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Search results 501 to 533 out of 533 for Ung

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Type

Details

Score

Publication

32024781 | J:286384

First Author:	Resendez SL
Year:	2020
Journal:	J Neurosci
Title:	Social Stimuli Induce Activation of Oxytocin Neurons Within the Paraventricular Nucleus of the Hypothalamus to Promote Social Behavior in Male Mice.
Volume:	40
Issue:	11
Pages:	2282-2295

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Publication

38383587 | J:345800

First Author:	Ortiz-Guzman J
Year:	2024
Journal:	eNeuro
Title:	Cholinergic Basal Forebrain Connectivity to the Basolateral Amygdala Modulates Food Intake.
Volume:	11
Issue:	3

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Publication

34344536 | J:322019

First Author:	Boitnott A
Year:	2021
Journal:	Biol Psychiatry
Title:	Developmental and Behavioral Phenotypes in a Mouse Model of DDX3X Syndrome.
Volume:	90
Issue:	11
Pages:	742-755

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Publication

33417013 | J:316220

First Author:	Jeanne M
Year:	2021
Journal:	Hum Genet
Title:	Haploinsufficiency of the HIRA gene located in the 22q11 deletion syndrome region is associated with abnormal neurodevelopment and impaired dendritic outgrowth.
Volume:	140
Issue:	6
Pages:	885-896

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Publication

33176134 | J:299937

First Author:	Rodriguez-Romaguera J
Year:	2020
Journal:	Cell Rep
Title:	Prepronociceptin-Expressing Neurons in the Extended Amygdala Encode and Promote Rapid Arousal Responses to Motivationally Salient Stimuli.
Volume:	33
Issue:	6
Pages:	108362

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Publication

37698928 | J:342906

First Author:	Kho I
Year:	2023
Journal:	JCI Insight
Title:	Severe kidney dysfunction in sialidosis mice reveals an essential role for neuraminidase 1 in reabsorption.
Volume:	8
Issue:	20

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Publication

17717151 | -

First Author:	Rosado CJ
Year:	2007
Journal:	Science
Title:	A common fold mediates vertebrate defense and bacterial attack.
Volume:	317
Issue:	5844
Pages:	1548-51

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Publication

31825825 | J:292698

First Author:	Feng WW
Year:	2019
Journal:	Cell Rep
Title:	CD36-Mediated Metabolic Rewiring of Breast Cancer Cells Promotes Resistance to HER2-Targeted Therapies.
Volume:	29
Issue:	11
Pages:	3405-3420.e5

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Publication

29273772 | J:258015

First Author:	Apicco DJ
Year:	2018
Journal:	Nat Neurosci
Title:	Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.
Volume:	21
Issue:	1
Pages:	72-80

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Publication

34160349 | J:313902

First Author:	Tang CC
Year:	2021
Journal:	Elife
Title:	Dual targeting of salt inducible kinases and CSF1R uncouples bone formation and bone resorption.
Volume:	10

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Publication

19008197 | -

First Author:	Visnes T
Year:	2009
Journal:	Philos Trans R Soc Lond B Biol Sci
Title:	Uracil in DNA and its processing by different DNA glycosylases.
Volume:	364
Issue:	1517
Pages:	563-8

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Publication

29596604 | -

First Author:	Earl C
Year:	2018
Journal:	Nucleic Acids Res
Title:	A structurally conserved motif in γ-herpesvirus uracil-DNA glycosylases elicits duplex nucleotide-flipping.
Volume:	46
Issue:	8
Pages:	4286-4300

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Protein Domain

IPR002043 | UDG_fam1

Type:

Family

Description:

Uracil-DNA glycosylase (UDG, UNG) []is a DNA repair enzyme that excises uracil residues from DNA by cleaving the N-glycosylic bond. Uracil in DNA can arise as a result of mis-incorporation of dUMP residues by DNA polymerase or deamination of cytosine. UDGs were classified into 4 families [, ].Family 1 enzymes are active against uracil in both ssDNA and dsDNA, and recognise uracil explicitly in an extrahelical conformation via a combination of protein and bound-water interactions []. Family 1 enzymes are present in Eubacteria, Eukarya and in some eukaryotic viruses. The sequence of uracil-DNA glycosylases is extremely well conserved []in bacteria and eukaryotes as well as in herpes viruses []. More distantly related uracil-DNA glycosylases are also found in poxviruses []. In eukaryotic cells, UNG activity is found in both the nucleus and the mitochondria. Human nuclear UNG2 and mitochondrial UNG1are both encoded by the UNG gene [, ]. The N-terminal 77 amino acids of UNG1 seem to be required for mitochondrial localisation []. The catalytic C-terminal domains of UNGs are highly conserved at both the sequence and structure level while the N-terminal domains are diverse and are thought to be involved in subcellular localisation and protein-protein interactions [].

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Publication

3052275 | -

First Author:	Sancar A
Year:	1988
Journal:	Annu Rev Biochem
Title:	DNA repair enzymes.
Volume:	57

Pages:	29-67

•

Publication

8332455 | -

First Author:	Slupphaug G
Year:	1993
Journal:	Nucleic Acids Res
Title:	Nuclear and mitochondrial forms of human uracil-DNA glycosylase are encoded by the same gene.
Volume:	21
Issue:	11
Pages:	2579-84

•

Protein

A0A0G2JDS8

Organism:	Mus musculus/domesticus
Length:	132
Fragment?:	false

•

Protein

P97931

Organism:	Mus musculus/domesticus
Length:	306
Fragment?:	false

•

Protein

D3YW18

Organism:	Mus musculus/domesticus
Length:	185
Fragment?:	true

•

Publication

11483530 | J:70852

First Author:	Nilsen H
Year:	2001
Journal:	EMBO J
Title:	Excision of deaminated cytosine from the vertebrate genome: role of the SMUG1 uracil-DNA glycosylase.
Volume:	20
Issue:	15
Pages:	4278-86

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Publication

20065039 | J:161735

First Author:	Lauritzen KH
Year:	2010
Journal:	Mol Cell Biol
Title:	Mitochondrial DNA toxicity in forebrain neurons causes apoptosis, neurodegeneration, and impaired behavior.
Volume:	30
Issue:	6
Pages:	1357-67

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Publication

29496532 | J:329569

First Author:	Green B
Year:	2018
Journal:	Exp Hematol
Title:	Deficiency in the DNA glycosylases UNG1 and OGG1 does not potentiate c-Myc-induced B-cell lymphomagenesis.
Volume:	61

Pages:	52-58

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Publication

11223884 | -

First Author:	Schärer OD
Year:	2001
Journal:	Bioessays
Title:	Recent progress in the biology, chemistry and structural biology of DNA glycosylases.
Volume:	23
Issue:	3
Pages:	270-81

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Publication

10946227 | -

First Author:	Pearl LH
Year:	2000
Journal:	Mutat Res
Title:	Structure and function in the uracil-DNA glycosylase superfamily.
Volume:	460
Issue:	3-4
Pages:	165-81

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Publication

7845459 | -

First Author:	Savva R
Year:	1995
Journal:	Nature
Title:	The structural basis of specific base-excision repair by uracil-DNA glycosylase.
Volume:	373
Issue:	6514
Pages:	487-93

•

Protein Domain

IPR018085 | Ura-DNA_Glyclase_AS

Type:

Active_site

Description:

Uracil-DNA glycosylase (UNG) []is a DNA repair enzyme that excises uracil residues from DNA by cleaving the N-glycosylic bond. Uracil in DNA can arise as a result of mis-incorporation of dUMP residues by DNA polymerase or deamination of cytosine.The sequence of uracil-DNA glycosylase is extremely well conserved []in bacteria and eukaryotes as well as in herpes viruses. More distantly related uracil-DNA glycosylases are also found in poxviruses []. In eukaryotic cells, UNG activity is found in both the nucleus and the mitochondria. Human UNG1 protein is transported to both the mitochondria and the nucleus []. The N-terminal 77 amino acids of UNG1 seem to be required for mitochondrial localisation [], but the presence of a mitochondrial transitpeptide has not been directly demonstrated. The most N-terminal conserved region contains an aspartic acid residue which has been proposed, based on X-ray structures [, ]to act as a general base in the catalytic mechanism.This signature pattern covers the most N-terminal conserved region, which contains an aspartic acid residue that has been proposed, based on X-ray structures [, ]to act as a general base in the catalytic mechanism.

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Publication

2555154 | -

First Author:	Olsen LC
Year:	1989
Journal:	EMBO J
Title:	Molecular cloning of human uracil-DNA glycosylase, a highly conserved DNA repair enzyme.
Volume:	8
Issue:	10
Pages:	3121-5

•

Publication

8389453 | -

First Author:	Upton C
Year:	1993
Journal:	Proc Natl Acad Sci U S A
Title:	Identification of a poxvirus gene encoding a uracil DNA glycosylase.
Volume:	90
Issue:	10
Pages:	4518-22

•

Publication

12718543 | J:83349

First Author:	Masaoka A
Year:	2003
Journal:	Biochemistry
Title:	Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions.
Volume:	42
Issue:	17
Pages:	5003-12

•

Publication

17591858 | J:125867

First Author:	Wu X
Year:	2007
Journal:	J Exp Med
Title:	DNA polymerase beta is able to repair breaks in switch regions and plays an inhibitory role during immunoglobulin class switch recombination.
Volume:	204
Issue:	7
Pages:	1677-89

•

Publication

34819671 | J:322351

First Author:	Rogier M
Year:	2021
Journal:	Nature
Title:	Fam72a enforces error-prone DNA repair during antibody diversification.
Volume:	600
Issue:	7888
Pages:	329-333

•

Publication

35450882 | J:343116

First Author:	Wu L
Year:	2022
Journal:	Genes Dev
Title:	HMCES protects immunoglobulin genes specifically from deletions during somatic hypermutation.
Volume:	36
Issue:	7-8
Pages:	433-450

•

Publication

26267846 | J:242780

First Author:	Kadungure T
Year:	2015
Journal:	PLoS One
Title:	Individual substitution mutations in the AID C terminus that ablate IgH class switch recombination.
Volume:	10
Issue:	8
Pages:	e0134397

•

Publication

7697717 | -

First Author:	Mol CD
Year:	1995
Journal:	Cell
Title:	Crystal structure and mutational analysis of human uracil-DNA glycosylase: structural basis for specificity and catalysis.
Volume:	80
Issue:	6
Pages:	869-78

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Search results 501 to 533 out of 533 for Ung

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