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Type Details Score
Interaction Experiment
Description: Ligand-of-Numb protein X is an endocytic scaffold for junctional adhesion molecule 4.
Interaction Experiment
Description: Bach2 represses plasma cell gene regulatory network in B cells to promote antibody class switch.
Interaction Experiment
Description: Ubiquitin-specific protease-14 reduces cellular aggregates and protects against mutant huntingtin-induced cell degeneration: involvement of the proteasome and ER stress-activated kinase IRE1
Interaction Experiment
Description: Tripartite Motif-containing 33 (TRIM33) protein functions in the poly(ADP-ribose) polymerase (PARP)-dependent DNA damage response through interaction with Amplified in Liver Cancer 1 (ALC1) protein.
Interaction Experiment
Description: Cytolethal Distending Toxins Require Components of the ER-Associated Degradation Pathway for Host Cell Entry.
Interaction Experiment
Description: KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.
Interaction Experiment
Description: Regulation of mTOR and cell growth in response to energy stress by REDD1.
Interaction Experiment
Description: Grail controls Th2 cell development by targeting STAT6 for degradation.
Interaction Experiment
Description: Regulation of neuronal survival and morphology by the E3 ubiquitin ligase RNF157.
Interaction Experiment
Description: Fam65b is important for formation of the HDAC6-dysferlin protein complex during myogenic cell differentiation.
Interaction Experiment
Description: Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair.
Interaction Experiment
Description: SUMO regulates proteasome-dependent degradation of FLASH/Casp8AP2.
Interaction Experiment
Description: Targeted disruption of neuronal 19S proteasome subunits induces the formation of ubiquitinated inclusions in the absence of cell death.
Interaction Experiment
Description: Processing body movement in Arabidopsis thaliana depends on an interaction between myosins and DCP1.
Interaction Experiment
Description: Grsf1-induced translation of the SNARE protein Use1 is required for expansion of the erythroid compartment.
Interaction Experiment
Description: Clasps are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts.
Interaction Experiment
Description: Parkin regulates kainate receptors by interacting with the GluK2 subunit.
Interaction Experiment
Description: Regulation of E2F1-induced apoptosis by poly(ADP-ribosyl)ation.
Interaction Experiment
Description: Gonadotropin gene transcription is activated by menin-mediated effects on the chromatin.
Interaction Experiment
Description: Alternatively spliced proline-rich cassettes link WNK1 to aldosterone action.
Interaction Experiment
Description: The effects of WW2/WW3 domains of Smurf2 molecule on TGF- signaling and arginase I gene expression.
Interaction Experiment
Description: Control of glioblastoma tumorigenesis by feed-forward cytokine signaling.
Interaction Experiment
Description: Apolipoprotein E controls ATP-binding cassette transporters in the ischemic brain.
Interaction Experiment
Description: Phosphorylation of CHO1 by Lats1/2 regulates the centrosomal activation of LIMK1 during cytokinesis.
Interaction Experiment
Description: P14ARF inhibits human glioblastoma-induced angiogenesis by upregulating the expression of TIMP3.
Interaction Experiment
Description: Toll-like Receptor (TLR) Signaling Interacts with CREBH to Modulate High-density Lipoprotein (HDL) in Response to Bacterial Endotoxin.
Interaction Experiment
Description: Disruption of the Phosphate Transporter Pit1 in Hepatocytes Improves Glucose Metabolism and Insulin Signaling by Modulating the USP7/IRS1 Interaction.
Interaction Experiment
Description: Forkhead transcription factor FoxF1 interacts with Fanconi anemia protein complexes to promote DNA damage response.
Interaction Experiment
Description: Protein interactome mining defines melatonin MT1 receptors as integral component of presynaptic protein complexes of neurons.
Interaction Experiment
Description: EHBP1L1 coordinates Rab8 and Bin1 to regulate apical-directed transport in polarized epithelial cells.
Interaction Experiment
Description: Serine/threonine phosphorylation of ShcA. Regulation of protein-tyrosine phosphatase-pest binding and involvement in insulin signaling.
Interaction Experiment
Description: p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis.
Interaction Experiment
Description: Smurf2-Mediated Stabilization of DNA Topoisomerase II Controls Genomic Integrity.
Interaction Experiment
Description: USP9X counteracts differential ubiquitination of NPHP5 by MARCH7 and BBS11 to regulate ciliogenesis.
Interaction Experiment
Description: p62/SQSTM1 by Binding to Vitamin D Receptor Inhibits Hepatic Stellate Cell Activity, Fibrosis, and Liver Cancer.
Interaction Experiment
Description: Structural insight into the specific interaction between murine SHPS-1/SIRP alpha and its ligand CD47.
Interaction Experiment
Description: Cross-activating c-Met/1 integrin complex drives metastasis and invasive resistance in cancer.
Interaction Experiment
Description: Conserved regulation of the Jak/STAT pathway by the endosomal protein asrij maintains stem cell potency.
Interaction Experiment
Description: Specific dephosphorylation at tyr-554 of git1 by ptprz promotes its association with paxillin and hic-5.
Interaction Experiment
Description: Calsyntenin-1 docks vesicular cargo to kinesin-1.
Interaction Experiment
Description: Cyclin-dependent kinase 5 (CDK5) regulates the circadian clock.
Interaction Experiment
Description: Interactome of vertebrate GAF/ThPOK reveals its diverse functions in gene regulation and DNA repair.
Interaction Experiment
Description: Ephrin Bs are essential components of the Reelin pathway to regulate neuronal migration.
Interaction Experiment
Description: APache Is an AP2-Interacting Protein Involved in Synaptic Vesicle Trafficking and Neuronal Development.
Interaction Experiment
Description: DNAJC17 is localized in nuclear speckles and interacts with splicing machinery components.
Interaction Experiment
Description: gamma-Syntrophin scaffolding is spatially and functionally distinct from that of the alpha/beta syntrophins.
Interaction Experiment
Description: DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal Inflammation via Expansion of Gamma-Delta T Cells.
Interaction Experiment
Description: Autophagy genes in myeloid cells counteract IFN?-induced TNF-mediated cell death and fatal TNF-induced shock.
Interaction Experiment
Description: CATACOMB: An endogenous inducible gene that antagonizes H3K27 methylation activity of Polycomb repressive complex 2 via an H3K27M-like mechanism.
Interaction Experiment
Description: Two distinct modes of DNMT1 recruitment ensure stable maintenance DNA methylation.
Interaction Experiment
Description: ?arrestin-1 regulates DNA repair by acting as an E3-ubiquitin ligase adaptor for 53BP1.
Interaction Experiment
Description: Identification of transmembrane protein 168 mutation in familial Brugada syndrome.
Interaction Experiment
Description: Alternative splicing of the mouse profilin II gene generates functionally different profilin isoforms.
Interaction Experiment
Description: Overlapping binding sites for importin ?1 and suppressor of fused (SuFu) on glioma-associated oncogene homologue 1 (Gli1) regulate its nuclear localization.
Interaction Experiment
Description: PIAS1 and TIF1? collaborate to promote SnoN SUMOylation and suppression of epithelial-mesenchymal transition.
Interaction Experiment
Description: Cell adhesion molecule close homolog of L1 binds to the dopamine receptor D2 and inhibits the internalization of its short isoform.
Interaction Experiment
Description: Expression of mRNA and protein-protein interaction of the antiviral endoribonuclease RNase L in mouse spleen.
Interaction Experiment
Description: Probing cellular protein complexes using single-molecule pull-down.
Interaction Experiment
Description: ATM loss disrupts the autophagy-lysosomal pathway.
Interaction Experiment
Description: STUB1/CHIP promotes ubiquitination and degradation of HIV-1 Vif to restore the cellular level of APOBEC3G protein.
Interaction Experiment
Description: The autophagy protein ATG16L1 cooperates with IFT20 and INPP5E to regulate the turnover of phosphoinositides at the primary cilium.
Interaction Experiment
Description: The RNA helicase DHX16 recognizes specific viral RNA to trigger RIG-I-dependent innate antiviral immunity.
Interaction Experiment
Description: ALS-linked loss of Cyclin-F function affects HSP90.
Interaction Experiment
Description: The Zip4 protein directly couples meiotic crossover formation to synaptonemal complex assembly.
Interaction Experiment
Description: A20 controls RANK-dependent osteoclast formation and bone physiology.
Interaction Experiment
Description: CBP-HSF2 structural and functional interplay in Rubinstein-Taybi neurodevelopmental disorder.
Interaction Experiment
Description: cBAF complex components and MYC cooperate early in CD8+ T cell fate.
Interaction Experiment
Description: ESYT1 tethers the ER to mitochondria and is required for mitochondrial lipid and calcium homeostasis.
Interaction Experiment
Description: Identification of new ciliary signaling pathways in the brain and insights into neurological disorders.
Interaction Experiment
Description: Ser46 phosphorylation and prolyl-isomerase Pin1-mediated isomerization of p53 are key events in p53-dependent apoptosis induced by mutant huntingtin.
Interaction Experiment
Description: Dynamic regulation of inter-organelle communication by ubiquitylation controls skeletal muscle development and disease onset.
Interaction Experiment
Description: Osteopontin depletion in macrophages perturbs proteostasis via regulating UCHL1-UPS axis and mitochondria-mediated apoptosis.
Interaction Experiment
Description: Biodistribution and Cellular Internalization of Inactivated SARS-CoV-2 in Wild-Type Mice.
Interaction Experiment
Description: Differential subcellular localization of the two alternatively spliced isoforms of the Kv3.1 potassium channel subunit in brain.
Interaction Experiment
Description: The Dnmt3a PWWP domain reads histone 3 lysine 36 trimethylation and guides DNA methylation.
Interaction Experiment
Description: Cloning and characterization of rat casein kinase 1epsilon.
Interaction Experiment
Description: Characterization of the EFC/F-BAR domain protein, FCHO2.
Interaction Experiment
Description: Targeted mutagenesis of Lis1 disrupts cortical development and LIS1 homodimerization.
Interaction Experiment
Description: Spartin recruits PKC- via the PKC--interacting proteins ZIP1 and ZIP3 to lipid droplets.
Interaction Experiment
Description: Functional interaction between mouse erbB3 and wild-type rat c-neu in transgenic mouse mammary tumor cells.
Interaction Experiment
Description: Control of biochemical reactions through supramolecular RING domain self-assembly.
Publication
First Author: Ray A
Year: 2012
Journal: Mol Cell Neurosci
Title: IgSF8: a developmentally and functionally regulated cell adhesion molecule in olfactory sensory neuron axons and synapses.
Volume: 50
Issue: 3-4
Pages: 238-49
Publication        
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
Publication  
First Author: Ewart-Toland A
Year: 2004
Journal: Toxicol Pathol
Title: The genetics of cancer susceptibility: from mouse to man.
Volume: 32 Suppl 1
Pages: 26-30
Publication
First Author: Ludwig A
Year: 1998
Journal: Nature
Title: A family of hyperpolarization-activated mammalian cation channels.
Volume: 393
Issue: 6685
Pages: 587-91
Publication
First Author: Hazel TG
Year: 1988
Journal: Proc Natl Acad Sci U S A
Title: A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.
Volume: 85
Issue: 22
Pages: 8444-8
Publication
First Author: Risco A
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: p38γ and p38δ kinases regulate the Toll-like receptor 4 (TLR4)-induced cytokine production by controlling ERK1/2 protein kinase pathway activation.
Volume: 109
Issue: 28
Pages: 11200-5
Protein Coding Gene
Type: protein_coding_gene
Organism: mouse, laboratory
Publication  
First Author: Skoda J
Year: 2022
Journal: Biochem Pharmacol
Title: Off-target lipid metabolism disruption by the mouse constitutive androstane receptor ligand TCPOBOP in humanized mice.
Volume: 197
Pages: 114905
Publication
First Author: Durand A
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Functional intestinal stem cells after Paneth cell ablation induced by the loss of transcription factor Math1 (Atoh1).
Volume: 109
Issue: 23
Pages: 8965-70
Publication
First Author: Ohta A
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: A2A adenosine receptor protects tumors from antitumor T cells.
Volume: 103
Issue: 35
Pages: 13132-7
GO Term
Publication
First Author: Galloway A
Year: 2016
Journal: Science
Title: RNA-binding proteins ZFP36L1 and ZFP36L2 promote cell quiescence.
Volume: 352
Issue: 6284
Pages: 453-9
Publication
First Author: Sen A
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Innate immune response to homologous rotavirus infection in the small intestinal villous epithelium at single-cell resolution.
Volume: 109
Issue: 50
Pages: 20667-72
Publication
First Author: Wijesekara N
Year: 2012
Journal: Diabetes
Title: miR-33a modulates ABCA1 expression, cholesterol accumulation, and insulin secretion in pancreatic islets.
Volume: 61
Issue: 3
Pages: 653-8
Publication
First Author: Al-Shami A
Year: 2013
Journal: J Immunol
Title: Integrin-α FG-GAP repeat-containing protein 2 is critical for normal B cell differentiation and controls disease development in a lupus model.
Volume: 191
Issue: 7
Pages: 3789-98
Publication  
First Author: Odunsi A
Year: 2020
Journal: J Immunother Cancer
Title: Fidelity of human ovarian cancer patient-derived xenografts in a partially humanized mouse model for preclinical testing of immunotherapies.
Volume: 8
Issue: 2
Genotype
Symbol: A/A Pepd/Pepd
Background: involves: C3H/HeJ * CBA/J
Zygosity: cx
Has Mutant Allele: true
Publication
First Author: Dutour A
Year: 1997
Journal: Eur J Endocrinol
Title: A new step understood in the cascade of tissue-specific regulators orchestrating pituitary lineage determination: the Prophet of Pit-1 (Prop-1).
Volume: 137
Issue: 6
Pages: 616-7
Publication
First Author: James NR
Year: 2016
Journal: Science
Title: Translational termination without a stop codon.
Volume: 354
Issue: 6318
Pages: 1437-1440