| Type |
Details |
Score |
| Publication |
| First Author: |
Davletov BA |
| Year: |
1993 |
| Journal: |
J Biol Chem |
| Title: |
A single C2 domain from synaptotagmin I is sufficient for high affinity Ca2+/phospholipid binding. |
| Volume: |
268 |
| Issue: |
35 |
| Pages: |
26386-90 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hadjighassem MR |
| Year: |
2011 |
| Journal: |
Eur J Neurosci |
| Title: |
Freud-2/CC2D1B mediates dual repression of the serotonin-1A receptor gene. |
| Volume: |
33 |
| Issue: |
2 |
| Pages: |
214-23 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
2282
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
724
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chih B |
| Year: |
2011 |
| Journal: |
Nat Cell Biol |
| Title: |
A ciliopathy complex at the transition zone protects the cilia as a privileged membrane domain. |
| Volume: |
14 |
| Issue: |
1 |
| Pages: |
61-72 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Stepan J |
| Year: |
2022 |
| Journal: |
Cell Rep |
| Title: |
Hippo-released WWC1 facilitates AMPA receptor regulatory complexes for hippocampal learning. |
| Volume: |
41 |
| Issue: |
10 |
| Pages: |
111766 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Morris NJ |
| Year: |
1999 |
| Journal: |
Biochim Biophys Acta |
| Title: |
Cloning and preliminary characterization of a 121 kDa protein with multiple predicted C2 domains. |
| Volume: |
1431 |
| Issue: |
2 |
| Pages: |
525-30 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fukuda M |
| Year: |
2001 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Synaptotagmin-like protein 1-3: a novel family of C-terminal-type tandem C2 proteins. |
| Volume: |
281 |
| Issue: |
5 |
| Pages: |
1226-33 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ye H |
| Year: |
2013 |
| Journal: |
Biochim Biophys Acta |
| Title: |
NMR solution structure of C2 domain of MFG-E8 and insights into its molecular recognition with phosphatidylserine. |
| Volume: |
1828 |
| Issue: |
3 |
| Pages: |
1083-93 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Parekh R |
| Year: |
1996 |
| Journal: |
J Biol Chem |
| Title: |
Inhibition of myogenesis in mouse C2 cells by double-stranded phosphorothioate oligodeoxynucleotides containing mef-1 sequence. |
| Volume: |
271 |
| Issue: |
29 |
| Pages: |
17372-6 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Brown RA |
| Year: |
1997 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Identification and cDNA cloning of a novel mammalian C2 domain-containing phosphoinositide 3-kinase, HsC2-PI3K. |
| Volume: |
233 |
| Issue: |
2 |
| Pages: |
537-44 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Saha S |
| Year: |
2016 |
| Journal: |
FEBS Lett |
| Title: |
N-terminal polar amino acids of the C2 insert of nonmuscle myosin II-C2 regulate its functional properties. |
| Volume: |
590 |
| Issue: |
23 |
| Pages: |
4223-4232 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Miyazaki K |
| Year: |
2004 |
| Journal: |
J Biol Chem |
| Title: |
NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1. |
| Volume: |
279 |
| Issue: |
12 |
| Pages: |
11327-35 |
|
•
•
•
•
•
|
| MP Term |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
653
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rogaeva A |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
Differential repression by freud-1/CC2D1A at a polymorphic site in the dopamine-D2 receptor gene. |
| Volume: |
282 |
| Issue: |
29 |
| Pages: |
20897-905 |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
cattle |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chimpanzee |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
chicken |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
macaque, rhesus |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
zebrafish |
|
•
•
•
•
•
|
| Gene |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, western clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
dog, domestic |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Gene |
| Type: |
gene |
| Organism: |
frog, African clawed |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shin OH |
| Year: |
2009 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Differential but convergent functions of Ca2+ binding to synaptotagmin-1 C2 domains mediate neurotransmitter release. |
| Volume: |
106 |
| Issue: |
38 |
| Pages: |
16469-74 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yagi H |
| Year: |
2015 |
| Journal: |
J Biol Chem |
| Title: |
Structural Basis for Ca2+-mediated Interaction of the Perforin C2 Domain with Lipid Membranes. |
| Volume: |
290 |
| Issue: |
42 |
| Pages: |
25213-26 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lazaro JB |
| Year: |
1997 |
| Journal: |
J Cell Sci |
| Title: |
Cyclin dependent kinase 5, cdk5, is a positive regulator of myogenesis in mouse C2 cells. |
| Volume: |
110 ( Pt 10) |
|
| Pages: |
1251-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kobayashi M |
| Year: |
1998 |
| Journal: |
Exp Cell Res |
| Title: |
Stable expression of antisense Rb-1 RNA inhibits terminal differentiation of mouse myoblast C2 cells. |
| Volume: |
239 |
| Issue: |
1 |
| Pages: |
40-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fu X |
| Year: |
2017 |
| Journal: |
Toxicol Appl Pharmacol |
| Title: |
Staphylococcal enterotoxin C2 mutant drives T lymphocyte activation through PI3K/mTOR and NF-ĸB signaling pathways. |
| Volume: |
333 |
|
| Pages: |
51-59 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1061
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kouchi Z |
| Year: |
2005 |
| Journal: |
J Biol Chem |
| Title: |
The role of EF-hand domains and C2 domain in regulation of enzymatic activity of phospholipase Czeta. |
| Volume: |
280 |
| Issue: |
22 |
| Pages: |
21015-21 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rasmussen CLM |
| Year: |
2023 |
| Journal: |
Mol Cell Neurosci |
| Title: |
The Npc2(Gt(LST105)BygNya) mouse signifies pathological changes comparable to human Niemann-Pick type C2 disease. |
| Volume: |
126 |
|
| Pages: |
103880 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liao YJ |
| Year: |
2012 |
| Journal: |
Mol Med |
| Title: |
Glycine N-methyltransferase deficiency affects Niemann-Pick type C2 protein stability and regulates hepatic cholesterol homeostasis. |
| Volume: |
18 |
|
| Pages: |
412-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gangadharan B |
| Year: |
2017 |
| Journal: |
Haematologica |
| Title: |
The C1 and C2 domains of blood coagulation factor VIII mediate its endocytosis by dendritic cells. |
| Volume: |
102 |
| Issue: |
2 |
| Pages: |
271-281 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Al-Tawashi A |
| Year: |
2012 |
| Journal: |
J Biol Chem |
| Title: |
Protein implicated in nonsyndromic mental retardation regulates protein kinase A (PKA) activity. |
| Volume: |
287 |
| Issue: |
18 |
| Pages: |
14644-58 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nalefski EA |
| Year: |
1996 |
| Journal: |
Protein Sci |
| Title: |
The C2 domain calcium-binding motif: structural and functional diversity. |
| Volume: |
5 |
| Issue: |
12 |
| Pages: |
2375-90 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
971
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1276
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liu L |
| Year: |
2006 |
| Journal: |
J Biol Chem |
| Title: |
Crystal structure of the C2 domain of class II phosphatidylinositide 3-kinase C2alpha. |
| Volume: |
281 |
| Issue: |
7 |
| Pages: |
4254-60 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shao X |
| Year: |
1996 |
| Journal: |
Science |
| Title: |
Bipartite Ca2+-binding motif in C2 domains of synaptotagmin and protein kinase C. |
| Volume: |
273 |
| Issue: |
5272 |
| Pages: |
248-51 |
|
•
•
•
•
•
|
| Protein Coding Gene |
| Type: |
protein_coding_gene |
| Organism: |
mouse, laboratory |
|
•
•
•
•
•
|
| Allele |
| Name: |
multiple C2 domains, transmembrane 1; deaf wanderer |
| Allele Type: |
Spontaneous |
| Attribute String: |
Modified regulatory region, Null/knockout |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tsang WY |
| Year: |
2009 |
| Journal: |
Dev Cell |
| Title: |
Cep76, a centrosomal protein that specifically restrains centriole reduplication. |
| Volume: |
16 |
| Issue: |
5 |
| Pages: |
649-60 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
A C2 domain is usually involved in targeting proteins to cell membranes. This entry represents a C2 domain found in the CEP76 proteins []. CEP76 is a centrosomal protein involved in regulation of centriole duplication []. |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
1082
 |
| Fragment?: |
true |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
903
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5435869 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2012-09-27 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1707420 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:5436321 |
| Age: |
embryonic day 12.5 |
| Image: |
2C |
| Note: |
Expression is present in the c2 domain. |
| Specimen Label: |
2C |
| Detected: |
true |
| Specimen Num: |
1 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5435869 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2012-09-27 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1707420 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:5436321 |
| Age: |
embryonic day 12.5 |
| Image: |
5A |
| Note: |
Expression is present in the c2 domain. |
| Specimen Label: |
5A |
| Detected: |
true |
| Specimen Num: |
2 |
|
•
•
•
•
•
|
| GXD Expression |
| Probe: |
MGI:5435869 |
| Assay Type: |
Immunohistochemistry |
| Annotation Date: |
2012-09-27 |
| Strength: |
Present |
| Sex: |
Not Specified |
| Emaps: |
EMAPS:1707420 |
| Pattern: |
Regionally restricted |
| Stage: |
TS20 |
| Assay Id: |
MGI:5436321 |
| Age: |
embryonic day 12.5 |
| Image: |
5B |
| Note: |
Expression is present in the c2 domain. |
| Specimen Label: |
5B |
| Detected: |
true |
| Specimen Num: |
3 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
97
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
722
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Allele |
| Name: |
glucosaminyl (N-acetyl) transferase 1, core 2; targeted mutation 2, Jamey Marth |
| Allele Type: |
Targeted |
| Attribute String: |
Conditional ready, No functional change |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Fukuda M |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
Slac2-c (synaptotagmin-like protein homologue lacking C2 domains-c), a novel linker protein that interacts with Rab27, myosin Va/VIIa, and actin. |
| Volume: |
277 |
| Issue: |
45 |
| Pages: |
43096-103 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Liao YJ |
| Year: |
2015 |
| Journal: |
Int J Cancer |
| Title: |
Niemann-Pick type C2 protein regulates liver cancer progression via modulating ERK1/2 pathway: Clinicopathological correlations and therapeutical implications. |
| Volume: |
137 |
| Issue: |
6 |
| Pages: |
1341-51 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Schrantz N |
| Year: |
2007 |
| Journal: |
J Exp Med |
| Title: |
The Niemann-Pick type C2 protein loads isoglobotrihexosylceramide onto CD1d molecules and contributes to the thymic selection of NKT cells. |
| Volume: |
204 |
| Issue: |
4 |
| Pages: |
841-52 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Markmann S |
| Year: |
2018 |
| Journal: |
Exp Neurol |
| Title: |
Attenuation of the Niemann-Pick type C2 disease phenotype by intracisternal administration of an AAVrh.10 vector expressing Npc2. |
| Volume: |
306 |
|
| Pages: |
22-33 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chazot PL |
| Year: |
1997 |
| Journal: |
J Neurochem |
| Title: |
Biochemical evidence for the existence of a pool of unassembled C2 exon-containing NR1 subunits of the mammalian forebrain NMDA receptor. |
| Volume: |
68 |
| Issue: |
2 |
| Pages: |
507-16 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
1 |
| Description: |
Doublesex- and mab-3-related transcription factor C2 |
| Type: |
chain |
| End: |
370 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
1 |
| Description: |
Phosphatidylinositol 3-kinase C2 domain-containing subunit gamma |
| Type: |
chain |
| End: |
1506 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
1 |
| Description: |
Multiple C2 and transmembrane domain-containing protein 1 |
| Type: |
chain |
| End: |
951 |
|
•
•
•
•
•
|
| UniProt Feature |
| Begin: |
1 |
| Description: |
Multiple C2 and transmembrane domain-containing protein 2 |
| Type: |
chain |
| End: |
878 |
|
•
•
•
•
•
|