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Search results 5401 to 5500 out of 6467 for Myc

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Type Details Score
Publication
First Author: Dildrop R
Year: 1989
Journal: EMBO J
Title: IgH enhancer-mediated deregulation of N-myc gene expression in transgenic mice: generation of lymphoid neoplasias that lack c-myc expression.
Volume: 8
Issue: 4
Pages: 1121-8
Publication
First Author: Hogarty MD
Year: 2003
Journal: Cancer Lett
Title: The requirement for evasion of programmed cell death in neuroblastomas with MYCN amplification.
Volume: 197
Issue: 1-2
Pages: 173-9
Publication
First Author: Silva S
Year: 2003
Journal: Cancer Res
Title: BCL2 accelerates inflammation-induced BALB/c plasmacytomas and promotes novel tumors with coexisting T(12;15) and T(6;15) translocations.
Volume: 63
Issue: 24
Pages: 8656-63
Publication
First Author: Hall NG
Year: 2003
Journal: Matrix Biol
Title: ADAMTSL-3/punctin-2, a novel glycoprotein in extracellular matrix related to the ADAMTS family of metalloproteases.
Volume: 22
Issue: 6
Pages: 501-10
Publication
First Author: Walkley CR
Year: 2004
Journal: Blood
Title: Identification of the molecular requirements for an RAR alpha-mediated cell cycle arrest during granulocytic differentiation.
Volume: 103
Issue: 4
Pages: 1286-95
Publication
First Author: Marinkovic D
Year: 2004
Journal: Int J Cancer
Title: Reversible lymphomagenesis in conditionally c-MYC expressing mice.
Volume: 110
Issue: 3
Pages: 336-42
Publication
First Author: Alexander WS
Year: 1987
Journal: Mol Cell Biol
Title: Expression of the c-myc oncogene under control of an immunoglobulin enhancer in E mu-myc transgenic mice.
Volume: 7
Issue: 4
Pages: 1436-44
Publication
First Author: McNeil N
Year: 2005
Journal: Genes Chromosomes Cancer
Title: Extraosseous IL-6 transgenic mouse plasmacytoma sometimes lacks Myc-activating chromosomal translocation.
Volume: 43
Issue: 2
Pages: 137-46
Publication
First Author: Haupt Y
Year: 1992
Journal: Oncogene
Title: Retroviral infection accelerates T lymphomagenesis in E mu-N-ras transgenic mice by activating c-myc or N-myc.
Volume: 7
Issue: 5
Pages: 981-6
Publication
First Author: Etiemble J
Year: 1994
Journal: Oncogene
Title: Liver-specific expression and high oncogenic efficiency of a c-myc transgene activated by woodchuck hepatitis virus insertion.
Volume: 9
Issue: 3
Pages: 727-37
Publication
First Author: Kobayashi M
Year: 2006
Journal: Cell Tissue Res
Title: Increased progenitor proliferation and apoptotic cell death in the sensory lineage of mice overexpressing N-myc.
Volume: 323
Issue: 1
Pages: 81-90
Publication
First Author: Fults DW
Year: 2005
Journal: Neurosurg Focus
Title: Modeling medulloblastoma with genetically engineered mice.
Volume: 19
Issue: 5
Pages: E7
Publication
First Author: Veracini L
Year: 2006
Journal: J Cell Sci
Title: Two distinct pools of Src family tyrosine kinases regulate PDGF-induced DNA synthesis and actin dorsal ruffles.
Volume: 119
Issue: Pt 14
Pages: 2921-34
Publication
First Author: Kang HM
Year: 2006
Journal: Cancer Genet Cytogenet
Title: DNA copy number alterations and expression of relevant genes in mouse thymic lymphomas induced by gamma-irradiation and N-methyl-N-nitrosourea.
Volume: 166
Issue: 1
Pages: 27-35
Publication
First Author: Renard CA
Year: 2007
Journal: Cancer Res
Title: Tbx3 is a downstream target of the Wnt/beta-catenin pathway and a critical mediator of beta-catenin survival functions in liver cancer.
Volume: 67
Issue: 3
Pages: 901-10
Publication
First Author: Li J
Year: 2007
Journal: Carcinogenesis
Title: Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability.
Volume: 28
Issue: 6
Pages: 1163-70
Publication
First Author: Ohi H
Year: 2007
Journal: Oncogene
Title: Multi-step lymphomagenesis deduced from DNA changes in thymic lymphomas and atrophic thymuses at various times after gamma-irradiation.
Volume: 26
Issue: 36
Pages: 5280-9
Publication
First Author: Carella C
Year: 2006
Journal: Blood
Title: The ETS factor TEL2 is a hematopoietic oncoprotein.
Volume: 107
Issue: 3
Pages: 1124-32
Publication
First Author: Maclean KH
Year: 2008
Journal: J Clin Invest
Title: Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis.
Volume: 118
Issue: 1
Pages: 79-88
Publication
First Author: Choi J
Year: 2008
Journal: PLoS Genet
Title: TERT promotes epithelial proliferation through transcriptional control of a Myc- and Wnt-related developmental program.
Volume: 4
Issue: 1
Pages: e10
Publication
First Author: Nguyen P
Year: 2008
Journal: Mol Cell Biol
Title: BAT3 and SET1A form a complex with CTCFL/BORIS to modulate H3K4 histone dimethylation and gene expression.
Volume: 28
Issue: 21
Pages: 6720-9
Publication
First Author: Uno S
Year: 2009
Journal: Biochem Pharmacol
Title: Suppression of beta-catenin signaling by liver X receptor ligands.
Volume: 77
Issue: 2
Pages: 186-95
Publication
First Author: Dangi-Garimella S
Year: 2009
Journal: EMBO J
Title: Raf kinase inhibitory protein suppresses a metastasis signalling cascade involving LIN28 and let-7.
Volume: 28
Issue: 4
Pages: 347-58
Publication
First Author: Ota S
Year: 2009
Journal: Hum Mol Genet
Title: The role of senescence and prosurvival signaling in controlling the oncogenic activity of FGFR2 mutants associated with cancer and birth defects.
Volume: 18
Issue: 14
Pages: 2609-21
Publication
First Author: Hill-Baskin AE
Year: 2009
Journal: Hum Mol Genet
Title: Diet-induced hepatocellular carcinoma in genetically predisposed mice.
Volume: 18
Issue: 16
Pages: 2975-88
Publication
First Author: Mukherjee P
Year: 2010
Journal: Mol Cell Biol
Title: Cell cycle arrest by transforming growth factor beta1 near G1/S is mediated by acute abrogation of prereplication complex activation involving an Rb-MCM interaction.
Volume: 30
Issue: 3
Pages: 845-56
Publication
First Author: Sanda T
Year: 2010
Journal: Blood
Title: Interconnecting molecular pathways in the pathogenesis and drug sensitivity of T-cell acute lymphoblastic leukemia.
Volume: 115
Issue: 9
Pages: 1735-45
Publication
First Author: Campaner S
Year: 2010
Journal: Nat Cell Biol
Title: Cdk2 suppresses cellular senescence induced by the c-myc oncogene.
Volume: 12
Issue: 1
Pages: 54-9; sup pp 1-14
Publication
First Author: Pan H
Year: 2011
Journal: Biol Reprod
Title: Sox2 modulates reprogramming of gene expression in two-cell mouse embryos.
Volume: 85
Issue: 2
Pages: 409-16
Publication
First Author: Westermark UK
Year: 2011
Journal: Semin Cancer Biol
Title: The MYCN oncogene and differentiation in neuroblastoma.
Volume: 21
Issue: 4
Pages: 256-66
Publication
First Author: Beverly LJ
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Ubiquitination, localization, and stability of an anti-apoptotic BCL2-like protein, BCL2L10/BCLb, are regulated by Ubiquilin1.
Volume: 109
Issue: 3
Pages: E119-26
Publication
First Author: Küçük C
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: PRDM1 is a tumor suppressor gene in natural killer cell malignancies.
Volume: 108
Issue: 50
Pages: 20119-24
Publication
First Author: Cascón A
Year: 2012
Journal: Cancer Res
Title: MAX and MYC: a heritable breakup.
Volume: 72
Issue: 13
Pages: 3119-24
Publication
First Author: Jauset T
Year: 2018
Journal: Oncotarget
Title: BET inhibition is an effective approach against KRAS-driven PDAC and NSCLC.
Volume: 9
Issue: 27
Pages: 18734-18746
Publication
First Author: Vella P
Year: 2012
Journal: Nucleic Acids Res
Title: Yin Yang 1 extends the Myc-related transcription factors network in embryonic stem cells.
Volume: 40
Issue: 8
Pages: 3403-18
Publication
First Author: Hu WT
Year: 2013
Journal: Biochem Biophys Res Commun
Title: Both core and F proteins of hepatitis C virus could enhance cell proliferation in transgenic mice.
Volume: 435
Issue: 1
Pages: 147-52
Publication
First Author: Khanna A
Year: 2013
Journal: Cancer Res
Title: Cancerous inhibitor of protein phosphatase 2A, an emerging human oncoprotein and a potential cancer therapy target.
Volume: 73
Issue: 22
Pages: 6548-53
Publication
First Author: Choi PS
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Addiction to multiple oncogenes can be exploited to prevent the emergence of therapeutic resistance.
Volume: 111
Issue: 32
Pages: E3316-24
Publication
First Author: Joshi A
Year: 2013
Journal: Exp Hematol
Title: Gene set control analysis predicts hematopoietic control mechanisms from genome-wide transcription factor binding data.
Volume: 41
Issue: 4
Pages: 354-66.e14
Publication
First Author: Zhang C
Year: 2014
Journal: Biochim Biophys Acta
Title: A chromatin modifier regulates Sertoli cell response to mono-(2-ethylhexyl) phthalate (MEHP) via tissue inhibitor of metalloproteinase 2 (TIMP2) signaling.
Volume: 1839
Issue: 11
Pages: 1170-82
Publication
First Author: Kim SK
Year: 2011
Journal: PLoS One
Title: Identification of gene expression signature modulated by nicotinamide in a mouse bladder cancer model.
Volume: 6
Issue: 10
Pages: e26131
Publication
First Author: Lidral AC
Year: 2015
Journal: Hum Mol Genet
Title: A single nucleotide polymorphism associated with isolated cleft lip and palate, thyroid cancer and hypothyroidism alters the activity of an oral epithelium and thyroid enhancer near FOXE1.
Volume: 24
Issue: 14
Pages: 3895-907
Publication
First Author: Thomas LR
Year: 2015
Journal: Cancer Res
Title: The MYC-WDR5 Nexus and Cancer.
Volume: 75
Issue: 19
Pages: 4012-5
Publication
First Author: Palanichamy JK
Year: 2016
Journal: J Clin Invest
Title: RNA-binding protein IGF2BP3 targeting of oncogenic transcripts promotes hematopoietic progenitor proliferation.
Volume: 126
Issue: 4
Pages: 1495-511
Publication
First Author: Stine ZE
Year: 2015
Journal: Cancer Discov
Title: MYC, Metabolism, and Cancer.
Volume: 5
Issue: 10
Pages: 1024-39
Publication
First Author: Donato E
Year: 2017
Journal: Leukemia
Title: Compensatory RNA polymerase 2 loading determines the efficacy and transcriptional selectivity of JQ1 in Myc-driven tumors.
Volume: 31
Issue: 2
Pages: 479-490
Publication
First Author: Brasó-Maristany F
Year: 2016
Journal: Nat Med
Title: PIM1 kinase regulates cell death, tumor growth and chemotherapy response in triple-negative breast cancer.
Volume: 22
Issue: 11
Pages: 1303-1313
Publication
First Author: Wang T
Year: 2025
Journal: Cancer Res
Title: Conditional Activation of c-MYC in Distinct Catecholaminergic Cells Drives Development of Neuroblastoma or Somatostatinoma.
Volume: 85
Issue: 3
Pages: 424-441
Publication
First Author: Hermosilla VE
Year: 2017
Journal: Carcinogenesis
Title: Developmental SALL2 transcription factor: a new player in cancer.
Volume: 38
Issue: 7
Pages: 680-690
Publication
First Author: Berrios C
Year: 2016
Journal: PLoS Pathog
Title: Merkel Cell Polyomavirus Small T Antigen Promotes Pro-Glycolytic Metabolic Perturbations Required for Transformation.
Volume: 12
Issue: 11
Pages: e1006020
Publication
First Author: Previte DM
Year: 2017
Journal: PLoS One
Title: Reactive oxygen species are required for driving efficient and sustained aerobic glycolysis during CD4+ T cell activation.
Volume: 12
Issue: 4
Pages: e0175549
Publication
First Author: Syed KM
Year: 2016
Journal: J Cell Sci
Title: Histone chaperone APLF regulates induction of pluripotency in murine fibroblasts.
Volume: 129
Issue: 24
Pages: 4576-4591
Publication
First Author: Yamamoto M
Year: 2017
Journal: Am J Pathol
Title: Oncogenic Determination of a Broad Spectrum of Phenotypes of Hepatocyte-Derived Mouse Liver Tumors.
Volume: 187
Issue: 12
Pages: 2711-2725
Publication
First Author: Link JM
Year: 2015
Journal: Biochim Biophys Acta
Title: The activities of MYC, MNT and the MAX-interactome in lymphocyte proliferation and oncogenesis.
Volume: 1849
Issue: 5
Pages: 554-62
Publication
First Author: Repouskou A
Year: 2016
Journal: Biochim Biophys Acta
Title: c-MYC targets the central oscillator gene Per1 and is regulated by the circadian clock at the post-transcriptional level.
Volume: 1859
Issue: 4
Pages: 541-52
Publication  
First Author: Pajcini KV
Year: 2017
Journal: Sci Signal
Title: MAFB enhances oncogenic Notch signaling in T cell acute lymphoblastic leukemia.
Volume: 10
Issue: 505
Publication
First Author: Leong WZ
Year: 2017
Journal: Genes Dev
Title: ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis.
Volume: 31
Issue: 23-24
Pages: 2343-2360
Publication
First Author: Qin XY
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Prevention of hepatocellular carcinoma by targeting MYCN-positive liver cancer stem cells with acyclic retinoid.
Volume: 115
Issue: 19
Pages: 4969-4974
Publication
First Author: Yim SY
Year: 2018
Journal: Mol Cancer Res
Title: Integrated Genomic Comparison of Mouse Models Reveals Their Clinical Resemblance to Human Liver Cancer.
Volume: 16
Issue: 11
Pages: 1713-1723
Publication
First Author: Dahlin JS
Year: 2018
Journal: Blood
Title: A single-cell hematopoietic landscape resolves 8 lineage trajectories and defects in Kit mutant mice.
Volume: 131
Issue: 21
Pages: e1-e11
Publication
First Author: Delaidelli A
Year: 2017
Journal: Cell Death Differ
Title: MYCN amplified neuroblastoma requires the mRNA translation regulator eEF2 kinase to adapt to nutrient deprivation.
Volume: 24
Issue: 9
Pages: 1564-1576
Publication
First Author: Hernandez C
Year: 2018
Journal: Cell Stem Cell
Title: Dppa2/4 Facilitate Epigenetic Remodeling during Reprogramming to Pluripotency.
Volume: 23
Issue: 3
Pages: 396-411.e8
Publication
First Author: Tameire F
Year: 2019
Journal: Nat Cell Biol
Title: ATF4 couples MYC-dependent translational activity to bioenergetic demands during tumour progression.
Volume: 21
Issue: 7
Pages: 889-899
Publication
First Author: Pillai MR
Year: 2019
Journal: PLoS One
Title: Myc-induced nuclear antigen constrains a latent intestinal epithelial cell-intrinsic anthelmintic pathway.
Volume: 14
Issue: 2
Pages: e0211244
Publication
First Author: Granados-Aparici S
Year: 2019
Journal: Sci Rep
Title: SMAD3 directly regulates cell cycle genes to maintain arrest in granulosa cells of mouse primordial follicles.
Volume: 9
Issue: 1
Pages: 6513
Publication
First Author: Han SJ
Year: 2019
Journal: Endocrinology
Title: Genomic Function of Estrogen Receptor β in Endometriosis.
Volume: 160
Issue: 11
Pages: 2495-2516
Publication
First Author: Koach J
Year: 2019
Journal: Cancer Res
Title: Drugging MYCN Oncogenic Signaling through the MYCN-PA2G4 Binding Interface.
Volume: 79
Issue: 21
Pages: 5652-5667
Publication
First Author: Ross J
Year: 2019
Journal: Cancer Res
Title: Deletion of the Miz-1 POZ Domain Increases Efficacy of Cytarabine Treatment in T- and B-ALL/Lymphoma Mouse Models.
Volume: 79
Issue: 16
Pages: 4184-4195
Publication
First Author: Tesi A
Year: 2019
Journal: EMBO Rep
Title: An early Myc-dependent transcriptional program orchestrates cell growth during B-cell activation.
Volume: 20
Issue: 9
Pages: e47987
Publication
First Author: Lafita-Navarro MC
Year: 2020
Journal: J Biol Chem
Title: The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells.
Volume: 295
Issue: 7
Pages: 2001-2017
Publication
First Author: Fukamizu A
Year: 1994
Journal: J Biol Chem
Title: Neuroectodermal tumors expressing c-, L-, and N-myc in transgenic mice that carry the E1A/E1B gene of human adenovirus type 12.
Volume: 269
Issue: 49
Pages: 31252-8
Publication
First Author: Kim D
Year: 2019
Journal: Hepatology
Title: Keratin 23 Is a Peroxisome Proliferator-Activated Receptor Alpha-Dependent, MYC-Amplified Oncogene That Promotes Hepatocyte Proliferation.
Volume: 70
Issue: 1
Pages: 154-167
Publication
First Author: Wen D
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Bromodomain and Extraterminal (BET) protein inhibition suppresses tumor progression and inhibits HGF-MET signaling through targeting cancer-associated fibroblasts in colorectal cancer.
Volume: 1866
Issue: 12
Pages: 165923
Publication
First Author: Zheng D
Year: 2020
Journal: Am J Pathol
Title: Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis.
Volume: 190
Issue: 11
Pages: 2267-2281
Publication
First Author: Borenäs M
Year: 2021
Journal: EMBO J
Title: ALK ligand ALKAL2 potentiates MYCN-driven neuroblastoma in the absence of ALK mutation.
Volume: 40
Issue: 3
Pages: e105784
Publication
First Author: Fukumoto K
Year: 2020
Journal: Blood
Title: VAV1 mutations contribute to development of T-cell neoplasms in mice.
Volume: 136
Issue: 26
Pages: 3018-3032
Publication
First Author: Sui Y
Year: 2021
Journal: Mol Cancer Res
Title: Crucial Functions of the JMJD1/KDM3 Epigenetic Regulators in Cancer.
Volume: 19
Issue: 1
Pages: 3-13
Publication
First Author: Xu Y
Year: 2019
Journal: Nat Med
Title: Translation control of the immune checkpoint in cancer and its therapeutic targeting.
Volume: 25
Issue: 2
Pages: 301-311
Publication  
First Author: Li W
Year: 2020
Journal: JCI Insight
Title: MUC1-C drives stemness in progression of colitis to colorectal cancer.
Volume: 5
Issue: 12
Publication  
First Author: Panza E
Year: 2021
Journal: J Clin Invest
Title: The clear cell sarcoma functional genomic landscape.
Volume: 131
Issue: 15
Publication
First Author: Guan F
Year: 2019
Journal: J Am Heart Assoc
Title: New Molecular Mechanism Underlying Myc-Mediated Cytochrome P450 2E1 Upregulation in Apoptosis and Energy Metabolism in the Myocardium.
Volume: 8
Issue: 1
Pages: e009871
Publication
First Author: Laine A
Year: 2021
Journal: Cancer Res
Title: CIP2A Interacts with TopBP1 and Drives Basal-Like Breast Cancer Tumorigenesis.
Volume: 81
Issue: 16
Pages: 4319-4331
Publication
First Author: Molina-Sánchez P
Year: 2020
Journal: Gastroenterology
Title: Cooperation Between Distinct Cancer Driver Genes Underlies Intertumor Heterogeneity in Hepatocellular Carcinoma.
Volume: 159
Issue: 6
Pages: 2203-2220.e14
Publication
First Author: Borland G
Year: 2016
Journal: Oncotarget
Title: Addiction to Runx1 is partially attenuated by loss of p53 in the Eµ-Myc lymphoma model.
Volume: 7
Issue: 17
Pages: 22973-87
Publication
First Author: Feng M
Year: 2021
Journal: Blood
Title: YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner.
Volume: 138
Issue: 1
Pages: 71-85
Publication
First Author: Kilbey A
Year: 2017
Journal: J Cell Biochem
Title: Runx1 Orchestrates Sphingolipid Metabolism and Glucocorticoid Resistance in Lymphomagenesis.
Volume: 118
Issue: 6
Pages: 1432-1441
Publication
First Author: Zhao H
Year: 2017
Journal: Oncogene
Title: p27T187A knockin identifies Skp2/Cks1 pocket inhibitors for advanced prostate cancer.
Volume: 36
Issue: 1
Pages: 60-70
Publication
First Author: Brown ZJ
Year: 2018
Journal: Cell Death Dis
Title: Carnitine palmitoyltransferase gene upregulation by linoleic acid induces CD4+ T cell apoptosis promoting HCC development.
Volume: 9
Issue: 6
Pages: 620
Publication
First Author: Healy JA
Year: 2016
Journal: Blood
Title: GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo.
Volume: 127
Issue: 22
Pages: 2723-31
Publication
First Author: Dutta A
Year: 2022
Journal: Leukemia
Title: Genetic ablation of Pim1 or pharmacologic inhibition with TP-3654 ameliorates myelofibrosis in murine models.
Volume: 36
Issue: 3
Pages: 746-759
Publication
First Author: Sementino E
Year: 2022
Journal: Mol Cancer Res
Title: Inactivation of p21-Activated Kinase 2 (Pak2) Inhibits the Development of Nf2-Deficient Tumors by Restricting Downstream Hedgehog and Wnt Signaling.
Volume: 20
Issue: 5
Pages: 699-711
Publication    
First Author: Thirimanne HN
Year: 2022
Journal: Elife
Title: Global and context-specific transcriptional consequences of oncogenic Fbw7 mutations.
Volume: 11
Publication
First Author: Chondronasiou D
Year: 2022
Journal: Aging Cell
Title: Multi-omic rejuvenation of naturally aged tissues by a single cycle of transient reprogramming.
Volume: 21
Issue: 3
Pages: e13578
Publication
First Author: Rokan A
Year: 2023
Journal: Mol Cancer Res
Title: Gut-derived Endotoxin-TLR4 Signaling Drives MYC-Ig Translocation to Promote Lymphoproliferation through c-JUN and STAT3 Activation.
Volume: 21
Issue: 2
Pages: 155-169
Publication  
First Author: Xiao J
Year: 2023
Journal: JCI Insight
Title: TRAF4 is crucial for ST2+ memory Th2 cell expansion in IL-33-driven airway inflammation.
Volume: 8
Issue: 18
Publication
First Author: Luo Z
Year: 2022
Journal: Nature
Title: Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis.
Volume: 612
Issue: 7941
Pages: 787-794
Publication  
First Author: Alexander WB
Year: 2024
Journal: Dis Model Mech
Title: Smad4 restricts injury-provoked biliary proliferation and carcinogenesis.
Volume: 17
Issue: 6
Publication
First Author: Friedel RH
Year: 2007
Journal: Brief Funct Genomic Proteomic
Title: EUCOMM--the European conditional mouse mutagenesis program.
Volume: 6
Issue: 3
Pages: 180-5
Protein
Organism: Mus musculus/domesticus
Length: 848  
Fragment?: false
Protein
Organism: Mus musculus/domesticus
Length: 883  
Fragment?: false