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Search results 5701 to 5800 out of 7122 for App

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Type Details Score
Protein Domain
IPR033874 | Memapsin-like
Type: Domain
Description: This entry includes the peptidase domain of aspartic endopeptidases known as memapsins. In humans there are two enzymes, memapsin-1 (also known as BACE2 or beta-site of APP cleaving enzyme 1; MEROPS identifier A01.041) and memapsin-2 (BACE1; MEROPS identifier A01.004).Beta-secretase is an aspartic-acid protease important in the pathogenesis of Alzheimer's disease, and in the formation of myelin sheaths in peripheral nerve cells. It cleaves amyloid precursor protein (APP) to reveal the N terminus of the beta-amyloid peptides. The beta-amyloid peptides are the major components of the amyloid plaques formed in the brain of patients with Alzheimer's disease (AD). Since BACE mediates one of the cleavages responsible for generation of AD, it is regarded as a potential target for pharmacological intervention in AD. Beta-secretase is a member of pepsin family of aspartic proteases (peptidase family A1) [, ].Aspartyl proteases (APs), also known as acid proteases, ([intenz:3.4.23.-]) are a widely distributed family of proteolytic enzymes [, , , , , ]known to exist in vertebrates, fungi, plants, retroviruses and some plant viruses. APs use an Asp dyad to hydrolyze peptide bonds.APs found in eukaryotic cells are alpha/beta monomers composed of two asymmetric lobes ("bilobed"). Each of the lobes provides a catalytic Asp residue, positioned within the hallmark motif Asp-Thr/Ser-Gly, to the active site. The N- and C-terminal domains, although structurally related by a 2-fold axis, have only limited sequence homology except the vicinity of the active site. This suggests that the enzymes evolved by an ancient duplication event. The enzymes specifically cleave bonds in peptides which have at least six residues in length with hydrophobic residues in both the P1 andP1' positions. The active site is located at the groove formed by the two lobes, with an extended loop projecting over the cleft to form an 11-residue flap, which encloses substrates and inhibitors in the active site. Specificity is determined by nearest-neighbour hydrophobic residues surrounding the catalytic aspartates, and by three residues in the flap. The enzymes are mostly secreted from cells as inactive proenzymes that activate autocatalytically at acidic pH. Eukaryotic APs form peptidase family A1 of clan AA.
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30737131 | J:277796
First Author: Merlini M
Year: 2019
Journal: Neuron
Title: Fibrinogen Induces Microglia-Mediated Spine Elimination and Cognitive Impairment in an Alzheimer's Disease Model.
Volume: 101
Issue: 6
Pages: 1099-1108.e6
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30323343 | J:282666
First Author: Ryu JK
Year: 2018
Journal: Nat Immunol
Title: Fibrin-targeting immunotherapy protects against neuroinflammation and neurodegeneration.
Volume: 19
Issue: 11
Pages: 1212-1223
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Publication
34258598 | J:348438
First Author: Tognatta R
Year: 2021
Journal: STAR Protoc
Title: In vivo two-photon microscopy protocol for imaging microglial responses and spine elimination at sites of fibrinogen deposition in mouse brain.
Volume: 2
Issue: 3
Pages: 100638
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Publication
31931285 | J:296795
 
First Author: Li X
Year: 2020
Journal: EBioMedicine
Title: OCIAD1 contributes to neurodegeneration in Alzheimer's disease by inducing mitochondria dysfunction, neuronal vulnerability and synaptic damages.
Volume: 51
Pages: 102569
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Publication
37667395 | J:340501
First Author: Jang J
Year: 2023
Journal: Acta Neuropathol Commun
Title: Abnormal accumulation of extracellular vesicles in hippocampal dystrophic axons and regulation by the primary cilia in Alzheimer's disease.
Volume: 11
Issue: 1
Pages: 142
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Publication
24055684 | J:207428
 
First Author: Buskila Y
Year: 2013
Journal: Neuroscience
Title: Synaptic deficits in layer 5 neurons precede overt structural decay in 5xFAD mice.
Volume: 254
Pages: 152-9
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Publication
36737476 | J:344602
First Author: Chen S
Year: 2023
Journal: Commun Biol
Title: Three-dimensional mapping in multi-samples with large-scale imaging and multiplexed post staining.
Volume: 6
Issue: 1
Pages: 148
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Publication
23417057 | J:214142
First Author: Crowe SE
Year: 2014
Journal: Brain Struct Funct
Title: Spine pruning in 5xFAD mice starts on basal dendrites of layer 5 pyramidal neurons.
Volume: 219
Issue: 2
Pages: 571-80
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Publication
32290105 | J:282558
 
First Author: Collin GB
Year: 2020
Journal: Cells
Title: Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.
Volume: 9
Issue: 4
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Publication
25168729 | J:215903
 
First Author: Fernandez-Echevarria C
Year: 2014
Journal: Neuroscience
Title: Aβ promotes VDAC1 channel dephosphorylation in neuronal lipid rafts. Relevance to the mechanisms of neurotoxicity in Alzheimer's disease.
Volume: 278
Pages: 354-66
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Publication
19861499 | J:154777
First Author: Aoyama T
Year: 2009
Journal: J Cell Sci
Title: Cayman ataxia protein caytaxin is transported by kinesin along neurites through binding to kinesin light chains.
Volume: 122
Issue: Pt 22
Pages: 4177-85
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Publication
1279693 | J:3302
First Author: Wasco W
Year: 1992
Journal: Proc Natl Acad Sci U S A
Title: Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.
Volume: 89
Issue: 22
Pages: 10758-62
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Publication
11839819 | J:74655
First Author: Weskamp G
Year: 2002
Journal: Mol Cell Biol
Title: Mice lacking the metalloprotease-disintegrin MDC9 (ADAM9) have no evident major abnormalities during development or adult life.
Volume: 22
Issue: 5
Pages: 1537-44
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19906677 | J:244161
First Author: Fang F
Year: 2010
Journal: FASEB J
Title: RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning/memory in a mouse model of Alzheimer's disease.
Volume: 24
Issue: 4
Pages: 1043-55
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9822620 | J:62652
First Author: Borg JP
Year: 1998
Journal: J Biol Chem
Title: Identification of an evolutionarily conserved heterotrimeric protein complex involved in protein targeting.
Volume: 273
Issue: 48
Pages: 31633-6
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Publication
28720718 | J:259183
 
First Author: Chen ZC
Year: 2017
Journal: Sci Signal
Title: Phosphorylation of amyloid precursor protein by mutant LRRK2 promotes AICD activity and neurotoxicity in Parkinson's disease.
Volume: 10
Issue: 488
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Publication
12716934 | J:83376
First Author: Li T
Year: 2003
Journal: J Neurosci
Title: Nicastrin is required for assembly of presenilin/gamma-secretase complexes to mediate Notch signaling and for processing and trafficking of beta-amyloid precursor protein in mammals.
Volume: 23
Issue: 8
Pages: 3272-7
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Publication
16174740 | J:101417
First Author: Andersen OM
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Neuronal sorting protein-related receptor sorLA/LR11 regulates processing of the amyloid precursor protein.
Volume: 102
Issue: 38
Pages: 13461-6
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Publication
9890987 | J:52276
First Author: Tomita S
Year: 1999
Journal: J Biol Chem
Title: Interaction of a neuron-specific protein containing PDZ domains with Alzheimer's amyloid precursor protein.
Volume: 274
Issue: 4
Pages: 2243-54
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Publication
22731248 | J:187639
First Author: Yang GZ
Year: 2012
Journal: J Neurochem
Title: Huntingtin associated protein 1 regulates trafficking of the amyloid precursor protein and modulates amyloid beta levels in neurons.
Volume: 122
Issue: 5
Pages: 1010-22
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Publication
21199326 | J:205664
First Author: Mishra M
Year: 2011
Journal: J Cell Mol Med
Title: P60TRP interferes with the GPCR/secretase pathway to mediate neuronal survival and synaptogenesis.
Volume: 15
Issue: 11
Pages: 2462-77
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Publication
20610758 | J:161773
First Author: Kocherhans S
Year: 2010
Journal: J Neurosci
Title: Reduced Reelin expression accelerates amyloid-beta plaque formation and tau pathology in transgenic Alzheimer's disease mice.
Volume: 30
Issue: 27
Pages: 9228-40
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Publication
21693591 | J:179191
First Author: Skyberg JA
Year: 2011
Journal: J Leukoc Biol
Title: Apple polyphenols require T cells to ameliorate dextran sulfate sodium-induced colitis and dampen proinflammatory cytokine expression.
Volume: 90
Issue: 6
Pages: 1043-54
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Publication
21880910 | J:176224
First Author: Li X
Year: 2011
Journal: J Neurosci
Title: Neuronal production of transthyretin in human and murine Alzheimer's disease: is it protective?
Volume: 31
Issue: 35
Pages: 12483-90
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Publication
17360897 | J:119470
First Author: Sontag E
Year: 2007
Journal: J Neurosci
Title: Protein phosphatase 2A methyltransferase links homocysteine metabolism with tau and amyloid precursor protein regulation.
Volume: 27
Issue: 11
Pages: 2751-9
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Publication
34690696 | J:312506
 
First Author: Westmark PR
Year: 2021
Journal: Front Mol Neurosci
Title: Testing Fmr1 KO Phenotypes in Response to GSK3 Inhibitors: SB216763 versus AFC03127.
Volume: 14
Pages: 751307
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Publication
25452762 | J:323481
 
First Author: Renoux AJ
Year: 2014
Journal: Front Genet
Title: Fragile X mental retardation protein expression in Alzheimer's disease.
Volume: 5
Pages: 360
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Publication
7522168 | J:112989
First Author: Libert C
Year: 1994
Journal: Eur J Immunol
Title: Response of interleukin-6-deficient mice to tumor necrosis factor-induced metabolic changes and lethality.
Volume: 24
Issue: 9
Pages: 2237-42
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Publication
19289507 | J:149372
First Author: Quinton LJ
Year: 2009
Journal: Infect Immun
Title: Mechanisms of the hepatic acute-phase response during bacterial pneumonia.
Volume: 77
Issue: 6
Pages: 2417-26
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Publication
23745722 | J:203972
First Author: Austin SA
Year: 2013
Journal: J Neurochem
Title: Endothelial nitric oxide deficiency promotes Alzheimer's disease pathology.
Volume: 127
Issue: 5
Pages: 691-700
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Publication
20607864 | J:168042
First Author: Kodam A
Year: 2010
Journal: Glia
Title: Altered levels and distribution of amyloid precursor protein and its processing enzymes in Niemann-Pick type C1-deficient mouse brains.
Volume: 58
Issue: 11
Pages: 1267-81
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Publication
38830763 | J:351462
 
First Author: Zhang K
Year: 2024
Journal: J Neurosci
Title: Norepinephrine Drives Sleep Fragmentation Activation of Asparagine Endopeptidase, Locus Ceruleus Degeneration, and Hippocampal Amyloid-β(42) Accumulation.
Volume: 44
Issue: 28
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Publication
22883210 | J:283334
First Author: Hammerschmidt T
Year: 2013
Journal: Biol Psychiatry
Title: Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP/PS1 mice.
Volume: 73
Issue: 5
Pages: 454-63
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Publication
14980721 | J:89996
First Author: Yang Y
Year: 2004
Journal: Neuroscience
Title: Presenilin-1 deficiency impairs glutamate-evoked intracellular calcium responses in neurons.
Volume: 124
Issue: 3
Pages: 501-5
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Publication
15128703 | J:91235
First Author: Tournoy J
Year: 2004
Journal: Hum Mol Genet
Title: Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice.
Volume: 13
Issue: 13
Pages: 1321-31
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Publication
15582748 | J:101963
First Author: Petit-Turcotte C
Year: 2005
Journal: Neurobiol Aging
Title: The apoE receptor apoER2 is involved in the maintenance of efficient synaptic plasticity.
Volume: 26
Issue: 2
Pages: 195-206
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Publication
31189938 | J:281589
First Author: Qin K
Year: 2019
Journal: Sci Rep
Title: "Dual Disease" TgAD/GSS mice exhibit enhanced Alzheimer's disease pathology and reveal PrPC-dependent secretion of Aβ.
Volume: 9
Issue: 1
Pages: 8524
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Publication
18562603 | J:135902
First Author: Maier M
Year: 2008
Journal: J Neurosci
Title: Complement C3 deficiency leads to accelerated amyloid beta plaque deposition and neurodegeneration and modulation of the microglia/macrophage phenotype in amyloid precursor protein transgenic mice.
Volume: 28
Issue: 25
Pages: 6333-41
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Publication
29995210 | J:289241
First Author: Khan SS
Year: 2018
Journal: Acta Neuropathol
Title: Bidirectional modulation of Alzheimer phenotype by alpha-synuclein in mice and primary neurons.
Volume: 136
Issue: 4
Pages: 589-605
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Publication
20530204 | J:163411
First Author: Sander LE
Year: 2010
Journal: J Exp Med
Title: Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function.
Volume: 207
Issue: 7
Pages: 1453-64
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Publication
31921164 | J:284624
 
First Author: Detanico T
Year: 2019
Journal: Front Immunol
Title: Co-expression Networks Identify DHX15 RNA Helicase as a B Cell Regulatory Factor.
Volume: 10
Pages: 2903
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Publication
23038755 | J:341942
First Author: Kraft AW
Year: 2013
Journal: FASEB J
Title: Attenuating astrocyte activation accelerates plaque pathogenesis in APP/PS1 mice.
Volume: 27
Issue: 1
Pages: 187-98
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Publication
15678112 | J:105268
First Author: Chen H
Year: 2005
Journal: J Cereb Blood Flow Metab
Title: Na(+)-dependent chloride transporter (NKCC1)-null mice exhibit less gray and white matter damage after focal cerebral ischemia.
Volume: 25
Issue: 1
Pages: 54-66
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Publication
22993429 | J:188282
First Author: Fitz NF
Year: 2012
Journal: J Neurosci
Title: Abca1 deficiency affects Alzheimer's disease-like phenotype in human ApoE4 but not in ApoE3-targeted replacement mice.
Volume: 32
Issue: 38
Pages: 13125-36
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Publication
28106559 | J:271876
First Author: Fitz NF
Year: 2017
Journal: J Alzheimers Dis
Title: ABCA1 Deficiency Affects Basal Cognitive Deficits and Dendritic Density in Mice.
Volume: 56
Issue: 3
Pages: 1075-1085
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Publication
16207713 | J:105902
First Author: Koldamova R
Year: 2005
Journal: J Biol Chem
Title: Lack of ABCA1 considerably decreases brain ApoE level and increases amyloid deposition in APP23 mice.
Volume: 280
Issue: 52
Pages: 43224-35
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Publication
20881129 | J:164876
First Author: Lane RF
Year: 2010
Journal: J Neurosci
Title: Diabetes-associated SorCS1 regulates Alzheimer's amyloid-beta metabolism: evidence for involvement of SorL1 and the retromer complex.
Volume: 30
Issue: 39
Pages: 13110-5
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Publication
19176820 | J:144825
First Author: Rose JB
Year: 2009
Journal: J Neurosci
Title: Neuropeptide Y fragments derived from neprilysin processing are neuroprotective in a transgenic model of Alzheimer's disease.
Volume: 29
Issue: 4
Pages: 1115-25
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Publication
22044482 | J:182717
First Author: Hoshino T
Year: 2012
Journal: J Neurochem
Title: Improvement of cognitive function in Alzheimer's disease model mice by genetic and pharmacological inhibition of the EP(4) receptor.
Volume: 120
Issue: 5
Pages: 795-805
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Publication
23365231 | J:193889
First Author: Kaufmann MR
Year: 2013
Journal: J Neurosci
Title: Dysregulation of hypoxia-inducible factor by presenilin/γ-secretase loss-of-function mutations.
Volume: 33
Issue: 5
Pages: 1915-26
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Publication
34958873 | J:351594
 
First Author: Wang ZH
Year: 2022
Journal: Prog Neurobiol
Title: Neuronal ApoE4 stimulates C/EBPβ activation, promoting Alzheimer's disease pathology in a mouse model.
Volume: 209
Pages: 102212
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Publication
25728909 | J:224563
First Author: Vnencak M
Year: 2015
Journal: J Comp Neurol
Title: Deletion of the amyloid precursor-like protein 1 (APLP1) enhances excitatory synaptic transmission, reduces network inhibition but does not impair synaptic plasticity in the mouse dentate gyrus.
Volume: 523
Issue: 11
Pages: 1717-29
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Publication
30031059 | J:352676
 
First Author: Ren R
Year: 2018
Journal: Life Sci
Title: Specific deletion connexin43 in astrocyte ameliorates cognitive dysfunction in APP/PS1 mice.
Volume: 208
Pages: 175-191
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Publication
20371803 | J:159624
First Author: Jorissen E
Year: 2010
Journal: J Neurosci
Title: The disintegrin/metalloproteinase ADAM10 is essential for the establishment of the brain cortex.
Volume: 30
Issue: 14
Pages: 4833-44
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Publication
15229191 | J:92095
First Author: Mann KM
Year: 2004
Journal: Hum Mol Genet
Title: Independent effects of APOE on cholesterol metabolism and brain Abeta levels in an Alzheimer disease mouse model.
Volume: 13
Issue: 17
Pages: 1959-68
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Publication
19074039 | J:143045
First Author: Her LS
Year: 2008
Journal: J Neurosci
Title: Enhanced sensitivity of striatal neurons to axonal transport defects induced by mutant huntingtin.
Volume: 28
Issue: 50
Pages: 13662-72
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Publication
22184106 | J:182777
First Author: Ma SL
Year: 2012
Journal: J Biol Chem
Title: Prolyl isomerase Pin1 promotes amyloid precursor protein (APP) turnover by inhibiting glycogen synthase kinase-3β (GSK3β) activity: novel mechanism for Pin1 to protect against Alzheimer disease.
Volume: 287
Issue: 10
Pages: 6969-73
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Publication
34140411 | J:338510
 
First Author: Wu Z
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Neurotrophic signaling deficiency exacerbates environmental risks for Alzheimer's disease pathogenesis.
Volume: 118
Issue: 25
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Publication
14960573 | J:89471
First Author: Mackey SL
Year: 2004
Journal: J Biol Chem
Title: CCAAT enhancer-binding protein alpha is required for interleukin-6 receptor alpha signaling in newborn hepatocytes.
Volume: 279
Issue: 16
Pages: 16206-13
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Publication
30594669 | J:291320
 
First Author: Song HL
Year: 2019
Journal: Mol Cell Neurosci
Title: Ouabain activates transcription factor EB and exerts neuroprotection in models of Alzheimer's disease.
Volume: 95
Pages: 13-24
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Publication
22511594 | J:185280
First Author: Cossec JC
Year: 2012
Journal: Hum Mol Genet
Title: Trisomy for synaptojanin1 in Down syndrome is functionally linked to the enlargement of early endosomes.
Volume: 21
Issue: 14
Pages: 3156-72
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Publication
23926248 | J:199866
First Author: Prox J
Year: 2013
Journal: J Neurosci
Title: Postnatal disruption of the disintegrin/metalloproteinase ADAM10 in brain causes epileptic seizures, learning deficits, altered spine morphology, and defective synaptic functions.
Volume: 33
Issue: 32
Pages: 12915-28, 12928a
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Publication
38920631 | J:360321
 
First Author: Rombaut B
Year: 2024
Journal: Cells
Title: Early Inhibition of Phosphodiesterase 4B (PDE4B) Instills Cognitive Resilience in APPswe/PS1dE9 Mice.
Volume: 13
Issue: 12
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Publication
14701757 | J:285020
First Author: Christensen MA
Year: 2004
Journal: Mol Cell Biol
Title: Transcriptional regulation of BACE1, the beta-amyloid precursor protein beta-secretase, by Sp1.
Volume: 24
Issue: 2
Pages: 865-74
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Publication
29016862 | J:250498
First Author: Singh BK
Year: 2017
Journal: Hum Mol Genet
Title: Ube3a deficiency inhibits amyloid plaque formation in APPswe/PS1δE9 mouse model of Alzheimer's disease.
Volume: 26
Issue: 20
Pages: 4042-4054
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Publication
22114267 | J:178060
First Author: Mazzitelli S
Year: 2011
Journal: J Neurosci
Title: The loss of c-Jun N-terminal protein kinase activity prevents the amyloidogenic cleavage of amyloid precursor protein and the formation of amyloid plaques in vivo.
Volume: 31
Issue: 47
Pages: 16969-76
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Publication
23838176 | J:211719
First Author: Stumm C
Year: 2013
Journal: Neurobiol Aging
Title: Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition.
Volume: 34
Issue: 11
Pages: 2574-84
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Publication
33149111 | J:355722
First Author: Mishra V
Year: 2020
Journal: Nat Commun
Title: Systematic elucidation of neuron-astrocyte interaction in models of amyotrophic lateral sclerosis using multi-modal integrated bioinformatics workflow.
Volume: 11
Issue: 1
Pages: 5579
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Publication
25316599 | J:329737
First Author: Joshi G
Year: 2015
Journal: Neurobiol Aging
Title: Increased Alzheimer's disease-like pathology in the APP/ PS1ΔE9 mouse model lacking Nrf2 through modulation of autophagy.
Volume: 36
Issue: 2
Pages: 664-79
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Publication
9278386 | J:42742
First Author: Itoh T
Year: 1997
Journal: J Biol Chem
Title: Unaltered secretion of beta-amyloid precursor protein in gelatinase A (matrix metalloproteinase 2)-deficient mice.
Volume: 272
Issue: 36
Pages: 22389-92
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Publication
20445063 | J:160557
First Author: Gimbel DA
Year: 2010
Journal: J Neurosci
Title: Memory impairment in transgenic Alzheimer mice requires cellular prion protein.
Volume: 30
Issue: 18
Pages: 6367-74
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20881126 | J:164877
First Author: Houeland G
Year: 2010
Journal: J Neurosci
Title: Transgenic mice with chronic NGF deprivation and Alzheimer's disease-like pathology display hippocampal region-specific impairments in short- and long-term plasticities.
Volume: 30
Issue: 39
Pages: 13089-94
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Publication
12388777 | J:79991
First Author: Rozmahel R
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: Alleles at the Nicastrin locus modify presenilin 1- deficiency phenotype.
Volume: 99
Issue: 22
Pages: 14452-7
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Publication
21471357 | J:171188
First Author: Hoshino T
Year: 2011
Journal: J Neurosci
Title: Suppression of Alzheimer's disease-related phenotypes by expression of heat shock protein 70 in mice.
Volume: 31
Issue: 14
Pages: 5225-34
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Publication
23472157 | J:200200
First Author: He P
Year: 2013
Journal: PLoS One
Title: Chronic administration of anti-stroke herbal medicine TongLuoJiuNao reduces amyloidogenic processing of amyloid precursor protein in a mouse model of Alzheimer's disease.
Volume: 8
Issue: 3
Pages: e58181
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Publication
25194880 | J:218438
First Author: Wu Y
Year: 2015
Journal: Neurobiol Aging
Title: Amyloid-β precursor protein facilitates the regulator of calcineurin 1-mediated apoptosis by downregulating proteasome subunit α type-5 and proteasome subunit β type-7.
Volume: 36
Issue: 1
Pages: 169-77
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Publication
24269917 | J:259960
 
First Author: Koldamova R
Year: 2014
Journal: Neurobiol Dis
Title: Genome-wide approaches reveal EGR1-controlled regulatory networks associated with neurodegeneration.
Volume: 63
Pages: 107-14
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Publication
38216110 | J:360270
 
First Author: Xu M
Year: 2024
Journal: Exp Neurol
Title: PCSK6 exacerbates Alzheimer's disease pathogenesis by promoting MT5-MMP maturation.
Volume: 374
Pages: 114688
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