMO1 activating enzyme subunit 1; gene trap CB0367, Wellcome Trust Sanger Institute
Allele Type: Gene trapped
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Allele
Sae1<Gt(PST26029)Mfgc> | MGI:3904998
 
Name: SUMO1 activating enzyme subunit 1; gene trap PST26029, Mammalian Functional Genomics Centre
Allele Type: Gene trapped
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Allele
Sae1<Gt(E306E10)Wrst> | MGI:3910516
 
Name: SUMO1 activating enzyme subunit 1; gene trap E306E10, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Sae1<Gt(E154E07)Wrst> | MGI:3916222
 
Name: SUMO1 activating enzyme subunit 1; gene trap E154E07, German Gene Trap Consortium
Allele Type: Gene trapped
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Strain
MGI:6440053 | B6;129S5-Sae1<Gt(OST32131)Lex>/Tac
Attribute String: mutant stock, gene trap
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Allele
Sae1<Gt(W184E01)Wrst> | MGI:4334064
 
Name: SUMO1 activating enzyme subunit 1; gene trap W184E01, German Gene Trap Consortium
Allele Type: Gene trapped
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Allele
Sae1<Gt(EUCE00103a05)Hmgu> | MGI:4371800
 
Name: SUMO1 activating enzyme subunit 1; gene trap EUCE00103a05, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Sae1<Gt(EUCE0167d10)Hmgu> | MGI:4372481
 
Name: SUMO1 activating enzyme subunit 1; gene trap EUCE0167d10, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Sae1<Gt(EUCE00146h06)Hmgu> | MGI:4373418
 
Name: SUMO1 activating enzyme subunit 1; gene trap EUCE00146h06, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Sae1<Gt(EUCE00108a09)Hmgu> | MGI:4377550
 
Name: SUMO1 activating enzyme subunit 1; gene trap EUCE00108a09, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Sae1<Gt(EUCE0061a06)Hmgu> | MGI:4394770
 
Name: SUMO1 activating enzyme subunit 1; gene trap EUCE0061a06, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Sae1<Gt(EUCE00133f09)Hmgu> | MGI:4397382
 
Name: SUMO1 activating enzyme subunit 1; gene trap EUCE00133f09, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Sae1<Gt(EUCJ0008b10)Hmgu> | MGI:4869770
 
Name: SUMO1 activating enzyme subunit 1; gene trap EUCJ0008b10, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Sae1<Gt(EUCJ0062a02)Hmgu> | MGI:4871823
 
Name: SUMO1 activating enzyme subunit 1; gene trap EUCJ0062a02, Helmholtz Zentrum Muenchen GmbH
Allele Type: Gene trapped
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Allele
Sae1<Gt(512B1)Cmhd> | MGI:4958689
 
Name: SUMO1 activating enzyme subunit 1; gene trap 512B1, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Sae1<Gt(344A2)Cmhd> | MGI:4965689
 
Name: SUMO1 activating enzyme subunit 1; gene trap 344A2, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Sae1<Gt(311C02)Cmhd> | MGI:4966764
 
Name: SUMO1 activating enzyme subunit 1; gene trap 311C02, Centre for Modeling Human Disease
Allele Type: Gene trapped
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Allele
Sae1<tm1a(EUCOMM)Hmgu> | MGI:5009587
Name: SUMO1 activating enzyme subunit 1; targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Conditional ready, Null/knockout, Reporter
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Allele
Sae1<tm1e(EUCOMM)Hmgu> | MGI:5009595
Name: SUMO1 activating enzyme subunit 1; targeted mutation 1e, Helmholtz Zentrum Muenchen GmbH
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Sae1<Gt(IST14056E1)Tigm> | MGI:5203112
 
Name: SUMO1 activating enzyme subunit 1; gene trap IST14056E1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Allele
Sae1<Gt(IST14393C1)Tigm> | MGI:5230555
 
Name: SUMO1 activating enzyme subunit 1; gene trap IST14393C1, Texas A&M Institute for Genomic Medicine
Allele Type: Gene trapped
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Strain
MGI:7471748 | C57BL/6NJ-Sae1<em1(IMPC)J>/J
Attribute String: coisogenic
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Strain
MGI:6860671 | C57BL/6NJ-Sae1<em1(IMPC)J>/Mmjax
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Allele
Sae1<em3Gpt> | MGI:7305737
Name: SUMO1 activating enzyme subunit 1; endonuclease-mediated mutation 3, GemPharmatech Co., Ltd
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:7838775 | C57BL/6N-Sae1<em2Cya>/Cya
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Genotype
Genotype
Symbol: Sae1/Sae1
Background: C57BL/6NJ-Sae1/J
Zygosity: hm
Has Mutant Allele: true
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Publication
23832333 | J:355660
First Author: Kanemaru A
Year: 2013
Journal: Biosci Biotechnol Biochem
Title: High-yield expression of mouse Aos1-Uba2-fusion SUMO-activating enzyme, mAU, in a baculovirus-insect cell system.
Volume: 77
Issue: 7
Pages: 1575-8
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Interaction Experiment
Czub B (2016)
Description: TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene.
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Allele
Sumo1<em1Smoc> | MGI:7292644
Name: small ubiquitin-like modifier 1; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Genotype
Genotype
Symbol: Sae1/Sae1<+>
Background: C57BL/6NJ-Sae1/J
Zygosity: ht
Has Mutant Allele: true
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Publication
21554500 | J:186944
First Author: Ban R
Year: 2011
Journal: Genes Cells
Title: Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis.
Volume: 16
Issue: 6
Pages: 652-69
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Publication
26872363 | -
First Author: Czub B
Year: 2016
Journal: PLoS One
Title: TOPORS, a Dual E3 Ubiquitin and Sumo1 Ligase, Interacts with 26 S Protease Regulatory Subunit 4, Encoded by the PSMC1 Gene.
Volume: 11
Issue: 2
Pages: e0148678
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Protein Coding Gene
MGI:1858313 | Uba2
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
15094046 | J:359368
First Author: Uchimura Y
Year: 2004
Journal: FEBS Lett
Title: Generation of SUMO-1 modified proteins in E. coli: towards understanding the biochemistry/structural biology of the SUMO-1 pathway.
Volume: 564
Issue: 1-2
Pages: 85-90
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Allele
Sumo1<tm1.1Bros> | MGI:5476974
Name: small ubiquitin-like modifier 1; targeted mutation 1.1, Nils Brose
Allele Type: Targeted
Attribute String: Null/knockout, Reporter
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Allele
Tg(Thy1-EGFP/RNAi:Sumo3/RNAi:Sumo2/RNAi:Sumo1)27Weiy | MGI:6150882
Name: transgene insertion 27, Wei Yang
Allele Type: Transgenic
Attribute String: Knockdown, Reporter
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Strain
MGI:6150885 | B6.FVB-Tg(Thy1-EGFP/RNAi:Sumo3/RNAi:Sumo2/RNAi:Sumo1)27Weiy/J
Attribute String: congenic, mutant strain, transgenic
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Genotype
Genotype
Symbol: Sumo1/Sumo1
Background: involves: 129 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Tg(Thy1-EGFP/RNAi:Sumo3/RNAi:Sumo2/RNAi:Sumo1)27Weiy/?
Background: involves: C57BL/6 * FVB/N
Zygosity: ot
Has Mutant Allele: true
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Allele
Tg(CAG-EGFP,-Sumo1,-Sumo2,-Sumo3,-mCherry)10Weiy | MGI:6150883
Name: transgene insertion 10, Wei Yang
Allele Type: Transgenic
Attribute String: Conditional ready, Epitope tag, Inserted expressed sequence, Reporter
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Publication
21722636 | J:175905
First Author: Shimshon L
Year: 2011
Journal: FEBS Lett
Title: SUMOylation of Blimp-1 promotes its proteasomal degradation.
Volume: 585
Issue: 15
Pages: 2405-9
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Strain
MGI:6151083 | B6.FVB-Tg(CAG-EGFP,-Sumo1,-Sumo2,-Sumo3,-mCherry)10Weiy/J
Attribute String: transgenic, mutant strain, congenic
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Publication
24569813 | J:260338
First Author: Yang W
Year: 2014
Journal: Stroke
Title: Small ubiquitin-like modifier 3-modified proteome regulated by brain ischemia in novel small ubiquitin-like modifier transgenic mice: putative protective proteins/pathways.
Volume: 45
Issue: 4
Pages: 1115-22
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Publication
29660340 | J:273337
First Author: Maruyama T
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Alteration of global protein SUMOylation in neurons and astrocytes in response to Alzheimer's disease-associated insults.
Volume: 500
Issue: 2
Pages: 470-475
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Publication
37943660 | J:343308
First Author: Zhang Q
Year: 2023
Journal: Cell Rep
Title: hnRNPA1 SUMOylation promotes cold hypersensitivity in chronic inflammatory pain by stabilizing TRPA1 mRNA.
Volume: 42
Issue: 11
Pages: 113401
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Publication
21769946 | J:175806
First Author: Foran E
Year: 2011
Journal: Glia
Title: Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2.
Volume: 59
Issue: 11
Pages: 1719-31
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Publication
24824215 | J:214328
First Author: Jiang H
Year: 2014
Journal: Hum Mol Genet
Title: Genetic deletion of TNFRII gene enhances the Alzheimer-like pathology in an APP transgenic mouse model via reduction of phosphorylated IκBα.
Volume: 23
Issue: 18
Pages: 4906-18
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Publication
19843541 | J:155115
First Author: Janer A
Year: 2010
Journal: Hum Mol Genet
Title: SUMOylation attenuates the aggregation propensity and cellular toxicity of the polyglutamine expanded ataxin-7.
Volume: 19
Issue: 1
Pages: 181-95
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Publication
31625212 | J:285043
First Author: Yu HI
Year: 2020
Journal: Dev Dyn
Title: The requirement of SUMO2/3 for SENP2 mediated extraembryonic and embryonic development.
Volume: 249
Issue: 2
Pages: 237-244
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Publication
27882949 | J:302692
First Author: Zhang H
Year: 2016
Journal: Cell Death Dis
Title: SUMO-specific protease 1 protects neurons from apoptotic death during transient brain ischemia/reperfusion.
Volume: 7
Issue: 11
Pages: e2484
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Publication
18703419 | J:140853
First Author: Ihara M
Year: 2008
Journal: Biol Reprod
Title: UBE2I (UBC9), a SUMO-conjugating enzyme, localizes to nuclear speckles and stimulates transcription in mouse oocytes.
Volume: 79
Issue: 5
Pages: 906-13
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Publication
21266332 | J:170127
First Author: Dai XQ
Year: 2011
Journal: Diabetes
Title: SUMOylation regulates insulin exocytosis downstream of secretory granule docking in rodents and humans.
Volume: 60
Issue: 3
Pages: 838-47
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Publication
25447205 | J:218782
First Author: Brantis-de-Carvalho CE
Year: 2015
Journal: Exp Cell Res
Title: MxA interacts with and is modified by the SUMOylation machinery.
Volume: 330
Issue: 1
Pages: 151-63
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Publication
24887641 | J:302691
 
First Author: Rossner MJ
Year: 2014
Journal: Brain Res
Title: Thy1.2 driven expression of transgenic His₆-SUMO2 in the brain of mice alters a restricted set of genes.
Volume: 1575
Pages: 1-11
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Publication
34695453 | J:322463
 
First Author: Chenfei Z
Year: 2022
Journal: Neurosci Lett
Title: Effects of aerobic exercise on hippocampal SUMOylation in APP/PS1 transgenic mice.
Volume: 767
Pages: 136303
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Publication
38172660 | J:344163
First Author: Chen CH
Year: 2024
Journal: BMC Mol Cell Biol
Title: Sumoylation of SAP130 regulates its interaction with FAF1 as well as its protein stability and transcriptional repressor function.
Volume: 25
Issue: 1
Pages: 2
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Publication
9388184 | J:52872
First Author: Chung CD
Year: 1997
Journal: Science
Title: Specific inhibition of Stat3 signal transduction by PIAS3.
Volume: 278
Issue: 5344
Pages: 1803-5
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Publication
11060035 | J:175118
First Author: Rödel B
Year: 2000
Journal: EMBO J
Title: The zinc finger protein Gfi-1 can enhance STAT3 signaling by interacting with the STAT3 inhibitor PIAS3.
Volume: 19
Issue: 21
Pages: 5845-55
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Publication
11709556 | -
First Author: Levy C
Year: 2002
Journal: J Biol Chem
Title: A new role for the STAT3 inhibitor, PIAS3: a repressor of microphthalmia transcription factor.
Volume: 277
Issue: 3
Pages: 1962-6
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Publication
16488448 | J:107713
First Author: Ouyang Y
Year: 2006
Journal: Mutat Res
Title: Loss of Ubr2, an E3 ubiquitin ligase, leads to chromosome fragility and impaired homologous recombinational repair.
Volume: 596
Issue: 1-2
Pages: 64-75
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Protein
Q3TM95
Organism: Mus musculus/domesticus
Length: 75  
Fragment?: true
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Publication
18793138 | -
First Author: Belgareh-Touzé N
Year: 2008
Journal: Biochem Soc Trans
Title: Versatile role of the yeast ubiquitin ligase Rsp5p in intracellular trafficking.
Volume: 36
Issue: Pt 5
Pages: 791-6
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Publication
18202552 | -
First Author: Loring GL
Year: 2008
Journal: Cell Cycle
Title: Yeast Chfr homologs retard cell cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-dependent ubiquitination.
Volume: 7
Issue: 1
Pages: 96-105
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Publication
14976165 | -
First Author: Morris JR
Year: 2004
Journal: Hum Mol Genet
Title: BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair.
Volume: 13
Issue: 8
Pages: 807-17
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Publication
25406032 | -
 
First Author: Park JH
Year: 2014
Journal: Nat Commun
Title: Modification of DBC1 by SUMO2/3 is crucial for p53-mediated apoptosis in response to DNA damage.
Volume: 5
Pages: 5483
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Publication
24651376 | -
First Author: Sun X
Year: 2014
Journal: PLoS One
Title: Characterization of nuclear localization and SUMOylation of the ATBF1 transcription factor in epithelial cells.
Volume: 9
Issue: 3
Pages: e92746
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Publication
9019411 | J:38226
First Author: Mahajan R
Year: 1997
Journal: Cell
Title: A small ubiquitin-related polypeptide involved in targeting RanGAP1 to nuclear pore complex protein RanBP2.
Volume: 88
Issue: 1
Pages: 97-107
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Publication
9654451 | -
First Author: Bayer P
Year: 1998
Journal: J Mol Biol
Title: Structure determination of the small ubiquitin-related modifier SUMO-1.
Volume: 280
Issue: 2
Pages: 275-86
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Publication
15931224 | -
First Author: Reverter D
Year: 2005
Journal: Nature
Title: Insights into E3 ligase activity revealed by a SUMO-RanGAP1-Ubc9-Nup358 complex.
Volume: 435
Issue: 7042
Pages: 687-92
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Publication
15189146 | -
 
First Author: Johnson ES
Year: 2004
Journal: Annu Rev Biochem
Title: Protein modification by SUMO.
Volume: 73
Pages: 355-82
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Publication
12133807 | -
 
First Author: Goettsch S
Year: 2002
Journal: Front Biosci
Title: Structural attributes in the conjugation of ubiquitin, SUMO and RUB to protein substrates.
Volume: 7
Pages: a148-62
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Publication
9357311 | -
First Author: Saitoh H
Year: 1997
Journal: Trends Biochem Sci
Title: SUMO-1: wrestling with a new ubiquitin-related modifier.
Volume: 22
Issue: 10
Pages: 374-6
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Publication
12429940 | -
First Author: Melchior F
Year: 2002
Journal: Cell Cycle
Title: SUMO-1 and p53.
Volume: 1
Issue: 4
Pages: 245-9
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Publication
16955485 | -
First Author: Um JW
Year: 2006
Journal: J Neurosci Res
Title: Functional modulation of parkin through physical interaction with SUMO-1.
Volume: 84
Issue: 7
Pages: 1543-54
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Protein Domain
IPR046332 | SUMO1_Ubl
Type: Domain
Description: This entry represents the ubiquitin-like (Ubl) domain found in small ubiquitin-related modifier 1 (SUMO1) and similar proteins from animals. SUMO1 is a binding partner of the RAD51/52 nucleoprotein filament proteins, which mediate DNA strand exchange [, , ]. Its conjugation to cellular proteins has been implicated in multiple important cellular processes, such as nuclear transport, cell cycle control, oncogenesis, inflammation, and the response to virus infection [, , , ]. SUMO resembles ubiquitin (Ub) in structure, binding to other proteins and the mechanism of ligation. Ubiquitin (Ub) is a protein modifier in eukaryotes that is involved in various cellular processes including transcriptional regulation, cell cycle control, and DNA repair. Ubiquitination is comprised of a cascade of E1, E2 and E3 enzymes that results in a covalent bond between the C terminus of Ub and the ε-amino group of a substrate lysine. SUMOs, like Ub, are covalently conjugated to lysine residues in a wide variety of target proteins in eukaryotic cells and regulate numerous cellular processes, such as transcription, epigenetic gene control, genomic instability, and protein degradation [, , ].
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Protein Domain
IPR017335 | RNF8
Type: Family
Description: This entry represents E3 ubiquitin-protein ligase RNF8, which may be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. This enzyme promotes the formation of 'Lys-63'-linked polyubiquitin chains and functions with the specific ubiquitin-conjugating UBC13-MMS2 (UBE2N-UBE2V2) heterodimer [, ]. Substrates that are poly-ubiquitinated at 'Lys-63' are usually not targeted for degradation. RNF8 acts following DNA double-strand break (DSB) formation, and is recruited to the sites of damage by ATM-phosphorylated MDC1, where it promotes the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF) [, ]. It may play a role in the regulation of RXRA-mediated transcriptional activity, but is not involved in RXRA ubiquitination by UBE2E2.Ubiquitinylation is an ATP-dependent process that involves the action of at least three enzymes: a ubiquitin-activating enzyme (E1, ), a ubiquitin-conjugating enzyme (E2, ), and a ubiquitin ligase (E3, , ), which work sequentially in a cascade. There are many different E3 ligases, which are responsible for the type of ubiquitin chain formed, the specificity of the target protein, and the regulation of the ubiquitinylation process []. Ubiquitinylation is an important regulatory tool that controls the concentration of key signalling proteins, such as those involved in cell cycle control, as well as removing misfolded, damaged or mutant proteins that could be harmful to the cell. Several ubiquitin-like molecules have been discovered, such as Ufm1 (), SUMO1 (), NEDD8, Rad23 (), Elongin B and Parkin (), the latter being involved in Parkinson's disease [].
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Protein Domain
IPR027226 | PIAS3
Type: Family
Description: PIAS3 is an E3-type small ubiquitin-like modifier (SUMO) ligases, stabilising the interaction between UBE2I and Ubc9 respectively and the substrate, and as a SUMO-tethering factor. It plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway [, , , ].PIAS3 sumoylates CCAR2, promoting its interaction with SIRT1 []and diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus [].SUMO proteins are ubiquitin like proteins that are covalently attached to and detached from other proteins in cells to modify their function. SUMO is first activated in an ATP-dependent reaction by formation of a thioester bond with an E1 (SUMO-activating) enzyme and then transferred to the SUMO conjugating (E2) enzyme Ubc9. Ubc9 catalyses the formation of an isopeptide bond between the C-terminal of SUMO and the amino group of lysine in the target protein. Sumoylated proteins can be targeted for different cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability [].
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Publication
30786847 | J:293239
First Author: Gorski PA
Year: 2019
Journal: Circ Res
Title: Role of SIRT1 in Modulating Acetylation of the Sarco-Endoplasmic Reticulum Ca2+-ATPase in Heart Failure.
Volume: 124
Issue: 9
Pages: e63-e80
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Publication
24910119 | J:225859
First Author: Chhunchha B
Year: 2014
Journal: FEBS J
Title: Aberrant sumoylation signaling evoked by reactive oxygen species impairs protective function of Prdx6 by destabilization and repression of its transcription.
Volume: 281
Issue: 15
Pages: 3357-81
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Publication
38565402 | J:360177
     
First Author: Chen Y
Year: 2024
Journal: J Adv Res
Title: Exercise-Induced Reduction of IGF1R Sumoylation Attenuates Neuroinflammation in APP/PS1 Transgenic Mice.
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Publication
32887693 | J:302441
 
First Author: Verma DK
Year: 2020
Journal: eNeuro
Title: The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson's Disease Models.
Volume: 7
Issue: 5
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Publication
12646216 | -
First Author: Hatakeyama S
Year: 2003
Journal: Biochem Biophys Res Commun
Title: U-box proteins as a new family of ubiquitin ligases.
Volume: 302
Issue: 4
Pages: 635-45
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Publication
15564047 | -
First Author: Ross CA
Year: 2004
Journal: Trends Cell Biol
Title: The ubiquitin-proteasome pathway in Parkinson's disease and other neurodegenerative diseases.
Volume: 14
Issue: 12
Pages: 703-11
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