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Search results 601 to 700 out of 701 for Atg7

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Type Details Score
Protein Domain
IPR007135 | Atg3/Atg10
Type: Family
Description: This entry represents a group of ubiquitin-like-conjugating enzymes, including Atg3 and Atg10.Atg3 is the E2 enzyme for the LC3 lipidation process []. It is essential for autophagocytosis. The super protein complex, the Atg16L complex, consists of multiple Atg12-Atg5 conjugates. Atg16L has an E3-like role in the LC3 lipidation reaction. The activated intermediate, LC3-Atg3 (E2), is recruited to the site where the lipidation takes place []. Atg3 catalyses the conjugation of Atg8 and phosphatidylethanolamine (PE). Atg3 has an alpha/β-fold, and its core region is topologically similar to canonical E2 enzymes. Atg3 has two regions inserted in the core region and another with a long α-helical structure that protrudes from the core region as far as 30 A []. It interacts with atg8 through an intermediate thioester bond between Cys-288 and the C-terminal Gly of atg8. It also interacts with the C-terminal region of the E1-like atg7 enzyme.Atg10 acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5 [].
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Publication
23112293 | J:347184
First Author: Choy A
Year: 2012
Journal: Science
Title: The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation.
Volume: 338
Issue: 6110
Pages: 1072-6
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Publication
29257951 | J:253962
First Author: Guo H
Year: 2017
Journal: Dev Cell
Title: Atg5 Disassociates the V1V0-ATPase to Promote Exosome Production and Tumor Metastasis Independent of Canonical Macroautophagy.
Volume: 43
Issue: 6
Pages: 716-730.e7
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Protein
Q504P1
Organism: Mus musculus/domesticus
Length: 68  
Fragment?: false
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Publication
9632726 | -
First Author: Taylor SV
Year: 1998
Journal: J Biol Chem
Title: Thiamin biosynthesis in Escherichia coli. Identification of ThiS thiocarboxylate as the immediate sulfur donor in the thiazole formation.
Volume: 273
Issue: 26
Pages: 16555-60
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Publication
11096062 | -
First Author: Tanida I
Year: 2001
Journal: J Biol Chem
Title: The human homolog of Saccharomyces cerevisiae Apg7p is a Protein-activating enzyme for multiple substrates including human Apg12p, GATE-16, GABARAP, and MAP-LC3.
Volume: 276
Issue: 3
Pages: 1701-6
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Protein Domain
IPR045886 | ThiF/MoeB/HesA
Type: Family
Description: This is a family of E1-like enzymes that contain the NAD/FAD-binding fold []. Proteins in this entry include ThiF/MoeB/HesA from bacteria and E1-like enzymes from eukaryotes. ThiF/MoeB/HesA are involved in molybdopterin and thiamine biosynthesis. The common reaction mechanism catalysed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD and ThiS, respectively, on the alpha-phosphate of an ATP molecule bound at the active site of the activating enzymes, leading to the formation of a high-energy acyladenylate intermediate and subsequently to the formation of a thiocarboxylate at the C termini of MoaD and ThiS. MoeB, as the MPT synthase (MoaE/MoaD complex) sulfurase, is involved in the biosynthesis of the molybdenum cofactor, a derivative of the tricyclic pterin, molybdopterin (MPT) []. ThiF catalyses the adenylation of ThiS, as part of the biosynthesis pathway of thiamin pyrophosphate (vitamin B1) []. Some ThiF/MoeB/HesA family members such as Atg7, MOCS3 andSAE1/2, have different functions. For instance, Atg7 is a protein-activating enzyme for multiple substrates [], while SAE1/2 acts as an E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4 []. MOCS3 is a adenylyltransferase and sulfurtransferase involved in 2-thiolation of mcm5S2U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) [].
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Publication
17190837 | J:125311
First Author: Pua HH
Year: 2007
Journal: J Exp Med
Title: A critical role for the autophagy gene Atg5 in T cell survival and proliferation.
Volume: 204
Issue: 1
Pages: 25-31
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Publication
31601814 | J:282114
First Author: Liu M
Year: 2019
Journal: Nat Commun
Title: BRG1 attenuates colonic inflammation and tumorigenesis through autophagy-dependent oxidative stress sequestration.
Volume: 10
Issue: 1
Pages: 4614
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Publication
26549682 | J:270139
First Author: Sun N
Year: 2015
Journal: Mol Cell
Title: Measuring In Vivo Mitophagy.
Volume: 60
Issue: 4
Pages: 685-96
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Publication
24203955 | J:206978
First Author: Chen S
Year: 2013
Journal: Cancer Discov
Title: Tumor-promoting and -suppressive roles of autophagy in the same mouse model of BrafV600E-driven lung cancer.
Volume: 3
Issue: 11
Pages: 1225-7
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Publication
29546328 | J:264554
First Author: Zhou J
Year: 2018
Journal: Biol Reprod
Title: Hypoxia-inducible factor-1α-dependent autophagy plays a role in glycolysis switch in mouse granulosa cells.
Volume: 99
Issue: 2
Pages: 308-318
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Publication
34187889 | J:343812
 
First Author: Xu Y
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: Autophagy deficiency modulates microglial lipid homeostasis and aggravates tau pathology and spreading.
Volume: 118
Issue: 27
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Publication
19017811 | -
First Author: Schlieker CD
Year: 2008
Journal: Proc Natl Acad Sci U S A
Title: A functional proteomics approach links the ubiquitin-related modifier Urm1 to a tRNA modification pathway.
Volume: 105
Issue: 47
Pages: 18255-60
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Publication
25678563 | J:292536
First Author: Lauranzano E
Year: 2015
Journal: Brain
Title: Peptidylprolyl isomerase A governs TARDBP function and assembly in heterogeneous nuclear ribonucleoprotein complexes.
Volume: 138
Issue: Pt 4
Pages: 974-91
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Publication
26581593 | J:252883
First Author: Xiao Y
Year: 2016
Journal: Diabetes
Title: Activation of ERK1/2 Ameliorates Liver Steatosis in Leptin Receptor-Deficient (db/db) Mice via Stimulating ATG7-Dependent Autophagy.
Volume: 65
Issue: 2
Pages: 393-405
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Publication
37302692 | J:348691
 
First Author: Oh J
Year: 2023
Journal: Metabolism
Title: High levels of intracellular endotrophin in adipocytes mediate COPII vesicle supplies to autophagosome to impair autophagic flux and contribute to systemic insulin resistance in obesity.
Volume: 145
Pages: 155629
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Publication
23117929 | J:192841
First Author: Jansen HJ
Year: 2012
Journal: Endocrinology
Title: Autophagy activity is up-regulated in adipose tissue of obese individuals and modulates proinflammatory cytokine expression.
Volume: 153
Issue: 12
Pages: 5866-74
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Publication
30102258 | J:266453
First Author: Feng D
Year: 2018
Journal: J Clin Invest
Title: SNAP23 regulates BAX-dependent adipocyte programmed cell death independently of canonical macroautophagy.
Volume: 128
Issue: 9
Pages: 3941-3956
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Publication
28422956 | J:246525
First Author: Jo E
Year: 2017
Journal: PLoS One
Title: Chronic activation of PPARα with fenofibrate reduces autophagic proteins in the liver of mice independent of FGF21.
Volume: 12
Issue: 4
Pages: e0173676
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Publication
20008137 | J:156484
First Author: Kimura A
Year: 2010
Journal: Am J Pathol
Title: The absence of interleukin-6 enhanced arsenite-induced renal injury by promoting autophagy of tubular epithelial cells with aberrant extracellular signal-regulated kinase activation.
Volume: 176
Issue: 1
Pages: 40-50
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Publication
21421856 | J:172749
First Author: Jia W
Year: 2011
Journal: J Immunol
Title: Temporal regulation of intracellular organelle homeostasis in T lymphocytes by autophagy.
Volume: 186
Issue: 9
Pages: 5313-22
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Publication
28808340 | J:256624
First Author: Sydor S
Year: 2017
Journal: Sci Rep
Title: Krüppel-like factor 6 is a transcriptional activator of autophagy in acute liver injury.
Volume: 7
Issue: 1
Pages: 8119
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Publication
28003215 | J:239164
First Author: Liu C
Year: 2017
Journal: Development
Title: Sirt1 regulates acrosome biogenesis by modulating autophagic flux during spermiogenesis in mice.
Volume: 144
Issue: 3
Pages: 441-451
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Publication
28548876 | J:316942
First Author: Tsai TH
Year: 2017
Journal: Autophagy
Title: The constitutive lipid droplet protein PLIN2 regulates autophagy in liver.
Volume: 13
Issue: 7
Pages: 1130-1144
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Publication
35008461 | J:331160
 
First Author: Ara A
Year: 2021
Journal: Int J Mol Sci
Title: The Energy Sensor AMPKα1 Is Critical in Rapamycin-Inhibition of mTORC1-S6K-Induced T-cell Memory.
Volume: 23
Issue: 1
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Publication
26982722 | J:232715
First Author: Ravindran R
Year: 2016
Journal: Nature
Title: The amino acid sensor GCN2 controls gut inflammation by inhibiting inflammasome activation.
Volume: 531
Issue: 7595
Pages: 523-527
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Publication
22294621 | J:196624
First Author: Sciarretta S
Year: 2012
Journal: Circulation
Title: Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome.
Volume: 125
Issue: 9
Pages: 1134-46
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Publication
28085543 | J:274495
First Author: Wang Q
Year: 2017
Journal: Autophagy
Title: Deletion of PRKAA triggers mitochondrial fission by inhibiting the autophagy-dependent degradation of DNM1L.
Volume: 13
Issue: 2
Pages: 404-422
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Publication
31314096 | J:279001
First Author: Kurashige T
Year: 2019
Journal: Endocrinology
Title: Basal Autophagy Deficiency Causes Thyroid Follicular Epithelial Cell Death in Mice.
Volume: 160
Issue: 9
Pages: 2085-2092
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Publication
24591579 | J:207394
First Author: Sebti S
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: BAT3 modulates p300-dependent acetylation of p53 and autophagy-related protein 7 (ATG7) during autophagy.
Volume: 111
Issue: 11
Pages: 4115-20
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Publication
24760879 | J:213744
First Author: Bang S
Year: 2014
Journal: Reproduction
Title: Autophagic activation in vitrified-warmed mouse oocytes.
Volume: 148
Issue: 1
Pages: 11-9
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Publication
33337568 | J:322817
First Author: Jo YR
Year: 2021
Journal: FASEB J
Title: Potential neuron-autonomous Purkinje cell degeneration by 2',3'-cyclic nucleotide 3'-phosphodiesterase promoter/Cre-mediated autophagy impairments.
Volume: 35
Issue: 1
Pages: e21225
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Publication
26417690 | J:233091
First Author: Fernández-Galilea M
Year: 2015
Journal: Biochem Biophys Res Commun
Title: AGPAT2 deficiency impairs adipogenic differentiation in primary cultured preadipocytes in a non-autophagy or apoptosis dependent mechanism.
Volume: 467
Issue: 1
Pages: 39-45
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Publication
38670239 | J:348034
 
First Author: Chen R
Year: 2024
Journal: Brain Behav Immun
Title: Destabilization of fear memory by Rac1-driven engram-microglia communication in hippocampus.
Volume: 119
Pages: 621-636
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Publication
19966812 | J:335668
First Author: Cooney R
Year: 2010
Journal: Nat Med
Title: NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation.
Volume: 16
Issue: 1
Pages: 90-7
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Publication
18974775 | J:158092
First Author: Huang Q
Year: 2009
Journal: Cell Death Differ
Title: A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress.
Volume: 16
Issue: 2
Pages: 264-77
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Publication
24296261 | J:210030
First Author: Suzuki M
Year: 2014
Journal: Biochim Biophys Acta
Title: Sirtuin1 and autophagy protect cells from fluoride-induced cell stress.
Volume: 1842
Issue: 2
Pages: 245-55
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Publication
24637330 | J:212487
First Author: Ghavami S
Year: 2014
Journal: Biochim Biophys Acta
Title: Airway mesenchymal cell death by mevalonate cascade inhibition: integration of autophagy, unfolded protein response and apoptosis focusing on Bcl2 family proteins.
Volume: 1843
Issue: 7
Pages: 1259-71
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Publication
27251173 | J:239637
First Author: Wang Y
Year: 2016
Journal: FASEB J
Title: Down-regulation of Risa improves insulin sensitivity by enhancing autophagy.
Volume: 30
Issue: 9
Pages: 3133-45
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Publication
28450279 | J:249937
First Author: Li C
Year: 2017
Journal: Am J Physiol Regul Integr Comp Physiol
Title: Autophagy upregulates (pro)renin receptor expression via reduction of P62/SQSTM1 and activation of ERK1/2 signaling pathway in podocytes.
Volume: 313
Issue: 1
Pages: R58-R64
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Publication
26807981 | J:249092
First Author: Pang J
Year: 2016
Journal: PLoS One
Title: Alcohol Dehydrogenase Protects against Endoplasmic Reticulum Stress-Induced Myocardial Contractile Dysfunction via Attenuation of Oxidative Stress and Autophagy: Role of PTEN-Akt-mTOR Signaling.
Volume: 11
Issue: 1
Pages: e0147322
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Publication
27653365 | J:317255
First Author: Chi HC
Year: 2016
Journal: Autophagy
Title: Thyroid hormone suppresses hepatocarcinogenesis via DAPK2 and SQSTM1-dependent selective autophagy.
Volume: 12
Issue: 12
Pages: 2271-2285
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Publication
34335611 | J:320986
 
First Author: Jang A
Year: 2021
Journal: Front Immunol
Title: Dependence on Autophagy for Autoreactive Memory B Cells in the Development of Pristane-Induced Lupus.
Volume: 12
Pages: 701066
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Publication
24362353 | J:320510
First Author: Strohecker AM
Year: 2014
Journal: Autophagy
Title: Autophagy promotes BrafV600E-driven lung tumorigenesis by preserving mitochondrial metabolism.
Volume: 10
Issue: 2
Pages: 384-5
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Publication
32066854 | J:341799
First Author: Robins E
Year: 2021
Journal: Cell Mol Immunol
Title: Conversion of effector CD4(+) T cells to a CD8(+) MHC II-recognizing lineage.
Volume: 18
Issue: 1
Pages: 150-161
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Protein
Q8VE47
Organism: Mus musculus/domesticus
Length: 403  
Fragment?: false
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Protein
Q8VBW6
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
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Protein
Q3TS59
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: true
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Protein
Q14BE0
Organism: Mus musculus/domesticus
Length: 186  
Fragment?: false
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Protein
A0A1L1SSH6
Organism: Mus musculus/domesticus
Length: 117  
Fragment?: true
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Protein
F6VRI6
Organism: Mus musculus/domesticus
Length: 99  
Fragment?: false
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Protein
H3BKY9
Organism: Mus musculus/domesticus
Length: 102  
Fragment?: true
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Protein
A2BH29
Organism: Mus musculus/domesticus
Length: 119  
Fragment?: true
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Protein
Q3UK27
Organism: Mus musculus/domesticus
Length: 534  
Fragment?: false
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Protein
E0CZE0
Organism: Mus musculus/domesticus
Length: 510  
Fragment?: false
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Protein
D6RH76
Organism: Mus musculus/domesticus
Length: 130  
Fragment?: false
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Publication
11451954 | -
First Author: Tatham MH
Year: 2001
Journal: J Biol Chem
Title: Polymeric chains of SUMO-2 and SUMO-3 are conjugated to protein substrates by SAE1/SAE2 and Ubc9.
Volume: 276
Issue: 38
Pages: 35368-74
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Publication
11713534 | -
First Author: Lake MW
Year: 2001
Journal: Nature
Title: Mechanism of ubiquitin activation revealed by the structure of a bacterial MoeB-MoaD complex.
Volume: 414
Issue: 6861
Pages: 325-9
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Publication
12504674 | -
First Author: Rizzi M
Year: 2002
Journal: Curr Opin Struct Biol
Title: Structural biology of enzymes involved in NAD and molybdenum cofactor biosynthesis.
Volume: 12
Issue: 6
Pages: 709-20
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Publication
34872976 | J:316316
First Author: Xu A
Year: 2022
Journal: J Immunol
Title: Prosurvival IL-7-Stimulated Weak Strength of mTORC1-S6K Controls T Cell Memory via Transcriptional FOXO1-TCF1-Id3 and Metabolic AMPKα1-ULK1-ATG7 Pathways.
Volume: 208
Issue: 1
Pages: 155-168
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Publication
39596118 | J:361432
 
First Author: Armeli F
Year: 2024
Journal: Int J Mol Sci
Title: FAAH Inhibition Counteracts Neuroinflammation via Autophagy Recovery in AD Models.
Volume: 25
Issue: 22
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Publication
24081881 | J:221464
First Author: Sciarretta S
Year: 2013
Journal: Circ Res
Title: Activation of NADPH oxidase 4 in the endoplasmic reticulum promotes cardiomyocyte autophagy and survival during energy stress through the protein kinase RNA-activated-like endoplasmic reticulum kinase/eukaryotic initiation factor 2α/activating transcription factor 4 pathway.
Volume: 113
Issue: 11
Pages: 1253-64
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Publication
30042417 | J:280449
First Author: Trachsel-Moncho L
Year: 2018
Journal: Cell Death Dis
Title: Oxidative stress and autophagy-related changes during retinal degeneration and development.
Volume: 9
Issue: 8
Pages: 812
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Publication
35153674 | J:325884
 
First Author: Xie D
Year: 2021
Journal: Front Cell Neurosci
Title: Autophagy Contributes to the Rapamycin-Induced Improvement of Otitis Media.
Volume: 15
Pages: 753369
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Publication
38164158 | J:344429
First Author: Um JH
Year: 2024
Journal: Theranostics
Title: Selective induction of Rab9-dependent alternative mitophagy using a synthetic derivative of isoquinoline alleviates mitochondrial dysfunction and cognitive deficits in Alzheimer's disease models.
Volume: 14
Issue: 1
Pages: 56-74
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Publication
32437957 | J:297734
First Author: Trivedi PC
Year: 2020
Journal: Biochim Biophys Acta Mol Basis Dis
Title: Loss of function of transcription factor EB remodels lipid metabolism and cell death pathways in the cardiomyocyte.
Volume: 1866
Issue: 10
Pages: 165832
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Publication
29772234 | J:270365
First Author: Fang X
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Effects of n-3PUFAs on autophagy and inflammation of hypothalamus and body weight in mice.
Volume: 501
Issue: 4
Pages: 927-932
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Publication
23474308 | J:202422
First Author: Dong M
Year: 2013
Journal: Biochim Biophys Acta
Title: Chronic Akt activation attenuated lipopolysaccharide-induced cardiac dysfunction via Akt/GSK3β-dependent inhibition of apoptosis and ER stress.
Volume: 1832
Issue: 6
Pages: 848-63
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Publication
24874076 | J:251427
First Author: Guo Y
Year: 2015
Journal: Biochim Biophys Acta
Title: A novel protective mechanism for mitochondrial aldehyde dehydrogenase (ALDH2) in type i diabetes-induced cardiac dysfunction: role of AMPK-regulated autophagy.
Volume: 1852
Issue: 2
Pages: 319-31
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Publication
30385152 | J:267207
 
First Author: Osanai T
Year: 2018
Journal: J Mol Cell Cardiol
Title: Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway.
Volume: 125
Pages: 174-184
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Publication
31234698 | J:329624
First Author: Jung S
Year: 2020
Journal: Autophagy
Title: Autophagic death of neural stem cells mediates chronic stress-induced decline of adult hippocampal neurogenesis and cognitive deficits.
Volume: 16
Issue: 3
Pages: 512-530
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Protein
Q9R1T2
Organism: Mus musculus/domesticus
Length: 350  
Fragment?: false
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Protein
Q61341
Organism: Mus musculus/domesticus
Length: 179  
Fragment?: true
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Protein
H3BLM2
Organism: Mus musculus/domesticus
Length: 132  
Fragment?: true
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Protein
H3BLR3
Organism: Mus musculus/domesticus
Length: 148  
Fragment?: true
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Publication
31184563 | J:310809
First Author: Deng J
Year: 2020
Journal: Autophagy
Title: Autophagy inhibition prevents glucocorticoid-increased adiposity via suppressing BAT whitening.
Volume: 16
Issue: 3
Pages: 451-465
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Publication
34085589 | J:356507
First Author: Rabinovich-Nikitin I
Year: 2021
Journal: Autophagy
Title: Mitochondrial autophagy and cell survival is regulated by the circadian Clock gene in cardiac myocytes during ischemic stress.
Volume: 17
Issue: 11
Pages: 3794-3812
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Protein
A2BDX3
Organism: Mus musculus/domesticus
Length: 460  
Fragment?: false
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Protein
Q8C878
Organism: Mus musculus/domesticus
Length: 462  
Fragment?: false
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Protein
Q9ET02
Organism: Mus musculus/domesticus
Length: 770  
Fragment?: true
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Protein
Q66JT6
Organism: Mus musculus/domesticus
Length: 438  
Fragment?: true
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Protein
H3BJA7
Organism: Mus musculus/domesticus
Length: 410  
Fragment?: false
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Protein
Q3TL72
Organism: Mus musculus/domesticus
Length: 448  
Fragment?: false
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Protein
Q9Z1F9
Organism: Mus musculus/domesticus
Length: 638  
Fragment?: false
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Protein
Q9ET03
Organism: Mus musculus/domesticus
Length: 775  
Fragment?: true
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Protein
Q8BTN4
Organism: Mus musculus/domesticus
Length: 905  
Fragment?: false
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Protein
Q8C7R4
Organism: Mus musculus/domesticus
Length: 1053  
Fragment?: false
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Protein
P31254
Organism: Mus musculus/domesticus
Length: 1058  
Fragment?: false
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Protein
Q02053
Organism: Mus musculus/domesticus
Length: 1058  
Fragment?: false
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Protein
Q9DBK7
Organism: Mus musculus/domesticus
Length: 977  
Fragment?: false
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Protein
D3Z061
Organism: Mus musculus/domesticus
Length: 1022  
Fragment?: false
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Protein
B9EHN0
Organism: Mus musculus/domesticus
Length: 1058  
Fragment?: false
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Protein
A0A1S6GWH5
Organism: Mus musculus/domesticus
Length: 1118  
Fragment?: false
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Publication
11042159 | J:68323
First Author: Carninci P
Year: 2000
Journal: Genome Res
Title: Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes.
Volume: 10
Issue: 10
Pages: 1617-30
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Publication
10349636 | J:80645
 
First Author: Carninci P
Year: 1999
Journal: Methods Enzymol
Title: High-efficiency full-length cDNA cloning.
Volume: 303
Pages: 19-44
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Publication
11076861 | J:68324
First Author: Shibata K
Year: 2000
Journal: Genome Res
Title: RIKEN integrated sequence analysis (RISA) system--384-format sequencing pipeline with 384 multicapillary sequencer.
Volume: 10
Issue: 11
Pages: 1757-71
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Publication
16141073 | -
First Author: Katayama S
Year: 2005
Journal: Science
Title: Antisense transcription in the mammalian transcriptome.
Volume: 309
Issue: 5740
Pages: 1564-6
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Publication
15489334 | -
First Author: Gerhard DS
Year: 2004
Journal: Genome Res
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
Volume: 14
Issue: 10B
Pages: 2121-7
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Publication
21183079 | J:292518
First Author: Huttlin EL
Year: 2010
Journal: Cell
Title: A tissue-specific atlas of mouse protein phosphorylation and expression.
Volume: 143
Issue: 7
Pages: 1174-89
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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