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Search results 601 to 700 out of 729 for Adam17

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Type Details Score
HT Experiment
E-GEOD-38830 | Conditional keratinocyte-specific ADAM17 knockout in mice alters skin homeostasis
Series Id: GSE38830
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
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UniProt Feature
UniProt Feature
Begin: 354
Description: Cleavage; by ADAM10 and ADAM17
Type: site
End: 355
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HT Experiment
GSE107687 | Next Generation Sequencing of skin from wild-type and ADAM17 cKO (Sox9-Cre x ADAM17fl/fl) mice
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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Publication
17010968 | J:143672
First Author: Tellier E
Year: 2006
Journal: Exp Cell Res
Title: The shedding activity of ADAM17 is sequestered in lipid rafts.
Volume: 312
Issue: 20
Pages: 3969-80
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Interaction Experiment
Wang X (2024)
Description: ADAM17 variant causes hair loss via ubiquitin ligase TRIM47-mediated degradation.
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Publication
29361535 | J:258334
 
First Author: Li R
Year: 2018
Journal: J Cell Sci
Title: Regulation of profibrotic responses by ADAM17 activation in high glucose requires its C-terminus and FAK.
Volume: 131
Issue: 4
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GXD Expression
GXD Expression
 
Probe: MGI:8249286
Assay Type: Immunohistochemistry
Annotation Date: 2025-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:8249335
Age: embryonic day 16.5
Note: Expression co-localized with Adam17 in cortical neurons.
Specimen Label: 4E/G,H/J
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:8249286
Assay Type: Immunohistochemistry
Annotation Date: 2025-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:8249335
Age: embryonic day 16.5
Note: Expression co-localized with Adam17 in cortical neurons.
Specimen Label: 4E/G,H/J
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:8249286
Assay Type: Immunohistochemistry
Annotation Date: 2025-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:8249335
Age: embryonic day 16.5
Note: Expression co-localized with Adam17 in cortical neurons.
Specimen Label: 4E/G,H/J
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:8249286
Assay Type: Immunohistochemistry
Annotation Date: 2025-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:8249335
Age: embryonic day 16.5
Note: Expression co-localized with Adam17 in cortical neurons.
Specimen Label: 4E/G,H/J
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:8249286
Assay Type: Immunohistochemistry
Annotation Date: 2025-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:8249335
Age: embryonic day 16.5
Note: Expression co-localized with Adam17 in cortical neurons.
Specimen Label: 4E/G,H/J
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:8249286
Assay Type: Immunohistochemistry
Annotation Date: 2025-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:8249335
Age: embryonic day 16.5
Note: Expression co-localized with Adam17 in cortical neurons.
Specimen Label: 4E/G,H/J
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:8249286
Assay Type: Immunohistochemistry
Annotation Date: 2025-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:8249335
Age: embryonic day 16.5
Note: Expression co-localized with Adam17 in cortical neurons.
Specimen Label: 4E/G,H/J
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:8249286
Assay Type: Immunohistochemistry
Annotation Date: 2025-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:8249335
Age: embryonic day 16.5
Note: Expression co-localized with Adam17 in cortical neurons.
Specimen Label: 4E/G,H/J
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:8249286
Assay Type: Immunohistochemistry
Annotation Date: 2025-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:8249335
Age: embryonic day 16.5
Note: Expression co-localized with Adam17 in cortical neurons.
Specimen Label: 4E/G,H/J
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:8249286
Assay Type: Immunohistochemistry
Annotation Date: 2025-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:8249335
Age: embryonic day 16.5
Note: Expression co-localized with Adam17 in cortical neurons.
Specimen Label: 4E/G,H/J
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:8249286
Assay Type: Immunohistochemistry
Annotation Date: 2025-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:8249335
Age: embryonic day 16.5
Note: Expression co-localized with Adam17 in cortical neurons.
Specimen Label: 4E/G,H/J
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:8249286
Assay Type: Immunohistochemistry
Annotation Date: 2025-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:8249335
Age: embryonic day 16.5
Note: Expression co-localized with Adam17 in cortical neurons.
Specimen Label: 4E/G,H/J
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:8249286
Assay Type: Immunohistochemistry
Annotation Date: 2025-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:8249335
Age: embryonic day 16.5
Note: Expression co-localized with Adam17 in cortical neurons.
Specimen Label: 4E/G,H/J
Detected: true
Specimen Num: 12
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GXD Expression
GXD Expression
 
Probe: MGI:8249286
Assay Type: Immunohistochemistry
Annotation Date: 2025-10-03
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1754424
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:8249335
Age: embryonic day 16.5
Note: Expression co-localized with Adam17 in cortical neurons.
Specimen Label: 4E/G,H/J
Detected: true
Specimen Num: 12
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Publication
- | J:304620
     
First Author: Lartey NL
Year: 2021
Journal: bioRxiv
Title: ADAM17 inhibition prevents neutrophilia and lung injury in a mouse model of Covid-19.
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Publication
36937050 | J:345219
 
First Author: Tian Y
Year: 2023
Journal: Front Mol Neurosci
Title: The role of ADAM17 in cerebrovascular and cognitive function in the APP/PS1 mouse model of Alzheimer's disease.
Volume: 16
Pages: 1125932
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GO Term
GO:0140910 | iRhom2/ADAM17 sheddase complex
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DO Term
DOID:0061192 | neonatal inflammatory skin and bowel disease 1
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Publication
24227843 | J:207757
First Author: Heurich A
Year: 2014
Journal: J Virol
Title: TMPRSS2 and ADAM17 cleave ACE2 differentially and only proteolysis by TMPRSS2 augments entry driven by the severe acute respiratory syndrome coronavirus spike protein.
Volume: 88
Issue: 2
Pages: 1293-307
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Allele
Adam17<em1Smoc> | MGI:7288105
Name: a disintegrin and metallopeptidase domain 17; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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GXD Expression
GXD Expression
Probe: MGI:6690292
Assay Type: Immunohistochemistry
Annotation Date: 2021-04-12
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1697423
Pattern: Regionally restricted
Stage: TS23
Assay Id: MGI:6690294
Age: embryonic day 15.5
Image: 4C
Note: Expression was detected in neurons in the substantia nigra and the ventral tegmental area and co-localized with Adam17 immunostaining.
Specimen Label: 4C
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:3580797
Assay Type: Immunohistochemistry
Annotation Date: 2005-07-06
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1750328
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:3580832
Age: postnatal adult
Image: 5H, 5I
Note: Expression was detected in the cell membrane. Expression did not colocalize with Adam17 in the cell membranes of the islets of Langerhans.
Specimen Label: 5H, 5I
Detected: true
Specimen Num: 3
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Publication
23521534 | -
First Author: D?sterh?ft S
Year: 2013
Journal: J Am Chem Soc
Title: Membrane-proximal domain of a disintegrin and metalloprotease-17 represents the putative molecular switch of its shedding activity operated by protein-disulfide isomerase.
Volume: 135
Issue: 15
Pages: 5776-81
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Publication
10415747 | -
 
First Author: Killar L
Year: 1999
Journal: Ann N Y Acad Sci
Title: Adamalysins. A family of metzincins including TNF-alpha converting enzyme (TACE).
Volume: 878
Pages: 442-52
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Protein Domain
IPR034025 | ADAM10_ADAM17
Type: Domain
Description: This entry includes proteins with reprolysin-like metallopeptidase domains and includes ADAM10 (also known as myelin-associated metalloendopeptidase, MEROPS identifier M12.210), ADAM17 (also known as tumour necrosis factor alpha-convertase, MEROPS identifier M12.217), kuzbanian (MEROPS identifiers M12.211 and M12.322) and ADM-4 (MEROPS identifier M12.329) [].
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Protein Domain
IPR032029 | ADAM17_MPD
Type: Domain
Description: This entry represents the membrane-proximal domain (MPD) of disintegrin and metalloproteinase domain-containing protein 17 (ADAM17) from animals. ADAM17 is a major sheddase responsible for the regulation of a wide range of biological processes, such as cellular differentiation, regeneration, and cancer progression.
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Protein Domain
IPR022241 | iRhom1_2_N
Type: Domain
Description: This entry represents an N-terminal helical segment of inactive rhomboid proteins (iRhom1/2), which are catalytically inactive rhomboid protease homologues that play crucial roles within the secretory pathway, including protein degradation, trafficking regulation, and inflammatory signalling []. These are metazoan specific pseudoproteases which regulate ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, acting as trafficking factors that escort ADAM17 from the ER to the later secretory pathway. They are required for the cleavage and release of a variety of membrane-associated proteins []. iRhoms share a common structure comprising 7-helix transmembrane-spanning domains (TMDs) which is a conserved rhomboid fold (), an extended N-terminal cytosolic domain and a luminal loop [, ].These proteins have been linked to the development and progression of several autoimmune diseases including rheumatoid arthritis, lupus nephritis, as well as hemophilic arthropathy []and also in neurological disorders such as Alzheimer's and Parkinson's diseases, inflammation, cancer and skin diseases [].
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Protein
A2AVE4
Organism: Mus musculus/domesticus
Length: 136  
Fragment?: true
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Protein Domain
IPR051512 | Inactive_Rhomboid
Type: Family
Description: The Inactive Rhomboid Protein family is characterized by members that regulate the ADAM17 protease, which is responsible for shedding epidermal growth factor (EGF) receptor ligands and TNF. Although members of this family are structurally related to peptidases, they do not exhibit proteolytic activity. Instead, they modulate various physiological processes including sleep, cell survival, proliferation, migration, and inflammation. Some family members indirectly activate the EGF receptor signaling pathway, further influencing these cellular functions.
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Protein
F2Z3W3
Organism: Mus musculus/domesticus
Length: 168  
Fragment?: false
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Protein
Q8BJ16
Organism: Mus musculus/domesticus
Length: 325  
Fragment?: false
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Publication
31369701 | -
First Author: Geesala R
Year: 2019
Journal: J Leukoc Biol
Title: Novel functions of inactive rhomboid proteins in immunity and disease.
Volume: 106
Issue: 4
Pages: 823-835
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Publication
27378062 | -
 
First Author: Lemberg MK
Year: 2016
Journal: Semin Cell Dev Biol
Title: Inactive rhomboid proteins: New mechanisms with implications in health and disease.
Volume: 60
Pages: 29-37
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Publication
34477920 | -
First Author: Burzenski LM
Year: 2021
Journal: Mamm Genome
Title: Inactive rhomboid proteins RHBDF1 and RHBDF2 (iRhoms): a decade of research in murine models.
Volume: 32
Issue: 6
Pages: 415-426
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Protein
Q6PIX5
Organism: Mus musculus/domesticus
Length: 856  
Fragment?: false
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Protein
Q80WQ6
Organism: Mus musculus/domesticus
Length: 827  
Fragment?: false
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Protein
A7M7T5
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: true
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Publication
21909096 | -
First Author: Greenblatt EJ
Year: 2011
Journal: Nat Struct Mol Biol
Title: Derlin-1 is a rhomboid pseudoprotease required for the dislocation of mutant ?-1 antitrypsin from the endoplasmic reticulum.
Volume: 18
Issue: 10
Pages: 1147-52
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Protein Domain
IPR035952 | Rhomboid-like_sf
Type: Homologous_superfamily
Description: This entry represents a six transmembrane helix rhomboid domain. This entry also includes derlins, inactive members of the rhomboid family of intramembrane proteases which lack an active site Ser-His dyad but retain the overall rhomboid architecture [].This domain is found in serine peptidases belonging to the MEROPS peptidase family S54 (Rhomboid, clan ST). They are integral membrane proteins related to the Drosophila melanogaster (Fruit fly) rhomboid protein . Members of this family are found in archaea, bacteria and eukaryotes.The rhomboid protease cleaves type-1 transmembrane domains usinga catalytic dyad composed of serine and histidine. The active site is embedded within the membrane and the active site residues are on different transmembrane regions. From the tertiary structure of the Escherichia coli homologue GlpG []it was shown that hydrolysis occurs in a fluid filled cavity within the membrane. Initially, a catalytic triad including a highly conserved asparagine had been proposed, but this residue has been shown not to be essential []. Drosophila rhomboid cleaves the transmembrane proteins Spitz, Gurken and Keren within their transmembrane domains to release a soluble TGFalpha-like growth factor. Cleavage occurs in the Golgi, following translocation of the substrates from the endoplasmic reticulum membrane by Star, another transmembrane protein. The growth factors are then able to activate the epidermal growth factor receptor [, ].Few substrates of mammalian rhomboid homologues have been determined, but rhomboid-like protein 2 has been shown to cleave ephrin B3 []. Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite. Invasion of host cells first requires their recognition and this is achieved by parasite transmembrane adhesins interacting with host cell receptors. Before the parasite can enter a host cell the adhesins must be released by cleavage. In Toxoplasma rhomboid TgROM5 cleaves the adhesins, and in Plasmodium, which lacks a TgROM5 orthologue, PfROMs 1 and 4 cleave the diverse array of malaria parasite adhesins [].This entry also includes catalytically inactive rhomboid protease homologues, iRhom1/2, which are metazoan-specific and play crucial roles within the secretory pathway, including protein degradation, trafficking regulation, and inflammatory signaling []. They regulate ADAM17 protease, acting as trafficking factors that escort ADAM17 from the ER to the later secretory pathway. They are required for the cleavage and release of a variety of membrane-associated proteins [, ]. iRhombs have been linked to the development and progression of several autoimmune diseases including rheumatoid arthritis, lupus nephritis, as well as hemophilic arthropathy []and also in neurological disorders such as Alzheimer's and Parkinson's diseases, inflammation, cancer and skin diseases [].
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Protein Domain
IPR022764 | Peptidase_S54_rhomboid_dom
Type: Domain
Description: This entry represents a six transmembrane helix rhomboid domain.This domain is found in serine peptidases belonging to the MEROPS peptidase family S54 (Rhomboid, clan ST). They are integral membrane proteins related to the Drosophila melanogaster (Fruit fly) rhomboid protein . Members of this family are found in archaea, bacteria and eukaryotes.The rhomboid protease cleaves type-1 transmembrane domains using a catalytic dyad composed of serine and histidine. The active site is embedded within the membrane and the active site residues are on different transmembrane regions. From the tertiary structure of the Escherichia coli homologue GlpG []it was shown that hydrolysis occurs in a fluid filled cavity within the membrane. Initially, a catalytic triad including a highly conserved asparagine had been proposed, but this residue has been shown not to be essential []. Drosophila rhomboid cleaves the transmembrane proteins Spitz, Gurken and Keren within their transmembrane domains to release a soluble TGFalpha-like growth factor. Cleavage occurs in the Golgi, following translocation of the substratesfrom the endoplasmic reticulum membrane by Star, another transmembrane protein. The growth factors are then able to activate the epidermal growth factor receptor [, ].Few substrates of mammalian rhomboid homologues have been determined, but rhomboid-like protein 2 has been shown to cleave ephrin B3 []. Parasite-encoded rhomboid enzymes are also important for invasion of host cells by Toxoplasma and the malaria parasite. Invasion of host cells first requires their recognition and this is achieved by parasite transmembrane adhesins interacting with host cell receptors. Before the parasite can enter a host cell the adhesins must be released by cleavage. In Toxoplasma rhomboid TgROM5 cleaves the adhesins, and in Plasmodium, which lacks a TgROM5 orthologue, PfROMs 1 and 4 cleave the diverse array of malaria parasite adhesins [].This entry also includes catalytically inactive rhomboid protease homologues, iRhom1/2, which are metazoan-specific and play crucial roles within the secretory pathway, including protein degradation, trafficking regulation, and inflammatory signaling []. They regulate ADAM17 protease, acting as trafficking factors that escort ADAM17 from the ER to the later secretory pathway. They are required for the cleavage and release of a variety of membrane-associated proteins [, ]. iRhombs have been linked to the development and progression of several autoimmune diseases including rheumatoid arthritis, lupus nephritis, as well as hemophilic arthropathy []and also in neurological disorders such as Alzheimer's and Parkinson's diseases, inflammation, cancer and skin diseases [].
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Publication
29321225 | J:259750
First Author: Song WM
Year: 2018
Journal: J Exp Med
Title: Humanized TREM2 mice reveal microglia-intrinsic and -extrinsic effects of R47H polymorphism.
Volume: 215
Issue: 3
Pages: 745-760
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Publication
34571815 | J:352821
 
First Author: Lee HJ
Year: 2021
Journal: Biology (Basel)
Title: Idebenone Decreases A? Pathology by Modulating RAGE/Caspase-3 Signaling and the A? Degradation Enzyme NEP in a Mouse Model of AD.
Volume: 10
Issue: 9
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Publication
35757773 | J:334874
 
First Author: Hedges JF
Year: 2022
Journal: Front Immunol
Title: An ADAM17-Neutralizing Antibody Reduces Inflammation and Mortality While Increasing Viral Burden in a COVID-19 Mouse Model.
Volume: 13
Pages: 918881
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Publication
28084316 | J:244044
 
First Author: Hurst LA
Year: 2017
Journal: Nat Commun
Title: TNF? drives pulmonary arterial hypertension by suppressing the BMP type-II receptor and altering NOTCH signalling.
Volume: 8
Pages: 14079
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Protein
Q5XJY4
Organism: Mus musculus/domesticus
Length: 377  
Fragment?: false
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Protein
Q8BHC7
Organism: Mus musculus/domesticus
Length: 315  
Fragment?: false
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Protein
Q8VEK2
Organism: Mus musculus/domesticus
Length: 361  
Fragment?: false
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Protein
A2AGA4
Organism: Mus musculus/domesticus
Length: 302  
Fragment?: false
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Protein
A0A338P6A0
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: false
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Protein
A0A338P6U4
Organism: Mus musculus/domesticus
Length: 343  
Fragment?: false
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Protein
A0A338P759
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: true
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Protein
Z4YMS1
Organism: Mus musculus/domesticus
Length: 192  
Fragment?: true
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Publication
2110920 | -
First Author: Bier E
Year: 1990
Journal: Genes Dev
Title: rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.
Volume: 4
Issue: 2
Pages: 190-203
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Publication
11672525 | -
First Author: Urban S
Year: 2001
Journal: Cell
Title: Drosophila rhomboid-1 defines a family of putative intramembrane serine proteases.
Volume: 107
Issue: 2
Pages: 173-82
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Publication
15047175 | -
First Author: Pascall JC
Year: 2004
Journal: Biochem Biophys Res Commun
Title: Intramembrane cleavage of ephrinB3 by the human rhomboid family protease, RHBDL2.
Volume: 317
Issue: 1
Pages: 244-52
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Publication
17051161 | -
First Author: Wang Y
Year: 2006
Journal: Nature
Title: Crystal structure of a rhomboid family intramembrane protease.
Volume: 444
Issue: 7116
Pages: 179-80
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Publication
15616571 | -
First Author: Lemberg MK
Year: 2005
Journal: EMBO J
Title: Mechanism of intramembrane proteolysis investigated with purified rhomboid proteases.
Volume: 24
Issue: 3
Pages: 464-72
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Publication
17040128 | -
First Author: Baker RP
Year: 2006
Journal: PLoS Pathog
Title: Two Plasmodium rhomboid proteases preferentially cleave different adhesins implicated in all invasive stages of malaria.
Volume: 2
Issue: 10
Pages: e113
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Protein
Q8BNI4
Organism: Mus musculus/domesticus
Length: 239  
Fragment?: false
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Protein
Q99J56
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: false
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Protein
Q9D8K3
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Protein
Q9WUH1
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: false
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Protein
A0A1W2P7B5
Organism: Mus musculus/domesticus
Length: 227  
Fragment?: false
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Protein
Q14C34
Organism: Mus musculus/domesticus
Length: 228  
Fragment?: false
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Protein
Q3U4J6
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: false
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Protein
Q3U957
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: false
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Protein
Q3UGB8
Organism: Mus musculus/domesticus
Length: 251  
Fragment?: false
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•
Protein
Q543Y8
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: false
•
•
•
•
•
Protein
F6TBL9
Organism: Mus musculus/domesticus
Length: 165  
Fragment?: false
•
•
•
•
•
Protein
J3QMF4
Organism: Mus musculus/domesticus
Length: 83  
Fragment?: false
•
•
•
•
•
Protein
Q8BP97
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: false
•
•
•
•
•
Protein
P58873
Organism: Mus musculus/domesticus
Length: 404  
Fragment?: false
•
•
•
•
•
Protein
Q8VC82
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
•
•
•
•
•
Protein
Q3USF1
Organism: Mus musculus/domesticus
Length: 373  
Fragment?: false
•
•
•
•
•
Protein
V9GX92
Organism: Mus musculus/domesticus
Length: 369  
Fragment?: false
•
•
•
•
•
Protein
B7ZNJ8
Organism: Mus musculus/domesticus
Length: 385  
Fragment?: false
•
•
•
•
•
Publication
28855301 | J:273534
First Author: Thornton P
Year: 2017
Journal: EMBO Mol Med
Title: TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.
Volume: 9
Issue: 10
Pages: 1366-1378
•
•
•
•
•
Publication
11897009 | J:126011
 
First Author: Gunn TM
Year: 2002
Journal: BMC Genet
Title: Identification and preliminary characterization of mouse Adam33.
Volume: 3
Pages: 2
•
•
•
•
•
Publication
24756098 | J:286374
First Author: Somineni HK
Year: 2014
Journal: J Endocrinol
Title: Daily exercise training protects against albuminuria and angiotensin converting enzyme 2 shedding in db/db diabetic mice.
Volume: 221
Issue: 2
Pages: 235-51
•
•
•
•
•
Publication
21712436 | J:174621
First Author: Spin JM
Year: 2011
Journal: Physiol Genomics
Title: Transcriptional profiling and network analysis of the murine angiotensin II-induced abdominal aortic aneurysm.
Volume: 43
Issue: 17
Pages: 993-1003
•
•
•
•
•
Publication
21704645 | J:178566
First Author: Raman D
Year: 2011
Journal: Toxicol Appl Pharmacol
Title: Chemokines, macrophage inflammatory protein-2 and stromal cell-derived factor-1?, suppress amyloid ?-induced neurotoxicity.
Volume: 256
Issue: 3
Pages: 300-13
•
•
•
•
•
Publication
32004659 | J:368818
 
First Author: Wang H
Year: 2020
Journal: Brain Res Bull
Title: IL-1R(-/-) alleviates cognitive deficits through microglial M2 polarization in AD mice.
Volume: 157
Pages: 10-17
•
•
•
•
•
Publication
38797477 | J:373862
First Author: Dashek RJ
Year: 2024
Journal: Cell Mol Gastroenterol Hepatol
Title: Hepatocellular RECK as a Critical Regulator of Metabolic Dysfunction-associated Steatohepatitis Development.
Volume: 18
Issue: 3
Pages: 101365
•
•
•
•
•
Publication
27623510 | J:238331
First Author: Mahnke K
Year: 2017
Journal: J Invest Dermatol
Title: Down-Regulation of CD62L Shedding in?T?Cells by CD39(+) Regulatory T Cells Leads?to Defective Sensitization in Contact?Hypersensitivity Reactions.
Volume: 137
Issue: 1
Pages: 106-114
•
•
•
•
•
Publication
22759926 | J:197509
First Author: Gil-Bea FJ
Year: 2012
Journal: Neurobiol Dis
Title: Cholinergic denervation exacerbates amyloid pathology and induces hippocampal atrophy in Tg2576 mice.
Volume: 48
Issue: 3
Pages: 439-46
•
•
•
•
•
Publication
21081501 | J:168499
First Author: Delarasse C
Year: 2011
Journal: J Biol Chem
Title: The purinergic receptor P2X7 triggers alpha-secretase-dependent processing of the amyloid precursor protein.
Volume: 286
Issue: 4
Pages: 2596-606
•
•
•
•
•
Publication
23401241 | J:232308
First Author: Fiorentino L
Year: 2013
Journal: EMBO Mol Med
Title: Loss of TIMP3 underlies diabetic nephropathy via FoxO1/STAT1 interplay.
Volume: 5
Issue: 3
Pages: 441-55
•
•
•
•
•
Publication
23299479 | J:214565
First Author: Hewing NJ
Year: 2013
Journal: Invest Ophthalmol Vis Sci
Title: Intravitreal injection of TIMP3 or the EGFR inhibitor erlotinib offers protection from oxygen-induced retinopathy in mice.
Volume: 54
Issue: 1
Pages: 864-70
•
•
•
•
•
Publication
26426268 | J:330455
First Author: Meyer zu Horste G
Year: 2015
Journal: J Neuropathol Exp Neurol
Title: Neuronal ADAM10 Promotes Outgrowth of Small-Caliber Myelinated Axons in the Peripheral Nervous System.
Volume: 74
Issue: 11
Pages: 1077-85
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•
•
•
•
Publication
31381863 | J:298593
First Author: Wichert R
Year: 2019
Journal: FASEB J
Title: Meprin ? induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage.
Volume: 33
Issue: 11
Pages: 11925-11940
•
•
•
•
•
Publication
27806985 | J:286428
First Author: Chodavarapu H
Year: 2016
Journal: Am J Physiol Regul Integr Comp Physiol
Title: High-fat diet-induced glucose dysregulation is independent of changes in islet ACE2 in mice.
Volume: 311
Issue: 6
Pages: R1223-R1233
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•
•
•
Publication
36907286 | J:351751
 
First Author: Lee HJ
Year: 2023
Journal: Pharmacol Res
Title: Inhibition of CDK4/6 regulates AD pathology, neuroinflammation and cognitive function through DYRK1A/STAT3 signaling.
Volume: 190
Pages: 106725
•
•
•
•
•
Publication
31662486 | J:280798
 
First Author: Sundaram B
Year: 2019
Journal: Sci Signal
Title: iRhom2 inhibits bile duct obstruction-induced liver fibrosis.
Volume: 12
Issue: 605
•
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•
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•
Publication
33950315 | J:310482
First Author: D?sterh?ft S
Year: 2021
Journal: Cell Mol Life Sci
Title: The iRhom homology domain is indispensable for ADAM17-mediated TNF? and EGF receptor ligand release.
Volume: 78
Issue: 11
Pages: 5015-5040
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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