|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 601 to 700 out of 751 for Cdk1

<< First    < Previous  |  Next >    Last >>
0.025s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
24497509 | J:206830
First Author: Xu J
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: DNMT3A Arg882 mutation drives chronic myelomonocytic leukemia through disturbing gene expression/DNA methylation in hematopoietic cells.
Volume: 111
Issue: 7
Pages: 2620-5
•
•
•
•
•
HT Experiment
GSE141190 | EXOSC10 sculpts the transcriptome during oocyte growth-to-maturation transition
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
HT Experiment
E-GEOD-60078 | Genetic characterization of p27Kip1 and stathmin role in controlling cell proliferation in vivo
Series Id: GSE60078
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Protein
Q9CZC6
Organism: Mus musculus/domesticus
Length: 150  
Fragment?: false
•
•
•
•
•
Publication
16964243 | -
First Author: Beausoleil SA
Year: 2006
Journal: Nat Biotechnol
Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.
Volume: 24
Issue: 10
Pages: 1285-92
•
•
•
•
•
Publication
15279789 | -
First Author: Chen Y
Year: 2004
Journal: DNA Repair (Amst)
Title: Chk1 in the DNA damage response: conserved roles from yeasts to mammals.
Volume: 3
Issue: 8-9
Pages: 1025-32
•
•
•
•
•
Publication
19473886 | -
First Author: Stracker TH
Year: 2009
Journal: DNA Repair (Amst)
Title: Taking the time to make important decisions: the checkpoint effector kinases Chk1 and Chk2 and the DNA damage response.
Volume: 8
Issue: 9
Pages: 1047-54
•
•
•
•
•
Publication
19230643 | -
First Author: Reinhardt HC
Year: 2009
Journal: Curr Opin Cell Biol
Title: Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.
Volume: 21
Issue: 2
Pages: 245-55
•
•
•
•
•
Publication
18424430 | -
First Author: Enders GH
Year: 2008
Journal: J Biol Chem
Title: Expanded roles for Chk1 in genome maintenance.
Volume: 283
Issue: 26
Pages: 17749-52
•
•
•
•
•
Publication
16969104 | -
First Author: Petermann E
Year: 2006
Journal: Cell Cycle
Title: Evidence that the ATR/Chk1 pathway maintains normal replication fork progression during unperturbed S phase.
Volume: 5
Issue: 19
Pages: 2203-9
•
•
•
•
•
Protein Domain
IPR026618 | MPLKIP-like_vertebrate
Type: Family
Description: This entry represents M-phase-specific PLK1-interacting protein and related uncharacterised sequences from vertebrates.M-phase-specific PLK1-interacting protein (also known as TTD non-photosensitive 1 protein, TTDN1) may play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis []. Its The subcellular location is regulated during cell cycle. During interphase, it is located in the nucleus. During mitosis, it is located at the centrosome and dispersed in the cytoplasm. During telophase, it is located in the midbody. It colocalizes with PLK1 at the centrosome in M phase [, ]. It is phosphorylated during mitosis in the cell cycle probably by CDK1 [, ]. Defects in MPLKIP are a cause of trichothiodystrophy non-photosensitive type 1 (TTDN1); also known as Amish brittle hair brain syndrome (ABHS), hair-brain syndrome and BIDS syndrome. TTDN1 is an autosomal recessive disorder characterised by short stature, intellectual impairment, sulfur-deficient brittle hair and decreased male fertility but not cutaneous photosensitivity [].
•
•
•
•
•
Protein Domain
IPR034670 | Chk1_catalytic_dom
Type: Domain
Description: Checkpoint kinase 1 (Chk1) is a serine/threonine kinase implicated in many major checkpoints of the cell cycle, providing a link between upstream sensors and the cell cycle engine. It plays an important role in DNA damage response and maintaining genomic stability [, , ]. Chk1 acts as an effector of the sensor kinase, ATR (ATM and Rad3-related), a member of the PI3K family, which is activated upon DNA replication stress []. Chk1 delays mitotic entry in response to replication blocks by inhibiting cyclin dependent kinase (Cdk) activity. In addition, Chk1 contributes to the function of centrosome and spindle-based checkpoints, inhibits firing of origins of DNA replication (Ori), and represses transcription of cell cycle proteins including cyclin B and Cdk1 [, ].
•
•
•
•
•
Protein
D6RGR7
Organism: Mus musculus/domesticus
Length: 38  
Fragment?: false
•
•
•
•
•
Protein Domain
IPR031719 | H2_M
Type: Domain
Description: This is the middle domain of the H2 subunit of the condensin II complex, found in eukaryotes but not fungi. This region represents the disordered section of CNDH2 between the N- and the C-terminal domains.Eukaryotes carry at least two condensin complexes, I and II, each made up of five subunits. The functions of the two complexes are collaborative but non-overlapping. CI appears to be functional in G2 phase in the cytoplasm beginning the process of chromosomal lateral compaction while the CII are concentrated in the nucleus, possibly to counteract the activity of cohesion at this stage. In prophase, CII contributes to axial shortening of chromatids while CI continues to bring about lateral chromatid compaction, during which time the sister chromatids are joined centrally by cohesins. There appears to be just one condensin complex in fungi. CI and CII each contain SMC2 and SMC4 (structural maintenance of chromosomes) subunits, then CI has non-SMC CAP-D2 (CND1), CAP-G (CND3), and CAP-H (CND2). CII has, in addition to the two SMCs, CAP-D3, CAPG2 and CAP-H2. All four of the CAP-D and CAP-G subunits have degenerate HEAT repeats, whereas the CAP-H are kleisins or SMC-interacting proteins (ie they bind directly to the SMC subunits in the complex). The SMC molecules are each long with a small hinge-like knob at the free end of a longish strand, articulating with each other at the hinge. Each strand ends in a knob-like head that binds to one or other end of the CAP-H subunit. The HEAT-repeat containing D and G subunits bind side-by-side between the ends of the H subunit. Activity of the various parts of the complex seem to be triggered by extensive phosphorylations, eg, entry of the complex, in Sch.pombe, into the nucleus during mitosis is promoted by Cdk1 phosphorylation of SMC4/Cut3; and it has been shown that Cdk1 phosphorylates CAP-D3 at Thr1415 in He-La cells thus promoting early stage chromosomal condensation by CII [, ].
•
•
•
•
•
Protein Domain
IPR009378 | H2_N
Type: Domain
Description: This entry represents the N-terminal domain of the H2 subunit of the condensing II complex, found in eukaryotes but not in fungi. Eukaryotes carry at least two condensin complexes, I and II, each made up of five subunits. The functions of the two complexes are collaborative but non-overlapping. CI appears to be functional in G2 phase in the cytoplasm beginning the process of chromosomal lateral compaction while the CII is concentrated in the nucleus, possibly to counteract the activity of cohesion at this stage. In prophase, CII contributes to axial shortening of chromatids while CI continues to bring about lateral chromatid compaction, during which time the sister chromatids are joined centrally by cohesins. There appears to be just one condensin complex in fungi. CI and CII each contain SMC2 and SMC4 (structural maintenance of chromosomes) subunits, then CI has non-SMC CAP-D2 (CND1), CAP-G (CND3), and CAP-H (CND2). CII has, in addition to the two SMCs, CAP-D3, CAPG2 and CAP-H2. All four of the CAP-D and CAP-G subunits have degenerate HEAT repeats, whereas the CAP-H are kleisins or SMC-interacting proteins (ie they bind directly to the SMC subunits in the complex). The SMC molecules are each long with a small hinge-like knob at the free end of a longish strand, articulating with each other at the hinge. Each strand ends in a knob-like head that binds to one or other end of the CAP-H subunit. The HEAT-repeat containing D and G subunits bind side-by-side between the ends of the H subunit. Activity of the various parts of the complex seem to be triggered by extensive phosphorylations, eg, entry of the complex, in Sch.pombe, into the nucleus during mitosis is promoted by Cdk1 phosphorylation of SMC4/Cut3; and it has been shown that Cdk1 phosphorylates CAP-D3 at Thr1415 in He-La cells thus promoting early stage chromosomal condensation by CII [, ].
•
•
•
•
•
Publication
21156286 | J:167609
First Author: Manchado E
Year: 2010
Journal: Cancer Cell
Title: Targeting mitotic exit leads to tumor regression in vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ phosphatase.
Volume: 18
Issue: 6
Pages: 641-54
•
•
•
•
•
Publication
27238018 | J:271692
First Author: Zhao X
Year: 2016
Journal: Cell
Title: Circadian Amplitude Regulation via FBXW7-Targeted REV-ERBα Degradation.
Volume: 165
Issue: 7
Pages: 1644-1657
•
•
•
•
•
Publication
17060449 | J:117672
First Author: Mori D
Year: 2007
Journal: Mol Cell Biol
Title: NDEL1 phosphorylation by Aurora-A kinase is essential for centrosomal maturation, separation, and TACC3 recruitment.
Volume: 27
Issue: 1
Pages: 352-67
•
•
•
•
•
Publication
37267950 | J:336652
First Author: Arora M
Year: 2023
Journal: Cell
Title: Rapid adaptation to CDK2 inhibition exposes intrinsic cell-cycle plasticity.
Volume: 186
Issue: 12
Pages: 2628-2643.e21
•
•
•
•
•
Publication
20513747 | J:163417
First Author: Ho KJ
Year: 2010
Journal: J Exp Med
Title: Tob1 is a constitutively expressed repressor of liver regeneration.
Volume: 207
Issue: 6
Pages: 1197-208
•
•
•
•
•
Publication
28502659 | J:277332
First Author: Rattani A
Year: 2017
Journal: Curr Biol
Title: APC/CCdh1 Enables Removal of Shugoshin-2 from the Arms of Bivalent Chromosomes by Moderating Cyclin-Dependent Kinase Activity.
Volume: 27
Issue: 10
Pages: 1462-1476.e5
•
•
•
•
•
Publication
26626423 | J:227995
 
First Author: Kim J
Year: 2015
Journal: Nat Commun
Title: LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice.
Volume: 6
Pages: 10116
•
•
•
•
•
Publication
36465100 | J:332013
First Author: Mehl JL
Year: 2022
Journal: iScience
Title: Blockage of lamin-A/C loss diminishes the pro-inflammatory macrophage response.
Volume: 25
Issue: 12
Pages: 105528
•
•
•
•
•
Publication
26028219 | J:239362
First Author: Yoshida S
Year: 2015
Journal: Dev Cell
Title: Inherent Instability of Correct Kinetochore-Microtubule Attachments during Meiosis I in Oocytes.
Volume: 33
Issue: 5
Pages: 589-602
•
•
•
•
•
Publication
32386556 | J:329437
First Author: Spevak CC
Year: 2020
Journal: Cell Stem Cell
Title: Hematopoietic Stem and Progenitor Cells Exhibit Stage-Specific Translational Programs via mTOR- and CDK1-Dependent Mechanisms.
Volume: 26
Issue: 5
Pages: 755-765.e7
•
•
•
•
•
Publication
29502971 | J:261125
First Author: Mohamed TMA
Year: 2018
Journal: Cell
Title: Regulation of Cell Cycle to Stimulate Adult Cardiomyocyte Proliferation and Cardiac Regeneration.
Volume: 173
Issue: 1
Pages: 104-116.e12
•
•
•
•
•
Publication
29074707 | J:255493
First Author: Strauss B
Year: 2018
Journal: J Cell Biol
Title: Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis.
Volume: 217
Issue: 1
Pages: 179-193
•
•
•
•
•
Publication
25071185 | J:213701
First Author: Hubbi ME
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: Cyclin-dependent kinases regulate lysosomal degradation of hypoxia-inducible factor 1α to promote cell-cycle progression.
Volume: 111
Issue: 32
Pages: E3325-34
•
•
•
•
•
Publication
30097513 | J:267475
First Author: Li J
Year: 2018
Journal: J Cell Biol
Title: Cyclin B2 can compensate for Cyclin B1 in oocyte meiosis I.
Volume: 217
Issue: 11
Pages: 3901-3911
•
•
•
•
•
Publication
30154440 | J:266254
First Author: Sha QQ
Year: 2018
Journal: Nat Commun
Title: CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes.
Volume: 9
Issue: 1
Pages: 3477
•
•
•
•
•
Publication
36697412 | J:332850
First Author: Takahashi N
Year: 2023
Journal: Nat Commun
Title: CPEB1-dependent disruption of the mRNA translation program in oocytes during maternal aging.
Volume: 14
Issue: 1
Pages: 416
•
•
•
•
•
Publication
28854370 | J:254222
First Author: He ZQ
Year: 2017
Journal: Cell Rep
Title: Generation of Mouse Haploid Somatic Cells by Small Molecules for Genome-wide Genetic Screening.
Volume: 20
Issue: 9
Pages: 2227-2237
•
•
•
•
•
Publication
32518258 | J:292325
First Author: Hagey DW
Year: 2020
Journal: Nat Commun
Title: CYCLIN-B1/2 and -D1 act in opposition to coordinate cortical progenitor self-renewal and lineage commitment.
Volume: 11
Issue: 1
Pages: 2898
•
•
•
•
•
Publication
21947081 | J:180706
First Author: Gruber R
Year: 2011
Journal: Nat Cell Biol
Title: MCPH1 regulates the neuroprogenitor division mode by coupling the centrosomal cycle with mitotic entry through the Chk1-Cdc25 pathway.
Volume: 13
Issue: 11
Pages: 1325-34
•
•
•
•
•
Publication
30723090 | J:273304
First Author: Karasu ME
Year: 2019
Journal: J Cell Biol
Title: Cyclin B3 promotes anaphase I onset in oocyte meiosis.
Volume: 218
Issue: 4
Pages: 1265-1281
•
•
•
•
•
Publication
32726637 | J:304325
First Author: Zhang F
Year: 2020
Journal: Cell Rep
Title: L ARP7 Is a BRCA1 Ubiquitinase Substrate and Regulates Genome Stability and Tumorigenesis.
Volume: 32
Issue: 4
Pages: 107974
•
•
•
•
•
Publication
17679094 | J:134816
First Author: Amador V
Year: 2007
Journal: Mol Cell
Title: APC/C(Cdc20) controls the ubiquitin-mediated degradation of p21 in prometaphase.
Volume: 27
Issue: 3
Pages: 462-73
•
•
•
•
•
Publication
21628425 | J:183058
First Author: Matsuyama M
Year: 2011
Journal: J Cell Sci
Title: Nuclear Chk1 prevents premature mitotic entry.
Volume: 124
Issue: Pt 13
Pages: 2113-9
•
•
•
•
•
Publication
23345398 | J:200465
First Author: Oh JS
Year: 2013
Journal: J Cell Sci
Title: Cdc25A activity is required for the metaphase II arrest in mouse oocytes.
Volume: 126
Issue: Pt 5
Pages: 1081-5
•
•
•
•
•
Publication
25324523 | J:216673
First Author: Zhao R
Year: 2014
Journal: Proc Natl Acad Sci U S A
Title: A nontranscriptional role for Oct4 in the regulation of mitotic entry.
Volume: 111
Issue: 44
Pages: 15768-73
•
•
•
•
•
Publication
26150388 | J:227306
First Author: Lim JM
Year: 2015
Journal: J Cell Biol
Title: Control of the pericentrosomal H2O2 level by peroxiredoxin I is critical for mitotic progression.
Volume: 210
Issue: 1
Pages: 23-33
•
•
•
•
•
Publication
27708105 | J:235861
First Author: Kanakkanthara A
Year: 2016
Journal: Science
Title: Cyclin A2 is an RNA binding protein that controls Mre11 mRNA translation.
Volume: 353
Issue: 6307
Pages: 1549-1552
•
•
•
•
•
Publication
27025256 | J:236827
 
First Author: Mikolcevic P
Year: 2016
Journal: Nat Commun
Title: Essential role of the Cdk2 activator RingoA in meiotic telomere tethering to the nuclear envelope.
Volume: 7
Pages: 11084
•
•
•
•
•
Publication
28461508 | J:242205
First Author: Dai YJ
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Conditional knockin of Dnmt3a R878H initiates acute myeloid leukemia with mTOR pathway involvement.
Volume: 114
Issue: 20
Pages: 5237-5242
•
•
•
•
•
Publication
26259146 | J:339375
 
First Author: Lee HS
Year: 2015
Journal: Nat Commun
Title: The chromatin remodeller RSF1 is essential for PLK1 deposition and function at mitotic kinetochores.
Volume: 6
Pages: 7904
•
•
•
•
•
Publication
30770433 | J:274627
First Author: Li Y
Year: 2019
Journal: J Cell Biol
Title: Cyclin B3 is required for metaphase to anaphase transition in oocyte meiosis I.
Volume: 218
Issue: 5
Pages: 1553-1563
•
•
•
•
•
Publication
32080348 | J:303271
First Author: Sanz-Gómez N
Year: 2020
Journal: Cell Death Differ
Title: Squamous differentiation requires G2/mitosis slippage to avoid apoptosis.
Volume: 27
Issue: 8
Pages: 2451-2467
•
•
•
•
•
Publication
35508654 | J:331857
First Author: Suski JM
Year: 2022
Journal: Nature
Title: CDC7-independent G1/S transition revealed by targeted protein degradation.
Volume: 605
Issue: 7909
Pages: 357-365
•
•
•
•
•
Publication
12679038 | -
First Author: Ayad NG
Year: 2003
Journal: Cell
Title: Tome-1, a trigger of mitotic entry, is degraded during G1 via the APC.
Volume: 113
Issue: 1
Pages: 101-13
•
•
•
•
•
Protein
Q99M54
Organism: Mus musculus/domesticus
Length: 266  
Fragment?: false
•
•
•
•
•
Protein
Q8BSP2
Organism: Mus musculus/domesticus
Length: 607  
Fragment?: false
•
•
•
•
•
Protein
D3Z3H6
Organism: Mus musculus/domesticus
Length: 213  
Fragment?: true
•
•
•
•
•
Protein
D3YZ81
Organism: Mus musculus/domesticus
Length: 187  
Fragment?: true
•
•
•
•
•
Protein
D3YXE3
Organism: Mus musculus/domesticus
Length: 180  
Fragment?: true
•
•
•
•
•
Protein
E9PY48
Organism: Mus musculus/domesticus
Length: 576  
Fragment?: false
•
•
•
•
•
Publication
22855829 | -
First Author: Hirano T
Year: 2012
Journal: Genes Dev
Title: Condensins: universal organizers of chromosomes with diverse functions.
Volume: 26
Issue: 15
Pages: 1659-78
•
•
•
•
•
Publication
17081983 | -
First Author: Olsen JV
Year: 2006
Journal: Cell
Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.
Volume: 127
Issue: 3
Pages: 635-48
•
•
•
•
•
Publication
17386261 | -
First Author: Larochelle S
Year: 2007
Journal: Mol Cell
Title: Requirements for Cdk7 in the assembly of Cdk1/cyclin B and activation of Cdk2 revealed by chemical genetics in human cells.
Volume: 25
Issue: 6
Pages: 839-50
•
•
•
•
•
Publication
9372954 | -
First Author: Ko LJ
Year: 1997
Journal: Mol Cell Biol
Title: p53 is phosphorylated by CDK7-cyclin H in a p36MAT1-dependent manner.
Volume: 17
Issue: 12
Pages: 7220-9
•
•
•
•
•
Publication
9840937 | -
First Author: Schneider E
Year: 1998
Journal: Oncogene
Title: Regulation of CAK kinase activity by p53.
Volume: 17
Issue: 21
Pages: 2733-41
•
•
•
•
•
Publication
16327805 | -
First Author: Larochelle S
Year: 2006
Journal: Nat Struct Mol Biol
Title: Dichotomous but stringent substrate selection by the dual-function Cdk7 complex revealed by chemical genetics.
Volume: 13
Issue: 1
Pages: 55-62
•
•
•
•
•
Publication
27759017 | -
 
First Author: Deshmukh AS
Year: 2016
Journal: Sci Rep
Title: Cdk7 mediates RPB1-driven mRNA synthesis in Toxoplasma gondii.
Volume: 6
Pages: 35288
•
•
•
•
•
Publication
25691663 | -
First Author: Devos M
Year: 2015
Journal: Mol Cell Biol
Title: Fission yeast Cdk7 controls gene expression through both its CAK and C-terminal domain kinase activities.
Volume: 35
Issue: 9
Pages: 1480-90
•
•
•
•
•
Publication
8752210 | -
First Author: Kaldis P
Year: 1996
Journal: Cell
Title: The Cdk-activating kinase (CAK) from budding yeast.
Volume: 86
Issue: 4
Pages: 553-64
•
•
•
•
•
Protein Domain
IPR038832 | CDCA3
Type: Family
Description: This entry includes cell division cycle-associated protein 3 (CDCA3; also known as trigger of mitotic entry protein 1 or TOME-1), which is required for entry into mitosis. The protein is found at high levels during the G2 and M phases of mitosis, but declines rapidly during the G2 phase. Entry into mitosis requires the relocalization to the nucleus and activation of cyclin-dependent kinase 1 (cdk1) by association with cyclin B, and exit from mitosis occurs when cyclin B is degraded and the kinase activity decreases. Anaphase promoting complex (APC) is an E3 ligase active during anaphase and G1, and is required for the degradation of cyclin B. CDCA3 is a cytosolic protein and a substrate of APC. It associates with Skp-1 and is required for the degradation of the cdk1 inhibitor wee1, a tyrosine kinase. Degradation of CDCA3 leads to an accumulation of wee1 during interphase []. The CDCA3 protein contains an F-box-like region and a KEN box; the latter is required for association with the APC complex.
•
•
•
•
•
Protein Domain
IPR037770 | CDK7
Type: Family
Description: Cyclin-dependent kinase 7 (CDK7) is a serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. It is activated by binding to a cyclin; binding to a different cyclin and phosphorylation of another kinase progresses the cell cycle. CDK7 binds cyclin-B and phosphorylates CDK1 during G2-M transition, and phosphorylates CDK2 and binds to cyclins during G1-S transition [, ]. CDK7 phosphorylates and activates p53 following DNA damage [], but CDK7 is then inactivated by p53, which arrests the cell cycle, allowing the cell to recover or undergo apoptosis []. CDK7 is also the catalytic subunit of the CDK-activating kinase (CAK) complex, which also contains cyclin-H (CCNH) and MAT1 [, ]. In turn, the CAK associates with the core-TFIIH to form the TFIIH basal transcription factor [].This entry includes CDK7 from animals, Kin28 from budding yeasts and Crk1 (also known as Mcs6) from fission yeasts. S. pombe possesses two CAKs, the nonessential Csk1 and the essential Mcs6 kinases, corresponding to the yeast Cak1 and the metazoan CDK7, respectively. Mcs6 modulates gene expression through both its CAK and CTD kinase activities []. Kin28 is the closest homologue of CDK7 from budding yeasts. It forms a complex with Ccl1 and Tfb3. This complex associate with TFIIH for transcription regulating activity, but does not display CAK activity []. Instead, Cak1, a single-subunit kinase distantly related to Cdk, catalyzes Cdk activation at both transitions of the budding yeast cell cycle [].
•
•
•
•
•
Publication
31437213 | J:279007
First Author: Gómez-H L
Year: 2019
Journal: PLoS Genet
Title: The PSMA8 subunit of the spermatoproteasome is essential for proper meiotic exit and mouse fertility.
Volume: 15
Issue: 8
Pages: e1008316
•
•
•
•
•
Publication
14993212 | J:114148
First Author: Sugimoto N
Year: 2004
Journal: J Biol Chem
Title: Cdt1 phosphorylation by cyclin A-dependent kinases negatively regulates its function without affecting geminin binding.
Volume: 279
Issue: 19
Pages: 19691-7
•
•
•
•
•
Publication
16025114 | J:100110
First Author: Ko MA
Year: 2005
Journal: Nat Genet
Title: Plk4 haploinsufficiency causes mitotic infidelity and carcinogenesis.
Volume: 37
Issue: 8
Pages: 883-8
•
•
•
•
•
Publication
10068472 | J:53603
First Author: Ravnik SE
Year: 1999
Journal: Dev Biol
Title: Regulation of meiosis during mammalian spermatogenesis: the A-type cyclins and their associated cyclin-dependent kinases are differentially expressed in the germ-cell lineage.
Volume: 207
Issue: 2
Pages: 408-18
•
•
•
•
•
Publication
11029659 | J:87924
First Author: Nakanishi M
Year: 2000
Journal: Genes Cells
Title: Identification and characterization of human Wee1B, a new member of the Wee1 family of Cdk-inhibitory kinases.
Volume: 5
Issue: 10
Pages: 839-47
•
•
•
•
•
Publication
11544477 | J:71950
First Author: Herceg Z
Year: 2001
Journal: Nat Genet
Title: Disruption of Trrap causes early embryonic lethality and defects in cell cycle progression.
Volume: 29
Issue: 2
Pages: 206-11
•
•
•
•
•
Publication
16371510 | J:111721
First Author: Fourest-Lieuvin A
Year: 2006
Journal: Mol Biol Cell
Title: Microtubule regulation in mitosis: tubulin phosphorylation by the cyclin-dependent kinase Cdk1.
Volume: 17
Issue: 3
Pages: 1041-50
•
•
•
•
•
Publication
21529751 | J:177951
First Author: Alkuraya FS
Year: 2011
Journal: Am J Hum Genet
Title: Human mutations in NDE1 cause extreme microcephaly with lissencephaly [corrected].
Volume: 88
Issue: 5
Pages: 536-47
•
•
•
•
•
Publication
25486569 | J:273120
First Author: Berton S
Year: 2014
Journal: Cell Cycle
Title: Genetic characterization of p27(kip1) and stathmin in controlling cell proliferation in vivo.
Volume: 13
Issue: 19
Pages: 3100-11
•
•
•
•
•
Publication
22517620 | J:192381
First Author: Demeestere I
Year: 2012
Journal: Biol Reprod
Title: Follicle-stimulating hormone accelerates mouse oocyte development in vivo.
Volume: 87
Issue: 1
Pages: 3, 1-11
•
•
•
•
•
Publication
26363457 | J:232950
First Author: Tane S
Year: 2015
Journal: Biochem Biophys Res Commun
Title: Two inhibitory systems and CKIs regulate cell cycle exit of mammalian cardiomyocytes after birth.
Volume: 466
Issue: 2
Pages: 147-54
•
•
•
•
•
Publication
22505032 | J:183925
First Author: Ganuza M
Year: 2012
Journal: EMBO J
Title: Genetic inactivation of Cdk7 leads to cell cycle arrest and induces premature aging due to adult stem cell exhaustion.
Volume: 31
Issue: 11
Pages: 2498-510
•
•
•
•
•
Publication
29462287 | J:285766
First Author: Lian G
Year: 2019
Journal: Cereb Cortex
Title: Cytoskeletal Associated Filamin A and RhoA Affect Neural Progenitor Specification During Mitosis.
Volume: 29
Issue: 3
Pages: 1280-1290
•
•
•
•
•
Publication
22532528 | J:194573
First Author: Lim S
Year: 2012
Journal: Stem Cells
Title: Loss of Cdk2 and Cdk4 induces a switch from proliferation to differentiation in neural stem cells.
Volume: 30
Issue: 7
Pages: 1509-20
•
•
•
•
•
Publication
21490060 | J:171431
First Author: Kim SY
Year: 2011
Journal: Development
Title: The Cdk4-E2f1 pathway regulates early pancreas development by targeting Pdx1+ progenitors and Ngn3+ endocrine precursors.
Volume: 138
Issue: 10
Pages: 1903-12
•
•
•
•
•
Publication
19158073 | J:148816
First Author: Metchat A
Year: 2009
Journal: J Biol Chem
Title: Mammalian heat shock factor 1 is essential for oocyte meiosis and directly regulates Hsp90alpha expression.
Volume: 284
Issue: 14
Pages: 9521-8
•
•
•
•
•
Publication
17940036 | J:125912
First Author: Natarajan A
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: The EGF receptor is required for efficient liver regeneration.
Volume: 104
Issue: 43
Pages: 17081-6
•
•
•
•
•
Publication
28244683 | J:265516
First Author: Li A
Year: 2017
Journal: J Cell Mol Med
Title: Rapamycin treatment dose-dependently improves the cystic kidney in a new ADPKD mouse model via the mTORC1 and cell-cycle-associated CDK1/cyclin axis.
Volume: 21
Issue: 8
Pages: 1619-1635
•
•
•
•
•
Publication
34850681 | J:320368
   
First Author: Houlard M
Year: 2021
Journal: Elife
Title: MCPH1 inhibits Condensin II during interphase by regulating its SMC2-Kleisin interface.
Volume: 10
•
•
•
•
•
Publication
12482952 | J:81015
First Author: Wang X
Year: 2002
Journal: Proc Natl Acad Sci U S A
Title: The Forkhead Box m1b transcription factor is essential for hepatocyte DNA replication and mitosis during mouse liver regeneration.
Volume: 99
Issue: 26
Pages: 16881-6
•
•
•
•
•
Publication
24802190 | J:212546
First Author: Gopinathan L
Year: 2014
Journal: Cancer Res
Title: Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis.
Volume: 74
Issue: 14
Pages: 3870-9
•
•
•
•
•
Publication
32313933 | J:293856
First Author: Wu D
Year: 2020
Journal: Nucleic Acids Res
Title: EXOSC10 sculpts the transcriptome during the growth-to-maturation transition in mouse oocytes.
Volume: 48
Issue: 10
Pages: 5349-5365
•
•
•
•
•
Publication
22837479 | J:192498
First Author: Solc P
Year: 2012
Journal: Biol Reprod
Title: Aurora kinase A drives MTOC biogenesis but does not trigger resumption of meiosis in mouse oocytes matured in vivo.
Volume: 87
Issue: 4
Pages: 85
•
•
•
•
•
Publication
22106411 | J:183657
First Author: Lin X
Year: 2012
Journal: Mol Cell Biol
Title: Protein tyrosine phosphatase-like A regulates myoblast proliferation and differentiation through MyoG and the cell cycling signaling pathway.
Volume: 32
Issue: 2
Pages: 297-308
•
•
•
•
•
Publication
34130995 | J:308471
 
First Author: Homma H
Year: 2021
Journal: Life Sci Alliance
Title: DNA damage in embryonic neural stem cell determines FTLDs' fate via early-stage neuronal necrosis.
Volume: 4
Issue: 7
•
•
•
•
•
Publication
27371320 | J:245061
First Author: Chauhan S
Year: 2016
Journal: Biochem J
Title: Cdk2 catalytic activity is essential for meiotic cell division in vivo.
Volume: 473
Issue: 18
Pages: 2783-98
•
•
•
•
•
Publication
31492966 | J:302674
First Author: Zhang J
Year: 2020
Journal: Cell Mol Life Sci
Title: The CRL4-DCAF13 ubiquitin E3 ligase supports oocyte meiotic resumption by targeting PTEN degradation.
Volume: 77
Issue: 11
Pages: 2181-2197
•
•
•
•
•
Publication
20043882 | J:157086
First Author: Kurabe N
Year: 2010
Journal: Biochem Biophys Res Commun
Title: The death effector domain-containing DEDD forms a complex with Akt and Hsp90, and supports their stability.
Volume: 391
Issue: 4
Pages: 1708-13
•
•
•
•
•
Publication
38627401 | J:349478
First Author: Molinuevo R
Year: 2024
Journal: Nat Commun
Title: Physiological DNA damage promotes functional endoreplication of mammary gland alveolar cells during lactation.
Volume: 15
Issue: 1
Pages: 3288
•
•
•
•
•
Publication
24553289 | J:208416
First Author: Holt JE
Year: 2014
Journal: Development
Title: The APC/C activator FZR1 is essential for meiotic prophase I in mice.
Volume: 141
Issue: 6
Pages: 1354-65
•
•
•
•
•
Publication
27725702 | J:250193
 
First Author: Redgrove KA
Year: 2016
Journal: Sci Rep
Title: Dynamin 2 is essential for mammalian spermatogenesis.
Volume: 6
Pages: 35084
•
•
•
•
•
Publication
30115978 | J:278069
First Author: Schulze S
Year: 2018
Journal: Sci Rep
Title: Cytosolic nucleic acid sensors of the innate immune system promote liver regeneration after partial hepatectomy.
Volume: 8
Issue: 1
Pages: 12271
•
•
•
•
•
Publication
26185128 | J:230257
First Author: Trakala M
Year: 2015
Journal: Blood
Title: Activation of the endomitotic spindle assembly checkpoint and thrombocytopenia in Plk1-deficient mice.
Volume: 126
Issue: 14
Pages: 1707-14
•
•
•
•
•
Publication
30364263 | J:290559
 
First Author: Mak W
Year: 2018
Journal: Cell Biosci
Title: A role of Pumilio 1 in mammalian oocyte maturation and maternal phase of embryogenesis.
Volume: 8
Pages: 54
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom