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Search results 5401 to 5500 out of 5657 for Cdh1

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Type Details Score
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Protein Coding Gene
MGI:1926790 | Fzr1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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GXD Expression
GXD Expression
 
Probe: MGI:6711096
Assay Type: Immunohistochemistry
Annotation Date: 2021-05-17
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1783926
Pattern: Not Specified
Stage: TS26
Assay Id: MGI:6711104
Age: embryonic day 18.5
Note: Expressed apically with respect to Cdh1 expression.
Specimen Label: 5A/A'/C/C'
Detected: true
Specimen Num: 6
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GXD Expression
GXD Expression
 
Probe: MGI:3812108
Assay Type: Immunohistochemistry
Annotation Date: 2024-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607311
Pattern: Regionally restricted
Stage: TS11
Assay Id: MGI:7734725
Age: embryonic day 7.5
Note: Significant basolateral colocalization with Cdh1 expression.
Specimen Label: 7f
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:5635606
Assay Type: Immunohistochemistry
Annotation Date: 2020-06-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3684028
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6435773
Age: postnatal adult
Image: 4C
Note: Co-expression with Cdh1 in cholangiocyte progenitors.
Specimen Label: 4C
Detected: true
Specimen Num: 23
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Pathway
R-MMU-174084 | Autodegradation of Cdh1 by Cdh1:APC/C
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Interaction Experiment
Naoe H (2010)
Description: The anaphase-promoting complex/cyclosome activator Cdh1 modulates Rho GTPase by targeting p190 RhoGAP for degradation.
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DO Term
DOID:0080345 | blepharocheilodontic syndrome 1
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GXD Expression
GXD Expression
 
Probe: MGI:7333233
Assay Type: Immunohistochemistry
Annotation Date: 2022-09-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1736321
Pattern: Regionally restricted
Stage: TS21
Assay Id: MGI:7334715
Age: embryonic day 13.5
Note: Coexpressed with Cdh1 at the medial edge epithelium.
Specimen Label: 4Ci
Detected: true
Specimen Num: 7
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GXD Expression
GXD Expression
Probe: MGI:2681585
Assay Type: Immunohistochemistry
Annotation Date: 2025-01-22
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3287326
Pattern: Regionally restricted
Stage: TS26
Assay Id: MGI:7855376
Age: embryonic day 18.5
Image: 4C/E Prkcz
Note: Expression predominantly at apical membrane domain, co-localized with Cdh1 expression.
Specimen Label: 4C/E Prkcz
Detected: true
Specimen Num: 1
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Allele
Cdh1<em3(dre/ERT2)Smoc> | MGI:6682115
Name: cadherin 1; endonuclease-mediated mutation 3, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Inducible, Recombinase
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GXD Expression
GXD Expression
 
Probe: MGI:3812108
Assay Type: Immunohistochemistry
Annotation Date: 2024-10-02
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607311
Pattern: Regionally restricted
Stage: TS11
Assay Id: MGI:7734725
Age: embryonic day 7.5
Note: Apical expression in microvilli of neuroepithelium. Minimal overlap with Cdh1 expression.
Specimen Label: 7e
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6448440
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607210
Pattern: Not Specified
Stage: TS10
Assay Id: MGI:6448451
Age: embryonic day 7.5
Note: Cytosolic levels of Ctnnb1 rise after mesodermal cells downregulate Cdh1 and traverse the primitive streak.
Specimen Label: 2B
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6448440
Assay Type: Immunohistochemistry
Annotation Date: 2020-08-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607210
Pattern: Regionally restricted
Stage: TS10
Assay Id: MGI:6448451
Age: embryonic day 7.5
Note: Ctnnb1 colocalized with Cdh1 at the cell membrane in the primitive streak of the mutant.
Specimen Label: 2E
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6866964
Assay Type: Immunohistochemistry
Annotation Date: 2022-02-10
Strength: Present
Sex: Not Specified
Emaps: EMAPS:160403
Pattern: Regionally restricted
Stage: TS03
Assay Id: MGI:6866990
Age: embryonic day 3.0
Note: Double staining revealed co-localization of Tjp2 and Cdh1 in the apicolateral junctional complex.
Specimen Label: 4A
Detected: true
Specimen Num: 17
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Strain
MGI:6354666 | C57BL/6JSmoc-Cdh1<em3(dre/ERT2)Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Cdh1<tm1Smoc> | MGI:7288887
Name: cadherin 1; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
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GXD Expression
GXD Expression
Probe: MGI:3839327
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-09
Strength: Present
Sex: Male
Emaps: EMAPS:3148228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3839434
Age: postnatal week 10
Image: S5A,C
Note: Expression was detected in type A single spermatogonia. Co-localization was seen with Cdh1 but not all Cdh1+ spermatogonia expressed Sohlh2.
Specimen Label: S5A,C
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
Probe: MGI:3839327
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-09
Strength: Present
Sex: Male
Emaps: EMAPS:3148228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3839434
Age: postnatal week 10
Image: S5D,F
Note: Expression was detected in type A paired spermatogonia. Co-localization was seen with Cdh1 but not all Cdh1+ spermatogonia expressed Sohlh2.
Specimen Label: S5D,F
Detected: true
Specimen Num: 13
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GXD Expression
GXD Expression
Probe: MGI:3839327
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-09
Strength: Present
Sex: Male
Emaps: EMAPS:3148228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3839434
Age: postnatal week 10
Image: S5G,I
Note: Expression was detected in type A aligned spermatogonia. Co-localization was seen with Cdh1 but not all Cdh1+ spermatogonia expressed Sohlh2.
Specimen Label: S5G,I
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
Probe: MGI:6324575
Assay Type: Immunohistochemistry
Annotation Date: 2019-08-13
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3295228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6343210
Age: postnatal day 5
Image: 3C
Note: Expression was detected in the lumen of the ductal pancreatic epithelium, which was demarcated by Cdh1 staining.
Specimen Label: 3C
Detected: true
Specimen Num: 5
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GXD Expression
GXD Expression
Probe: MGI:2158661
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Pattern: Non-Uniform
Stage: TS28
Assay Id: MGI:3580817
Age: postnatal adult
Image: 5J, 5L
Note: Expression was detected in the cytoplasm. Expression did not colocalize with Cdh1 (E-Cadherin) in the islets of Langerhans.
Specimen Label: 5J, 5L
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:2158661
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Pattern: Non-Uniform
Stage: TS28
Assay Id: MGI:3580824
Age: postnatal adult
Image: 5J, 5L
Note: Expression was detected in the cytoplasm. Expression did not colocalize with Cdh1 (E-Cadherin) in the islets of Langerhans.
Specimen Label: 5J, 5L
Detected: true
Specimen Num: 1
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Publication
17942546 | -
First Author: Tran K
Year: 2008
Journal: J Virol
Title: Accumulation of substrates of the anaphase-promoting complex (APC) during human cytomegalovirus infection is associated with the phosphorylation of Cdh1 and the dissociation and relocalization of APC subunits.
Volume: 82
Issue: 1
Pages: 529-37
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Allele
Cdh1<tm3.1Mpst> | MGI:5426969
Name: cadherin 1; targeted mutation 3.1, Marc P Stemmler
Allele Type: Targeted
Attribute String: Inserted expressed sequence
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Allele
Tg(Cdh3-cre/ERT2)NIDA158Htz | MGI:5882705
Name: transgene insertion NIDA158, Nathaniel Heintz
Allele Type: Transgenic
Attribute String: Inducible, Recombinase
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GXD Expression
GXD Expression
Probe: MGI:3839327
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-09
Strength: Present
Sex: Male
Emaps: EMAPS:3148228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3839434
Age: postnatal week 10
Image: S4I,K
Note: Expression was detected in type A undifferentiated spermatogonia. Co-localization was seen with Cdh1, but some Cdh1 positive cells did not express Sohlh2.
Specimen Label: S4I,K
Detected: true
Specimen Num: 11
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GXD Expression
GXD Expression
Probe: MGI:3839327
Assay Type: Immunohistochemistry
Annotation Date: 2009-04-09
Strength: Present
Sex: Male
Emaps: EMAPS:3148228
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3839434
Age: postnatal week 10
Image: S5J,L
Note: Expression was detected in type A aligned spermatogonia at the 16-cell stage. Co-localization was seen with Cdh1 but not all Cdh1+ spermatogonia expressed Sohlh2.
Specimen Label: S5J,L
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
 
Probe: MGI:6202368
Assay Type: Immunohistochemistry
Annotation Date: 2018-10-16
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1607511
Pattern: Regionally restricted
Stage: TS11
Assay Id: MGI:6202410
Age: embryonic day 7.5-7.75
Note: In ventral node pit cells, Pifo is localized apically to the adherens junction marker Cdh1 and at the base of the primary cilium in a ciliary necklace-like pattern.
Specimen Label: 4E ventral node pit cells 3
Detected: true
Specimen Num: 16
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GXD Expression
GXD Expression
 
Probe: MGI:5792660
Assay Type: Immunohistochemistry
Annotation Date: 2025-01-07
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3595723
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:7798838
Age: embryonic day 15.0
Note: Coexpressed with Cdh1 in the developing epithelia consisting of future Harderian gland, superficial glands of the third membrane, and the flanking epithelia of the nascent nictitating membrane.
Specimen Label: 3L
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:3580790
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3580818
Age: postnatal adult
Image: 5D, 5F
Note: Expression was predominantly localized to the outer cell membrane in both the endocrine and exocrine compartment. Expression colocalized with Cdh1 (E-cadherin).
Specimen Label: 5D, 5F
Detected: true
Specimen Num: 15
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GXD Expression
GXD Expression
Probe: MGI:3580788
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3292728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3580815
Age: postnatal adult
Image: 5A, 5C
Note: Expression was detected in both the cytoplasm and the outer cell membrane of adult islets. Expression colocalized with Cdh1 (E-Cadherin) in the outer cell membrane.
Specimen Label: 5A, 5C
Detected: true
Specimen Num: 14
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GXD Expression
GXD Expression
Probe: MGI:3580786
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:3292728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:3580820
Age: postnatal adult
Image: 5G, 5I
Note: Expression was detected in the cell cytoplasm but was not detectable in the outer cell membrane of the islets. Expression did not colocalize with Cdh1 (E-Cadherin).
Specimen Label: 5G, 5I
Detected: true
Specimen Num: 14
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Allele
Tg(Cdh1-EGFP)AR201Gsat | MGI:4846926
Name: transgene insertion AR201, GENSAT Project at Rockefeller University
Allele Type: Transgenic
Attribute String: Reporter
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Strain
MGI:5882722 | C57BL/6J-Tg(Cdh3-cre/ERT2)NIDA158Htz/J
Attribute String: coisogenic, mutant strain, transgenic
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Strain
MGI:6354667 | C57BL/6JSmoc-Cdh1<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Cdh1/Cdh1
Background: involves: C57BL/6 * FVB/N
Zygosity: hm
Has Mutant Allele: true
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Protein
Q9CPV2
Organism: Mus musculus/domesticus
Length: 110  
Fragment?: false
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Allele
Cdh1<tm1.1Mpst> | MGI:4821988
Name: cadherin 1; targeted mutation 1.1, Marc P Stemmler
Allele Type: Targeted
Attribute String: Hypomorph, Reporter
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Strain
MGI:5003576 | STOCK Tg(Cdh1-EGFP)AR201Gsat/Mmucd
Attribute String: mutant stock, transgenic
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Strain
MGI:4822055 | B6.129P2-Cdh1<tm1.1Mpst>
Attribute String: congenic, mutant strain, targeted mutation
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Genotype
Genotype
Symbol: Cdh1/Cdh1
Background: B6.129P2-Cdh1
Zygosity: hm
Has Mutant Allele: true
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Protein
G3UWS6
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: true
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Publication
24853335 | -
 
First Author: Qin S
Year: 2014
Journal: Nat Commun
Title: Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.
Volume: 5
Pages: 3952
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Publication
12127990 | -
First Author: Jae Yoo E
Year: 2002
Journal: Biochem Biophys Res Commun
Title: Hrp3, a chromodomain helicase/ATPase DNA binding protein, is required for heterochromatin silencing in fission yeast.
Volume: 295
Issue: 4
Pages: 970-4
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Protein Domain
IPR041150 | Cdh1_DBD
Type: Domain
Description: This domain can be found in chromodomain helicase DNA-binding protein 1 (Chd1) present in Saccharomyces cerevisiae. Cdh1 proteins have been associated with the efficient assembly and spacing of nucleosomes []. Chd1 consists of a double chromodomain, an Snf2-related ATPase domain and a C-terminal DNA binding domain [, ].This domain comprises the first four helices of the Chd1 DNA binding domain, which can be divided into regions SANT, HL1 and the β-linker. The HL1 region comprises of some 40 residues specific to budding yeast that are unlikely to form such a prominent feature or perform a conserved function in other species. Basic residues on the alpha-1 helix are thought to be important for DNA interaction [].This domain is also found in the Hrp3 protein, another member of the Cdh1 family in Schizosaccharomyces pombe. Like Cdh1, Hrp3 also comprises two chromo-domains, SNF2-like ATPase/7 helicase domains, and a C-terminal DNA binding domain [].
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Protein Domain
IPR040793 | CDH1_2_SANT_HL1
Type: Domain
Description: CDH1 is an ATP-dependent chromatin-remodelling factor and plays an important role in regulating nucleosome assembly and mobilization. CHD1 consists of double chromodomain, SNF2-related ATPase domain, and a C-terminal DNA-binding domain. The DNA-binding domain contains SANT (Swi3, Ada2, N-CoR, TFIIIB) and SLIDE (SANT-like ISWI) domains in its C-terminal region []. SANT domains are structurally related to Myb-like domains are common motifs found in chromatin interacting proteins. Deletion of individual SANT or SLIDE domains in CDH1 does not significantly affect nucleosome binding, but combined deletion of both domains severely compromise binding, suggesting that the SANT-SLIDE motif recognizes DNA/nucleosomes as a single cooperative unit. SANT sequences of Chd1 proteins are the most distantly relation group of sequences relation to other SANT/Myb sequences, and are more diverse than other SANT proteins []. The SANT and SLIDE regions are well conserved in both Chd1 and ISWI (imitation switch) remodelling enzymes []. This domain comprises the SANT region and the helical linker region 1 (HL1).
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Protein
Q9R1K5
Organism: Mus musculus/domesticus
Length: 493  
Fragment?: false
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Publication
21623345 | -
First Author: Ryan DP
Year: 2011
Journal: EMBO J
Title: The DNA-binding domain of the Chd1 chromatin-remodelling enzyme contains SANT and SLIDE domains.
Volume: 30
Issue: 13
Pages: 2596-609
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HT Experiment
GSE64303 | Expression Data from Pten mutant epithelial cells
Series Id: E-GEOD-64303
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: GEO
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Publication
25632142 | J:253661
First Author: Firl A
Year: 2015
Journal: J Neurosci
Title: Elucidating the role of AII amacrine cells in glutamatergic retinal waves.
Volume: 35
Issue: 4
Pages: 1675-86
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Protein
S4R1V1
Organism: Mus musculus/domesticus
Length: 32  
Fragment?: false
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Protein
S4R2B6
Organism: Mus musculus/domesticus
Length: 129  
Fragment?: false
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Publication
23466868 | -
First Author: Bassermann F
Year: 2014
Journal: Biochim Biophys Acta
Title: The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer.
Volume: 1843
Issue: 1
Pages: 150-62
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Publication
20392738 | -
First Author: Kops GJ
Year: 2010
Journal: J Cell Sci
Title: APC16 is a conserved subunit of the anaphase-promoting complex/cyclosome.
Volume: 123
Issue: Pt 10
Pages: 1623-33
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Protein Domain
IPR029641 | APC16
Type: Family
Description: The anaphase promoting complex/cyclosome (APC/C) is a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C consists of thirteen different subunits and, in somatic cells, has two co-activators: Cdc20 and Cdh1 (also known as Fzr1), which associate with the APC/C core at defined stages of the cell cycle. APC/C is only active between metaphase and the end of the next G1 phase. During this time, APC/CCdc20 initiates anaphase and mitotic exit,while APC/CCdh1 contributes to mitotic exit and establishment of a stable G1 state []. This entry represents the APC/C subunit 16 [].
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Publication
10799291 | -
First Author: Yudkovsky Y
Year: 2000
Journal: Biochem Biophys Res Commun
Title: Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint.
Volume: 271
Issue: 2
Pages: 299-304
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Publication
23101628 | -
First Author: Okaz E
Year: 2012
Journal: Cell
Title: Meiotic prophase requires proteolysis of M phase regulators mediated by the meiosis-specific APC/CAma1.
Volume: 151
Issue: 3
Pages: 603-18
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Publication
26650195 | -
First Author: de Boer HR
Year: 2016
Journal: Cell Mol Life Sci
Title: Controlling the response to DNA damage by the APC/C-Cdh1.
Volume: 73
Issue: 5
Pages: 949-60
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Publication
17251266 | -
First Author: Swan A
Year: 2007
Journal: Development
Title: The Cdc20 (Fzy)/Cdh1-related protein, Cort, cooperates with Fzy in cyclin destruction and anaphase progression in meiosis I and II in Drosophila.
Volume: 134
Issue: 5
Pages: 891-9
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Publication
18020708 | -
First Author: Pesin JA
Year: 2007
Journal: PLoS Genet
Title: Developmental role and regulation of cortex, a meiosis-specific anaphase-promoting complex/cyclosome activator.
Volume: 3
Issue: 11
Pages: e202
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Protein Domain
IPR033010 | Cdc20/Fizzy
Type: Family
Description: The anaphase promoting complex/cyclosome (APC/C) is a multisubunit ubiquitin ligase that targets mitotic regulators for degradation in exit from mitosis. At the end of mitosis, APC/C is activated by phosphorylation and association with the WD-40 protein Cdc20/Fizzy []. The inhibitory phosphorylation of Cdc20/Fizzy may have a role as a safeguard to keep the cyclosome inactive in early mitosis and under conditions of mitotic checkpoint arrest []. This entry includes Cdc20/Fizzy homologues from fungi, plants and animals.Three characterised budding yeasts homologues are included in this entry: Cdc20, Cdh1 and Ama1. Cdc20 and Cdh1 have been shown to activate APC/C during mitosis, while Ama1 is a meiosis-specific activator of the APC/C []. The APC/C-Cdh1 is also found involved in the cellular response to DNA damage []. Protein cortex from Drosophila melanogasterwhich is a female meiosis-specific activator of the anaphase promoting complex/cyclosome (APC/C) required for the completion of meiosis in oocytes, is also included in this entry. Cortex activates the ubiquitin ligase activity and substrate specificity of APC/C and triggers the sequential degradation of mitotic cyclins in meiosis [, ].
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Publication
35292986 | J:361307
First Author: Keeley PW
Year: 2023
Journal: J Anat
Title: Cell numbers, cell ratios, and developmental plasticity in the rod pathway of the mouse retina.
Volume: 243
Issue: 2
Pages: 204-222
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Publication
32109390 | J:353803
First Author: Gamlin CR
Year: 2020
Journal: Curr Biol
Title: Distinct Developmental Mechanisms Act Independently to Shape Biased Synaptic Divergence from an Inhibitory Neuron.
Volume: 30
Issue: 7
Pages: 1258-1268.e2
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Publication
32165320 | J:299458
First Author: Schrock MS
Year: 2020
Journal: Semin Cancer Biol
Title: APC/C ubiquitin ligase: Functions and mechanisms in tumorigenesis.
Volume: 67
Issue: Pt 2
Pages: 80-91
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Publication
27591891 | -
First Author: Mohanty B
Year: 2016
Journal: J Mol Biol
Title: The Chromatin Remodelling Protein CHD1 Contains a Previously Unrecognised C-Terminal Helical Domain.
Volume: 428
Issue: 21
Pages: 4298-4314
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Protein
A0A0G2JEZ3
Organism: Mus musculus/domesticus
Length: 220  
Fragment?: true
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Publication
24301314 | J:206142
 
First Author: Delgado-Esteban M
Year: 2013
Journal: Nat Commun
Title: APC/C-Cdh1 coordinates neurogenesis and cortical size during development.
Volume: 4
Pages: 2879
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Publication
32434143 | J:310343
First Author: Valdez-Sinon AN
Year: 2020
Journal: iScience
Title: Cdh1-APC Regulates Protein Synthesis and Stress Granules in Neurons through an FMRP-Dependent Mechanism.
Volume: 23
Issue: 5
Pages: 101132
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Publication
35479397 | J:337995
First Author: Aibara D
Year: 2022
Journal: iScience
Title: Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferation.
Volume: 25
Issue: 5
Pages: 104196
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Publication
19270695 | J:158181
First Author: Gao D
Year: 2009
Journal: Nat Cell Biol
Title: Phosphorylation by Akt1 promotes cytoplasmic localization of Skp2 and impairs APCCdh1-mediated Skp2 destruction.
Volume: 11
Issue: 4
Pages: 397-408
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Publication
14724179 | J:87782
First Author: Wirth KG
Year: 2004
Journal: Genes Dev
Title: Loss of the anaphase-promoting complex in quiescent cells causes unscheduled hepatocyte proliferation.
Volume: 18
Issue: 1
Pages: 88-98
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Publication
18552834 | J:137456
First Author: García-Higuera I
Year: 2008
Journal: Nat Cell Biol
Title: Genomic stability and tumour suppression by the APC/C cofactor Cdh1.
Volume: 10
Issue: 7
Pages: 802-11
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Publication
28502659 | J:277332
First Author: Rattani A
Year: 2017
Journal: Curr Biol
Title: APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity.
Volume: 27
Issue: 10
Pages: 1462-1476.e5
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Publication
28396402 | J:242133
First Author: Bobo-Jiménez V
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: APC/CCdh1-Rock2 pathway controls dendritic integrity and memory.
Volume: 114
Issue: 17
Pages: 4513-4518
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Publication
32152291 | J:302821
First Author: Chen Z
Year: 2020
Journal: Cell Death Dis
Title: A Cdh1-FoxM1-Apc axis controls muscle development and regeneration.
Volume: 11
Issue: 3
Pages: 180
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Publication
26387737 | J:311574
First Author: Lee SB
Year: 2015
Journal: Mol Cell
Title: Parkin Regulates Mitosis and Genomic Stability through Cdc20/Cdh1.
Volume: 60
Issue: 1
Pages: 21-34
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Publication
25913861 | J:221567
First Author: Huang J
Year: 2015
Journal: Neuron
Title: A Cdh1-APC/FMRP Ubiquitin Signaling Link Drives mGluR-Dependent Synaptic Plasticity in the Mammalian Brain.
Volume: 86
Issue: 3
Pages: 726-39
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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