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Type Details Score
Publication
28813665 | J:254282
First Author: Van Keymeulen A
Year: 2017
Journal: Cell Rep
Title: Lineage-Restricted Mammary Stem Cells Sustain the Development, Homeostasis, and Regeneration of the Estrogen Receptor Positive Lineage.
Volume: 20
Issue: 7
Pages: 1525-1532
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Publication
10963672 | J:64380
First Author: Puech A
Year: 2000
Journal: Proc Natl Acad Sci U S A
Title: Normal cardiovascular development in mice deficient for 16 genes in 550 kb of the velocardiofacial/DiGeorge syndrome region.
Volume: 97
Issue: 18
Pages: 10090-5
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Publication
29073096 | J:256920
First Author: de Morrée A
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Staufen1 inhibits MyoD translation to actively maintain muscle stem cell quiescence.
Volume: 114
Issue: 43
Pages: E8996-E9005
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Interaction Experiment
Celeste A (2003)
Description: Histone H2AX phosphorylation is dispensable for the initial recognition of DNA breaks.
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Interaction Experiment
Limnander A (2004)
Description: v-Abl signaling disrupts SOCS-1 function in transformed pre-B cells.
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Interaction Experiment
Simpson A (2001)
Description: Differential expression and subcellular distribution of the mouse metastasis-associated proteins Mta1 and Mta3.
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Interaction Experiment
Marti A (1997)
Description: Actin-binding protein-280 binds the stress-activated protein kinase (SAPK) activator SEK-1 and is required for tumor necrosis factor-alpha activation of SAPK in melanoma cells.
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Interaction Experiment
Hogan A (2001)
Description: Interaction of gamma 1-syntrophin with diacylglycerol kinase-zeta. Regulation of nuclear localization by PDZ interactions.
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Interaction Experiment
Charest A (1996)
Description: Phosphotyrosine-independent binding of SHC to the NPLH sequence of murine protein-tyrosine phosphatase-PEST. Evidence for extended phosphotyrosine binding/phosphotyrosine interaction domain recognition specificity.
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Interaction Experiment
Kamal A (2000)
Description: Axonal transport of amyloid precursor protein is mediated by direct binding to the kinesin light chain subunit of kinesin-I.
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Interaction Experiment
Benecke A (2002)
Description: ADA3-containing complexes associate with estrogen receptor alpha.
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Interaction Experiment
Ramalingam A (2007)
Description: Bin1 interacts with and restrains the DNA end-binding protein complex Ku.
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Interaction Experiment
Hubberstey A (1996)
Description: Mammalian CAP interacts with CAP, CAP2, and actin.
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Interaction Experiment
Pichler A (2002)
Description: The nucleoporin RanBP2 has SUMO1 E3 ligase activity.
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Interaction Experiment
Duggan A (2002)
Description: The PDZ domain protein PICK1 and the sodium channel BNaC1 interact and localize at mechanosensory terminals of dorsal root ganglion neurons and dendrites of central neurons.
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Interaction Experiment
Emili A (2002)
Description: Splicing and transcription-associated proteins PSF and p54nrb/nonO bind to the RNA polymerase II CTD.
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Interaction Experiment
Naito A (2002)
Description: TRAF6-deficient mice display hypohidrotic ectodermal dysplasia.
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Interaction Experiment
Lockett A (2008)
Description: Transient membrane recruitment of IRAK-1 in response to LPS and IL-1beta requires TNF R1.
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Interaction Experiment
Carlucci A (2008)
Description: Proteolysis of AKAP121 regulates mitochondrial activity during cellular hypoxia and brain ischaemia.
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Interaction Experiment
Wright A (2007)
Description: Regulation of early wave of germ cell apoptosis and spermatogenesis by deubiquitinating enzyme CYLD.
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Interaction Experiment
Laine A (2006)
Description: Regulation of p53 localization and activity by Ubc13.
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Interaction Experiment
Matsuyama A (2002)
Description: In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation.
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Interaction Experiment
Mansukhani A (2005)
Description: Sox2 induction by FGF and FGFR2 activating mutations inhibits Wnt signaling and osteoblast differentiation.
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Interaction Experiment
Strom A (2007)
Description: Unique mechanisms of growth regulation and tumor suppression upon Apc inactivation in the pancreas.
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Interaction Experiment
Mejat A (2005)
Description: Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression.
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Interaction Experiment
Ueda A (2005)
Description: Thr176 regulates the activity of the mouse nuclear receptor CAR and is conserved in the NR1I subfamily members PXR and VDR.
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Interaction Experiment
Messlik A (2009)
Description: Loss of Toll-like receptor 2 and 4 leads to differential induction of endoplasmic reticulum stress and proapoptotic responses in the intestinal epithelium under conditions of chronic inflammation.
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Interaction Experiment
Doetzlhofer A (1999)
Description: Histone deacetylase 1 can repress transcription by binding to Sp1.
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Interaction Experiment
Micsenyi A (2004)
Description: Beta-catenin is temporally regulated during normal liver development.
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Interaction Experiment
Hatano A (2010)
Description: Phosphorylation of the chromodomain changes the binding specificity of Cbx2 for methylated histone H3.
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Interaction Experiment
Zur A (2001)
Description: Securin degradation is mediated by fzy and fzr, and is required for complete chromatid separation but not for cytokinesis.
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Interaction Experiment
Galli A (2010)
Description: Distinct roles of Hand2 in initiating polarity and posterior Shh expression during the onset of mouse limb bud development.
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Interaction Experiment
Morrione A (1999)
Description: mGrb10 interacts with Nedd4.
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Interaction Experiment
Albor A (2006)
Description: The interaction of Piasy with Trim32, an E3-ubiquitin ligase mutated in limb-girdle muscular dystrophy type 2H, promotes Piasy degradation and regulates UVB-induced keratinocyte apoptosis through NFkappaB.
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Interaction Experiment
Yoshikawa A (2009)
Description: Crystal structure of the NEMO ubiquitin-binding domain in complex with Lys 63-linked di-ubiquitin.
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Interaction Experiment
Simonin A (2010)
Description: Nedd4-1 and beta-arrestin-1 are key regulators of Na+/H+ exchanger 1 ubiquitylation, endocytosis, and function.
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Interaction Experiment
Chen A (2009)
Description: The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination.
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Interaction Experiment
Sedelnikova A (2002)
Description: Phosphorylation of the recombinant rho1 GABA receptor.
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Interaction Experiment
Mizutani A (2010)
Description: Arkadia complexes with clathrin adaptor AP2 and regulates EGF signalling.
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Interaction Experiment
Aguirre A (2010)
Description: Notch and EGFR pathway interaction regulates neural stem cell number and self-renewal.
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Interaction Experiment
Mouri A (2012)
Description: MAGE-D1 regulates expression of depression-like behavior through serotonin transporter ubiquitylation.
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Interaction Experiment
Nawshad A (2003)
Description: TGFbeta3 signaling activates transcription of the LEF1 gene to induce epithelial mesenchymal transformation during mouse palate development.
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Interaction Experiment
Stanhill A (2006)
Description: An arsenite-inducible 19S regulatory particle-associated protein adapts proteasomes to proteotoxicity.
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Interaction Experiment
Sfeir A (2012)
Description: Removal of shelterin reveals the telomere end-protection problem.
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Interaction Experiment
Bugge A (2012)
Description: Rev-erb and Rev-erb coordinately protect the circadian clock and normal metabolic function.
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Interaction Experiment
Gortat A (2012)
Description: Single point mutation in Bin/Amphiphysin/Rvs (BAR) sequence of endophilin impairs dimerization, membrane shaping, and Src homology 3 domain-mediated partnership.
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Interaction Experiment
Yokoyama A (2011)
Description: Proteolytically cleaved MLL subunits are susceptible to distinct degradation pathways.
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Interaction Experiment
Kimura A (2002)
Description: The insulin receptor catalyzes the tyrosine phosphorylation of caveolin-1.
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Interaction Experiment
Nitzsche A (2011)
Description: RAD21 cooperates with pluripotency transcription factors in the maintenance of embryonic stem cell identity.
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Interaction Experiment
Takamura A (2011)
Description: Lysosomal accumulation of Trk protein in brain of GM -gangliosidosis mouse and its restoration by chemical chaperone.
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Interaction Experiment
Oguro A (2011)
Description: Protective role of the ubiquitin binding protein Tollip against the toxicity of polyglutamine-expansion proteins.
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Interaction Experiment
Kobielak A (2004)
Description: Mammalian formin-1 participates in adherens junctions and polymerization of linear actin cables.
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Interaction Experiment
Besse A (2007)
Description: TAK1-dependent signaling requires functional interaction with TAB2/TAB3.
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Interaction Experiment
Sanchez-Perez A (2007)
Description: GRK2 interacts with and phosphorylates Nedd4 and Nedd4-2.
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Interaction Experiment
Kumar A (2001)
Description: The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A.
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Interaction Experiment
Maruyama A (2011)
Description: The novel Nrf2-interacting factor KAP1 regulates susceptibility to oxidative stress by promoting the Nrf2-mediated cytoprotective response.
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Interaction Experiment
Dey A (2012)
Description: Loss of the tumor suppressor BAP1 causes myeloid transformation.
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Interaction Experiment
Hishiya A (2010)
Description: BAG3 and Hsc70 interact with actin capping protein CapZ to maintain myofibrillar integrity under mechanical stress.
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Interaction Experiment
Lavi-Itzkovitz A (2012)
Description: Functional consequences of necdin nucleocytoplasmic localization.
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Interaction Experiment
Chakraborty A (2008)
Description: HSP90 regulates cell survival via inositol hexakisphosphate kinase-2.
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Interaction Experiment
Sakane A (2007)
Description: Involvement of Rabring7 in EGF receptor degradation as an E3 ligase.
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Interaction Experiment
Madeira A (2011)
Description: Caveolin-1 interacts with alpha-synuclein and mediates toxic actions of cellular alpha-synuclein overexpression.
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Interaction Experiment
Miura A (2004)
Description: Insulin substrates 1 and 2 are corequired for activation of atypical protein kinase C and Cbl-dependent phosphatidylinositol 3-kinase during insulin action in immortalized brown adipocytes.
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Interaction Experiment
Pierce A (2008)
Description: Axl and Tyro3 modulate female reproduction by influencing gonadotropin-releasing hormone neuron survival and migration.
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Interaction Experiment
Leri A (1999)
Description: Overexpression of insulin-like growth factor-1 attenuates the myocyte renin-angiotensin system in transgenic mice.
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Interaction Experiment
Liu A (2006)
Description: Two conserved domains in PCIF1 mediate interaction with pancreatic transcription factor PDX-1.
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Interaction Experiment
Polesskaya A (2007)
Description: Lin-28 binds IGF-2 mRNA and participates in skeletal myogenesis by increasing translation efficiency.
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Interaction Experiment
Adato A (2005)
Description: Interactions in the network of Usher syndrome type 1 proteins.
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Interaction Experiment
Oganesian A (2006)
Description: The NH2-terminal propeptide of type I procollagen acts intracellularly to modulate cell function.
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Interaction Experiment
Junco A (2001)
Description: Kinesin light-chain KLC3 expression in testis is restricted to spermatids.
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Interaction Experiment
Rodriguez A (2006)
Description: Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62.
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Interaction Experiment
Nemajerova A (2007)
Description: Impaired DNA damage checkpoint response in MIF-deficient mice.
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Interaction Experiment
Ballabeni A (2011)
Description: Cell cycle adaptations of embryonic stem cells.
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Interaction Experiment
Ishiguro A (2004)
Description: Molecular properties of Zic4 and Zic5 proteins: functional diversity within Zic family.
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Interaction Experiment
Nakajima A (2006)
Description: An antiapoptotic protein, c-FLIPL, directly binds to MKK7 and inhibits the JNK pathway.
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Interaction Experiment
Saiardi A (1997)
Description: Antiproliferative role of dopamine: loss of D2 receptors causes hormonal dysfunction and pituitary hyperplasia.
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Interaction Experiment
Kolleker A (2003)
Description: Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors.
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Interaction Experiment
Gagnon A (2003)
Description: Regulation of endogenous SH2 domain-containing inositol 5-phosphatase (SHIP2) in 3T3-L1 and human preadipocytes.
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Interaction Experiment
Duran A (2004)
Description: Crosstalk between PKCzeta and the IL4/Stat6 pathway during T-cell-mediated hepatitis.
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Interaction Experiment
Glading A (2004)
Description: Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation.
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Interaction Experiment
Tun-Kyi A (2011)
Description: Essential role for the prolyl isomerase Pin1 in Toll-like receptor signaling and type I interferon-mediated immunity.
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Interaction Experiment
Teckchandani A (2012)
Description: The clathrin adaptor Dab2 recruits EH domain scaffold proteins to regulate integrin 1 endocytosis.
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Interaction Experiment
Wilcox A (2004)
Description: Asb6, an adipocyte-specific ankyrin and SOCS box protein, interacts with APS to enable recruitment of elongins B and C to the insulin receptor signaling complex.
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Interaction Experiment
Bongiovanni A (2012)
Description: Alix protein is substrate of Ozz-E3 ligase and modulates actin remodeling in skeletal muscle.
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Interaction Experiment
Motegi A (2004)
Description: ALK receptor tyrosine kinase promotes cell growth and neurite outgrowth.
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Interaction Experiment
Iwata A (2003)
Description: Alpha-synuclein degradation by serine protease neurosin: implication for pathogenesis of synucleinopathies.
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Interaction Experiment
Diefenbach A (2002)
Description: Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D.
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Interaction Experiment
Hartsock A (2012)
Description: Competitive regulation of E-cadherin juxtamembrane domain degradation by p120-catenin binding and Hakai-mediated ubiquitination.
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Interaction Experiment
Sugawara A (2002)
Description: Transcription suppression of thromboxane receptor gene by peroxisome proliferator-activated receptor-gamma via an interaction with Sp1 in vascular smooth muscle cells.
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Interaction Experiment
Sorokin A (1998)
Description: Insulin stimulates the tyrosine dephosphorylation of docking protein p130cas (Crk-associated substrate), promoting the switch of the adaptor protein crk from p130cas to newly phosphorylated insulin receptor substrate-1.
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Interaction Experiment
Weber A (2013)
Description: Mouse Noxa uses only the C-terminal BH3-domain to inactivate Mcl-1.
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Interaction Experiment
Shamma A (2013)
Description: ATM mediates pRB function to control DNMT1 protein stability and DNA methylation
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Interaction Experiment
Sugiura A (2013)
Description: MITOL Regulates Endoplasmic Reticulum-Mitochondria Contacts via Mitofusin2.
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Interaction Experiment
Yoshida A (2013)
Description: COP1 targets C/EBP for degradation and induces acute myeloid leukemia via Trib1.
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Interaction Experiment
Lass A (2006)
Description: Adipose triglyceride lipase-mediated lipolysis of cellular fat stores is activated by CGI-58 and defective in Chanarin-Dorfman Syndrome.
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Interaction Experiment
Frangini A (2013)
Description: The Aurora B Kinase and the Polycomb Protein Ring1B Combine to Regulate Active Promoters in Quiescent Lymphocytes.
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Interaction Experiment
Nishiyama A (2013)
Description: Uhrf1-dependent H3K23 ubiquitylation couples maintenance DNA methylation and replication.
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Interaction Experiment
Volchuk A (1998)
Description: Perturbation of dynamin II with an amphiphysin SH3 domain increases GLUT4 glucose transporters at the plasma membrane in 3T3-L1 adipocytes. Dynamin II participates in GLUT4 endocytosis.
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Interaction Experiment
Basters A (2014)
Description: Molecular characterization of ubiquitin-specific protease 18 reveals substrate specificity for interferon-stimulated gene 15.
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Interaction Experiment
Teckchandani A (2014)
Description: Cullin 5 destabilizes Cas to inhibit Src-dependent cell transformation.
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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