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Search results 501 to 538 out of 538 for Tspo

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0.033s

Type

Details

Score

Genotype

Symbol:	Rimbp2/Rimbp2 Tspoap1/Tspoap1
Background:	involves: C57BL/6
Zygosity:	cx
Has Mutant Allele:	true

•

Publication

26327117 | J:227228

First Author:	Shrestha A
Year:	2015
Journal:	PLoS One
Title:	Generation and Validation of miR-142 Knock Out Mice.
Volume:	10
Issue:	9
Pages:	e0136913

•

Publication

34767769 | J:324135

First Author:	Banerjee A
Year:	2022
Journal:	Neuron
Title:	Molecular and functional architecture of striatal dopamine release sites.
Volume:	110
Issue:	2
Pages:	248-265.e9

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Publication

7673149 | J:28695

First Author:	Yeliseev AA
Year:	1995
Journal:	J Biol Chem
Title:	A sensory transducer homologous to the mammalian peripheral-type benzodiazepine receptor regulates photosynthetic membrane complex formation in Rhodobacter sphaeroides 2.4.1.
Volume:	270
Issue:	36
Pages:	21167-75

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Protein

E0CYC8

Organism:	Mus musculus/domesticus
Length:	68
Fragment?:	false

•

Protein Domain

IPR004307 | TspO_MBR

Type:

Family

Description:

Members of this group are involved in transmembrane signalling. In both prokaryotes and mitochondria they are localized to the outer membrane, and have been shown to bind and transport dicarboxylic tetrapyrrole intermediates of the haem biosynthetic pathway [, ]. They are associated with the major outer membrane porins (in prokaryotes) and with the voltage-dependent anion channel (in mitochondria) [].Rhodobacter sphaeroides TspO (previously CrtK) is involved in signal transduction, functioning as a negative regulator of the expression of some photosynthesis genes (PpsR/AppA repressor/antirepressor regulon). This down-regulation is believed to be in response to oxygen levels. TspO works through (or modulates) the PpsR/AppA system and acts upstream of the site of action of these regulatory proteins []. It has been suggested that the TspO regulatory pathway works by regulating the efflux of certain tetrapyrrole intermediates of the haem/bacteriochlorophyll biosynthetic pathways in response to the availability of molecular oxygen, thereby causing the accumulation of a biosynthetic intermediate that serves as a corepressor for the regulated genes []. A homologue of the TspO protein in Rhizobium meliloti (Sinorhizobium meliloti) is involved in regulating expression of the ndi locus in response to stress conditions []. There is evidence that the S. meliloti TspO acts through, or in addition to, the FixL regulatory system.In animals, translocator protein (TSPO), previously known as peripheral-type benzodiazepine receptor (PBR, MBR) is a mitochondrial protein (located in the outer mitochondrial membrane) where it forms a complex with several proteins of the mitochondrial permeability transition pore (MPTP). TSPO is involved in multiple processes, including regulation of cell death, cholesterol transport and steroid biosynthesis, mitochondrial respiration and oxidation and mitochondrial protein import [, ].These observations suggest that fundamental aspects of this receptor and the downstream signal transduction pathway are conserved in bacteria and higher eukaryotic mitochondria. The alpha-3 subdivision of the purple bacteria is considered to be a likely source of the endosymbiont that ultimately gave rise to the mitochondrion. Therefore, it is possible that the mammalian PBR remains both evolutionarily and functionally related to the TspO of R. sphaeroides.

•

Protein Domain

IPR038330 | TspO/MBR-related_sf

Type:

Homologous_superfamily

Description:

Members of this group are involved in transmembrane signalling. In both prokaryotes and mitochondria they are localized to the outer membrane, and have been shown to bind and transport dicarboxylic tetrapyrrole intermediates of the haem biosynthetic pathway [, ]. They are associated with the major outer membrane porins (in prokaryotes) and with the voltage-dependent anion channel (in mitochondria) [].Rhodobacter sphaeroides TspO (previously CrtK) is involved in signal transduction, functioning as a negative regulator of the expression of some photosynthesis genes (PpsR/AppA repressor/antirepressor regulon). This down-regulation is believed to be in response to oxygen levels. TspO works through (or modulates) the PpsR/AppA system and acts upstream of the site of action of these regulatory proteins []. It has been suggested that the TspO regulatory pathway works by regulating the efflux of certain tetrapyrrole intermediates of the haem/bacteriochlorophyll biosynthetic pathways in response to the availability of molecular oxygen, thereby causing the accumulation of abiosynthetic intermediate that serves as a corepressor for the regulated genes []. A homologue of the TspO protein in Rhizobium meliloti (Sinorhizobium meliloti) is involved in regulating expression of the ndi locus in response to stress conditions []. There is evidence that the S. meliloti TspO acts through, or in addition to, the FixL regulatory system.In animals, translocator protein (TSPO), previously known as peripheral-type benzodiazepine receptor (PBR, MBR) is a mitochondrial protein (located in the outer mitochondrial membrane) where it forms a complex with several proteins of the mitochondrial permeability transition pore (MPTP). TSPO is involved in multiple processes, including regulation of cell death, cholesterol transport and steroid biosynthesis, mitochondrial respiration and oxidation and mitochondrial protein import [, ].These observations suggest that fundamental aspects of this receptor and the downstream signal transduction pathway are conserved in bacteria and higher eukaryotic mitochondria. The alpha-3 subdivision of the purple bacteria is considered to be a likely source of the endosymbiont that ultimately gave rise to the mitochondrion. Therefore, it is possible that the mammalian PBR remains both evolutionarily and functionally related to the TspO of R. sphaeroides.

•

Protein

Q9CRZ8

Organism:	Mus musculus/domesticus
Length:	162
Fragment?:	false

•

Protein

E0CX84

Organism:	Mus musculus/domesticus
Length:	134
Fragment?:	false

•

Publication

1373486 | -

First Author:	McEnery MW
Year:	1992
Journal:	Proc Natl Acad Sci U S A
Title:	Isolation of the mitochondrial benzodiazepine receptor: association with the voltage-dependent anion channel and the adenine nucleotide carrier.
Volume:	89
Issue:	8
Pages:	3170-4

•

Publication

17124501 | J:119934

First Author:	Schoch S
Year:	2006
Journal:	EMBO J
Title:	Redundant functions of RIM1alpha and RIM2alpha in Ca(2+)-triggered neurotransmitter release.
Volume:	25
Issue:	24
Pages:	5852-63

•

Publication

39363102 | J:359349

First Author:	Salinas L
Year:	2024
Journal:	Commun Biol
Title:	Sexual dimorphism in a mouse model of Friedreich's ataxia with severe cardiomyopathy.
Volume:	7
Issue:	1
Pages:	1250

•

Publication

9144197 | J:40379

First Author:	Yeliseev AA
Year:	1997
Journal:	Proc Natl Acad Sci U S A
Title:	A mammalian mitochondrial drug receptor functions as a bacterial "oxygen" sensor.
Volume:	94
Issue:	10
Pages:	5101-6

•

Publication

28559417 | J:242126

First Author:	Kleinberger G
Year:	2017
Journal:	EMBO J
Title:	The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism.
Volume:	36
Issue:	13
Pages:	1837-1853

•

Publication

37108685 | J:335255

First Author:	Tang JM
Year:	2023
Journal:	Int J Mol Sci
Title:	A Protocol for Simultaneous In Vivo Imaging of Cardiac and Neuroinflammation in Dystrophin-Deficient MDX Mice Using [(18)F]FEPPA PET.
Volume:	24
Issue:	8

•

Publication

37240402 | J:336166

First Author:	Puig-Bosch X
Year:	2023
Journal:	Int J Mol Sci
Title:	Neurosteroids Mediate Neuroprotection in an In Vitro Model of Hypoxic/Hypoglycaemic Excitotoxicity via δ-GABA(A) Receptors without Affecting Synaptic Plasticity.
Volume:	24
Issue:	10

•

Publication

21430171 | J:170310

First Author:	Maeda J
Year:	2011
Journal:	J Neurosci
Title:	In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders.
Volume:	31
Issue:	12
Pages:	4720-30

•

Publication

32929122 | J:296166

First Author:	Song S
Year:	2020
Journal:	Sci Rep
Title:	Norepinephrine depleting toxin DSP-4 and LPS alter gut microbiota and induce neurotoxicity in α-synuclein mutant mice.
Volume:	10
Issue:	1
Pages:	15054

•

Publication

35069106 | J:351801

First Author:	Freyssin A
Year:	2021
Journal:	Front Neurosci
Title:	Trans ε-Viniferin Decreases Amyloid Deposits With Greater Efficiency Than Resveratrol in an Alzheimer's Mouse Model.
Volume:	15

Pages:	803927

•

Publication

28973423 | J:249465

First Author:	Biswas L
Year:	2017
Journal:	Hum Mol Genet
Title:	Retinal pigment epithelium cholesterol efflux mediated by the 18 kDa translocator protein, TSPO, a potential target for treating age-related macular degeneration.
Volume:	26
Issue:	22
Pages:	4327-4339

•

Publication

29649428 | J:268409

First Author:	Pantaleão L
Year:	2018
Journal:	Exp Cell Res
Title:	Connections of annexin A1 and translocator protein-18 kDa on toll like receptor stimulated BV-2 cells.
Volume:	367
Issue:	2
Pages:	282-290

•

Publication

31536603 | J:279961

First Author:	Shimoyama S
Year:	2019
Journal:	PLoS One
Title:	Lipopolysaccharide induces mouse translocator protein (18 kDa) expression via the AP-1 complex in the microglial cell line, BV-2.
Volume:	14
Issue:	9
Pages:	e0222861

•

Publication

35628296 | J:326396

First Author:	Kang S
Year:	2022
Journal:	Int J Mol Sci
Title:	MicroPET Imaging Assessment of Brain Tau and Amyloid Deposition in 6 × Tg Alzheimer's Disease Model Mice.
Volume:	23
Issue:	10

•

Publication

35676734 | J:351733

First Author:	Rejc L
Year:	2022
Journal:	Alzheimers Res Ther
Title:	Longitudinal evaluation of neuroinflammation and oxidative stress in a mouse model of Alzheimer disease using positron emission tomography.
Volume:	14
Issue:	1
Pages:	80

•

Publication

35690868 | J:325368

First Author:	Xia D
Year:	2022
Journal:	Mol Neurodegener
Title:	Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
Volume:	17
Issue:	1
Pages:	41

•

Publication

33132817 | J:324382

First Author:	Hu W
Year:	2020
Journal:	Front Neurosci
Title:	PET Imaging for Dynamically Monitoring Neuroinflammation in APP/PS1 Mouse Model Using [¹⁸F]DPA714.
Volume:	14

Pages:	810

•

Publication

36906584 | J:339796

First Author:	Ballweg A
Year:	2023
Journal:	J Neuroinflammation
Title:	[(18)F]F-DED PET imaging of reactive astrogliosis in neurodegenerative diseases: preclinical proof of concept and first-in-human data.
Volume:	20
Issue:	1
Pages:	68

•

Publication

33385560 | J:303142

First Author:	Biechele G
Year:	2020
Journal:	Neuroimage
Title:	Microglial activation in the right amygdala-entorhinal-hippocampal complex is associated with preserved spatial learning in App^NL-G-F mice.
Volume:	230

Pages:	117707

•

Publication

12693553 | J:83413

First Author:	Okazaki N
Year:	2003
Journal:	DNA Res
Title:	Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries.
Volume:	10
Issue:	1
Pages:	35-48

•

Publication

- | J:237616

First Author:	MGI and IMPC
Year:	2017
Journal:	MGI Direct Data Submission
Title:	MGI Curation of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)

•

Publication

- | J:157065

First Author:	Helmholtz Zentrum Muenchen GmbH
Year:	2010
Journal:	MGI Direct Data Submission
Title:	Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)

•

Publication

- | J:211773

First Author:	Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year:	2014
Journal:	Database Release
Title:	Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database

•

Publication

- | J:346132

First Author:	The Gene Ontology Consortium
Year:	2016

Title:	Automatic assignment of GO terms using logical inference, based on on inter-ontology links

•

Publication

- | J:342587

First Author:	AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year:	2011

Title:	Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity

•

Publication

- | J:342604

First Author:	UniProt-GOA
Year:	2012

Title:	Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt

•

Publication

- | J:85000

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2003

Title:	MGI Sequence Curation Reference

•

Publication

- | J:78475

First Author:	Mouse Genome Informatics Scientific Curators
Year:	2002

Title:	Chromosome assignment of mouse genes using the Mouse Genome Sequencing Consortium (MGSC) assembly and the ENSEMBL Database

•

Publication

12466851 | J:80000

First Author:	Okazaki Y
Year:	2002
Journal:	Nature
Title:	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume:	420
Issue:	6915
Pages:	563-73

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