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Search results 5901 to 6000 out of 8285 for C2

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Type Details Score
Publication
21565611 | J:173396
First Author: Sang L
Year: 2011
Journal: Cell
Title: Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways.
Volume: 145
Issue: 4
Pages: 513-28
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Protein Coding Gene
MGI:2385277 | Ctu1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
12578829 | J:83108
First Author: Fukuda M
Year: 2003
Journal: J Biol Chem
Title: Distinct Rab binding specificity of Rim1, Rim2, rabphilin, and Noc2. Identification of a critical determinant of Rab3A/Rab27A recognition by Rim2.
Volume: 278
Issue: 17
Pages: 15373-80
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Publication
24705606 | J:213752
First Author: Ramalingam L
Year: 2014
Journal: Diabetologia
Title: Doc2b enrichment enhances glucose homeostasis in mice via potentiation of insulin secretion and peripheral insulin sensitivity.
Volume: 57
Issue: 7
Pages: 1476-84
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Publication
29506054 | J:357907
First Author: Aslamy A
Year: 2018
Journal: J Clin Endocrinol Metab
Title: Exocytosis Protein DOC2B as a Biomarker of Type 1 Diabetes.
Volume: 103
Issue: 5
Pages: 1966-1976
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Publication
30376688 | J:267541
First Author: Inman KE
Year: 2018
Journal: Dev Dyn
Title: Foxc2 is required for proper cardiac neural crest cell migration, outflow tract septation, and ventricle expansion.
Volume: 247
Issue: 12
Pages: 1286-1296
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Publication
27368196 | J:320193
First Author: Golder ZJ
Year: 2016
Journal: BMC Cell Biol
Title: Extra-renal locations of the a4 subunit of H(+)ATPase.
Volume: 17
Issue: 1
Pages: 27
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Publication
8562047 | J:28424
First Author: Palis J
Year: 1995
Journal: Mol Reprod Dev
Title: Differential gene expression during early murine yolk sac development.
Volume: 42
Issue: 1
Pages: 19-27
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Protein
Q62077
Organism: Mus musculus/domesticus
Length: 1302  
Fragment?: false
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Protein
Q2M4I9
Organism: Mus musculus/domesticus
Length: 1178  
Fragment?: false
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Protein
Q3UZ68
Organism: Mus musculus/domesticus
Length: 1178  
Fragment?: false
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Protein
A2A4A6
Organism: Mus musculus/domesticus
Length: 1290  
Fragment?: false
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Publication
17350798 | J:121808
First Author: Tamura M
Year: 2007
Journal: Genomics
Title: Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner.
Volume: 89
Issue: 5
Pages: 618-29
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Publication
9799614 | J:47258
First Author: Royaux I
Year: 1998
Journal: Genomics
Title: A DnaJ-like gene, Hsj2, maps to mouse chromosome 5, at approximately 24 cM from the centromere.
Volume: 53
Issue: 3
Pages: 415
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Publication
8375339 | J:11921
First Author: Sasaki H
Year: 1993
Journal: Development
Title: Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo.
Volume: 118
Issue: 1
Pages: 47-59
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Publication
9115736 | J:39117
First Author: Saito N
Year: 1997
Journal: Neuron
Title: KIFC2 is a novel neuron-specific C-terminal type kinesin superfamily motor for dendritic transport of multivesicular body-like organelles.
Volume: 18
Issue: 3
Pages: 425-38
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Publication
9858566 | J:51700
First Author: Liu B
Year: 1999
Journal: Mol Cell Biol
Title: FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals.
Volume: 19
Issue: 1
Pages: 424-30
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Publication
17360972 | J:127489
First Author: Nath S
Year: 2007
Journal: Mol Biol Cell
Title: Kif5B and Kifc1 interact and are required for motility and fission of early endocytic vesicles in mouse liver.
Volume: 18
Issue: 5
Pages: 1839-49
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Publication
31216030 | J:322374
First Author: Rezazadeh S
Year: 2019
Journal: Nucleic Acids Res
Title: SIRT6 promotes transcription of a subset of NRF2 targets by mono-ADP-ribosylating BAF170.
Volume: 47
Issue: 15
Pages: 7914-7928
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Publication
37767708 | J:341378
First Author: Iyer D
Year: 2023
Journal: Arterioscler Thromb Vasc Biol
Title: eNOS Regulates Lymphatic Valve Specification by Controlling β-Catenin Signaling During Embryogenesis in Mice.
Volume: 43
Issue: 11
Pages: 2197-2212
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Publication
18545664 | J:137147
First Author: Hayashi H
Year: 2008
Journal: PLoS One
Title: Foxc transcription factors directly regulate Dll4 and Hey2 expression by interacting with the VEGF-Notch signaling pathways in endothelial cells.
Volume: 3
Issue: 6
Pages: e2401
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Publication
10660670 | J:60307
First Author: Pressman CL
Year: 2000
Journal: Genesis
Title: LMX1B, a LIM homeodomain class transcription factor, is necessary for normal development of multiple tissues in the anterior segment of the murine eye.
Volume: 26
Issue: 1
Pages: 15-25
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Publication
8666231 | J:33767
First Author: Hatini V
Year: 1996
Journal: Genes Dev
Title: Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2.
Volume: 10
Issue: 12
Pages: 1467-78
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Publication
18369153 | J:138461
First Author: Paradkar PN
Year: 2008
Journal: Blood
Title: Iron depletion limits intracellular bacterial growth in macrophages.
Volume: 112
Issue: 3
Pages: 866-74
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Publication
23974113 | J:214711
First Author: Tuoc TC
Year: 2013
Journal: Cell Cycle
Title: BAF chromatin remodeling complex: cortical size regulation and beyond.
Volume: 12
Issue: 18
Pages: 2953-9
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Publication
37988464 | J:349394
First Author: Fattinger SA
Year: 2023
Journal: Proc Natl Acad Sci U S A
Title: Gasdermin D is the only Gasdermin that provides protection against acute Salmonella gut infection in mice.
Volume: 120
Issue: 48
Pages: e2315503120
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Publication
21059267 | J:166893
 
First Author: Côté M
Year: 2010
Journal: BMC Dev Biol
Title: Apolipoprotein C-II and lipoprotein lipase show a temporal and geographic correlation with surfactant lipid synthesis in preparation for birth.
Volume: 10
Pages: 111
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Publication
7961887 | J:21503
First Author: Fukuda M
Year: 1994
Journal: J Biol Chem
Title: Inositol-1,3,4,5-tetrakisphosphate binding to C2B domain of IP4BP/synaptotagmin II.
Volume: 269
Issue: 46
Pages: 29206-11
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Protein Domain
IPR043567 | SYTL1-5_C2B
Type: Domain
Description: Synaptotagmin-like proteins (Slps) contain a N-terminal RabBD (Rab-binding) domain and two C-terminal C2 domains, C2A and C2B []. The characteristic feature of the Slp family is the N-terminal domain (referred to as SHD for Slp Homology Domain), which is not found in other C-type tandem C2 proteins []. SHD functions as a specific Rab27A/B-binding domain []. This entry represents the C2B domain. The C2 domain is a Ca2+-dependent membrane-targeting module found in many cellular proteins involved in signal transduction or membrane trafficking. C2 domains are unique among membrane targeting domains in that they show wide range of lipid selectivity for the major components of cell membranes, including phosphatidylserine and phosphatidylcholine. This C2 domain is about 116 amino-acid residues and is located between the two copies of the C1 domain in Protein Kinase C and the protein kinase catalytic domain []. Regions with significant homology []to the C2-domain have been found in many proteins. The C2 domain is thought to be involved in calcium-dependent phospholipid binding []and in membrane targetting processes such as subcellular localisation. The 3D structure of the C2 domain of synaptotagmin has been reported[], the domain forms an eight-stranded β-sandwich constructed around a conserved 4-stranded motif, designated a C2 key []. Calcium binds in a cup-shaped depression formed by the N- and C-terminal loops of the C2-key motif. Structural analyses of several C2 domains have shown them to consist of similar ternary structures in which three Ca2+-binding loops are located at the end of an 8 stranded antiparallel β-sandwich.
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Protein Domain
IPR037303 | SLP-4/5_C2A
Type: Domain
Description: Synaptotagmin-like proteins (Slps) contain a N-terminal RabBD (Rab-binding) domain and two C-terminal C2 domains, C2A and C2B []. The characteristic feature of the Slp family is the N-terminal domain (referred to as SHD for Slp Homology Domain), which is not found in other C-type tandem C2 proteins []. SHD functions as a specific Rab27A/B-binding domain []. The C2B domain of Slp4 (also known as Granuphilin) interact with the plasma membrane lipid phosphatidylinositol-(4,5)-bisphosphate [PI(4,5)P2][]. C2 domains fold into an 8-standed β-sandwich that can adopt 2 structural arrangements, type I and type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin andintersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions [, , , , , , , ].
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Protein Domain
IPR013184 | Lactococcus_phage_c2_E2
Type: Family
Description: This is a family of short conserved proteins of 37 amino acids, described in Lactococcus phage c2 and in related phage. The function of these proteins is unknown.
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Protein Domain
IPR013583 | PRibTrfase_C
Type: Domain
Description: This domain is found at the C terminus of phosphoribosyltransferases and phosphoribosyltransferase-like proteins. It contains putative transmembrane regions. It often appears together with calcium-ion dependent C2 domains ().
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Protein
Q6AXC6
Organism: Mus musculus/domesticus
Length: 906  
Fragment?: false
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Protein
O08811
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
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Protein
Q5SXJ3
Organism: Mus musculus/domesticus
Length: 1174  
Fragment?: false
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Protein
Q0VGM9
Organism: Mus musculus/domesticus
Length: 1203  
Fragment?: false
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Protein
A0A2Y9CZM3
Organism: Mus musculus/domesticus
Length: 880  
Fragment?: false
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Protein
Q8K223
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
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Protein
E9Q6K1
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
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Protein
F6YA33
Organism: Mus musculus/domesticus
Length: 684  
Fragment?: true
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Protein
Q3UKK7
Organism: Mus musculus/domesticus
Length: 760  
Fragment?: false
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Protein
Q3TER9
Organism: Mus musculus/domesticus
Length: 898  
Fragment?: true
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Publication
10508862 | J:57915
First Author: Wang X
Year: 1999
Journal: J Cell Biol
Title: Aczonin, a 550-kD putative scaffolding protein of presynaptic active zones, shares homology regions with Rim and Bassoon and binds profilin.
Volume: 147
Issue: 1
Pages: 151-62
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Publication
19948740 | J:159941
First Author: Wan T
Year: 2010
Journal: J Biol Chem
Title: AIP1 functions as Arf6-GAP to negatively regulate TLR4 signaling.
Volume: 285
Issue: 6
Pages: 3750-7
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Publication
28772122 | -
First Author: Michelassi F
Year: 2017
Journal: Neuron
Title: A C1-C2 Module in Munc13 Inhibits Calcium-Dependent Neurotransmitter Release.
Volume: 95
Issue: 3
Pages: 577-590.e5
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Protein Domain
IPR037302 | Unc-13_C2B
Type: Domain
Description: C. elegans Unc-13 is a phorbol ester/diacylglycerol-binding protein that plays a role in vesicle maturation during exocytosis [, ]. Unc-13 disruption causes diverse defects in the nervous system [, ]. Mammals contain three Unc-13 homologues: Unc-13 A, B and C (also known as Munc13-1/2/3) []. Unc13 homologue C is cerebellum-specific and regulates cerebellar synaptic transmission []. Homologues A and B are involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion []. They are essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses [].Unc-13 and its homologues contain both C1 and C2 domains. There are at least two C2 related domains present, one central and one at the carboxyl end. Munc13-1 contains a third C2-like domain. The central C2 domain (C2B) is part of a C1-C2 tandem that functions in part to inhibit calcium-triggered neurotransmitter release. The C1 domain of Munc13 binds diacylglycerol (DAG) and beta phorbol esters (beta-PEs), while the neighbouring C2 domain (C2B) binds calcium and anionic phospholipids with a preference for both PI(4)P and PI(4,5)P2 []. This entry represents the second C2 domain, C2B, and has a type-II topology.C2 domains fold into an 8-standed β-sandwich that can adopt 2 structural arrangements, type I and type II, distinguished by a circular permutation involving their N- and C-terminal beta strands. Many C2 domains are Ca2+-dependent membrane-targeting modules that bind a wide variety of substances including phospholipids, inositol polyphosphates, and intracellular proteins. Most C2 domain proteins are either signal transduction enzymes that contain a single C2 domain, such as protein kinase C, or membrane trafficking proteins which contain at least two C2 domains, such as synaptotagmin 1. However, there are a few exceptions to this including RIM isoforms and some splice variants of piccolo/aczonin and intersectin which only have a single C2 domain. C2 domains with a calcium binding region have negatively charged residues, primarily aspartates, that serve as ligands for calcium ions [, , , , , , , ].
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Publication
26091037 | J:223512
First Author: Dow LE
Year: 2015
Journal: Cell
Title: Apc Restoration Promotes Cellular Differentiation and Reestablishes Crypt Homeostasis in Colorectal Cancer.
Volume: 161
Issue: 7
Pages: 1539-1552
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Publication
37083555 | J:354941
   
First Author: Kwok SJJ
Year: 2023
Journal: Elife
Title: Single-cell transcriptomics of a dynamic cell behavior in murine airways.
Volume: 12
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Publication
12788067 | J:84023
First Author: Fukuda M
Year: 2003
Journal: Biochem Biophys Res Commun
Title: Molecular cloning and characterization of human, rat, and mouse synaptotagmin XV.
Volume: 306
Issue: 1
Pages: 64-71
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Publication
11439176 | -
First Author: Wishart MJ
Year: 2001
Journal: Cell
Title: Phoxy lipids: revealing PX domains as phosphoinositide binding modules.
Volume: 105
Issue: 7
Pages: 817-20
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Protein
A2BE28
Organism: Mus musculus/domesticus
Length: 776  
Fragment?: false
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Publication
23175604 | -
First Author: Castle CD
Year: 2013
Journal: Nucleic Acids Res
Title: Las1 interacts with Grc3 polynucleotide kinase and is required for ribosome synthesis in Saccharomyces cerevisiae.
Volume: 41
Issue: 2
Pages: 1135-50
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Publication
26638174 | -
First Author: Gasse L
Year: 2015
Journal: Mol Cell
Title: Coordinated Ribosomal ITS2 RNA Processing by the Las1 Complex Integrating Endonuclease, Polynucleotide Kinase, and Exonuclease Activities.
Volume: 60
Issue: 5
Pages: 808-815
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Publication
28652339 | -
First Author: Pillon MC
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Grc3 programs the essential endoribonuclease Las1 for specific RNA cleavage.
Volume: 114
Issue: 28
Pages: E5530-E5538
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Publication
29440475 | -
First Author: Pillon MC
Year: 2018
Journal: RNA
Title: Characterization of the molecular crosstalk within the essential Grc3/Las1 pre-rRNA processing complex.
Volume: 24
Issue: 5
Pages: 721-738
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Protein Domain
IPR007174 | Las1
Type: Family
Description: Las1 is an endoribonuclease responsible for cleavage at the C2 site during pre-rRNA processing []. It interacts with Grc3 polynucleotide kinase and is required for ribosome synthesis []. Las1-mediated C2 cleavage depends on the functional integrity of the associated Grc3 phosphotransferase, while phosphorylation of the 26S pre-rRNA by Grc3 relies on a functionally competent Las1 nuclease [, ].
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Publication
12432077 | -
First Author: Côté JF
Year: 2002
Journal: J Cell Sci
Title: Identification of an evolutionarily conserved superfamily of DOCK180-related proteins with guanine nucleotide exchange activity.
Volume: 115
Issue: Pt 24
Pages: 4901-13
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Publication
19123136 | J:142493
First Author: Escalante-Alcalde D
Year: 2009
Journal: Int J Dev Biol
Title: Generation of a reporter-null allele of Ppap2b/Lpp3and its expression during embryogenesis.
Volume: 53
Issue: 1
Pages: 139-47
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Allele
Dysf<im> | MGI:1857883
Name: dysferlin; inflammatory myopathy
Allele Type: Spontaneous
Attribute String: Null/knockout
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Publication
14517301 | J:85960
First Author: Takenaka K
Year: 2003
Journal: Mol Cell Biol
Title: Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling.
Volume: 23
Issue: 20
Pages: 7329-38
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Allele
Syngap1<tm1Rlh> | MGI:3576223
Name: synaptic Ras GTPase activating protein 1 homolog (rat); targeted mutation 1, Richard L Huganir
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Pik3c2b<tm1.1Pkha> | MGI:3611683
Name: phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta; targeted mutation 1.1, Paul A Khavari
Allele Type: Targeted
Attribute String: Null/knockout
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Allele
Unc13d<Jinx> | MGI:3628822
 
Name: unc-13 homolog D; Jinx
Allele Type: Chemically induced (ENU)
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Allele
Del(MTmt-Tk-mt-Nd5)1Jiha | MGI:3776665
Name: deletion, MT, Jun-Ichi Hayashi 1
Allele Type: Spontaneous
Attribute String: Null/knockout
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Publication
11017072 | J:65025
First Author: Inoue K
Year: 2000
Journal: Nat Genet
Title: Generation of mice with mitochondrial dysfunction by introducing mouse mtDNA carrying a deletion into zygotes.
Volume: 26
Issue: 2
Pages: 176-81
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Publication
23853091 | J:218365
First Author: Katada S
Year: 2013
Journal: G3 (Bethesda)
Title: Mitochondrial DNA with a large-scale deletion causes two distinct mitochondrial disease phenotypes in mice.
Volume: 3
Issue: 9
Pages: 1545-52
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Publication
16120309 | J:192157
First Author: Nakada K
Year: 2002
Journal: Mitochondrion
Title: A novel defense system of mitochondria in mice and human subjects for preventing expression of mitochondrial dysfunction by pathogenic mutant mtDNAs.
Volume: 2
Issue: 1-2
Pages: 59-70
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Publication
15953585 | J:132407
First Author: Ishikawa K
Year: 2005
Journal: Biochem Biophys Res Commun
Title: Application of ES cells for generation of respiration-deficient mice carrying mtDNA with a large-scale deletion.
Volume: 333
Issue: 2
Pages: 590-5
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Publication
16275929 | J:103743
First Author: Sato A
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Gene therapy for progeny of mito-mice carrying pathogenic mtDNA by nuclear transplantation.
Volume: 102
Issue: 46
Pages: 16765-70
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Publication
20816751 | J:165855
First Author: Nishiyama S
Year: 2010
Journal: Biochem Biophys Res Commun
Title: Over-expression of Tfam improves the mitochondrial disease phenotypes in a mouse model system.
Volume: 401
Issue: 1
Pages: 26-31
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Publication
20600007 | J:165039
First Author: Inoue S
Year: 2010
Journal: FEBS Lett
Title: Mitochondrial respiration defects modulate differentiation but not proliferation of hematopoietic stem and progenitor cells.
Volume: 584
Issue: 15
Pages: 3402-9
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Publication
17005726 | J:115155
First Author: Nakada K
Year: 2006
Journal: Proc Natl Acad Sci U S A
Title: Mitochondria-related male infertility.
Volume: 103
Issue: 41
Pages: 15148-53
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Publication
11688994 | J:72614
First Author: Nakada K
Year: 2001
Journal: Biochem Biophys Res Commun
Title: Correlation of functional and ultrastructural abnormalities of mitochondria in mouse heart carrying a pathogenic mutant mtDNA with a 4696-bp deletion.
Volume: 288
Issue: 4
Pages: 901-7
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Publication
16613898 | J:307849
First Author: Inoue S
Year: 2006
Journal: Hum Mol Genet
Title: Suppression of disease phenotypes of adult mito-mice carrying pathogenic mtDNA by bone marrow transplantation.
Volume: 15
Issue: 11
Pages: 1801-7
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Publication
15382041 | J:92536
First Author: Iavnilovitch E
Year: 2004
Journal: Int J Cancer
Title: Deregulation of Stat5 expression and activation causes mammary tumors in transgenic mice.
Volume: 112
Issue: 4
Pages: 607-19
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Allele
Lgr5<tm1(cre/ERT2)Fjs> | MGI:5294796
Name: leucine rich repeat containing G protein coupled receptor 5; targeted mutation 1, Frederick J de Sauvage
Allele Type: Targeted
Attribute String: Inducible, Null/knockout, Recombinase
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Allele
Lgr5<tm2(Hbegf/EGFP)Fjs> | MGI:5294798
Name: leucine rich repeat containing G protein coupled receptor 5; targeted mutation 2, Frederick J de Sauvage
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout, Reporter
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Allele
Col1a1<tm1.1(tetO-mStrawberry/Atg4b*C74A)Kmln> | MGI:6111715
Name: collagen, type I, alpha 1; targeted mutation 1.1, Bjorn Knollmann
Allele Type: Targeted
Attribute String: Inducible, Inserted expressed sequence, Reporter
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Allele
Tg(tetO-Doc2b,-EGFP)#Dct | MGI:6199045
Name: transgene insertion, Debbie C Thurmond
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
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Publication
39181879 | J:359008
First Author: Kawai T
Year: 2024
Journal: Nat Commun
Title: The significance of electrical signals in maturing spermatozoa for phosphoinositide regulation through voltage-sensing phosphatase.
Volume: 15
Issue: 1
Pages: 7289
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Genotype
Genotype
Symbol: Plcl2/Plcl2
Background: involves: 129P2/OlaHsd
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Hras/Hras Syngap1/Syngap1<+>
Background: involves: 129P2/OlaHsd * MF1
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Pik3c2b/Pik3c2b
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(MTmt-Tk-mt-Nd5)1Jiha/?
Background: involves: C57BL/6J * CBA
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(MTmt-Tk-mt-Nd5)1Jiha/?
Background: involves: C57BL/6J * CBA * DBA/2
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Ighm/Ighm Igkc/Igkc Igl/Igl
Background: involves: 129
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Plpp3/Plpp3
Background: involves: 129S1/Sv * C57BL/6J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Del(MTmt-Tk-mt-Nd5)1Jiha/?
Background: involves: C57BL/6JJcl * C57BL/6NCrlj * CBA/JNCrlj
Zygosity: ot
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Plpp3/Plpp3<+>
Background: involves: 129S1/Sv * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Publication
28195124 | J:244538
 
First Author: Fujii K
Year: 2017
Journal: Nat Commun
Title: Pervasive translational regulation of the cell signalling circuitry underlies mammalian development.
Volume: 8
Pages: 14443
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Genotype
Genotype
Symbol: Wwc1/Wwc1 Wwc2/Wwc2 Speer6-ps1/Speer6-ps1<+>
Background: involves: 129 * C57BL/6 * C57BL/6J * DBA
Zygosity: cn
Has Mutant Allele: true
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Publication
8840145 | J:34760
First Author: Watanabe Y
Year: 1996
Journal: Exp Anim
Title: Chromosomal mapping of human angiotensinogen gene and human renin gene by fluorescence in situ hybridization (FISH) in transgenic mice.
Volume: 45
Issue: 3
Pages: 265-9
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Publication
11773082 | J:75312
First Author: Kuroda TS
Year: 2002
Journal: J Biol Chem
Title: The Slp homology domain of synaptotagmin-like proteins 1-4 and Slac2 functions as a novel Rab27A binding domain.
Volume: 277
Issue: 11
Pages: 9212-8
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Publication
25005332 | J:218125
First Author: Li J
Year: 2014
Journal: Diabetologia
Title: DOC2 isoforms play dual roles in insulin secretion and insulin-stimulated glucose uptake.
Volume: 57
Issue: 10
Pages: 2173-82
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Publication
11716773 | J:73334
First Author: Fukuda M
Year: 2001
Journal: Biochem J
Title: The N-terminal cysteine cluster is essential for membrane targeting of B/K protein.
Volume: 360
Issue: Pt 2
Pages: 441-8
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Publication
30992372 | J:276133
First Author: Yang CY
Year: 2019
Journal: J Neurosci
Title: Conditional Deletion of CC2D1A Reduces Hippocampal Synaptic Plasticity and Impairs Cognitive Function through Rac1 Hyperactivation.
Volume: 39
Issue: 25
Pages: 4959-4975
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Publication
27220631 | -
First Author: Wang H
Year: 2016
Journal: J Mol Biol
Title: Structure of Human GIVD Cytosolic Phospholipase A2 Reveals Insights into Substrate Recognition.
Volume: 428
Issue: 13
Pages: 2769-79
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Protein Domain
IPR025219 | PLCC
Type: Family
Description: A small family of bacterial proteins, found in several Bacteroides species. Structure determination (NMR and Xray) shows an immunoglobulin β-barrel fold. Multiple homologues have been found in human gut metagenomics data sets. Structural experimentation shows it to share features with two well-established protein architectures in the SCOP database, ie, C2 (calcium/lipid-binding domain) of the C2 domain ()and the PLAT/LH2 domain (). The C2 and PLAT/LH2 domains bind Ca2+ in their functions of targeting proteins to cell-membranes; this domain is also shown to bind Ca2+ as well as to be a novel fold [].
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Protein Domain
IPR040723 | cPLA2_C2
Type: Domain
Description: Cytosolic phospholipases A2 (cPLA2s) consist of a family of calcium-sensitive enzymes that function to generate lipid second messengers through hydrolysis of membrane-associated glycerophospholipids. In humans, the cPLA2 family contains six isoforms. Structural information of full length cPLA2alpha apo form, shows that it is composed of two domains; an N-terminal Ca2 + binding C2 domain and a C-terminal alpha/beta hydrolase core. This entry describes the N-terminal Ca2+ binding C2 domain which is composed of an eight-stranded antiparallel β-sandwich consisting of two four-stranded β-sheets. C2 domains are present in many lipid-binding proteins including Copines, CAPRI and Rabphilin-3A all of which are involved in membrane trafficking [].
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Publication
25343783 | J:244666
First Author: Han Y
Year: 2015
Journal: J Neurophysiol
Title: RIM1 and RIM2 redundantly determine Ca2+ channel density and readily releasable pool size at a large hindbrain synapse.
Volume: 113
Issue: 1
Pages: 255-63
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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