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Search results 601 to 700 out of 831 for Atg5

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Type Details Score
Publication
27407143 | J:235155
First Author: Doucet-Beaupré H
Year: 2016
Journal: Proc Natl Acad Sci U S A
Title: Lmx1a and Lmx1b regulate mitochondrial functions and survival of adult midbrain dopaminergic neurons.
Volume: 113
Issue: 30
Pages: E4387-96
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Publication
28474670 | J:250342
 
First Author: Wang F
Year: 2017
Journal: Nat Commun
Title: Protein kinase C-alpha suppresses autophagy and induces neural tube defects via miR-129-2 in diabetic pregnancy.
Volume: 8
Pages: 15182
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Publication
31059511 | J:275030
First Author: Ferder IC
Year: 2019
Journal: PLoS Genet
Title: Meiotic gatekeeper STRA8 suppresses autophagy by repressing Nr1d1 expression during spermatogenesis in mice.
Volume: 15
Issue: 5
Pages: e1008084
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Publication
36198274 | J:329967
First Author: Li H
Year: 2022
Journal: Cell Rep
Title: Destabilization of TP53 by USP10 is essential for neonatal autophagy and survival.
Volume: 41
Issue: 1
Pages: 111435
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Publication
38218976 | J:344311
First Author: Yan W
Year: 2024
Journal: Commun Biol
Title: Loss of Mptx2 alters bacteria composition and intestinal homeostasis potentially by impairing autophagy.
Volume: 7
Issue: 1
Pages: 94
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Publication
27568566 | J:239017
First Author: Steinmetz CC
Year: 2016
Journal: Cell Rep
Title: Upregulation of μ3A Drives Homeostatic Plasticity by Rerouting AMPAR into the Recycling Endosomal Pathway.
Volume: 16
Issue: 10
Pages: 2711-2722
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Publication
27383629 | J:316639
 
First Author: He MY
Year: 2016
Journal: Open Biol
Title: Nrf2 signalling and autophagy are involved in diabetes mellitus-induced defects in the development of mouse placenta.
Volume: 6
Issue: 7
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Publication
29180572 | J:253982
 
First Author: Norlin S
Year: 2018
Journal: Development
Title: The ATPase activity of Asna1/TRC40 is required for pancreatic progenitor cell survival.
Volume: 145
Issue: 1
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Publication
23907538 | J:203690
First Author: Martinez-Lopez N
Year: 2013
Journal: EMBO Rep
Title: Autophagy in Myf5+ progenitors regulates energy and glucose homeostasis through control of brown fat and skeletal muscle development.
Volume: 14
Issue: 9
Pages: 795-803
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Publication
33436499 | J:308926
 
First Author: Yang J
Year: 2021
Journal: Sci Signal
Title: Augmented BMP signaling commits cranial neural crest cells to a chondrogenic fate by suppressing autophagic β-catenin degradation.
Volume: 14
Issue: 665
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Publication
22904094 | J:212629
First Author: Papanicolaou KN
Year: 2012
Journal: Circ Res
Title: Mitofusins 1 and 2 are essential for postnatal metabolic remodeling in heart.
Volume: 111
Issue: 8
Pages: 1012-26
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Publication
30818059 | J:291414
 
First Author: Pérez-Estrada JR
Year: 2019
Journal: Free Radic Biol Med
Title: Reduced lifespan of mice lacking catalase correlates with altered lipid metabolism without oxidative damage or premature aging.
Volume: 135
Pages: 102-115
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Publication
19463158 | J:149994
 
First Author: Hughes DS
Year: 2009
Journal: BMC Dev Biol
Title: Extensive molecular differences between anterior- and posterior-half-sclerotomes underlie somite polarity and spinal nerve segmentation.
Volume: 9
Pages: 30
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Publication
32027825 | J:284925
     
First Author: Luo L
Year: 2020
Journal: Neuron
Title: Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.
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Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
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Publication
32290105 | J:282558
 
First Author: Collin GB
Year: 2020
Journal: Cells
Title: Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss.
Volume: 9
Issue: 4
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Publication
- | J:101977
     
First Author: The Jackson Laboratory
Year: 2005
Journal: Unpublished
Title: Information obtained from The Jackson Laboratory, Bar Harbor, ME
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Publication
- | J:342607
       
First Author: Birgit Meldal and Sandra Orchard (1). (1) European Bioinformatics Institute (EBI), Hinxton, Cambridgeshire, United Kingdom
Year: 2023
Title: Manual transfer of experimentally-verified manual GO annotation data to homologous complexes by curator judgment of sequence, composition and function similarity
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10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
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Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
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Publication
- | J:80001
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: FANTOM2 Data Curation in Mouse Genome Informatics
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Publication
- | J:346132
       
First Author: The Gene Ontology Consortium
Year: 2016
Title: Automatic assignment of GO terms using logical inference, based on on inter-ontology links
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Publication
- | J:80155
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations for FANTOM2 data
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Publication
12520002 | J:91812
First Author: Stryke D
Year: 2003
Journal: Nucleic Acids Res
Title: BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.
Volume: 31
Issue: 1
Pages: 278-81
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Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
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Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
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Publication
- | J:23000
       
First Author: MGD Nomenclature Committee
Year: 1995
Title: Nomenclature Committee Use
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:342587
       
First Author: AgBase, BHF-UCL, Parkinson's UK-UCL, dictyBase, HGNC, Roslin Institute, FlyBase and UniProtKB curators
Year: 2011
Title: Manual transfer of experimentally-verified manual GO annotation data to orthologs by curator judgment of sequence similarity
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
23059785 | J:205624
First Author: Keil E
Year: 2013
Journal: Cell Death Differ
Title: Phosphorylation of Atg5 by the Gadd45β-MEKK4-p38 pathway inhibits autophagy.
Volume: 20
Issue: 2
Pages: 321-32
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Publication
29257951 | J:253962
First Author: Guo H
Year: 2017
Journal: Dev Cell
Title: Atg5 Disassociates the V1V0-ATPase to Promote Exosome Production and Tumor Metastasis Independent of Canonical Macroautophagy.
Volume: 43
Issue: 6
Pages: 716-730.e7
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Publication
31086810 | J:288680
First Author: Xie X
Year: 2019
Journal: Sci Adv
Title: The immunoproteasome catalytic β5i subunit regulates cardiac hypertrophy by targeting the autophagy protein ATG5 for degradation.
Volume: 5
Issue: 5
Pages: eaau0495
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Publication
23912709 | J:229002
First Author: He Z
Year: 2013
Journal: Cell Death Differ
Title: p73 regulates autophagy and hepatocellular lipid metabolism through a transcriptional activation of the ATG5 gene.
Volume: 20
Issue: 10
Pages: 1415-24
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Publication
33369639 | J:300164
First Author: Ji L
Year: 2020
Journal: Invest Ophthalmol Vis Sci
Title: Immunosubunit β5i Knockout Suppresses Neovascularization and Restores Autophagy in Retinal Neovascularization by Targeting ATG5 for Degradation.
Volume: 61
Issue: 14
Pages: 30
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DO Term
DOID:0080259 | autosomal recessive spinocerebellar ataxia 25
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Interaction Experiment
Arbogast F (2019)
Description: ATG5 is required for B cell polarization and presentation of particulate antigens.
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Interaction Experiment
Baines K (2022)
Description: The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.
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Allele
Atg5<em2Smoc> | MGI:7275259
Name: autophagy related 5; endonuclease-mediated mutation 2, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Null/knockout
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Strain
MGI:6354553 | C57BL/6JSmoc-Atg5<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Allele
Tg(Eno2-EGFP/Atg5)1Nmz | MGI:6887941
Name: transgene insertion 1, Noboru Mizushima
Allele Type: Transgenic
Attribute String: Inserted expressed sequence, Reporter
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Publication
35449600 | -
First Author: Baines K
Year: 2022
Journal: Autophagy Rep
Title: The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery.
Volume: 1
Issue: 1
Pages: 88-118
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Strain
MGI:6147319 | C57BL/6J-Tg(Eno2-GFP/Atg5)1Nmz
Attribute String: mutant strain, coisogenic, transgenic
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Allele
Col1a1<tm1(tetO-GFP/RNAi:Atg5)Mnar> | MGI:6504237
Name: collagen, type I, alpha 1; targeted mutation 1, Masashi Narita
Allele Type: Targeted
Attribute String: Inducible, Knockdown, Reporter, RMCE-ready
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Publication
18321988 | J:343387
First Author: Fujita N
Year: 2008
Journal: Mol Biol Cell
Title: The Atg16L complex specifies the site of LC3 lipidation for membrane biogenesis in autophagy.
Volume: 19
Issue: 5
Pages: 2092-100
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Publication
25642769 | J:220375
First Author: Zhu X
Year: 2015
Journal: J Clin Invest
Title: Cytosolic HMGB1 controls the cellular autophagy/apoptosis checkpoint during inflammation.
Volume: 125
Issue: 3
Pages: 1098-110
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Publication
9852036 | -
First Author: Mizushima N
Year: 1998
Journal: J Biol Chem
Title: A new protein conjugation system in human. The counterpart of the yeast Apg12p conjugation system essential for autophagy.
Volume: 273
Issue: 51
Pages: 33889-92
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Protein Domain
IPR007242 | Atg12
Type: Family
Description: Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In yeast, 15 Atg proteins coordinate the formation of autophagosomes. The pre-autophagosomal structure contains at least five Atg proteins: Atg1p, Atg2p, Atg5p, Aut7p/Atg8p and Atg16p, found in the vacuole [, ]. The C-terminal glycine of Atg12p is conjugated to a lysine residue of Atg5p via an isopeptide bond. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. Autophagy protein 16 (Atg16) has been shown to bind to Atg5 and is required for the function of the Atg12p-Atg5p conjugate []. Autophagy protein 5 (Atg5) is directly required for the import of aminopeptidase I via the cytoplasm-to-vacuole targeting pathway [].This entry represents the C-terminal domain of Atg12, which is covalently bound to Atg5 [].
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Publication
31949142 | J:289934
First Author: Cassidy LD
Year: 2020
Journal: Nat Commun
Title: Temporal inhibition of autophagy reveals segmental reversal of ageing with increased cancer risk.
Volume: 11
Issue: 1
Pages: 307
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Protein
Q9CQY1
Organism: Mus musculus/domesticus
Length: 141  
Fragment?: false
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Protein
D3YZW7
Organism: Mus musculus/domesticus
Length: 154  
Fragment?: true
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Protein
D6RHC1
Organism: Mus musculus/domesticus
Length: 81  
Fragment?: false
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Protein
Q6EBV9
Organism: Mus musculus/domesticus
Length: 922  
Fragment?: false
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Protein
Q8R1P4
Organism: Mus musculus/domesticus
Length: 215  
Fragment?: false
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Protein
Q9CPX6
Organism: Mus musculus/domesticus
Length: 314  
Fragment?: false
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Protein
Q68FE2
Organism: Mus musculus/domesticus
Length: 839  
Fragment?: false
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Protein
A0A087WQ26
Organism: Mus musculus/domesticus
Length: 176  
Fragment?: false
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Protein
A0A0R4J029
Organism: Mus musculus/domesticus
Length: 211  
Fragment?: false
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Protein
A0A087WRG3
Organism: Mus musculus/domesticus
Length: 47  
Fragment?: true
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Protein
A0A087WPL8
Organism: Mus musculus/domesticus
Length: 278  
Fragment?: true
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Protein
Q8BRS1
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: false
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Protein
A1A4C2
Organism: Mus musculus/domesticus
Length: 492  
Fragment?: true
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Protein
A0A087WP33
Organism: Mus musculus/domesticus
Length: 847  
Fragment?: true
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Publication
18398292 | -
First Author: Noda T
Year: 2008
Journal: Autophagy
Title: The Ubi brothers reunited.
Volume: 4
Issue: 4
Pages: 540-1
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Publication
17227760 | -
First Author: Yamada Y
Year: 2007
Journal: J Biol Chem
Title: The crystal structure of Atg3, an autophagy-related ubiquitin carrier protein (E2) enzyme that mediates Atg8 lipidation.
Volume: 282
Issue: 11
Pages: 8036-43
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Publication
23255127 | -
First Author: Flanagan MD
Year: 2013
Journal: Cell Cycle
Title: An Atg10-like E2 enzyme is essential for cell cycle progression but not autophagy in Schizosaccharomyces pombe.
Volume: 12
Issue: 2
Pages: 271-7
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Publication
10662773 | -
First Author: Noda T
Year: 2000
Journal: J Cell Biol
Title: Apg9p/Cvt7p is an integral membrane protein required for transport vesicle formation in the Cvt and autophagy pathways.
Volume: 148
Issue: 3
Pages: 465-80
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Publication
33106658 | -
First Author: Matoba K
Year: 2020
Journal: Nat Struct Mol Biol
Title: Atg9 is a lipid scramblase that mediates autophagosomal membrane expansion.
Volume: 27
Issue: 12
Pages: 1185-1193
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Publication
24185444 | -
First Author: Zhang H
Year: 2013
Journal: Autophagy
Title: The two C. elegans ATG-16 homologs have partially redundant functions in the basal autophagy pathway.
Volume: 9
Issue: 12
Pages: 1965-74
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Publication
26687600 | -
First Author: Wu F
Year: 2015
Journal: Mol Cell
Title: Structural Basis of the Differential Function of the Two C. elegans Atg8 Homologs, LGG-1 and LGG-2, in Autophagy.
Volume: 60
Issue: 6
Pages: 914-29
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Protein Domain
IPR007135 | Atg3/Atg10
Type: Family
Description: This entry represents a group of ubiquitin-like-conjugating enzymes, including Atg3 and Atg10.Atg3 is the E2 enzyme for the LC3 lipidation process []. It is essential for autophagocytosis. The super protein complex, the Atg16L complex, consists of multiple Atg12-Atg5 conjugates. Atg16L has an E3-like role in the LC3 lipidation reaction. The activated intermediate, LC3-Atg3 (E2), is recruited to the site where the lipidation takes place []. Atg3 catalyses the conjugation of Atg8 and phosphatidylethanolamine (PE). Atg3 has an alpha/β-fold, and its core region is topologically similar to canonical E2 enzymes. Atg3 has two regions inserted in the core region and another with a long α-helical structure that protrudes from the core region as far as 30 A []. It interacts with atg8 through an intermediate thioester bond between Cys-288 and the C-terminal Gly of atg8. It also interacts with the C-terminal region of the E1-like atg7 enzyme.Atg10 acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5 [].
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Protein Domain
IPR007241 | Autophagy-rel_prot_9
Type: Family
Description: Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In yeast, 15 Atg proteins coordinate the formation of autophagosomes. The pre-autophagosomal structure contains at least five Atg proteins: Atg1p, Atg2p, Atg5p, Aut7p/Atg8p and Atg16p, found in the vacuole [, ]. The C-terminal glycine of Atg12p is conjugated to a lysine residue of Atg5p via an isopeptide bond. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. Autophagy protein 16 (Atg16) has been shown to bind to Atg5 and is required for the function of the Atg12p-Atg5p conjugate []. Autophagy protein 5 (Atg5) is directly required for the import of aminopeptidase I via the cytoplasm-to-vacuole targeting pathway [].Atg9 plays a direct role in the formation of the cytoplasm to vacuole targeting and autophagic vesicles. It colocalizes with Atg2 at the expanding edge of the isolation membrane and acts as a lipid scramblase that translocates phospholipids delivered by Atg2 from the cytoplasmic to the luminal leaflet [, ].
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Protein Domain
IPR007240 | Atg17
Type: Family
Description: Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In yeast, 15 Atg proteins coordinate the formation of autophagosomes. The pre-autophagosomal structure contains at least five Atg proteins: Atg1p, Atg2p, Atg5p, Aut7p/Atg8p and Atg16p, found in the vacuole [, ]. The C-terminal glycine of Atg12p is conjugated to a lysine residue of Atg5p via an isopeptide bond. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. Autophagy protein 16 (Atg16) has been shown to bind to Atg5 and is required for the function of the Atg12p-Atg5p conjugate []. Autophagy protein 5 (Atg5) is directly required for the import of aminopeptidase I via the cytoplasm-to-vacuole targeting pathway [].Autophagy protein 17 (Atg17) forms complex with Atg29 and Atg31, and this complex is critical for both PAS (preautophagosomal structure) formation and autophagy [].
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Protein Domain
IPR013923 | Autophagy-rel_prot_16_dom
Type: Domain
Description: Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In yeast, 15 Atg proteins coordinate the formation of autophagosomes. The pre-autophagosomal structure contains at least five Atg proteins: Atg1p, Atg2p, Atg5p, Aut7p/Atg8p and Atg16p, found in the vacuole [, ]. The C-terminal glycine of Atg12p is conjugated to a lysine residue of Atg5p via an isopeptide bond. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. Autophagy protein 16 (Atg16) has been shown to bind to Atg5 and is required for the function of the Atg12p-Atg5p conjugate []. Autophagy protein 5 (Atg5) is directly required for the import of aminopeptidase I via the cytoplasm-to-vacuole targeting pathway [].This entry represents autophagy protein 16 (Apg16), which is required for the function of the Apg12p-Apg5p conjugate.
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Protein Domain
IPR045160 | ATG16
Type: Family
Description: Macroautophagy is a bulk degradation process induced by starvation in eukaryotic cells. In yeast, 15 Atg proteins coordinate the formation of autophagosomes. The pre-autophagosomal structure contains at least five Atg proteins: Atg1p, Atg2p, Atg5p, Aut7p/Atg8p and Atg16p, found in the vacuole [, ]. The C-terminal glycine of Atg12p is conjugated to a lysine residue of Atg5p via an isopeptide bond. During autophagy, cytoplasmic components are enclosed in autophagosomes and delivered to lysosomes/vacuoles. Autophagy protein 16 (Atg16) has been shown to bind to Atg5 and is required for the function of the Atg12p-Atg5p conjugate []. Autophagy protein 5 (Atg5) is directly required for the import of aminopeptidase I via the cytoplasm-to-vacuole targeting pathway [].This entry includes ATG16-1 and ATG16-2 [, ].
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