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Search results 5901 to 6000 out of 7671 for Th

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Type Details Score
Publication
24235143 | J:207186
First Author: Broege A
Year: 2013
Journal: J Biol Chem
Title: Bone morphogenetic proteins signal via SMAD and mitogen-activated protein (MAP) kinase pathways at distinct times during osteoclastogenesis.
Volume: 288
Issue: 52
Pages: 37230-40
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Publication
25217661 | J:222195
First Author: Ryu MH
Year: 2014
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Chronic exposure to perfluorinated compounds: Impact on airway hyperresponsiveness and inflammation.
Volume: 307
Issue: 10
Pages: L765-74
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Publication
25522163 | J:223980
First Author: Kim HS
Year: 2015
Journal: Stem Cells
Title: Human umbilical cord blood mesenchymal stem cell-derived PGE2 and TGF-β1 alleviate atopic dermatitis by reducing mast cell degranulation.
Volume: 33
Issue: 4
Pages: 1254-66
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Publication
25693145 | J:224183
First Author: Zheng F
Year: 2015
Journal: PLoS Genet
Title: Systemic delivery of microRNA-101 potently inhibits hepatocellular carcinoma in vivo by repressing multiple targets.
Volume: 11
Issue: 2
Pages: e1004873
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Publication
26490858 | J:226688
First Author: Kedar GH
Year: 2015
Journal: J Neurosci
Title: A Post-Docking Role of Synaptotagmin 1-C2B Domain Bottom Residues R398/399 in Mouse Chromaffin Cells.
Volume: 35
Issue: 42
Pages: 14172-82
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Publication
26045618 | J:228577
First Author: Yu C
Year: 2015
Journal: Am J Physiol Gastrointest Liver Physiol
Title: Mitochondrial STAT3 contributes to transformation of Barrett's epithelial cells that express oncogenic Ras in a p53-independent fashion.
Volume: 309
Issue: 3
Pages: G146-61
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Publication
25278292 | J:230469
First Author: Straub AC
Year: 2014
Journal: Arterioscler Thromb Vasc Biol
Title: Hemoglobin α/eNOS coupling at myoendothelial junctions is required for nitric oxide scavenging during vasoconstriction.
Volume: 34
Issue: 12
Pages: 2594-600
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Publication
26747769 | J:231020
First Author: Kojima T
Year: 2015
Journal: Invest Ophthalmol Vis Sci
Title: Effects of Oxidative Stress on the Conjunctiva in Cu, Zn-Superoxide Dismutase-1 (Sod1)-Knockout Mice.
Volume: 56
Issue: 13
Pages: 8382-91
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Publication
27590741 | J:236857
First Author: Jung JG
Year: 2016
Journal: Cancer Res
Title: Ovarian Cancer Chemoresistance Relies on the Stem Cell Reprogramming Factor PBX1.
Volume: 76
Issue: 21
Pages: 6351-6361
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Publication
28053109 | J:239532
 
First Author: Ashley SL
Year: 2017
Journal: J Virol
Title: Matrix Metalloproteinase Activity in Infections by an Encephalitic Virus, Mouse Adenovirus Type 1.
Volume: 91
Issue: 6
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Publication
27126641 | J:242426
First Author: Li Q
Year: 2016
Journal: Mamm Genome
Title: Mouse genome-wide association study identifies polymorphisms on chromosomes 4, 11, and 15 for age-related cardiac fibrosis.
Volume: 27
Issue: 5-6
Pages: 179-90
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Publication
28524857 | J:268916
First Author: Stein M
Year: 2017
Journal: Cell Death Differ
Title: A defined metabolic state in pre B cells governs B-cell development and is counterbalanced by Swiprosin-2/EFhd1.
Volume: 24
Issue: 7
Pages: 1239-1252
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Publication
30342159 | J:270480
First Author: Nigro C
Year: 2019
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Methylglyoxal accumulation de-regulates HoxA5 expression, thereby impairing angiogenesis in glyoxalase 1 knock-down mouse aortic endothelial cells.
Volume: 1865
Issue: 1
Pages: 73-85
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Publication
25506936 | J:274739
First Author: Morgan AP
Year: 2014
Journal: PLoS One
Title: The antipsychotic olanzapine interacts with the gut microbiome to cause weight gain in mouse.
Volume: 9
Issue: 12
Pages: e115225
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Publication
30962539 | J:279022
First Author: Pais H
Year: 2019
Journal: Sci Rep
Title: Surfaceome interrogation using an RNA-seq approach highlights leukemia initiating cell biomarkers in an LMO2 T cell transgenic model.
Volume: 9
Issue: 1
Pages: 5760
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Publication
21323770 | J:279673
First Author: Lee J
Year: 2011
Journal: Int J Exp Pathol
Title: Transgenic overexpression of p23 induces spontaneous hydronephrosis in mice.
Volume: 92
Issue: 4
Pages: 251-9
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Publication
31431460 | J:280002
First Author: Chuang HC
Year: 2019
Journal: Cancer Res
Title: MAP4K3/GLK Promotes Lung Cancer Metastasis by Phosphorylating and Activating IQGAP1.
Volume: 79
Issue: 19
Pages: 4978-4993
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Publication
21242463 | J:283444
First Author: Sparks MA
Year: 2011
Journal: Hypertension
Title: Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension.
Volume: 57
Issue: 3
Pages: 577-85
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Publication
19420084 | J:286406
First Author: Rockx B
Year: 2009
Journal: J Virol
Title: Early upregulation of acute respiratory distress syndrome-associated cytokines promotes lethal disease in an aged-mouse model of severe acute respiratory syndrome coronavirus infection.
Volume: 83
Issue: 14
Pages: 7062-74
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Publication
32853266 | J:295937
First Author: Jo W
Year: 2020
Journal: PLoS One
Title: Association of smoking with incident CKD risk in the general population: A community-based cohort study.
Volume: 15
Issue: 8
Pages: e0238111
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Publication
32491248 | J:297518
First Author: Yeung JHY
Year: 2020
Journal: J Neurochem
Title: Amyloid-beta1-42 induced glutamatergic receptor and transporter expression changes in the mouse hippocampus.
Volume: 155
Issue: 1
Pages: 62-80
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Publication
32755598 | J:300093
First Author: Liu YM
Year: 2020
Journal: Cell Rep
Title: A Carbohydrate-Binding Protein from the Edible Lablab Beans Effectively Blocks the Infections of Influenza Viruses and SARS-CoV-2.
Volume: 32
Issue: 6
Pages: 108016
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Publication
32948685 | J:303628
First Author: Sokulsky LA
Year: 2020
Journal: J Immunol
Title: A Critical Role for the CXCL3/CXCL5/CXCR2 Neutrophilic Chemotactic Axis in the Regulation of Type 2 Responses in a Model of Rhinoviral-Induced Asthma Exacerbation.
Volume: 205
Issue: 9
Pages: 2468-2478
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Publication
27100146 | J:302850
First Author: Liu M
Year: 2016
Journal: Hepatology
Title: CHD1L promotes lineage reversion of hepatocellular carcinoma through opening chromatin for key developmental transcription factors.
Volume: 63
Issue: 5
Pages: 1544-59
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Publication
33772011 | J:303845
First Author: Saraswat D
Year: 2021
Journal: Nat Commun
Title: Overcoming the inhibitory microenvironment surrounding oligodendrocyte progenitor cells following experimental demyelination.
Volume: 12
Issue: 1
Pages: 1923
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Publication
22158267 | J:307011
First Author: Li X
Year: 2012
Journal: Int J Obes (Lond)
Title: A novel obesity model: synphilin-1-induced hyperphagia and obesity in mice.
Volume: 36
Issue: 9
Pages: 1215-21
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Publication
33767581 | J:308936
First Author: Cho EJ
Year: 2021
Journal: Int J Biol Sci
Title: Preclinical evaluation of radiation therapy of BRCA1-associated mammary tumors using a mouse model.
Volume: 17
Issue: 3
Pages: 689-701
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Publication
34239362 | J:308989
First Author: Gan CL
Year: 2021
Journal: Int J Biol Sci
Title: Inhibition of Death-associated Protein Kinase 1 protects against Epileptic Seizures in mice.
Volume: 17
Issue: 9
Pages: 2356-2366
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Publication
32213464 | J:312845
First Author: Xu YX
Year: 2020
Journal: iScience
Title: EDEM3 Modulates Plasma Triglyceride Level through Its Regulation of LRP1 Expression.
Volume: 23
Issue: 4
Pages: 100973
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Publication
33881363 | J:343917
First Author: Pati P
Year: 2021
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Liver circadian clock disruption alters perivascular adipose tissue gene expression and aortic function in mice.
Volume: 320
Issue: 6
Pages: R960-R971
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Publication
18568035 | J:314379
First Author: Shankar GM
Year: 2008
Journal: Nat Med
Title: Amyloid-beta protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory.
Volume: 14
Issue: 8
Pages: 837-42
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Publication
34433061 | J:310808
First Author: Zhang Y
Year: 2021
Journal: Cell Rep
Title: The Amot/integrin protein complex transmits mechanical forces required for vascular expansion.
Volume: 36
Issue: 8
Pages: 109616
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Publication
24922076 | J:318186
 
First Author: Kim HJ
Year: 2014
Journal: Cell Death Dis
Title: Augmentation of NAD(+) by NQO1 attenuates cisplatin-mediated hearing impairment.
Volume: 5
Pages: e1292
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Publication
27999308 | J:318381
 
First Author: Jiang HZ
Year: 2016
Journal: Int J Mol Sci
Title: Downregulation of Homer1b/c in SOD1 G93A Models of ALS: A Novel Mechanism of Neuroprotective Effect of Lithium and Valproic Acid.
Volume: 17
Issue: 12
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Publication
29128406 | J:331020
 
First Author: Pinheiro CR
Year: 2018
Journal: Cytokine
Title: Recognition of Candida albicans by gingival fibroblasts: The role of TLR2, TLR4/CD14, and MyD88.
Volume: 106
Pages: 67-75
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Publication
34461306 | J:335380
 
First Author: Del Rio ML
Year: 2022
Journal: Transl Res
Title: The impact of CD160 deficiency on alloreactive CD8 T cell responses and allograft rejection.
Volume: 239
Pages: 103-123
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Publication
37047547 | J:334733
 
First Author: Alanazi MM
Year: 2023
Journal: Int J Mol Sci
Title: Cadmium Exposure Is Associated with Behavioral Deficits and Neuroimmune Dysfunction in BTBR T(+) Itpr3tf/J Mice.
Volume: 24
Issue: 7
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Publication
36920908 | J:342752
First Author: Hahn AM
Year: 2023
Journal: Cell Rep
Title: A monoclonal Trd chain supports the development of the complete set of functional γδ T cell lineages.
Volume: 42
Issue: 3
Pages: 112253
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Publication
37367944 | J:343783
 
First Author: Bouch RJ
Year: 2023
Journal: J Exp Med
Title: Distinct inflammatory Th17 subsets emerge in autoimmunity and infection.
Volume: 220
Issue: 10
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Publication
17158205 | J:356461
First Author: Huh JI
Year: 2007
Journal: Endocrinology
Title: 2-methoxyestradiol induces mammary gland differentiation through amphiregulin-epithelial growth factor receptor-mediated signaling: molecular distinctions from the mammary gland of pregnant mice.
Volume: 148
Issue: 3
Pages: 1266-77
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Publication
28514665 | J:356829
First Author: Greiff V
Year: 2017
Journal: Cell Rep
Title: Systems Analysis Reveals High Genetic and Antigen-Driven Predetermination of Antibody Repertoires throughout B Cell Development.
Volume: 19
Issue: 7
Pages: 1467-1478
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Publication
23395904 | -
First Author: Hsieh YL
Year: 2013
Journal: EMBO J
Title: Ubc9 acetylation modulates distinct SUMO target modification and hypoxia response.
Volume: 32
Issue: 6
Pages: 791-804
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Protein
F6W1T9
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: true
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Publication
9218782 | -
First Author: Hyvönen M
Year: 1997
Journal: EMBO J
Title: Structure of the PH domain and Btk motif from Bruton's tyrosine kinase: molecular explanations for X-linked agammaglobulinaemia.
Volume: 16
Issue: 12
Pages: 3396-404
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Publication
8070576 | -
First Author: Vihinen M
Year: 1994
Journal: FEBS Lett
Title: Tec homology (TH) adjacent to the PH domain.
Volume: 350
Issue: 2-3
Pages: 263-5
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Publication
9796816 | -
First Author: Jiang Y
Year: 1998
Journal: Nature
Title: The G protein G alpha12 stimulates Bruton's tyrosine kinase and a rasGAP through a conserved PH/BM domain.
Volume: 395
Issue: 6704
Pages: 808-13
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Publication
15661031 | -
 
First Author: Lindvall JM
Year: 2005
Journal: Immunol Rev
Title: Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling.
Volume: 203
Pages: 200-15
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Protein Domain
IPR037343 | SOCS5_SOCS
Type: Domain
Description: This entry represents the SOCS box domain of SOCS5.Suppressor of cytokine signalling (SOCS) proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS5 inhibits the IL4 signaling pathway, which promotes the Th (helper T) 2 cell development []. SOCS5 and SOCS4 regulate epidermal growth factor receptor signaling [].The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions [, ].
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Protein Domain
IPR001562 | Znf_Btk_motif
Type: Conserved_site
Description: The Btk-type zinc finger or Btk motif (BM) is a conserved zinc-binding motif containing conserved cysteines and a histidine that is present in certain eukaryotic signalling proteins. The motif is named after Bruton's tyrosine kinase (Btk), an enzyme which is essential for B cell maturation in humans and mice [, ]. Btk is a member of the Tec family of protein tyrosine kinases (PTK). These kinases contain a conserved Tec homology (TH) domain between the N-terminal pleckstrin homology (PH) domain () and the Src homology 3 (SH3) domain (). The N-terminal of the TH domain is highly conserved and known as the Btf motif, while the C-terminal region of the TH domain contains a proline-rich region (PRR). The Btk motif contains a conserved His and three Cys residues that form a zinc finger (although these differ from known zinc finger topologies), while PRRs are commonly involved in protein-protein interactions, including interactions with G proteins [, ]. The TH domain may be of functional importance in various signalling pathways in different species []. A complete TH domain, containing both the Btk and PRR regions, has not been found outside the Tec family; however, the Btk motif on its own does occur in other proteins, usually C-terminal to a PH domain (note that although a Btk motif always occurs C-terminal to a PH domain, not all PH domains are followed by a Btk motif).The crystal structures of Btk show that the Btk-type zinc finger has a globular core, formed by a long loop which is held together by a zinc ion, and that the Btk motif is packed against the PH domain []. The zinc-binding residues are a histidine and three cysteines, which are fully conserved in the Btk motif []. Proteins known to contain a Btk-type zinc finger include:Mammalian Bruton's tyrosine kinase (Btk), a protein tyrosine kinase involved in modulation of diverse cellular processes. Mutations affecting Btk are the cause of X-linked agammaglobulinemia (XLA) in humans and X-linked immunodeficiency in mice. Mammalian Tec, Bmx, and Itk proteins, which are tyrosine protein kinases of the Tec subfamily. Drosophila tyrosine-protein kinase Btk29A, which is required for the development of proper ring canals and of male genitalia and required for adult survival. Mammalian Ras GTPase-activating proteins (RasGAP), which regulate the activation of inactive GDP-bound Ras by converting GDP to GTP.
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Strain
MGI:7442150 | C57BL/6-Tg(Th-SNCA*)MI2Mgsp Del(6Snca)1Slab/J
Attribute String: coisogenic, mutant strain, transgenic, spontaneous mutation
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Publication
31165254 | J:333800
First Author: Wegrzynowicz M
Year: 2019
Journal: Acta Neuropathol
Title: Depopulation of dense α-synuclein aggregates is associated with rescue of dopamine neuron dysfunction and death in a new Parkinson's disease model.
Volume: 138
Issue: 4
Pages: 575-595
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Publication
21238448 | J:170637
First Author: Oh-McGinnis R
Year: 2011
Journal: Dev Biol
Title: Partial loss of Ascl2 function affects all three layers of the mature placenta and causes intrauterine growth restriction.
Volume: 351
Issue: 2
Pages: 277-86
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Publication
22622041 | J:190434
First Author: Hoshii T
Year: 2012
Journal: J Clin Invest
Title: mTORC1 is essential for leukemia propagation but not stem cell self-renewal.
Volume: 122
Issue: 6
Pages: 2114-29
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Allele
Tg(Th-SNCA*)1702Yosh | MGI:3757756
Name: transgene insertion 1702, Makoto Yoshimoto
Allele Type: Transgenic
Attribute String: Humanized sequence, Inserted expressed sequence
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Strain
MGI:4949657 | B6.129S4-Pglyrp2<tm1Lky>/J
Attribute String: congenic, mutant strain
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Publication
15340057 | J:159600
First Author: Xu M
Year: 2004
Journal: Mol Cell Biol
Title: Innate immune responses in peptidoglycan recognition protein L-deficient mice.
Volume: 24
Issue: 18
Pages: 7949-57
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Genotype
Genotype
Symbol: Pglyrp2/Pglyrp2
Background: involves: 129S4/SvJae * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Publication
1670919 | J:10927
First Author: Hess EJ
Year: 1991
Journal: Neuron
Title: Tottering and leaner mutations perturb transient developmental expression of tyrosine hydroxylase in embryologically distinct Purkinje cells.
Volume: 6
Issue: 1
Pages: 123-32
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Publication
19684026 | J:153719
First Author: Lefebvre L
Year: 2009
Journal: Hum Mol Genet
Title: The interval between Ins2 and Ascl2 is dispensable for imprinting centre function in the murine Beckwith-Wiedemann region.
Volume: 18
Issue: 22
Pages: 4255-67
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Publication
24832488 | J:214321
First Author: Sievert H
Year: 2014
Journal: Dis Model Mech
Title: A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation.
Volume: 7
Issue: 8
Pages: 963-76
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Publication
15888484 | J:105062
First Author: Gorgels TG
Year: 2005
Journal: Hum Mol Genet
Title: Disruption of Abcc6 in the mouse: novel insight in the pathogenesis of pseudoxanthoma elasticum.
Volume: 14
Issue: 13
Pages: 1763-73
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Publication
27843125 | -
First Author: Seymen F
Year: 2016
Journal: Am J Hum Genet
Title: Recessive Mutations in ACPT, Encoding Testicular Acid Phosphatase, Cause Hypoplastic Amelogenesis Imperfecta.
Volume: 99
Issue: 5
Pages: 1199-1205
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Publication
12668656 | J:82737
First Author: Engelholm LH
Year: 2003
Journal: J Cell Biol
Title: uPARAP/Endo180 is essential for cellular uptake of collagen and promotes fibroblast collagen adhesion.
Volume: 160
Issue: 7
Pages: 1009-15
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Publication
10051567 | J:53333
First Author: Valenzuela DM
Year: 1999
Journal: Proc Natl Acad Sci U S A
Title: Angiopoietins 3 and 4: diverging gene counterparts in mice and humans.
Volume: 96
Issue: 5
Pages: 1904-9
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Publication
8673129 | J:33734
First Author: Perou CM
Year: 1996
Journal: Nat Genet
Title: Identification of the murine beige gene by YAC complementation and positional cloning.
Volume: 13
Issue: 3
Pages: 303-8
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Publication
27518565 | J:236080
First Author: Park IY
Year: 2016
Journal: Cell
Title: Dual Chromatin and Cytoskeletal Remodeling by SETD2.
Volume: 166
Issue: 4
Pages: 950-962
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Publication
16914726 | J:112130
First Author: Suh WK
Year: 2006
Journal: Mol Cell Biol
Title: Generation and characterization of B7-H4/B7S1/B7x-deficient mice.
Volume: 26
Issue: 17
Pages: 6403-11
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Publication
19039139 | -
First Author: Singh R
Year: 2008
Journal: Science
Title: PA-824 kills nonreplicating Mycobacterium tuberculosis by intracellular NO release.
Volume: 322
Issue: 5906
Pages: 1392-5
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Publication
34578375 | -
 
First Author: Brennecke N
Year: 2021
Journal: Viruses
Title: Characterization of Prion Disease Associated with a Two-Octapeptide Repeat Insertion.
Volume: 13
Issue: 9
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Publication
22933543 | -
First Author: Dauber A
Year: 2012
Journal: J Clin Endocrinol Metab
Title: Novel microcephalic primordial dwarfism disorder associated with variants in the centrosomal protein ninein.
Volume: 97
Issue: 11
Pages: E2140-51
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Publication
19250911 | J:146216
First Author: Kirkin V
Year: 2009
Journal: Mol Cell
Title: A role for NBR1 in autophagosomal degradation of ubiquitinated substrates.
Volume: 33
Issue: 4
Pages: 505-16
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Publication
23136374 | -
First Author: Couzigou JM
Year: 2012
Journal: Plant Cell
Title: NODULE ROOT and COCHLEATA maintain nodule development and are legume orthologs of Arabidopsis BLADE-ON-PETIOLE genes.
Volume: 24
Issue: 11
Pages: 4498-510
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Publication
34610416 | J:314038
 
First Author: Kanagasabai T
Year: 2021
Journal: Cancer Lett
Title: MicroRNA-21 deficiency suppresses prostate cancer progression through downregulation of the IRS1-SREBP-1 signaling pathway.
Volume: 525
Pages: 46-54
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Publication
26383163 | J:226779
First Author: Tian Y
Year: 2015
Journal: Cancer Res
Title: Histone Deacetylase HDAC8 Promotes Insulin Resistance and β-Catenin Activation in NAFLD-Associated Hepatocellular Carcinoma.
Volume: 75
Issue: 22
Pages: 4803-16
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Publication
21593203 | J:186756
First Author: Prawitt J
Year: 2011
Journal: Diabetes
Title: Farnesoid X receptor deficiency improves glucose homeostasis in mouse models of obesity.
Volume: 60
Issue: 7
Pages: 1861-71
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Publication
19136651 | J:151045
First Author: Hwang JH
Year: 2009
Journal: Diabetes
Title: Pharmacological stimulation of NADH oxidation ameliorates obesity and related phenotypes in mice.
Volume: 58
Issue: 4
Pages: 965-74
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Publication
30600262 | J:277435
 
First Author: Schneditz G
Year: 2019
Journal: Sci Signal
Title: GPR35 promotes glycolysis, proliferation, and oncogenic signaling by engaging with the sodium potassium pump.
Volume: 12
Issue: 562
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Publication
30979776 | J:290961
 
First Author: Chen F
Year: 2019
Journal: EMBO J
Title: YY1 regulates skeletal muscle regeneration through controlling metabolic reprogramming of satellite cells.
Volume: 38
Issue: 10
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Publication
17570480 | J:122865
First Author: Zuo T
Year: 2007
Journal: Cell
Title: FOXP3 is an X-linked breast cancer suppressor gene and an important repressor of the HER-2/ErbB2 oncogene.
Volume: 129
Issue: 7
Pages: 1275-86
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Publication
27994068 | J:238779
First Author: He B
Year: 2017
Journal: J Exp Med
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