Type |
Details |
Score |
Publication |
First Author: |
DDB, FB, MGI, GOA, ZFIN curators |
Year: |
2001 |
|
Title: |
Gene Ontology annotation through association of InterPro records with GO terms |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2003 |
|
Title: |
MGI Sequence Curation Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Kawai J |
Year: |
2001 |
Journal: |
Nature |
Title: |
Functional annotation of a full-length mouse cDNA collection. |
Volume: |
409 |
Issue: |
6821 |
Pages: |
685-90 |
|
•
•
•
•
•
|
Publication |
First Author: |
Adams DJ |
Year: |
2024 |
Journal: |
Nature |
Title: |
Genetic determinants of micronucleus formation in vivo. |
Volume: |
627 |
Issue: |
8002 |
Pages: |
130-136 |
|
•
•
•
•
•
|
Publication |
First Author: |
MGD Nomenclature Committee |
Year: |
1995 |
|
Title: |
Nomenclature Committee Use |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Zambrowicz BP |
Year: |
2003 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. |
Volume: |
100 |
Issue: |
24 |
Pages: |
14109-14 |
|
•
•
•
•
•
|
Publication |
First Author: |
GemPharmatech |
Year: |
2020 |
|
Title: |
GemPharmatech Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Skarnes WC |
Year: |
2011 |
Journal: |
Nature |
Title: |
A conditional knockout resource for the genome-wide study of mouse gene function. |
Volume: |
474 |
Issue: |
7351 |
Pages: |
337-42 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI) |
Year: |
2008 |
Journal: |
Database Download |
Title: |
Mouse Gene Trap Data Load from dbGSS |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Cyagen Biosciences Inc. |
Year: |
2022 |
|
Title: |
Cyagen Biosciences Website. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators |
Year: |
2011 |
|
Title: |
Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
GOA curators |
Year: |
2016 |
|
Title: |
Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
The Jackson Laboratory Mouse Radiation Hybrid Database |
Year: |
2004 |
Journal: |
Database Release |
Title: |
Mouse T31 Radiation Hybrid Data Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Okazaki Y |
Year: |
2002 |
Journal: |
Nature |
Title: |
Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. |
Volume: |
420 |
Issue: |
6915 |
Pages: |
563-73 |
|
•
•
•
•
•
|
Publication |
First Author: |
The Gene Ontology Consortium |
Year: |
2010 |
|
Title: |
Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Diez-Roux G |
Year: |
2011 |
Journal: |
PLoS Biol |
Title: |
A high-resolution anatomical atlas of the transcriptome in the mouse embryo. |
Volume: |
9 |
Issue: |
1 |
Pages: |
e1000582 |
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2002 |
|
Title: |
Mouse Genome Informatics Computational Sequence to Gene Associations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2). |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas |
Year: |
2010 |
|
Title: |
Annotation inferences using phylogenetic trees |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Database and National Center for Biotechnology Information |
Year: |
2000 |
Journal: |
Database Release |
Title: |
Entrez Gene Load |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Allen Institute for Brain Science |
Year: |
2004 |
Journal: |
Allen Institute |
Title: |
Allen Brain Atlas: mouse riboprobes |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI) |
Year: |
2010 |
Journal: |
Database Download |
Title: |
Consensus CDS project |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Group |
Year: |
2003 |
Journal: |
Database Procedure |
Title: |
Automatic Encodes (AutoE) Reference |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Bairoch A |
Year: |
1999 |
Journal: |
Database Release |
Title: |
SWISS-PROT Annotated protein sequence database |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics |
Year: |
2010 |
Journal: |
Database Release |
Title: |
Protein Ontology Association Load. |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2005 |
|
Title: |
Obtaining and loading genome assembly coordinates from NCBI annotations |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Mouse Genome Informatics Scientific Curators |
Year: |
2009 |
Journal: |
Database Download |
Title: |
Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform |
|
|
|
|
•
•
•
•
•
|
Publication |
First Author: |
Feng J |
Year: |
2015 |
Journal: |
Nat Neurosci |
Title: |
Role of Tet1 and 5-hydroxymethylcytosine in cocaine action. |
Volume: |
18 |
Issue: |
4 |
Pages: |
536-44 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yang Q |
Year: |
2023 |
Journal: |
Oncogene |
Title: |
Hypoxia switches TET1 from being tumor-suppressive to oncogenic. |
Volume: |
42 |
Issue: |
20 |
Pages: |
1634-1648 |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
2007
 |
Fragment?: |
false |
|
•
•
•
•
•
|
Protein |
Organism: |
Mus musculus/domesticus |
Length: |
47
 |
Fragment?: |
true |
|
•
•
•
•
•
|
HT Experiment |
Series Id: |
GSE71744 |
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
ArrayExpress |
|
•
•
•
•
•
|
Publication |
First Author: |
Li W |
Year: |
2020 |
Journal: |
Nucleic Acids Res |
Title: |
Nono deficiency compromises TET1 chromatin association and impedes neuronal differentiation of mouse embryonic stem cells. |
Volume: |
48 |
Issue: |
9 |
Pages: |
4827-4838 |
|
•
•
•
•
•
|
Publication |
First Author: |
Choi C |
Year: |
2019 |
Journal: |
EMBO J |
Title: |
DSCR1-mediated TET1 splicing regulates miR-124 expression to control adult hippocampal neurogenesis. |
Volume: |
38 |
Issue: |
14 |
Pages: |
e101293 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen L |
Year: |
2025 |
Journal: |
EMBO Rep |
Title: |
The DNA demethylase TET1 modifies the impact of maternal folic acid status on embryonic brain development. |
Volume: |
26 |
Issue: |
1 |
Pages: |
175-199 |
|
•
•
•
•
•
|
Allele |
Name: |
tet methylcytosine dioxygenase 1; targeted mutation 1, Shanghai Model Organisms Center |
Allele Type: |
Targeted |
Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
TET1 and hydroxymethylcytosine in transcription and DNA methylation fidelity. |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
NANOG-dependent function of TET1 and TET2 in establishment of pluripotency. |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 9.5 |
Stage: |
15 |
Structure . Name: |
embryo |
Notes: |
the father was heterozygous for the Tet1 allele |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 9.5 |
Stage: |
15 |
Structure . Name: |
embryo |
Notes: |
the father was heterozygous for the Tet1 allele |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 9.5 |
Stage: |
15 |
Structure . Name: |
embryo |
Notes: |
the father was heterozygous for the Tet1 allele |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 9.5 |
Stage: |
15 |
Structure . Name: |
embryo |
Notes: |
the father was homozygous for the Tet1 allele |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 9.5 |
Stage: |
15 |
Structure . Name: |
embryo |
Notes: |
the father was homozygous for the Tet1 allele |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 9.5 |
Stage: |
15 |
Structure . Name: |
embryo |
Notes: |
the father was homozygous for the Tet1 allele |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 9.5 |
Stage: |
15 |
Structure . Name: |
embryo |
Notes: |
the father was homozygous for the Tet1 allele |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 9.5 |
Stage: |
15 |
Structure . Name: |
embryo |
Notes: |
the father was homozygous for the Tet1 allele |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 9.5 |
Stage: |
15 |
Structure . Name: |
embryo |
Notes: |
the father was homozygous for the Tet1 allele |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 9.5 |
Stage: |
15 |
Structure . Name: |
embryo |
Notes: |
the father was homozygous for the Tet1 allele |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 9.5 |
Stage: |
15 |
Structure . Name: |
embryo |
Notes: |
the father was homozygous for the Tet1 allele |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 9.5 |
Stage: |
15 |
Structure . Name: |
embryo |
Notes: |
the father was homozygous for the Tet1 allele |
Curation Status: |
Curated |
|
•
•
•
•
•
|
HT Sample |
Organism Name: |
mouse, laboratory |
Sex: |
Not Specified |
Age: |
embryonic day 9.5 |
Stage: |
15 |
Structure . Name: |
embryo |
Notes: |
the father was homozygous for the Tet1 allele |
Curation Status: |
Curated |
|
•
•
•
•
•
|
Interaction Experiment |
Description: |
Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation. |
|
•
•
•
•
•
|
Publication |
First Author: |
Arroyo M |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
Isoform-specific and ubiquitination dependent recruitment of Tet1 to replicating heterochromatin modulates methylcytosine oxidation. |
Volume: |
13 |
Issue: |
1 |
Pages: |
5173 |
|
•
•
•
•
•
|
Publication |
First Author: |
Takai H |
Year: |
2014 |
Journal: |
Cell Rep |
Title: |
5-Hydroxymethylcytosine plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex. |
Volume: |
9 |
Issue: |
1 |
Pages: |
48-60 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Cnops G |
Year: |
2006 |
Journal: |
Plant Cell |
Title: |
The TORNADO1 and TORNADO2 genes function in several patterning processes during early leaf development in Arabidopsis thaliana. |
Volume: |
18 |
Issue: |
4 |
Pages: |
852-66 |
|
•
•
•
•
•
|
Publication |
First Author: |
Olmos E |
Year: |
2003 |
Journal: |
Biochem Biophys Res Commun |
Title: |
The ekeko mutant demonstrates a role for tetraspanin-like protein in plant development. |
Volume: |
310 |
Issue: |
4 |
Pages: |
1054-61 |
|
•
•
•
•
•
|
Publication |
First Author: |
Chiu WH |
Year: |
2007 |
Journal: |
Plant Mol Biol |
Title: |
Mutations in the TORNADO2 gene affect cellular decisions in the peripheral zone of the shoot apical meristem of Arabidopsis thaliana. |
Volume: |
63 |
Issue: |
6 |
Pages: |
731-44 |
|
•
•
•
•
•
|
Protein Domain |
Type: |
Family |
Description: |
This entry represents tetraspanin (TET) from plants, including TET1-17 from Arabidopsis. TET1, also known as TORNADO 2, is involved in the basipetal transport of auxin (IAA) that modulates growth and organs organization, as well as cell differentiation [, ]. It plays an role in cellular decisions in the peripheral zone of the shoot apical meristem []. Together with WIH1 and WIH2, TET1 promotes megasporogenesis [].Tetraspanins are a distinct family of proteins, containing four transmembrane domains: a small outer loop (EC1), a larger outer loop (EC2), a small inner loop (IL) and short cytoplasmic tails. They contain characteristic structural features, including 4-6 conserved extracellular cysteine residues, and polar residues within transmembrane domains. A fundamental role of tetraspanins appears to be organizing other proteins into a network of multimolecular membrane microdomains, sometimes called the 'tetraspanin web'. |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Lieber D |
Year: |
2011 |
Journal: |
Curr Biol |
Title: |
Arabidopsis WIH1 and WIH2 genes act in the transition from somatic to reproductive cell fate. |
Volume: |
21 |
Issue: |
12 |
Pages: |
1009-17 |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
HT Experiment |
|
Experiment Type: |
RNA-Seq |
Study Type: |
WT vs. Mutant |
Source: |
GEO |
|
•
•
•
•
•
|
Publication |
First Author: |
Chen R |
Year: |
2017 |
Journal: |
J Biol Chem |
Title: |
The 5-Hydroxymethylcytosine (5hmC) Reader UHRF2 Is Required for Normal Levels of 5hmC in Mouse Adult Brain and Spatial Learning and Memory. |
Volume: |
292 |
Issue: |
11 |
Pages: |
4533-4543 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tie G |
Year: |
2017 |
Journal: |
Cancer Res |
Title: |
Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells. |
Volume: |
77 |
Issue: |
9 |
Pages: |
2351-2362 |
|
•
•
•
•
•
|
Publication |
First Author: |
Sun M |
Year: |
2013 |
Journal: |
Proc Natl Acad Sci U S A |
Title: |
HMGA2/TET1/HOXA9 signaling pathway regulates breast cancer growth and metastasis. |
Volume: |
110 |
Issue: |
24 |
Pages: |
9920-5 |
|
•
•
•
•
•
|
Publication |
First Author: |
Jiang D |
Year: |
2015 |
Journal: |
Brain |
Title: |
Alteration in 5-hydroxymethylcytosine-mediated epigenetic regulation leads to Purkinje cell vulnerability in ATM deficiency. |
Volume: |
138 |
Issue: |
Pt 12 |
Pages: |
3520-36 |
|
•
•
•
•
•
|
Publication |
First Author: |
Weng YL |
Year: |
2017 |
Journal: |
Neuron |
Title: |
An Intrinsic Epigenetic Barrier for Functional Axon Regeneration. |
Volume: |
94 |
Issue: |
2 |
Pages: |
337-346.e6 |
|
•
•
•
•
•
|
Publication |
First Author: |
Thaler R |
Year: |
2022 |
Journal: |
Nat Commun |
Title: |
Vitamin C epigenetically controls osteogenesis and bone mineralization. |
Volume: |
13 |
Issue: |
1 |
Pages: |
5883 |
|
•
•
•
•
•
|
Publication |
First Author: |
Yu H |
Year: |
2015 |
Journal: |
Nat Neurosci |
Title: |
Tet3 regulates synaptic transmission and homeostatic plasticity via DNA oxidation and repair. |
Volume: |
18 |
Issue: |
6 |
Pages: |
836-43 |
|
•
•
•
•
•
|
Publication |
First Author: |
Dai Q |
Year: |
2017 |
Journal: |
Nucleic Acids Res |
Title: |
Striking a balance: regulation of transposable elements by Zfp281 and Mll2 in mouse embryonic stem cells. |
Volume: |
45 |
Issue: |
21 |
Pages: |
12301-12310 |
|
•
•
•
•
•
|
Publication |
First Author: |
Tran KA |
Year: |
2019 |
Journal: |
EMBO J |
Title: |
Coordinated removal of repressive epigenetic modifications during induced reversal of cell identity. |
Volume: |
38 |
Issue: |
22 |
Pages: |
e101681 |
|
•
•
•
•
•
|
Publication |
First Author: |
Pan H |
Year: |
2020 |
Journal: |
Cell Death Dis |
Title: |
UHRF1-repressed 5'-hydroxymethylcytosine is essential for the male meiotic prophase I. |
Volume: |
11 |
Issue: |
2 |
Pages: |
142 |
|
•
•
•
•
•
|
Publication |
First Author: |
Meng S |
Year: |
2023 |
Journal: |
Nat Cell Biol |
Title: |
Young LINE-1 transposon 5' UTRs marked by elongation factor ELL3 function as enhancers to regulate naïve pluripotency in embryonic stem cells. |
Volume: |
25 |
Issue: |
9 |
Pages: |
1319-1331 |
|
•
•
•
•
•
|
Publication |
First Author: |
Deplus R |
Year: |
2013 |
Journal: |
EMBO J |
Title: |
TET2 and TET3 regulate GlcNAcylation and H3K4 methylation through OGT and SET1/COMPASS. |
Volume: |
32 |
Issue: |
5 |
Pages: |
645-55 |
|
•
•
•
•
•
|
Publication |
First Author: |
Liu N |
Year: |
2013 |
Journal: |
PLoS One |
Title: |
Intrinsic and extrinsic connections of Tet3 dioxygenase with CXXC zinc finger modules. |
Volume: |
8 |
Issue: |
5 |
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