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Search results 501 to 600 out of 615 for Wnk1

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Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:4427987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:1768022
Stage: TS22
Assay Id: MGI:5422491
Age: embryonic day 14.5
Note: Expression was not detected in the skull (base and vault).
Specimen Label: MH1821; Specimen C1791
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4427987
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Male
Emaps: EMAPS:2823628
Stage: TS28
Assay Id: MGI:5540652
Age: postnatal day 84
Image: GUDMAP:14686
Specimen Label: GUDMAP:14686
Detected: false
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:4427987
Assay Type: RNA in situ
Annotation Date: 2012-06-12
Strength: Moderate
Sex: Not Specified
Emaps: EMAPS:2672022
Pattern: Regionally restricted
Stage: TS22
Assay Id: MGI:5422491
Age: embryonic day 14.5
Image: MH1821; Specimen C1791
Note: Expression was detected in whisker follicle.
Specimen Label: MH1821; Specimen C1791
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4427987
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Absent
Sex: Not Specified
Emaps: EMAPS:2801126
Stage: TS26
Assay Id: MGI:5540652
Age: embryonic day 17.5
Image: GUDMAP:14685
Specimen Label: GUDMAP:14685
Detected: false
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:4427987
Assay Type: RNA in situ
Annotation Date: 2014-02-07
Strength: Ambiguous
Sex: Male
Emaps: EMAPS:2801128
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:5540652
Age: postnatal day 84
Image: GUDMAP:14686
Specimen Label: GUDMAP:14686
Specimen Num: 2
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HT Experiment
GSE234068 | Meiotic completion of the spermatocytes requires the kinase WNK1
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
31615901 | J:283808
 
First Author: Watanabe M
Year: 2019
Journal: Sci Signal
Title: Developmentally regulated KCC2 phosphorylation is essential for dynamic GABA-mediated inhibition and survival.
Volume: 12
Issue: 603
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Publication
27782176 | J:278187
 
First Author: Zhang J
Year: 2016
Journal: Sci Rep
Title: Functional kinomics establishes a critical node of volume-sensitive cation-Cl- cotransporter regulation in the mammalian brain.
Volume: 6
Pages: 35986
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Publication
20573213 | J:355868
 
First Author: Revil T
Year: 2010
Journal: BMC Genomics
Title: Alternative splicing is frequent during early embryonic development in mouse.
Volume: 11
Pages: 399
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Publication
38324473 | J:353360
First Author: Cesari E
Year: 2024
Journal: Nucleic Acids Res
Title: Differential expression of paralog RNA binding proteins establishes a dynamic splicing program required for normal cerebral cortex development.
Volume: 52
Issue: 8
Pages: 4167-4184
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Publication
15582152 | J:102103
First Author: Jensen P
Year: 2004
Journal: Brain Res Mol Brain Res
Title: A neurogenomics approach to gene expression analysis in the developing brain.
Volume: 132
Issue: 2
Pages: 116-27
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Publication
16141072 | J:99680
First Author: Carninci P
Year: 2005
Journal: Science
Title: The transcriptional landscape of the mammalian genome.
Volume: 309
Issue: 5740
Pages: 1559-63
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Publication
- | J:77000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: MGC Data curation in Mouse Genome Informatics
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Publication
- | J:342608
       
First Author: GO Central curators, GOA curators, Rhea curators
Year: 2020
Title: Automatic Gene Ontology annotation based on Rhea mapping
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Publication
- | J:72245
       
First Author: GOA curators, MGI curators
Year: 2001
Title: Gene Ontology annotation based on Enzyme Commission mapping
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:171409
     
First Author: GUDMAP Consortium
Year: 2004
Journal: www.gudmap.org
Title: GUDMAP: the GenitoUrinary Development Molecular Anatomy Project
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Protein
Q7TPR2
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: true
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UniProt Feature
UniProt Feature
Begin: 371
Description: Phosphoserine; by WNK1 and WNK4
Type: modified residue
End: 371
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Protein
P83741
Organism: Mus musculus/domesticus
Length: 2377  
Fragment?: false
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Protein
P83741-6
Organism: Mus musculus/domesticus
Length: 788  
Fragment?: false
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Protein
P83741-3
Organism: Mus musculus/domesticus
Length: 2635  
Fragment?: false
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Protein
P83741-4
Organism: Mus musculus/domesticus
Length: 2128  
Fragment?: false
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Protein
P83741-7
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: false
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Protein
P83741-2
Organism: Mus musculus/domesticus
Length: 2626  
Fragment?: false
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Protein
P83741-5
Organism: Mus musculus/domesticus
Length: 2195  
Fragment?: false
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Protein
F6S7V4
Organism: Mus musculus/domesticus
Length: 85  
Fragment?: true
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Protein
F6TAR7
Organism: Mus musculus/domesticus
Length: 200  
Fragment?: true
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Protein
A0A0R4J274
Organism: Mus musculus/domesticus
Length: 433  
Fragment?: false
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Protein
F6U2S8
Organism: Mus musculus/domesticus
Length: 281  
Fragment?: true
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Protein
F7B663
Organism: Mus musculus/domesticus
Length: 67  
Fragment?: true
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Protein
F7CZC4
Organism: Mus musculus/domesticus
Length: 407  
Fragment?: true
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Protein
F6TW99
Organism: Mus musculus/domesticus
Length: 252  
Fragment?: true
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Protein
J3QPK0
Organism: Mus musculus/domesticus
Length: 238  
Fragment?: true
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Protein
F6V9V5
Organism: Mus musculus/domesticus
Length: 61  
Fragment?: true
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Protein
F7CBK9
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: true
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Publication
16204408 | -
First Author: Subramanya AR
Year: 2006
Journal: Am J Physiol Renal Physiol
Title: Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform.
Volume: 290
Issue: 3
Pages: F619-24
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Interaction Experiment
Roy A (2015)
Description: Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action.
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Publication
18955660 | J:281501
First Author: Delaloy C
Year: 2008
Journal: Hypertension
Title: Deletion of WNK1 first intron results in misregulation of both isoforms in renal and extrarenal tissues.
Volume: 52
Issue: 6
Pages: 1149-54
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Allele
Gt(ROSA)26Sor<tm1(Wnk1)Clhu> | MGI:4360975
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Chou-Long Huang
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence
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DO Term
DOID:0070155 | hereditary sensory and autonomic neuropathy type 2A
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HT Experiment
GSE144802 | Identification of a Novel PP2A Regulator, WNK1, as Critical For Uterine Function
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
15656989 | -
 
First Author: Zeng G
Year: 2005
Journal: Gene
Title: Expression of the mouse WNK1 gene in correlation with ganglioside GD3 and functional analysis of the mouse WNK1 promoter.
Volume: 344
Pages: 233-9
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Allele
Klhl3<tm1.1Esoh> | MGI:5646378
Name: kelch-like 3; targeted mutation 1.1, Eisei Sohara
Allele Type: Targeted
Attribute String: Not Specified
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Publication
15060842 | -
First Author: Lafreniere RG
Year: 2004
Journal: Am J Hum Genet
Title: Identification of a novel gene (HSN2) causing hereditary sensory and autonomic neuropathy type II through the Study of Canadian Genetic Isolates.
Volume: 74
Issue: 5
Pages: 1064-73
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Publication
28743496 | J:251049
First Author: Susa K
Year: 2017
Journal: Biochem Biophys Res Commun
Title: WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.
Volume: 491
Issue: 3
Pages: 727-732
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Genotype
Genotype
Symbol: Klhl3/Klhl3<+>
Background: involves: C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Klhl3/Klhl3
Background: involves: C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
28052936 | J:244278
 
First Author: Sasaki E
Year: 2017
Journal: Mol Cell Biol
Title: KLHL3 Knockout Mice Reveal the Physiological Role of KLHL3 and the Pathophysiology of Pseudohypoaldosteronism Type II Caused by Mutant KLHL3.
Volume: 37
Issue: 7
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Kdr/Kdr<+> Wnk1/Wnk1
Background: involves: 129S1/Sv * 129S5/SvEvBrd
Zygosity: cn
Has Mutant Allele: true
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Publication
23542070 | J:220505
First Author: Park S
Year: 2013
Journal: Gastroenterology
Title: Irbit mediates synergy between ca(2+) and cAMP signaling pathways during epithelial transport in mice.
Volume: 145
Issue: 1
Pages: 232-41
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Wnk1/Wnk1 Tg(Tek-cre)12Flv/?
Background: involves: 129S5/SvEvBrd * C3H * C57BL/6
Zygosity: cn
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Gt(ROSA)26Sor/Gt(ROSA)26Sor<+> Wnk1/Wnk1 Edil3/Edil3<+>
Background: involves: 129S5/SvEvBrd * C57BL/6 * CBA
Zygosity: cn
Has Mutant Allele: true
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Publication
36318922 | J:331415
First Author: Boyd-Shiwarski CR
Year: 2022
Journal: Cell
Title: WNK kinases sense molecular crowding and rescue cell volume via phase separation.
Volume: 185
Issue: 24
Pages: 4488-4506.e20
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Publication
17488636 | J:129716
First Author: Yang SS
Year: 2007
Journal: Cell Metab
Title: Molecular pathogenesis of pseudohypoaldosteronism type II: generation and analysis of a Wnk4(D561A/+) knockin mouse model.
Volume: 5
Issue: 5
Pages: 331-44
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Publication
18800028 | J:162717
First Author: Chiga M
Year: 2008
Journal: Kidney Int
Title: Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone.
Volume: 74
Issue: 11
Pages: 1403-9
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Publication
24610784 | J:209614
First Author: Richards J
Year: 2014
Journal: J Biol Chem
Title: A role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cells.
Volume: 289
Issue: 17
Pages: 11791-806
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Publication
12515852 | J:84958
First Author: Wilson FH
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Molecular pathogenesis of inherited hypertension with hyperkalemia: the Na-Cl cotransporter is inhibited by wild-type but not mutant WNK4.
Volume: 100
Issue: 2
Pages: 680-4
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Publication
17975670 | J:127376
First Author: Yang CL
Year: 2007
Journal: J Clin Invest
Title: The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complex.
Volume: 117
Issue: 11
Pages: 3403-11
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Publication
23213404 | J:181538
First Author: Oi K
Year: 2012
Journal: Biol Open
Title: A minor role of WNK3 in regulating phosphorylation of renal NKCC2 and NCC co-transporters in vivo.
Volume: 1
Issue: 2
Pages: 120-7
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Publication
28289184 | J:290403
First Author: Al-Qusairi L
Year: 2017
Journal: J Am Soc Nephrol
Title: Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion.
Volume: 28
Issue: 8
Pages: 2431-2442
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Publication
27009335 | J:280677
First Author: Al-Qusairi L
Year: 2016
Journal: Am J Physiol Renal Physiol
Title: Renal tubular SGK1 deficiency causes impaired K+ excretion via loss of regulation of NEDD4-2/WNK1 and ENaC.
Volume: 311
Issue: 2
Pages: F330-42
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Publication
30148674 | J:284284
First Author: Lin CM
Year: 2019
Journal: FASEB J
Title: Generation and analysis of a mouse model of pseudohypoaldosteronism type II caused by KLHL3 mutation in BTB domain.
Volume: 33
Issue: 1
Pages: 1051-1061
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Publication
24655003 | J:241978
 
First Author: Takahashi D
Year: 2014
Journal: Biosci Rep
Title: WNK4 is the major WNK positively regulating NCC in the mouse kidney.
Volume: 34
Issue: 3
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Publication
30765526 | J:274218
     
First Author: Chen JC
Year: 2019
Journal: Proc Natl Acad Sci U S A
Title: WNK4 kinase is a physiological intracellular chloride sensor.
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Publication
36511337 | J:334397
 
First Author: Chen B
Year: 2023
Journal: Neurobiol Dis
Title: Activation of Swell1 in microglia suppresses neuroinflammation and reduces brain damage in ischemic stroke.
Volume: 176
Pages: 105936
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Publication
22114204 | J:181787
First Author: Zhou B
Year: 2012
Journal: Am J Physiol Renal Physiol
Title: WNK4 inhibits NCC protein expression through MAPK ERK1/2 signaling pathway.
Volume: 302
Issue: 5
Pages: F533-9
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Publication
16275913 | J:172996
First Author: Rinehart J
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: WNK3 kinase is a positive regulator of NKCC2 and NCC, renal cation-Cl- cotransporters required for normal blood pressure homeostasis.
Volume: 102
Issue: 46
Pages: 16777-82
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

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