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Search results 601 to 700 out of 877 for Atr

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Hits by Pathway

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Hits by Strain

Type Details Score
Protein Coding Gene
MGP_CASTEiJ_G0017376 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_CBAJ_G0017789 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_DBA2J_G0017899 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_FVBNJ_G0017891 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_LPJ_G0017970 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_NODShiLtJ_G0017917 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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•
Protein Coding Gene
MGP_NZOHlLtJ_G0018494 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PWKPhJ_G0017156 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_WSBEiJ_G0017430 | -
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGP_PahariEiJ_G0016780 | -
Type: protein_coding_gene
Organism: Mus pahari
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Protein Coding Gene
MGP_SPRETEiJ_G0016953 | -
Type: protein_coding_gene
Organism: Mus spretus
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Protein
Q8C551
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
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Protein
A0A0R4J1H1
Organism: Mus musculus/domesticus
Length: 336  
Fragment?: false
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Protein
A0A0R4J1G4
Organism: Mus musculus/domesticus
Length: 337  
Fragment?: false
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Publication
16990250 | -
First Author: Kovalenko OV
Year: 2006
Journal: Nucleic Acids Res
Title: RAD51AP2, a novel vertebrate- and meiotic-specific protein, shares a conserved RAD51-interacting C-terminal domain with RAD51AP1/PIR51.
Volume: 34
Issue: 18
Pages: 5081-92
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Protein Coding Gene
MGI:1202065 | Chek1
Type: protein_coding_gene
Organism: mouse, laboratory
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Publication
21399614 | -
First Author: Jakobsen L
Year: 2011
Journal: EMBO J
Title: Novel asymmetrically localizing components of human centrosomes identified by complementary proteomics methods.
Volume: 30
Issue: 8
Pages: 1520-35
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Publication
15448695 | J:314386
First Author: Demonacos C
Year: 2004
Journal: Nat Cell Biol
Title: A new effector pathway links ATM kinase with the DNA damage response.
Volume: 6
Issue: 10
Pages: 968-76
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Publication
22556254 | J:184522
First Author: Sfeir A
Year: 2012
Journal: Science
Title: Removal of shelterin reveals the telomere end-protection problem.
Volume: 336
Issue: 6081
Pages: 593-7
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Publication
22522401 | J:191367
First Author: Lee Y
Year: 2012
Journal: Nat Neurosci
Title: Neurogenesis requires TopBP1 to prevent catastrophic replicative DNA damage in early progenitors.
Volume: 15
Issue: 6
Pages: 819-26
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Publication
18854157 | J:147247
First Author: Buis J
Year: 2008
Journal: Cell
Title: Mre11 nuclease activity has essential roles in DNA repair and genomic stability distinct from ATM activation.
Volume: 135
Issue: 1
Pages: 85-96
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Publication
17803909 | J:129929
First Author: Schaetzlein S
Year: 2007
Journal: Cell
Title: Exonuclease-1 deletion impairs DNA damage signaling and prolongs lifespan of telomere-dysfunctional mice.
Volume: 130
Issue: 5
Pages: 863-77
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Publication
27239034 | J:238099
First Author: Pinzaru AM
Year: 2016
Journal: Cell Rep
Title: Telomere Replication Stress Induced by POT1 Inactivation Accelerates Tumorigenesis.
Volume: 15
Issue: 10
Pages: 2170-2184
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Publication
23352430 | J:193481
First Author: Barlow JH
Year: 2013
Journal: Cell
Title: Identification of early replicating fragile sites that contribute to genome instability.
Volume: 152
Issue: 3
Pages: 620-32
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Publication
22908299 | J:189889
First Author: Singh N
Year: 2012
Journal: Proc Natl Acad Sci U S A
Title: Dual recognition of phosphoserine and phosphotyrosine in histone variant H2A.X by DNA damage response protein MCPH1.
Volume: 109
Issue: 36
Pages: 14381-6
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Publication
38696471 | J:348825
First Author: Bai L
Year: 2024
Journal: Proc Natl Acad Sci U S A
Title: BRCA1 safeguards genome integrity by activating chromosome asynapsis checkpoint to eliminate recombination-defective oocytes.
Volume: 121
Issue: 19
Pages: e2401386121
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Publication
28790064 | J:245669
First Author: Perkhofer L
Year: 2017
Journal: Cancer Res
Title: ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage.
Volume: 77
Issue: 20
Pages: 5576-5590
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Publication
29805078 | J:262539
First Author: Cánovas B
Year: 2018
Journal: Cancer Cell
Title: Targeting p38α Increases DNA Damage, Chromosome Instability, and the Anti-tumoral Response to Taxanes in Breast Cancer Cells.
Volume: 33
Issue: 6
Pages: 1094-1110.e8
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Publication
37867192 | J:342032
First Author: Lei WL
Year: 2023
Journal: BMC Biol
Title: SRSF2 is required for mRNA splicing during spermatogenesis.
Volume: 21
Issue: 1
Pages: 231
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Publication
24388752 | J:206873
First Author: Bruhn C
Year: 2014
Journal: Cell Rep
Title: The essential function of the MRN complex in the resolution of endogenous replication intermediates.
Volume: 6
Issue: 1
Pages: 182-95
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Publication
37390209 | J:337800
First Author: Oropeza E
Year: 2023
Journal: Sci Adv
Title: Molecular portraits of cell cycle checkpoint kinases in cancer evolution, progression, and treatment responsiveness.
Volume: 9
Issue: 26
Pages: eadf2860
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Publication
31757956 | J:284769
First Author: Kim W
Year: 2019
Journal: Nat Commun
Title: ZFP161 regulates replication fork stability and maintenance of genomic stability by recruiting the ATR/ATRIP complex.
Volume: 10
Issue: 1
Pages: 5304
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Publication
27401717 | J:240838
 
First Author: Yang CC
Year: 2016
Journal: Nat Commun
Title: Claspin recruits Cdc7 kinase for initiation of DNA replication in human cells.
Volume: 7
Pages: 12135
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Publication
15108799 | J:90177
First Author: Motoyama N
Year: 2004
Journal: Curr Opin Genet Dev
Title: DNA damage tumor suppressor genes and genomic instability.
Volume: 14
Issue: 1
Pages: 11-6
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Publication
18804090 | J:142718
First Author: Iwabuchi K
Year: 2008
Journal: Biochem Biophys Res Commun
Title: Characterization of a cancer cell line that expresses a splicing variant form of 53BP1: separation of checkpoint and repair functions in 53BP1.
Volume: 376
Issue: 3
Pages: 509-13
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Publication
20368419 | J:159288
First Author: Kumar A
Year: 2010
Journal: Proc Natl Acad Sci U S A
Title: Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair.
Volume: 107
Issue: 16
Pages: 7491-6
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Publication
21383063 | J:172816
First Author: Ginjala V
Year: 2011
Journal: Mol Cell Biol
Title: BMI1 is recruited to DNA breaks and contributes to DNA damage-induced H2A ubiquitination and repair.
Volume: 31
Issue: 10
Pages: 1972-82
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Publication
21113148 | J:186973
First Author: Liu Y
Year: 2011
Journal: Cell Death Differ
Title: Proapoptotic Bid mediates the Atr-directed DNA damage response to replicative stress.
Volume: 18
Issue: 5
Pages: 841-52
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Publication
22155347 | J:192067
First Author: Chen BP
Year: 2012
Journal: Cancer Lett
Title: New insights into the roles of ATM and DNA-PKcs in the cellular response to oxidative stress.
Volume: 327
Issue: 1-2
Pages: 103-10
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Publication
27513301 | J:249185
First Author: Connolly PF
Year: 2016
Journal: FEBS J
Title: DNA-PK activity is associated with caspase-dependent myogenic differentiation.
Volume: 283
Issue: 19
Pages: 3626-3636
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Publication
31123184 | J:277567
First Author: Chen BR
Year: 2019
Journal: J Cell Biol
Title: XLF and H2AX function in series to promote replication fork stability.
Volume: 218
Issue: 7
Pages: 2113-2123
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Publication
38391183 | J:358025
   
First Author: Ascenção C
Year: 2024
Journal: Elife
Title: A TOPBP1 allele causing male infertility uncouples XY silencing dynamics from sex body formation.
Volume: 12
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Publication
18243098 | J:177150
First Author: Shimada M
Year: 2008
Journal: Cell
Title: Chk1 is a histone H3 threonine 11 kinase that regulates DNA damage-induced transcriptional repression.
Volume: 132
Issue: 2
Pages: 221-32
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Protein
A0A0A6YXK7
Organism: Mus musculus/domesticus
Length: 787  
Fragment?: true
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Protein
A0A0A6YVZ3
Organism: Mus musculus/domesticus
Length: 296  
Fragment?: true
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Protein
A0A0A6YX99
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: true
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Publication
25931565 | -
First Author: Räschle M
Year: 2015
Journal: Science
Title: DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links.
Volume: 348
Issue: 6234
Pages: 1253671
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Publication
20871616 | -
First Author: Dray E
Year: 2010
Journal: Nat Struct Mol Biol
Title: Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2.
Volume: 17
Issue: 10
Pages: 1255-9
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Publication
15616186 | -
First Author: Guarguaglini G
Year: 2005
Journal: Mol Biol Cell
Title: The forkhead-associated domain protein Cep170 interacts with Polo-like kinase 1 and serves as a marker for mature centrioles.
Volume: 16
Issue: 3
Pages: 1095-107
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Publication
15279789 | -
First Author: Chen Y
Year: 2004
Journal: DNA Repair (Amst)
Title: Chk1 in the DNA damage response: conserved roles from yeasts to mammals.
Volume: 3
Issue: 8-9
Pages: 1025-32
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Publication
19473886 | -
First Author: Stracker TH
Year: 2009
Journal: DNA Repair (Amst)
Title: Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.
Volume: 8
Issue: 9
Pages: 1047-54
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Publication
19230643 | -
First Author: Reinhardt HC
Year: 2009
Journal: Curr Opin Cell Biol
Title: Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.
Volume: 21
Issue: 2
Pages: 245-55
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Publication
18424430 | -
First Author: Enders GH
Year: 2008
Journal: J Biol Chem
Title: Expanded roles for Chk1 in genome maintenance.
Volume: 283
Issue: 26
Pages: 17749-52
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Publication
16969104 | -
First Author: Petermann E
Year: 2006
Journal: Cell Cycle
Title: Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase.
Volume: 5
Issue: 19
Pages: 2203-9
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Protein Domain
IPR026217 | Ddc1
Type: Family
Description: This entry represents the budding yeast Ddc1, which is homologous to the fission yeast and human Rad9.DNA-damage checkpoint protein 1 (Ddc1) forms a checkpoint clamp complex with Mec3 and Rad17 [, ]. This complex plays a role in the surveillance system that permits DNA-repair pathways to restore the integrity of DNA in advance of DNA synthesis or separation of replicated chromosomes, thereby ensuring that new phases are not entered if DNA is damaged []. Ddc1 can activate Mec1 (the principal checkpoint protein kinase, human ATR homologue) in G1 phase. In G2 phase, Ddc1 can either activate Mec1 directly or recruit Dpb11 (ortholog of human TopBP1) and subsequently activate Mec1 []. Ddc1 does not have the DNA exonuclease function [].
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Protein Domain
IPR034670 | Chk1_catalytic_dom
Type: Domain
Description: Checkpoint kinase 1 (Chk1) is a serine/threonine kinase implicated in many major checkpoints of the cell cycle, providing a link between upstream sensors and the cell cycle engine. It plays an important role in DNA damage response and maintaining genomic stability [, , ]. Chk1 acts as an effector of the sensor kinase, ATR (ATM and Rad3-related), a member of the PI3K family, which is activated upon DNA replication stress []. Chk1 delays mitotic entry in response to replication blocks by inhibiting cyclin dependent kinase (Cdk) activity. In addition, Chk1 contributes to the function of centrosome and spindle-based checkpoints, inhibits firing of origins of DNA replication (Ori), and represses transcription of cell cycle proteins including cyclin B and Cdk1 [, ].
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Protein Coding Gene
MGI:2146571 | Rfc4
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1919401 | Rfc5
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1341868 | Rfc2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1916513 | Rfc3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
Q9D0F6
Organism: Mus musculus/domesticus
Length: 339  
Fragment?: false
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Protein
Q9WUK4
Organism: Mus musculus/domesticus
Length: 349  
Fragment?: false
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Protein
Q8R323
Organism: Mus musculus/domesticus
Length: 356  
Fragment?: false
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Protein
Q99J62
Organism: Mus musculus/domesticus
Length: 364  
Fragment?: false
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Publication
28700664 | J:246066
First Author: Sundberg JP
Year: 2017
Journal: PLoS One
Title: Systematic screening for skin, hair, and nail abnormalities in a large-scale knockout mouse program.
Volume: 12
Issue: 7
Pages: e0180682
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Publication
20005839 | -
First Author: Navadgi-Patil VM
Year: 2009
Journal: Mol Cell
Title: The unstructured C-terminal tail of the 9-1-1 clamp subunit Ddc1 activates Mec1/ATR via two distinct mechanisms.
Volume: 36
Issue: 5
Pages: 743-53
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Protein Coding Gene
MGI:104772 | Cdk2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915525 | Rpa1
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1339939 | Rpa2
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein Coding Gene
MGI:1915490 | Rpa3
Type: protein_coding_gene
Organism: mouse, laboratory
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Protein
P97377
Organism: Mus musculus/domesticus
Length: 346  
Fragment?: false
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Protein
Q9CQ71
Organism: Mus musculus/domesticus
Length: 121  
Fragment?: false
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Protein
Q62193
Organism: Mus musculus/domesticus
Length: 270  
Fragment?: false
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Protein
Q8VEE4
Organism: Mus musculus/domesticus
Length: 623  
Fragment?: false
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Publication
11571274 | J:341403
First Author: Burma S
Year: 2001
Journal: J Biol Chem
Title: ATM phosphorylates histone H2AX in response to DNA double-strand breaks.
Volume: 276
Issue: 45
Pages: 42462-7
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Publication
19131340 | J:148373
First Author: Hou R
Year: 2009
Journal: J Biol Chem
Title: Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells.
Volume: 284
Issue: 11
Pages: 6955-65
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Publication
22012619 | J:177489
First Author: Blazek D
Year: 2011
Journal: Genes Dev
Title: The Cyclin K/Cdk12 complex maintains genomic stability via regulation of expression of DNA damage response genes.
Volume: 25
Issue: 20
Pages: 2158-72
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Publication
15195100 | J:169789
First Author: Bernardi R
Year: 2004
Journal: Nat Cell Biol
Title: PML regulates p53 stability by sequestering Mdm2 to the nucleolus.
Volume: 6
Issue: 7
Pages: 665-72
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Publication
21159655 | J:167598
First Author: Sung YH
Year: 2010
Journal: Cancer Res
Title: Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response.
Volume: 70
Issue: 24
Pages: 10454-63
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Publication
12192050 | J:78491
First Author: Hirao A
Year: 2002
Journal: Mol Cell Biol
Title: Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner.
Volume: 22
Issue: 18
Pages: 6521-32
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Publication
24489120 | J:209425
First Author: Kang TH
Year: 2014
Journal: Nucleic Acids Res
Title: Modulation of ATR-mediated DNA damage checkpoint response by cryptochrome 1.
Volume: 42
Issue: 7
Pages: 4427-34
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Publication
23593030 | J:223053
First Author: Becherel OJ
Year: 2013
Journal: PLoS Genet
Title: Senataxin plays an essential role with DNA damage response proteins in meiotic recombination and gene silencing.
Volume: 9
Issue: 4
Pages: e1003435
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Publication
12234250 | J:175207
First Author: Sapkota GP
Year: 2002
Journal: Biochem J
Title: Ionizing radiation induces ataxia telangiectasia mutated kinase (ATM)-mediated phosphorylation of LKB1/STK11 at Thr-366.
Volume: 368
Issue: Pt 2
Pages: 507-16
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Publication
18353733 | J:168190
First Author: Göhler T
Year: 2008
Journal: DNA Repair (Amst)
Title: PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage.
Volume: 7
Issue: 5
Pages: 775-87
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Publication
27376578 | J:240137
First Author: Adriaens C
Year: 2016
Journal: Nat Med
Title: p53 induces formation of NEAT1 lncRNA-containing paraspeckles that modulate replication stress response and chemosensitivity.
Volume: 22
Issue: 8
Pages: 861-8
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Publication
34521752 | J:310613
 
First Author: Wang XS
Year: 2021
Journal: Proc Natl Acad Sci U S A
Title: DNA damage-induced phosphorylation of CtIP at a conserved ATM/ATR site T855 promotes lymphomagenesis in mice.
Volume: 118
Issue: 38
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Publication
11231155 | J:67533
First Author: Gurley KE
Year: 2001
Journal: Curr Biol
Title: Synthetic lethality between mutation in Atm and DNA-PK(cs) during murine embryogenesis.
Volume: 11
Issue: 3
Pages: 191-4
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Publication
33802342 | J:317991
 
First Author: Zhang JQJ
Year: 2021
Journal: Cells
Title: Effect of Reducing Ataxia-Telangiectasia Mutated (ATM) in Experimental Autosomal Dominant Polycystic Kidney Disease.
Volume: 10
Issue: 3
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Publication
24449270 | J:207367
First Author: Frescas D
Year: 2014
Journal: Genes Dev
Title: A TIN2 dyskeratosis congenita mutation causes telomerase-independent telomere shortening in mice.
Volume: 28
Issue: 2
Pages: 153-66
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Publication
15870200 | J:99240
First Author: Fishkin NE
Year: 2005
Journal: Proc Natl Acad Sci U S A
Title: Isolation and characterization of a retinal pigment epithelial cell fluorophore: an all-trans-retinal dimer conjugate.
Volume: 102
Issue: 20
Pages: 7091-6
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Publication
21921034 | J:178164
First Author: Amable L
Year: 2011
Journal: J Biol Chem
Title: Disruption of serine/threonine protein phosphatase 5 (PP5:PPP5c) in mice reveals a novel role for PP5 in the regulation of ultraviolet light-induced phosphorylation of serine/threonine protein kinase Chk1 (CHEK1).
Volume: 286
Issue: 47
Pages: 40413-22
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Publication
31274379 | J:289416
First Author: Muenstermann M
Year: 2019
Journal: Virulence
Title: Distinct roles of the anaphylatoxin receptors C3aR, C5aR1 and C5aR2 in experimental meningococcal infections.
Volume: 10
Issue: 1
Pages: 677-694
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Publication
23975433 | J:228556
First Author: Wallace MD
Year: 2014
Journal: Oncogene
Title: Role of DNA damage response pathways in preventing carcinogenesis caused by intrinsic replication stress.
Volume: 33
Issue: 28
Pages: 3688-95
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Publication
29360988 | J:260789
First Author: Abe H
Year: 2018
Journal: Hum Mol Genet
Title: CHEK1 coordinates DNA damage signaling and meiotic progression in the male germline of mice.
Volume: 27
Issue: 7
Pages: 1136-1149
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Publication
22575700 | J:185363
First Author: Balmus G
Year: 2012
Journal: Hum Mol Genet
Title: Disease severity in a mouse model of ataxia telangiectasia is modulated by the DNA damage checkpoint gene Hus1.
Volume: 21
Issue: 15
Pages: 3408-20
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Publication
32571801 | J:305083
 
First Author: Muralidharan SV
Year: 2020
Journal: Life Sci Alliance
Title: Small molecule inhibitors and a kinase-dead expressing mouse model demonstrate that the kinase activity of Chk1 is essential for mouse embryos and cancer cells.
Volume: 3
Issue: 8
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Publication
30445628 | J:277844
First Author: Xu X
Year: 2019
Journal: Hum Mol Genet
Title: BRCA1 represses DNA replication initiation through antagonizing estrogen signaling and maintains genome stability in parallel with WEE1-MCM2 signaling during pregnancy.
Volume: 28
Issue: 5
Pages: 842-857
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Publication
24914237 | J:215795
First Author: Broering TJ
Year: 2014
Journal: J Cell Biol
Title: BRCA1 establishes DNA damage signaling and pericentric heterochromatin of the X chromosome in male meiosis.
Volume: 205
Issue: 5
Pages: 663-75
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Publication
38499540 | J:349049
First Author: Bidany-Mizrahi T
Year: 2024
Journal: Cell Death Discov
Title: Unveiling the relationship between WWOX and BRCA1 in mammary tumorigenicity and in DNA repair pathway selection.
Volume: 10
Issue: 1
Pages: 145
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Publication
19995905 | J:160503
First Author: Kibe T
Year: 2010
Journal: Mol Cell Biol
Title: Telomere protection by TPP1 is mediated by POT1a and POT1b.
Volume: 30
Issue: 4
Pages: 1059-66
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