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Search results 601 to 700 out of 739 for Ada

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Type Details Score
Publication
17339464 | J:144281
First Author: Touma M
Year: 2007
Journal: J Immunol
Title: Importance of the CD3gamma ectodomain terminal beta-strand and membrane proximal stalk in thymic development and receptor assembly.
Volume: 178
Issue: 6
Pages: 3668-79
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Publication
19342663 | J:147507
First Author: Brodeur JF
Year: 2009
Journal: J Immunol
Title: Critical and multiple roles for the CD3epsilon intracytoplasmic tail in double negative to double positive thymocyte differentiation.
Volume: 182
Issue: 8
Pages: 4844-53
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Protein Domain
IPR035451 | Ada-like_dom_sf
Type: Homologous_superfamily
Description: The Escherichia coli Ada protein repairs O6-methylguanine residues and methyl phosphotriesters in DNA by direct transfer of the methyl group to a cysteine residue. This domain contains four conserved cysteines that form a zinc binding site [, ]. One of these cysteines is a methyl group acceptor. The methylated domain can then specifically bind to the ada box on a DNA duplex. The zinc binding site is located in the N-terminal region and consists of four beta strands [].The methylation of the N-terminal site of Ada induces a structural change, which is independent of the transferred methyl group but enhances the promoter affinity of a remodeled surface region, trigger of the transcriptional enhancement of the ada regulon [, ].This superfamily represents the N-terminal domain of the Ada domain as well as the C-terminal domain of some ribosomal proteins (L17 from Actinobacteria and S1 from Candidatus Peregrinibacteria).
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Publication
36346347 | J:335563
 
First Author: Schumann T
Year: 2023
Journal: J Exp Med
Title: Deficiency for SAMHD1 activates MDA5 in a cGAS/STING-dependent manner.
Volume: 220
Issue: 1
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Publication
11092970 | J:66212
First Author: Qin X
Year: 2000
Journal: Jpn J Cancer Res
Title: Protection against malignant progression of spontaneously developing liver tumors in transgenic mice expressing O(6)-methylguanine-DNA methyltransferase.
Volume: 91
Issue: 11
Pages: 1085-9
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Genotype
Genotype
Symbol: Ada/Ada Tg(Afp-ADA)#Xiay/?
Background: involves: 129S7/SvEvBrd * C3H/HeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Publication
16412509 | J:108113
First Author: Pan Q
Year: 2006
Journal: Mol Immunol
Title: Different role for mouse and human CD3delta/epsilon heterodimer in preT cell receptor (preTCR) function: human CD3delta/epsilon heterodimer restores the defective preTCR function in CD3gamma- and CD3gammadelta-deficient mice.
Volume: 43
Issue: 11
Pages: 1741-50
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Publication
10435582 | J:110456
First Author: Haks MC
Year: 1999
Journal: Immunity
Title: Pre-TCR signaling and inactivation of p53 induces crucial cell survival pathways in pre-T cells.
Volume: 11
Issue: 1
Pages: 91-101
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Publication
15452180 | J:93376
First Author: Hagenbeek TJ
Year: 2004
Journal: J Exp Med
Title: The loss of PTEN allows TCR alphabeta lineage thymocytes to bypass IL-7 and Pre-TCR-mediated signaling.
Volume: 200
Issue: 7
Pages: 883-94
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Publication
10523604 | J:114561
First Author: Jacobs H
Year: 1999
Journal: J Exp Med
Title: PIM1 reconstitutes thymus cellularity in interleukin 7- and common gamma chain-mutant mice and permits thymocyte maturation in Rag- but not CD3gamma-deficient mice.
Volume: 190
Issue: 8
Pages: 1059-68
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Publication
3780980 | J:12932
First Author: Geiger JD
Year: 1986
Journal: FEBS Lett
Title: Lack of adenosine deaminase deficiency in the mutant mouse wasted.
Volume: 208
Issue: 2
Pages: 431-4
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Publication
22363401 | J:185323
First Author: Zhou CC
Year: 2012
Journal: PLoS One
Title: Targeted expression of Cre recombinase provokes placental-specific DNA recombination in transgenic mice.
Volume: 7
Issue: 2
Pages: e29236
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Publication
14965359 | J:88757
First Author: Ishikawa T
Year: 2004
Journal: Cancer Sci
Title: DNA repair and cancer: lessons from mutant mouse models.
Volume: 95
Issue: 2
Pages: 112-7
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Allele
Tg(Ada*-cre)5Xiay | MGI:5444884
Name: transgene insertion 5, Yang Xia
Allele Type: Transgenic
Attribute String: Recombinase
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Publication
36804959 | J:340980
First Author: Chora ÂF
Year: 2023
Journal: Immunity
Title: Interplay between liver and blood stages of Plasmodium infection dictates malaria severity via γδ T cells and IL-17-promoted stress erythropoiesis.
Volume: 56
Issue: 3
Pages: 592-605.e8
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Protein
Q8R0L9
Organism: Mus musculus/domesticus
Length: 432  
Fragment?: false
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Protein
A0A0R4J1I2
Organism: Mus musculus/domesticus
Length: 232  
Fragment?: false
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Protein
Q3V3H2
Organism: Mus musculus/domesticus
Length: 164  
Fragment?: false
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Publication
8413201 | -
First Author: Piña B
Year: 1993
Journal: Mol Cell Biol
Title: ADA3: a gene, identified by resistance to GAL4-VP16, with properties similar to and different from those of ADA2.
Volume: 13
Issue: 10
Pages: 5981-9
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Publication
17272277 | -
First Author: Nag A
Year: 2007
Journal: J Biol Chem
Title: An essential role of human Ada3 in p53 acetylation.
Volume: 282
Issue: 12
Pages: 8812-20
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Protein Domain
IPR019340 | Histone_AcTrfase_su3
Type: Family
Description: This entry is found in Ada3 and homologous proteins which function as part of histone acetyltransferase complexes []. Ada3 is an essential component of the Ada transcriptional coactivator (alteration/deficiency in activation) complex. It plays a key role in linking histone acetyltransferase-containing complexes to p53 (tumour suppressor protein) thereby regulating p53 acetylation, stability and transcriptional activation following DNA damage [].
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Strain
MGI:6780714 | B6.FVB-Tg(Ada*-cre)5Xiay/J
Attribute String: congenic, transgenic, mutant strain
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Genotype
Genotype
Symbol: Ada/Ada Adora2b/Adora2b Tg(Afp-ADA)#Xiay/?
Background: involves: 129P2/OlaHsd * 129S7/SvEvBrd * C3H/HeJ * C57BL/6J
Zygosity: cx
Has Mutant Allele: true
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Publication
18829440 | -
First Author: Bowles T
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: Structure and DNA binding of alkylation response protein AidB.
Volume: 105
Issue: 40
Pages: 15299-304
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Publication
9732461 | -
First Author: Krasko A
Year: 1998
Journal: J Mol Evol
Title: Identification and expression of the SOS response, aidB-like, gene in the marine sponge Geodia cydonium: implication for the phylogenetic relationships of metazoan acyl-CoA dehydrogenases and acyl-CoA oxidases.
Volume: 47
Issue: 3
Pages: 343-52
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Publication
3278898 | -
First Author: Volkert MR
Year: 1988
Journal: Environ Mol Mutagen
Title: Adaptive response of Escherichia coli to alkylation damage.
Volume: 11
Issue: 2
Pages: 241-55
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Publication
12220590 | -
First Author: Kleibl K
Year: 2002
Journal: Mutat Res
Title: Molecular mechanisms of adaptive response to alkylating agents in Escherichia coli and some remarks on O(6)-methylguanine DNA-methyltransferase in other organisms.
Volume: 512
Issue: 1
Pages: 67-84
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Publication
25981666 | -
First Author: Ma DK
Year: 2015
Journal: Cell
Title: Acyl-CoA Dehydrogenase Drives Heat Adaptation by Sequestering Fatty Acids.
Volume: 161
Issue: 5
Pages: 1152-1163
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Protein Domain
IPR034184 | AidB
Type: Family
Description: AidB is one of several genes involved in the SOS adaptive response to DNA alkylation damage, whose expression is activated by the Ada protein [, ]. Its function has not been entirely elucidated; however, it is similar in sequence and function to acyl-CoA dehydrogenases [, ]. It has been proposed that aidB directly destroys DNA alkylating agents such as nitrosoguanidines (nitrosated amides) or their reaction intermediates [, ].
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Publication
10903440 | -
First Author: Li S
Year: 2000
Journal: Gene
Title: A family of genes with growth factor and adenosine deaminase similarity are preferentially expressed in the salivary glands of Glossina m. morsitans.
Volume: 252
Issue: 1-2
Pages: 83-93
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Publication
18032387 | -
First Author: Iijima R
Year: 2008
Journal: J Biol Chem
Title: The extracellular adenosine deaminase growth factor, ADGF/CECR1, plays a role in Xenopus embryogenesis via the adenosine/P1 receptor.
Volume: 283
Issue: 4
Pages: 2255-64
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Publication
17439545 | -
First Author: Zhang J
Year: 2007
Journal: Insect Mol Biol
Title: Molecular characterization of MbADGF, a novel member of the adenosine deaminase-related growth factor in the cabbage armyworm, Mamestra brassicae: the functional roles in the midgut cell proliferation.
Volume: 16
Issue: 3
Pages: 351-60
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Publication
15579078 | -
First Author: Akalal DB
Year: 2004
Journal: Curr Pharm Des
Title: Mollusk-derived growth factor and the new subfamily of adenosine deaminase-related growth factors.
Volume: 10
Issue: 31
Pages: 3893-900
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Publication
15907156 | -
First Author: Dolezal T
Year: 2005
Journal: PLoS Biol
Title: A role for adenosine deaminase in Drosophila larval development.
Volume: 3
Issue: 7
Pages: e201
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Protein Domain
IPR006331 | ADGF
Type: Family
Description: Members of this family have been described as secreted proteins with growth factor activity and regions of adenosine deaminase homology in insects, molluscs, and vertebrates [].Adenosine deaminase-related growth factors (ADGF) are also known as CECR1 in vertebrates. They are a novel family of growth factors with sequence similarity to classical cellular adenosine deaminase. In Xenopus, it is essential for growth factor activity and is expressed in the somites, pronephros, eyes, cement gland, neural tube, and neural floor plate of the embryos []. It is also essential for insect development []. The mollusc derived growth factor (MDGF) is a member of the adenosine deaminase-related growth factor (ADGF) subfamily. ADGFs from vertebrates and invertebrates contain both an ADA domain and a novel N-terminal region of about 100 amino acids []. Adenosine deaminase (ADA) is an enzyme that catalyses the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine []. Catalytic residues involved in ADA activity are conserved in ADGFs, and inhibitors of ADA can block ADGF activity [].
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Publication
33770509 | J:309689
First Author: Kusuyama J
Year: 2021
Journal: Cell Metab
Title: Placental superoxide dismutase 3 mediates benefits of maternal exercise on offspring health.
Volume: 33
Issue: 5
Pages: 939-956.e8
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Publication
36480593 | J:344568
First Author: Xu P
Year: 2023
Journal: Cell Prolif
Title: AMPK regulates homeostasis of invasion and viability in trophoblasts by redirecting glucose metabolism: Implications for pre-eclampsia.
Volume: 56
Issue: 2
Pages: e13358
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Publication
17301242 | J:219098
First Author: Wiper-Bergeron N
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPbeta by GCN5.
Volume: 104
Issue: 8
Pages: 2703-8
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Protein
E9Q1F7
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: true
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Protein
F6ZCH1
Organism: Mus musculus/domesticus
Length: 66  
Fragment?: true
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Protein
F6SIC5
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: true
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Protein Domain
IPR037800 | GCN5
Type: Family
Description: This entry includes histone acetyltransferases GCN5, KAT2A and KAT2B (all of which are included in ). GCN5 acetylates histones H2B, H3 and H4, providing a specific tag for epigenetic transcription activation. GCN5 is a component of the transcription regulatory histone acetylation (HAT) complexes SAGA [], SLIK [], SALSA []and ADA []. Mammals have two paralogues: KAT2A (also known as GCN5) and KAT2B. KAT2A acetylates core histones to provide a specific tag for epigenetic transcription activation, but not nucleosome core particles. It also acetylates proteins such as CEBPB []. KAT2A is a component of the ATAC complex, which has acetyltransferase activity on histones H3 and H4 []. KAT2B (also known as P300/calcium-binding protein (CBP)-associated factor or PCAF) can acetylate the core histones H3 and H4 as well as nucleosome core particles and non-histone proteins such as ACLY [].The transcription regulatory histone acetylation complex Spt-Ada-Gcn5 acetyltransferase (SAGA) is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. SAGA preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B []. SAGA is known as PCAF in vertebrates and PCAF acetylates nucleosomal histone H3 []. The SAGA complex consists of at least TRA1, CHD1, SPT7, TAF5, ADA3, SGF73, SPT20/ADA5, SPT8, TAF12, TAF6, HFI1/ADA1, UBP8, GCN5, ADA2, SPT3, SGF29, TAF10, TAF9, SGF11 and SUS1, and some of these components are present as two copies. The complex is built up from distinct modules, each of which has a separate function and crosslinks with either other proteins or other modules in the complex [].SLIK (SAGA-like) is a multi-subunit histone acetyltransferase complex that preferentially acetylates histones H3 and H2B and deubiquitinates histone H2B. It is an embellishment of the SAGA complex. The yeast SLIK complex consists of at least TRA1, CHD1, SPT7, CC TAF5, ADA3, SPT20, RTG2, TAF12, TAF6, HFI1, UBP8 (a deubiquitinase), GCN5, ADA2, SPT3, SGF29, TAF10 and TAF9 [, ].The yeast SALSA complex is an altered form of the SAGA complex and consists of at least TRA1, SPT7 (C-terminal truncated form), TAF5, ADA3, SPT20, TAF12, TAF6, HFI1, GCN5, ADA2 and SPT3 [].The ADA complex is a transcription regulatory histone acetylation (HAT) complex. ADA preferentially acetylates nucleosomal histones H3 (at 'Lys-14' and 'Lys-18') and H2B. The complex consists of at least ADA2, ADA3, AHC1, and GCN5. AHC1 is required for the overall structural integrity of the ADA complex [].
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Publication
11376694 | J:69736
First Author: Fukushima S
Year: 2001
Journal: Mutat Res
Title: Possible involvement of O6-methylguanine formation and p53 dysfunction in mouse urinary bladder carcinogenesis.
Volume: 477
Issue: 1-2
Pages: 125-30
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Publication
9629661 | J:47827
First Author: Ben-Shooshan I
Year: 1998
Journal: Comp Biochem Physiol B Biochem Mol Biol
Title: The CP-I subunit of adenosine deaminase complexing protein from calf kidney is identical to human, mouse, and rat dipeptidyl peptidase IV.
Volume: 119
Issue: 2
Pages: 289-92
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Protein
Q9EQ80
Organism: Mus musculus/domesticus
Length: 376  
Fragment?: false
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Protein
Q5FWC8
Organism: Mus musculus/domesticus
Length: 345  
Fragment?: false
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Protein
D3Z0G0
Organism: Mus musculus/domesticus
Length: 329  
Fragment?: false
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Protein
Q3V2R8
Organism: Mus musculus/domesticus
Length: 376  
Fragment?: false
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Protein
Q8C608
Organism: Mus musculus/domesticus
Length: 340  
Fragment?: false
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Publication
11124544 | J:66699
First Author: Tascou S
Year: 2000
Journal: Cytogenet Cell Genet
Title: Isolation and characterization of a novel human gene, NIF3L1, and its mouse ortholog, Nif3l1, highly conserved from bacteria to mammals.
Volume: 90
Issue: 3-4
Pages: 330-6
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Publication
8663102 | -
First Author: Martens JA
Year: 1996
Journal: J Biol Chem
Title: Transcriptional activation by yeast PDR1p is inhibited by its association with NGG1p/ADA3p.
Volume: 271
Issue: 27
Pages: 15884-90
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Publication
23825549 | -
First Author: Choi HP
Year: 2013
Journal: PLoS One
Title: Biochemical Characterization of Hypothetical Proteins from Helicobacter pylori.
Volume: 8
Issue: 6
Pages: e66605
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Publication
23295494 | -
First Author: Kuan SM
Year: 2013
Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun
Title: Crystallization and preliminary X-ray diffraction analysis of the Nif3-family protein MJ0927 from Methanocaldococcus jannaschii.
Volume: 69
Issue: Pt 1
Pages: 80-2
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Publication
25243119 | -
 
First Author: Chen SC
Year: 2014
Journal: Biomed Res Int
Title: Crystal structure of a conserved hypothetical protein MJ0927 from Methanocaldococcus jannaschii reveals a novel quaternary assembly in the Nif3 family.
Volume: 2014
Pages: 171263
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Publication
34572495 | -
 
First Author: Reed CJ
Year: 2021
Journal: Biomolecules
Title: Comparative Genomic Analysis of the DUF34 Protein Family Suggests Role as a Metal Ion Chaperone or Insertase.
Volume: 11
Issue: 9
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Publication
23932781 | -
First Author: Lin R
Year: 2013
Journal: Mol Cell
Title: Acetylation stabilizes ATP-citrate lyase to promote lipid biosynthesis and tumor growth.
Volume: 51
Issue: 4
Pages: 506-518
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Publication
10026213 | -
First Author: Grant PA
Year: 1999
Journal: J Biol Chem
Title: Expanded lysine acetylation specificity of Gcn5 in native complexes.
Volume: 274
Issue: 9
Pages: 5895-900
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Publication
9885573 | -
First Author: Grant PA
Year: 1998
Journal: Mol Cell
Title: The ATM-related cofactor Tra1 is a component of the purified SAGA complex.
Volume: 2
Issue: 6
Pages: 863-7
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Protein Domain
IPR002678 | DUF34/NIF3
Type: Family
Description: This family includes DUF34/metal-binding proteins from bacteria, NIF3 from budding yeasts and NIF3-like proteins from animals. This entry includes the DUF34/metal-binding protein/NIF3 proteins, which are widely distributed across superkingdoms. They were previously annotated as GTP cyclohydrolase 1 type 2 []and, recently, through a comprehensive literature review and integrative bioinformatic analyses it was revealed that annotations for these members are misleading as they were based on a single set of in vitro results examining the NIF3 homolog of Helicobacter pylori []. Actually, they have varied phenotypes with the unifying functional role as metal-binding proteins [].NIF3 interacts with the yeast transcriptional coactivator Ngg1p which is part of the ADA complex, the exact function of this interaction is unknown [, ].The structure of the Methanocaldococcus jannaschii MJ0927 NIF3 protein has been determined [, ]. It binds to both single-stranded and double-stranded DNA [].
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Protein Domain
IPR017221 | DUF34/NIF3_bac
Type: Family
Description: This family represents DUF34/metal-binding proteins (previously known as GTP cyclohydrolase 1 type 2) from bacteria.This entry includes the DUF34/metal-binding protein/NIF3 proteins, which are widely distributed across superkingdoms. They were previously annotated as GTP cyclohydrolase 1 type 2 []and, recently, through a comprehensive literature review and integrative bioinformatic analyses it was revealed that annotations for these members are misleading as they were based on a single set of in vitro results examining the NIF3 homolog of Helicobacter pylori []. Actually, they have varied phenotypes with the unifying functional role as metal-binding proteins [].NIF3 interacts with the yeast transcriptional coactivator Ngg1p which is part of the ADA complex, the exact function of this interaction is unknown [, ].
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Protein Domain
IPR017222 | DUF34/NIF3_animal
Type: Family
Description: This entry represents DUF34/metal-binding proteins (also referred to as NIF3-like protein 1) from animals. They share protein sequence similarity with budding yeast NIF3, which interacts with the yeast transcriptional coactivator Ngg1p that is part of the ADA complex [, ].This entry includes the DUF34/metal-binding protein/NIF3 proteins, which are widely distributed across superkingdoms. They were previously annotated as GTP cyclohydrolase 1 type 2 []and, recently, through a comprehensive literature review and integrative bioinformatic analyses it was revealed that annotations for these members are misleading as they were based on a single set of in vitro results examining the NIF3 homologue of Helicobacter pylori []. Actually, they have varied phenotypes with the unifying functional role as metal-binding proteins [].
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Protein Domain
IPR036069 | DUF34/NIF3_sf
Type: Homologous_superfamily
Description: This superfamily includes DUF34/metal-binding proteins (also known as GTP cyclohydrolase 1 type 2 proteins) from bacteria, NIF3 from budding yeasts and NIF3-like proteins from animals.This entry includes the DUF34/metal-binding protein/NIF3 proteins, which are widely distributed across superkingdoms. They were previously annotated as GTP cyclohydrolase 1 type 2 []and, recently, through a comprehensive literature review and integrative bioinformatic analyses it was revealed that annotations for these members are misleading as they were based on a single set of in vitro results examining the NIF3 homolog of Helicobacter pylori []. Actually, they have varied phenotypes with the unifying functional role as metal-binding proteins [].NIF3 interacts with the yeast transcriptional coactivator Ngg1p which is part of the ADA complex, the exact function of this interaction is unknown [, ].
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Protein
D3YYF0
Organism: Mus musculus/domesticus
Length: 131  
Fragment?: true
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Protein
E9PWJ6
Organism: Mus musculus/domesticus
Length: 155  
Fragment?: false
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Protein
Q9D146
Organism: Mus musculus/domesticus
Length: 159  
Fragment?: false
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Publication
- | J:13694
 
First Author: Phillips RJS
Year: 1976
Journal: Mouse News Lett
Title: New A-alleles
Volume: 55
Pages: 14
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Publication
38128533 | J:355267
First Author: Wallace RP
Year: 2024
Journal: Cell Rep Med
Title: Synthetically mannosylated antigens induce antigen-specific humoral tolerance and reduce anti-drug antibody responses to immunogenic biologics.
Volume: 5
Issue: 1
Pages: 101345
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Publication
2776485 | J:9998
First Author: Jhanwar SC
Year: 1989
Journal: Cytogenet Cell Genet
Title: Localization of human adenosine deaminase (ADA) gene sequences to the q12----q13.11 region of chromosome 20 by in situ hybridization.
Volume: 50
Issue: 2-3
Pages: 168-71
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Publication
7945283 | J:20567
First Author: Lee S
Year: 1994
Journal: Biochem Biophys Res Commun
Title: Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway.
Volume: 203
Issue: 3
Pages: 1371-7
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Publication
32332749 | J:292057
First Author: Péladeau C
Year: 2020
Journal: Nat Commun
Title: Identification of therapeutics that target eEF1A2 and upregulate utrophin A translation in dystrophic muscles.
Volume: 11
Issue: 1
Pages: 1990
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Allele
Eef1a2<wst> | MGI:1857093
 
Name: eukaryotic translation elongation factor 1 alpha 2; wasted
Allele Type: Spontaneous
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Publication
7078649 | J:6766
First Author: Shultz LD
Year: 1982
Journal: Nature
Title: 'Wasted', a new mutant of the mouse with abnormalities characteristic to ataxia telangiectasia.
Volume: 297
Issue: 5865
Pages: 402-4
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Publication
9756641 | J:50410
First Author: Potter M
Year: 1998
Journal: Cell Immunol
Title: The wst gene regulates multiple forms of thymocyte apoptosis.
Volume: 188
Issue: 2
Pages: 111-7
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Publication
22848658 | J:189690
First Author: Griffiths LA
Year: 2012
Journal: PLoS One
Title: Haploinsufficiency for translation elongation factor eEF1A2 in aged mouse muscle and neurons is compatible with normal function.
Volume: 7
Issue: 7
Pages: e41917
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Publication
3874230 | J:7903
First Author: Kaiserlian D
Year: 1985
Journal: J Immunol
Title: The wasted mutant mouse. I. An animal model of secretory IgA deficiency with normal serum IgA.
Volume: 135
Issue: 2
Pages: 1126-31
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Publication
- | J:24753
 
First Author: Sweet HO
Year: 1981
Journal: Mouse News Lett
Title: Wasted (wst)
Volume: 65
Pages: 27
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Publication
24460877 | J:216709
First Author: Doig J
Year: 2013
Journal: FEBS J
Title: In vivo characterization of the role of tissue-specific translation elongation factor 1A2 in protein synthesis reveals insights into muscle atrophy.
Volume: 280
Issue: 24
Pages: 6528-40
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Publication
- | J:13960
 
First Author: Thacker J
Year: 1984
Journal: Mouse News Lett
Title: Radiation sensitivity of cells cultured from 'wasted` mice
Volume: 70
Pages: 80
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Publication
2425937 | J:8348
First Author: Inoue T
Year: 1986
Journal: Cancer Res
Title: Effect of DNA-damaging agents on isolated spleen cells and lung fibroblasts from the mouse mutant "wasted," a putative animal model for ataxia-telangiectasia.
Volume: 46
Issue: 8
Pages: 3979-82
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Publication
3702898 | J:8276
First Author: Tezuka H
Year: 1986
Journal: Mutat Res
Title: Evaluation of the mouse mutant "wasted" as an animal model for ataxia telangiectasia. I. Age-dependent and tissue-specific effects.
Volume: 161
Issue: 1
Pages: 83-90
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Publication
17640869 | J:125352
First Author: Newbery HJ
Year: 2007
Journal: J Biol Chem
Title: Translation elongation factor eEF1A2 is essential for post-weaning survival in mice.
Volume: 282
Issue: 39
Pages: 28951-9
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Publication
9635401 | J:48050
First Author: Hafezparast M
Year: 1998
Journal: Trends Genet
Title: Wasted by an elongation factor.
Volume: 14
Issue: 6
Pages: 215-7
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Publication
8968049 | J:37955
First Author: Woloschak GE
Year: 1996
Journal: Carcinogenesis
Title: Regulation of thymus PCNA expression is altered in radiation-sensitive wasted mice.
Volume: 17
Issue: 11
Pages: 2357-65
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Publication
6206393 | J:7561
First Author: Nordeen SK
Year: 1984
Journal: Mutat Res
Title: Evaluations of wasted mouse fibroblasts and SV-40 transformed human fibroblasts as models of ataxia telangiectasia in vitro.
Volume: 140
Issue: 4
Pages: 219-22
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Publication
3456164 | J:8181
First Author: Abbott CM
Year: 1986
Journal: Proc Natl Acad Sci U S A
Title: Deficiency of adenosine deaminase in the wasted mouse.
Volume: 83
Issue: 3
Pages: 693-5
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Publication
9539760 | J:47466
First Author: Chambers DM
Year: 1998
Journal: Proc Natl Acad Sci U S A
Title: The lethal mutation of the mouse wasted (wst) is a deletion that abolishes expression of a tissue-specific isoform of translation elongation factor 1alpha, encoded by the Eef1a2 gene.
Volume: 95
Issue: 8
Pages: 4463-8
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Publication
11294870 | J:70131
First Author: Khalyfa A
Year: 2001
Journal: J Biol Chem
Title: Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted mice.
Volume: 276
Issue: 25
Pages: 22915-22
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Publication
15835265 | J:104855
First Author: Newbery HJ
Year: 2005
Journal: J Neuropathol Exp Neurol
Title: Progressive loss of motor neuron function in wasted mice: effects of a spontaneous null mutation in the gene for the eEF1 A2 translation factor.
Volume: 64
Issue: 4
Pages: 295-303
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Publication
8035837 | J:19431
First Author: Libertin CR
Year: 1994
Journal: Mol Immunol
Title: Cytokine and T-cell subset abnormalities in immunodeficient wasted mice.
Volume: 31
Issue: 10
Pages: 753-9
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Publication
2423278 | J:8288
First Author: Kaiserlian D
Year: 1986
Journal: Clin Exp Immunol
Title: The wasted mutant mouse. II. Immunological abnormalities in a mouse described as a model of ataxia-telangiectasia.
Volume: 63
Issue: 3
Pages: 562-9
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Genotype
Genotype
Symbol: Eef1a2/Eef1a2
Background: B6C3Fe a/a-Eef1a2/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Eef1a2/Eef1a2
Background: involves: HRS/J
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Eef1a2/Eef1a2
Background: Not Specified
Zygosity: hm
Has Mutant Allele: true
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Publication
19103755 | J:145720
First Author: Guelman S
Year: 2009
Journal: Mol Cell Biol
Title: The double-histone-acetyltransferase complex ATAC is essential for mammalian development.
Volume: 29
Issue: 5
Pages: 1176-88
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Protein
Q99KW4
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
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Protein
Q3UVE8
Organism: Mus musculus/domesticus
Length: 660  
Fragment?: true
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Strain
MGI:2164047 | B6C3Fe a/a-Eef1a2<wst>/J
Attribute String: mutant stock, spontaneous mutation
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Publication
1720867 | J:4646
First Author: van Buul PP
Year: 1991
Journal: Mutat Res
Title: Cytogenetic characterization of radiosensitive mouse mutants.
Volume: 251
Issue: 2
Pages: 171-9
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Publication
22936179 | J:208484
First Author: Zhong J
Year: 2013
Journal: Diabetes
Title: A potential role for dendritic cell/macrophage-expressing DPP4 in obesity-induced visceral inflammation.
Volume: 62
Issue: 1
Pages: 149-57
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Publication
22492673 | J:202578
First Author: Luo X
Year: 2012
Journal: Cardiovasc Res
Title: Increased plasma S-adenosyl-homocysteine levels induce the proliferation and migration of VSMCs through an oxidative stress-ERK1/2 pathway in apoE(-/-) mice.
Volume: 95
Issue: 2
Pages: 241-50
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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