|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 601 to 700 out of 2004 for Arc

<< First    < Previous  |  Next >    Last >>
0.029s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Protein
Q8QZU1
Organism: Mus musculus/domesticus
Length: 247  
Fragment?: true
•
•
•
•
•
Protein
Q3UTB0
Organism: Mus musculus/domesticus
Length: 325  
Fragment?: false
•
•
•
•
•
Protein
Q3UE54
Organism: Mus musculus/domesticus
Length: 366  
Fragment?: false
•
•
•
•
•
Protein
Q66JY3
Organism: Mus musculus/domesticus
Length: 359  
Fragment?: false
•
•
•
•
•
Protein
B9EKH4
Organism: Mus musculus/domesticus
Length: 655  
Fragment?: false
•
•
•
•
•
Protein
A0A1Y7VJ51
Organism: Mus musculus/domesticus
Length: 325  
Fragment?: false
•
•
•
•
•
Protein
H3BKX2
Organism: Mus musculus/domesticus
Length: 82  
Fragment?: true
•
•
•
•
•
Protein
A6PWA3
Organism: Mus musculus/domesticus
Length: 348  
Fragment?: false
•
•
•
•
•
Protein
A0A0R4J1W2
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
•
•
•
•
•
Protein
E0CZ63
Organism: Mus musculus/domesticus
Length: 126  
Fragment?: true
•
•
•
•
•
Protein
A0A0G2JGK7
Organism: Mus musculus/domesticus
Length: 657  
Fragment?: false
•
•
•
•
•
Protein
Q3TQZ3
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
•
•
•
•
•
Protein
F7CTA1
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
•
•
•
•
•
Protein
A0A087WSL7
Organism: Mus musculus/domesticus
Length: 359  
Fragment?: false
•
•
•
•
•
Protein
E0CYG4
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: true
•
•
•
•
•
Protein
Q8C1H0
Organism: Mus musculus/domesticus
Length: 90  
Fragment?: true
•
•
•
•
•
Protein
Q9D5E1
Organism: Mus musculus/domesticus
Length: 112  
Fragment?: false
•
•
•
•
•
Protein
K7N5Y9
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
•
•
•
•
•
Protein
F7A0T4
Organism: Mus musculus/domesticus
Length: 86  
Fragment?: true
•
•
•
•
•
Protein
A0A087WP31
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: true
•
•
•
•
•
Protein
B6D4V6
Organism: Mus musculus/domesticus
Length: 54  
Fragment?: true
•
•
•
•
•
Protein
A0A5H1ZRN3
Organism: Mus musculus/domesticus
Length: 80  
Fragment?: true
•
•
•
•
•
Protein
Q5XK27
Organism: Mus musculus/domesticus
Length: 359  
Fragment?: false
•
•
•
•
•
Protein
Q3V3U7
Organism: Mus musculus/domesticus
Length: 360  
Fragment?: false
•
•
•
•
•
Protein
F6U1P7
Organism: Mus musculus/domesticus
Length: 289  
Fragment?: false
•
•
•
•
•
Protein
D3YTL1
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: true
•
•
•
•
•
Protein
A0A1L1SUR1
Organism: Mus musculus/domesticus
Length: 65  
Fragment?: true
•
•
•
•
•
Protein
Q3TSD5
Organism: Mus musculus/domesticus
Length: 76  
Fragment?: true
•
•
•
•
•
Protein
Q8C0S8
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
•
•
•
•
•
Protein
A6PWB1
Organism: Mus musculus/domesticus
Length: 328  
Fragment?: false
•
•
•
•
•
Protein
A0A3B2W7N5
Organism: Mus musculus/domesticus
Length: 188  
Fragment?: false
•
•
•
•
•
Protein
A2AWL3
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
•
•
•
•
•
Protein
H3BK71
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: true
•
•
•
•
•
Protein
A2AHA7
Organism: Mus musculus/domesticus
Length: 463  
Fragment?: false
•
•
•
•
•
Protein
A0A2I3BQY9
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
•
•
•
•
•
Protein
A0A1B0GSW2
Organism: Mus musculus/domesticus
Length: 409  
Fragment?: false
•
•
•
•
•
Protein
B2RY70
Organism: Mus musculus/domesticus
Length: 739  
Fragment?: false
•
•
•
•
•
Protein
Q8C0W2
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
•
•
•
•
•
Protein
A0A1Y7VJG6
Organism: Mus musculus/domesticus
Length: 326  
Fragment?: false
•
•
•
•
•
Protein
Q8C2X7
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
•
•
•
•
•
Protein
L7MUB4
Organism: Mus musculus/domesticus
Length: 467  
Fragment?: false
•
•
•
•
•
Protein
D3YY70
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
•
•
•
•
•
Protein
D6RHN1
Organism: Mus musculus/domesticus
Length: 73  
Fragment?: false
•
•
•
•
•
Protein
Q7TPV5
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
•
•
•
•
•
Protein
L7N469
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
•
•
•
•
•
Protein
E9PZS2
Organism: Mus musculus/domesticus
Length: 359  
Fragment?: false
•
•
•
•
•
Protein
Q9DCX4
Organism: Mus musculus/domesticus
Length: 234  
Fragment?: false
•
•
•
•
•
Protein
A2AWL1
Organism: Mus musculus/domesticus
Length: 463  
Fragment?: false
•
•
•
•
•
Protein
Q3V1V2
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: false
•
•
•
•
•
Protein
Q9D4Z5
Organism: Mus musculus/domesticus
Length: 464  
Fragment?: false
•
•
•
•
•
Protein
Q8C6S1
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: false
•
•
•
•
•
Protein
B2RWC4
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: false
•
•
•
•
•
Publication
7999761 | -
First Author: Burgering MJ
Year: 1994
Journal: Biochemistry
Title: Solution structure of dimeric Mnt repressor (1-76).
Volume: 33
Issue: 50
Pages: 15036-45
•
•
•
•
•
Publication
11733997 | -
First Author: Murayama K
Year: 2001
Journal: J Mol Biol
Title: Crystal structure of omega transcriptional repressor encoded by Streptococcus pyogenes plasmid pSM19035 at 1.5 A resolution.
Volume: 314
Issue: 4
Pages: 789-96
•
•
•
•
•
Publication
11053393 | -
First Author: Vander Byl C
Year: 2000
Journal: J Bacteriol
Title: Sequence of the genome of Salmonella bacteriophage P22.
Volume: 182
Issue: 22
Pages: 6472-81
•
•
•
•
•
Publication
17715295 | -
First Author: Wollert T
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Thermodynamically reengineering the listerial invasion complex InlA/E-cadherin.
Volume: 104
Issue: 35
Pages: 13960-5
•
•
•
•
•
Protein Domain
IPR034486 | hnRNPA2B1_RRM1
Type: Domain
Description: This entry represents the RNA recognition motif 1 (RRM1) of hnRNP A2/B1. Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 is an RNA trafficking response element-binding protein that interacts with the hnRNP A2 response element (A2RE), a cis-acting signal present in certain trafficked mRNAs, including those encoding myelin basic protein (MBP), CaMKII, neurogranin, and Arc [, , ]. Besides RNA trafficking, hnRNP A2/B1 is also involved in many aspectsof mRNA processing, including packaging of nascent transcripts, splicing of pre-mRNAs, and translational regulation []. For instance, it functions as a splicing factor that regulates alternative splicing of tumour suppressors, such as BIN1, WWOX, the antiapoptotic proteins c-FLIP and caspase-9B, the insulin receptor (IR), and the RON proto-oncogene among others []. The overexpression of hnRNP A2/B1 has been linked to many cancers and may play a role in tumor cell differentiation []. hnRNP A2/B1 contains two RNA recognition motifs (RRMs), followed by a long glycine-rich region at the C terminus [].
•
•
•
•
•
Protein Domain
IPR034489 | hnRNP_A2/B1
Type: Family
Description: Heterogeneous nuclear ribonucleoprotein (hnRNP) A2/B1 is an RNA trafficking response element-binding protein that interacts with the hnRNP A2 response element (A2RE), a cis-acting signal present in certain trafficked mRNAs, including those encoding myelin basic protein (MBP), CaMKII, neurogranin, and Arc [, , ]. Besides RNA trafficking, hnRNP A2/B1 is also involved in many aspects of mRNA processing, including packaging of nascent transcripts, splicing of pre-mRNAs, and translational regulation []. For instance, it functions as a splicing factor that regulates alternative splicing of tumour suppressors, such as BIN1, WWOX, the antiapoptotic proteins c-FLIP and caspase-9B, the insulin receptor (IR), and the RON proto-oncogene among others []. The overexpression of hnRNP A2/B1 has been linked to many cancers and may play a role in tumor cell differentiation []. hnRNP A2/B1 contains two RNA recognition motifs (RRMs), followed by a long glycine-rich region at the C terminus [].
•
•
•
•
•
Protein Domain
IPR032675 | LRR_dom_sf
Type: Homologous_superfamily
Description: This superfamily represents a leucine-rich repeat (LRR), right-handed beta-alpha superhelix domain, such as that found in bacterial invasion protein internalin []or in the L domain from members of the epidermal growth-factor receptor (EGFR) family [].Leucine-rich repeats (LRR) consist of 2-45 motifs of 20-30 amino acids in length that generally folds into an arc or horseshoe shape []. LRRs occur in proteins ranging from viruses to eukaryotes, and appear to provide a structural framework for the formation of protein-protein interactions [, ].Proteins containing LRRs include tyrosine kinase receptors, cell-adhesion molecules, virulence factors, and extracellular matrix-binding glycoproteins, and are involved in a variety of biological processes, including signal transduction, cell adhesion, DNA repair, recombination, transcription, RNA processing, disease resistance, apoptosis, and the immune response [].
•
•
•
•
•
Publication
12243756 | -
First Author: Brumwell C
Year: 2002
Journal: Exp Cell Res
Title: Intracellular trafficking of hnRNP A2 in oligodendrocytes.
Volume: 279
Issue: 2
Pages: 310-20
•
•
•
•
•
Publication
20406423 | -
First Author: Han SP
Year: 2010
Journal: Traffic
Title: Differential subcellular distributions and trafficking functions of hnRNP A2/B1 spliceoforms.
Volume: 11
Issue: 7
Pages: 886-98
•
•
•
•
•
Publication
10567417 | -
First Author: Munro TP
Year: 1999
Journal: J Biol Chem
Title: Mutational analysis of a heterogeneous nuclear ribonucleoprotein A2 response element for RNA trafficking.
Volume: 274
Issue: 48
Pages: 34389-95
•
•
•
•
•
Publication
14523087 | -
First Author: Shan J
Year: 2003
Journal: J Neurosci
Title: A molecular mechanism for mRNA trafficking in neuronal dendrites.
Volume: 23
Issue: 26
Pages: 8859-66
•
•
•
•
•
Publication
21586613 | -
First Author: Golan-Gerstl R
Year: 2011
Journal: Cancer Res
Title: Splicing factor hnRNP A2/B1 regulates tumor suppressor gene splicing and is an oncogenic driver in glioblastoma.
Volume: 71
Issue: 13
Pages: 4464-72
•
•
•
•
•
Publication
20604928 | -
 
First Author: Cui H
Year: 2010
Journal: BMC Cancer
Title: Up-regulation and subcellular localization of hnRNP A2/B1 in the development of hepatocellular carcinoma.
Volume: 10
Pages: 356
•
•
•
•
•
Publication
16505176 | J:121501
First Author: Donath S
Year: 2006
Journal: Circulation
Title: Apoptosis repressor with caspase recruitment domain is required for cardioprotection in response to biomechanical and ischemic stress.
Volume: 113
Issue: 9
Pages: 1203-12
•
•
•
•
•
Publication
22082675 | J:193803
First Author: Zaiman AL
Year: 2011
Journal: Circulation
Title: A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension.
Volume: 124
Issue: 23
Pages: 2533-42
•
•
•
•
•
Publication
24312627 | J:211017
First Author: Davis J
Year: 2013
Journal: PLoS One
Title: Apoptosis repressor with a CARD domain (ARC) restrains Bax-mediated pathogenesis in dystrophic skeletal muscle.
Volume: 8
Issue: 12
Pages: e82053
•
•
•
•
•
Publication
22505735 | J:184694
First Author: Tomikawa J
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain.
Volume: 109
Issue: 20
Pages: E1294-301
•
•
•
•
•
Publication
14645204 | J:87688
First Author: Abmayr S
Year: 2004
Journal: Hum Mol Genet
Title: Characterization of ARC, apoptosis repressor interacting with CARD, in normal and dystrophin-deficient skeletal muscle.
Volume: 13
Issue: 2
Pages: 213-21
•
•
•
•
•
Publication
16172617 | J:151302
First Author: Martin NM
Year: 2006
Journal: Int J Obes (Lond)
Title: Abnormalities of the somatotrophic axis in the obese agouti mouse.
Volume: 30
Issue: 3
Pages: 430-8
•
•
•
•
•
Publication
19628573 | J:157328
First Author: Villanueva EC
Year: 2009
Journal: Endocrinology
Title: Complex regulation of mammalian target of rapamycin complex 1 in the basomedial hypothalamus by leptin and nutritional status.
Volume: 150
Issue: 10
Pages: 4541-51
•
•
•
•
•
Publication
21846903 | J:182172
First Author: Reaux-Le Goazigo A
Year: 2011
Journal: Am J Physiol Endocrinol Metab
Title: Apelin and the proopiomelanocortin system: a new regulatory pathway of hypothalamic α-MSH release.
Volume: 301
Issue: 5
Pages: E955-66
•
•
•
•
•
Publication
17202473 | J:117213
First Author: Münzberg H
Year: 2007
Journal: J Neurosci
Title: Appropriate inhibition of orexigenic hypothalamic arcuate nucleus neurons independently of leptin receptor/STAT3 signaling.
Volume: 27
Issue: 1
Pages: 69-74
•
•
•
•
•
Publication
24166765 | J:203061
First Author: Gao Y
Year: 2014
Journal: Glia
Title: Hormones and diet, but not body weight, control hypothalamic microglial activity.
Volume: 62
Issue: 1
Pages: 17-25
•
•
•
•
•
Publication
27207522 | J:249420
First Author: Sun Y
Year: 2016
Journal: Diabetes
Title: The Acute-Phase Protein Orosomucoid Regulates Food Intake and Energy Homeostasis via Leptin Receptor Signaling Pathway.
Volume: 65
Issue: 6
Pages: 1630-41
•
•
•
•
•
Publication
28263184 | J:243376
First Author: Claflin KE
Year: 2017
Journal: J Clin Invest
Title: Angiotensin AT1A receptors on leptin receptor-expressing cells control resting metabolism.
Volume: 127
Issue: 4
Pages: 1414-1424
•
•
•
•
•
Publication
30938715 | J:290747
First Author: Bouyakdan K
Year: 2019
Journal: J Clin Invest
Title: The gliotransmitter ACBP controls feeding and energy homeostasis via the melanocortin system.
Volume: 129
Issue: 6
Pages: 2417-2430
•
•
•
•
•
Publication
21325051 | J:173859
First Author: Quennell JH
Year: 2011
Journal: Endocrinology
Title: Leptin deficiency and diet-induced obesity reduce hypothalamic kisspeptin expression in mice.
Volume: 152
Issue: 4
Pages: 1541-50
•
•
•
•
•
Publication
35917179 | J:335840
 
First Author: Hwang E
Year: 2022
Journal: JCI Insight
Title: Sustained inhibition of NPY/AgRP neuronal activity by FGF1.
Volume: 7
Issue: 17
•
•
•
•
•
Publication
22381575 | J:187483
First Author: Yi CX
Year: 2012
Journal: Dis Model Mech
Title: High-fat-diet exposure induces IgG accumulation in hypothalamic microglia.
Volume: 5
Issue: 5
Pages: 686-90
•
•
•
•
•
Publication
31245789 | J:286156
First Author: Mirzadeh Z
Year: 2019
Journal: Nat Metab
Title: Perineuronal Net Formation during the Critical Period for Neuronal Maturation in the Hypothalamic Arcuate Nucleus.
Volume: 1
Issue: 2
Pages: 212-221
•
•
•
•
•
Publication
29522093 | J:260503
First Author: Pan W
Year: 2018
Journal: Endocrinology
Title: Essential Role for Hypothalamic Calcitonin Receptor‒Expressing Neurons in the Control of Food Intake by Leptin.
Volume: 159
Issue: 4
Pages: 1860-1872
•
•
•
•
•
Publication
9868202 | J:52175
First Author: Jang M
Year: 1998
Journal: J Nutr
Title: Neuropeptide Y and corticotropin-releasing hormone concentrations within specific hypothalamic regions of lean but not ob/ob mice respond to food-deprivation and refeeding.
Volume: 128
Issue: 12
Pages: 2520-5
•
•
•
•
•
Publication
18784302 | J:141262
First Author: Wu Q
Year: 2008
Journal: J Neurosci
Title: Ablation of neurons expressing agouti-related protein activates fos and gliosis in postsynaptic target regions.
Volume: 28
Issue: 37
Pages: 9218-26
•
•
•
•
•
Publication
26873854 | J:323118
First Author: Chen Y
Year: 2017
Journal: Mol Neurobiol
Title: Neuronal Activity-Induced Sterol Regulatory Element Binding Protein-1 (SREBP1) is Disrupted in Dysbindin-Null Mice-Potential Link to Cognitive Impairment in Schizophrenia.
Volume: 54
Issue: 3
Pages: 1699-1709
•
•
•
•
•
Publication
30242133 | J:266535
First Author: Yan J
Year: 2018
Journal: Proc Natl Acad Sci U S A
Title: Activation of autophagy rescues synaptic and cognitive deficits in fragile X mice.
Volume: 115
Issue: 41
Pages: E9707-E9716
•
•
•
•
•
Publication
24911373 | J:213483
First Author: Wu LL
Year: 2014
Journal: Am J Pathol
Title: Commensal bacterial endocytosis in epithelial cells is dependent on myosin light chain kinase-activated brush border fanning by interferon-γ.
Volume: 184
Issue: 8
Pages: 2260-74
•
•
•
•
•
Publication
19750198 | J:180422
 
First Author: Matsuo N
Year: 2009
Journal: Front Behav Neurosci
Title: Neural activity changes underlying the working memory deficit in alpha-CaMKII heterozygous knockout mice.
Volume: 3
Pages: 20
•
•
•
•
•
Publication
19005016 | J:143542
First Author: Asarian L
Year: 2009
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Loss of cholecystokinin and glucagon-like peptide-1-induced satiation in mice lacking serotonin 2C receptors.
Volume: 296
Issue: 1
Pages: R51-6
•
•
•
•
•
Publication
30776325 | J:276275
 
First Author: Ikeda Y
Year: 2019
Journal: Brain Res
Title: Expression of progesterone receptor, estrogen receptors α and β, and kisspeptin in the hypothalamus during perinatal development of gonad-lacking steroidogenic factor-1 knockout mice.
Volume: 1712
Pages: 167-179
•
•
•
•
•
Publication
24130552 | J:261765
 
First Author: Knoll JG
Year: 2013
Journal: Front Endocrinol (Lausanne)
Title: Developmental profile and sexually dimorphic expression of kiss1 and kiss1r in the fetal mouse brain.
Volume: 4
Pages: 140
•
•
•
•
•
Publication
15930502 | J:110077
First Author: Zhang WP
Year: 2005
Journal: Learn Mem
Title: Mapping neuronal activation and the influence of adrenergic signaling during contextual memory retrieval.
Volume: 12
Issue: 3
Pages: 239-47
•
•
•
•
•
Publication
29515368 | J:290171
 
First Author: Subbanna S
Year: 2018
Journal: Front Mol Neurosci
Title: CB1R-Mediated Activation of Caspase-3 Causes Epigenetic and Neurobehavioral Abnormalities in Postnatal Ethanol-Exposed Mice.
Volume: 11
Pages: 45
•
•
•
•
•
Publication
24531537 | J:229335
First Author: Bo L
Year: 2014
Journal: Cell Death Differ
Title: Autophagic program is regulated by miR-325.
Volume: 21
Issue: 6
Pages: 967-77
•
•
•
•
•
Publication
15655183 | J:112541
First Author: Sobol SE
Year: 2005
Journal: Arch Otolaryngol Head Neck Surg
Title: Abnormal mesenchymal differentiation in the superior semicircular canal of brn4/pou3f4 knockout mice.
Volume: 131
Issue: 1
Pages: 41-5
•
•
•
•
•
Publication
10747854 | J:62272
First Author: Zhu Y
Year: 2000
Journal: J Biol Chem
Title: Deletion of PBP/PPARBP, the gene for nuclear receptor coactivator peroxisome proliferator-activated receptor-binding protein, results in embryonic lethality.
Volume: 275
Issue: 20
Pages: 14779-82
•
•
•
•
•
Publication
30353127 | J:269763
First Author: Dalby MJ
Year: 2018
Journal: Sci Rep
Title: Diet induced obesity is independent of metabolic endotoxemia and TLR4 signalling, but markedly increases hypothalamic expression of the acute phase protein, SerpinA3N.
Volume: 8
Issue: 1
Pages: 15648
•
•
•
•
•
Publication
9729427 | J:50229
First Author: Guan XM
Year: 1998
Journal: Brain Res Mol Brain Res
Title: Evidence of altered hypothalamic pro-opiomelanocortin/ neuropeptide Y mRNA expression in tubby mice.
Volume: 59
Issue: 2
Pages: 273-9
•
•
•
•
•
Publication
23283339 | J:193919
First Author: Lu F
Year: 2013
Journal: J Neurosci
Title: Rax is a selector gene for mediobasal hypothalamic cell types.
Volume: 33
Issue: 1
Pages: 259-72
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom