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Search results 601 to 700 out of 1056 for Cdk2

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Hits by Strain

Type Details Score
Allele
Cdk2<em1Smoc> | MGI:7288897
Name: cyclin dependent kinase 2; endonuclease-mediated mutation 1, Shanghai Model Organisms Center
Allele Type: Endonuclease-mediated
Attribute String: Conditional ready, No functional change
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Strain
MGI:6354669 | C57BL/6JSmoc-Cdk2<em2Smoc>/Smoc
Attribute String: coisogenic, mutant strain, endonuclease-mediated mutation
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Interaction Experiment
Srivastava R (2012)
Description: ADAP Regulates Cell Cycle Progression of T Cells via Control of Cyclin E and Cdk2 Expression through Two Distinct CARMA1-Dependent Signaling Pathways.
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Publication
17942597 | -
First Author: Satyanarayana A
Year: 2008
Journal: Mol Biol Cell
Title: p21 Inhibits Cdk1 in the absence of Cdk2 to maintain the G1/S phase DNA damage checkpoint.
Volume: 19
Issue: 1
Pages: 65-77
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Publication
17601773 | -
First Author: Li X
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Role of cdk2 in the sequential phosphorylation/activation of C/EBPbeta during adipocyte differentiation.
Volume: 104
Issue: 28
Pages: 11597-602
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Publication
8259216 | -
First Author: Gu Y
Year: 1993
Journal: Nature
Title: Inhibition of CDK2 activity in vivo by an associated 20K regulatory subunit.
Volume: 366
Issue: 6456
Pages: 707-10
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Publication
21596315 | -
First Author: Huang X
Year: 2011
Journal: Mol Cell
Title: Deubiquitinase USP37 is activated by CDK2 to antagonize APC(CDH1) and promote S phase entry.
Volume: 42
Issue: 4
Pages: 511-23
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Publication
11463824 | -
First Author: Bhattacharjee RN
Year: 2001
Journal: Mol Cell Biol
Title: Histone H1 phosphorylation by Cdk2 selectively modulates mouse mammary tumor virus transcription through chromatin remodeling.
Volume: 21
Issue: 16
Pages: 5417-25
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Publication
8769642 | -
First Author: Clurman BE
Year: 1996
Journal: Genes Dev
Title: Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation.
Volume: 10
Issue: 16
Pages: 1979-90
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Publication
17371838 | -
First Author: Giono LE
Year: 2007
Journal: Mol Cell Biol
Title: Mdm2 is required for inhibition of Cdk2 activity by p21, thereby contributing to p53-dependent cell cycle arrest.
Volume: 27
Issue: 11
Pages: 4166-78
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Publication
10938106 | -
First Author: Shintani S
Year: 2000
Journal: Mol Cell Biol
Title: p12(DOC-1) is a novel cyclin-dependent kinase 2-associated protein.
Volume: 20
Issue: 17
Pages: 6300-7
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Protein
O35207
Organism: Mus musculus/domesticus
Length: 114  
Fragment?: false
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Protein
Q9CPY4
Organism: Mus musculus/domesticus
Length: 127  
Fragment?: false
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Protein
F2Z4B3
Organism: Mus musculus/domesticus
Length: 87  
Fragment?: false
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Protein
G3UX88
Organism: Mus musculus/domesticus
Length: 59  
Fragment?: false
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Protein
G3UYI1
Organism: Mus musculus/domesticus
Length: 107  
Fragment?: false
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Protein Domain
IPR017266 | DOC_1/2
Type: Family
Description: This group represents the cyclin-dependent kinase 2-associated protein 1/2 (DOC-1/1R). DOC-1 is a specific inhibitor of the cell-cycle kinase CDK2 []. DOC-1R associates with CDK2 and inhibits CDK2 activation by obstructing its association with cyclin E and A [].
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Allele
Cdk4<tm2.2Bbd> | MGI:5705761
Name: cyclin dependent kinase 4; targeted mutation 2.2, Mariano Barbacid
Allele Type: Targeted
Attribute String: Conditional ready
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Strain
MGI:7623333 | C57BL/6JSmoc-Cdk2<em1Smoc>/Smoc
Attribute String: coisogenic, endonuclease-mediated mutation, mutant strain
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Publication
12972555 | -
First Author: Porter LA
Year: 2003
Journal: Mol Biol Cell
Title: Spy1 interacts with p27Kip1 to allow G1/S progression.
Volume: 14
Issue: 9
Pages: 3664-74
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Protein
Q5IBH7
Organism: Mus musculus/domesticus
Length: 310  
Fragment?: false
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Protein
Q5IBH6
Organism: Mus musculus/domesticus
Length: 268  
Fragment?: false
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Protein
B9EIX3
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
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Protein
Q8CDE8
Organism: Mus musculus/domesticus
Length: 236  
Fragment?: false
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Protein
A0A7D9NM65
Organism: Mus musculus/domesticus
Length: 172  
Fragment?: false
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Protein
A2AQG6
Organism: Mus musculus/domesticus
Length: 115  
Fragment?: true
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Protein
B8JJB9
Organism: Mus musculus/domesticus
Length: 309  
Fragment?: false
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Protein
Q9D5G0
Organism: Mus musculus/domesticus
Length: 173  
Fragment?: false
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Protein
A0A0G2JEI8
Organism: Mus musculus/domesticus
Length: 231  
Fragment?: false
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Protein
I6XKQ3
Organism: Mus musculus/domesticus
Length: 339  
Fragment?: false
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Protein
B2RWC8
Organism: Mus musculus/domesticus
Length: 283  
Fragment?: false
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Publication
17671428 | -
First Author: McAndrew CW
Year: 2007
Journal: Cell Cycle
Title: Spy1 enhances phosphorylation and degradation of the cell cycle inhibitor p27.
Volume: 6
Issue: 15
Pages: 1937-45
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Publication
28666995 | -
First Author: McGrath DA
Year: 2017
Journal: EMBO J
Title: Structural basis of divergent cyclin-dependent kinase activation by Spy1/RINGO proteins.
Volume: 36
Issue: 15
Pages: 2251-2262
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Protein Domain
IPR020984 | Speedy
Type: Family
Description: Speedy (Spy1, also known as RINGO A) is a cell cycle regulatory protein which binds and activates CDK1 and CDK2 [], protein kinases that allows progression through G1/S phase and further replication events. Spy1 activates CDK2 inducing a conformational change of the CDK2 T-loop that avoids its phosphorylation []. Spy1 expression overcomes a p27-induced cell cycle arrest to allow for DNA synthesis, so cell cycle progression occurs due to an interaction between Spy1 and p27 [].
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Allele
Cdkn1c<tm1.1(Cdkn1b*)Kei> | MGI:3840687
Name: cyclin dependent kinase inhibitor 1C; targeted mutation 1.1, Keiichi I Nakayama
Allele Type: Targeted
Attribute String: Inserted expressed sequence, Null/knockout
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Strain
MGI:5704506 | STOCK Cdk4<tm2.2Bbd>/Cnbc
Attribute String: mutant stock, targeted mutation
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Genotype
Genotype
Symbol: Cdk4/Cdk4
Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CD-1 * SJL
Zygosity: hm
Has Mutant Allele: true
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Strain
MGI:6146825 | B6.129P2-Cdkn1c<tm1.1(Cdkn1b*)Kei>/KeiRbrc
Attribute String: targeted mutation, mutant strain, congenic
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Strain
MGI:5294551 | B6.129P2-Cdkn1c<tm1.1(Cdkn1b*)Kei>
Attribute String: mutant strain, targeted mutation, congenic
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Genotype
Genotype
Symbol: Cdkn1c/Cdkn1c<+>
Background: involves: 129P2/OlaHsd * C57BL/6J
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdkn1c/Cdkn1c<+>
Background: B6.129P2-Cdkn1c
Zygosity: ht
Has Mutant Allele: true
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Publication
19276117 | J:147145
First Author: Susaki E
Year: 2009
Journal: Proc Natl Acad Sci U S A
Title: Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model.
Volume: 106
Issue: 13
Pages: 5192-7
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Protein
Q9D0V8
Organism: Mus musculus/domesticus
Length: 212  
Fragment?: false
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Protein
A0A1Y7VLF5
Organism: Mus musculus/domesticus
Length: 118  
Fragment?: false
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Protein
A0A1Y7VMK7
Organism: Mus musculus/domesticus
Length: 116  
Fragment?: true
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Protein
A0A1Y7VN75
Organism: Mus musculus/domesticus
Length: 262  
Fragment?: false
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Protein
Q8VDH2
Organism: Mus musculus/domesticus
Length: 322  
Fragment?: false
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Protein
A0A1Y7VJ98
Organism: Mus musculus/domesticus
Length: 145  
Fragment?: false
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Protein
A0A1Y7VMU4
Organism: Mus musculus/domesticus
Length: 139  
Fragment?: false
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Protein
A0A1Y7VJ59
Organism: Mus musculus/domesticus
Length: 71  
Fragment?: false
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Publication
8127873 | -
First Author: Hannon GJ
Year: 1994
Journal: Proc Natl Acad Sci U S A
Title: KAP: a dual specificity phosphatase that interacts with cyclin-dependent kinases.
Volume: 91
Issue: 5
Pages: 1731-5
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Publication
10987270 | -
First Author: Yeh CT
Year: 2000
Journal: Cancer Res
Title: Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma.
Volume: 60
Issue: 17
Pages: 4697-700
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Protein Domain
IPR023250 | Cyclin-dep_Kinase_2_interact
Type: Family
Description: Cyclin-dependent kinase 2-interacting protein (CINP) is a component of theactive cyclin E/Cdk2 and cyclin A/Cdk2 complexes []. It is phopshorylated by Cdc7, but not by Cdk2 []. CINP has also been shown to bind to chromatin in a replication-dependent manner, and to associate with Origin Recognition Complex-2 (ORC2)-containing complexes and minichromosome maintenance/DNA replication licensing complex, MCM []. It has been proposed that CINP is part of the Cdc7-dependent mechanism of origin firing, and constitutes a physical link between Cdk2 and Cdc7 complexes at the origins [].
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Publication
12034829 | -
First Author: Liu H
Year: 2002
Journal: Nucleic Acids Res
Title: Distinct proteins encoded by alternative transcripts of the PURG gene, located contrapodal to WRN on chromosome 8, determined by differential termination/polyadenylation.
Volume: 30
Issue: 11
Pages: 2417-26
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Publication
11781350 | -
First Author: Donato JL
Year: 2002
Journal: J Clin Invest
Title: Human HTm4 is a hematopoietic cell cycle regulator.
Volume: 109
Issue: 1
Pages: 51-8
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Publication
15671017 | -
First Author: Chinami M
Year: 2005
Journal: J Biol Chem
Title: Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2.
Volume: 280
Issue: 17
Pages: 17235-42
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Publication
19818099 | -
First Author: Kutok JL
Year: 2011
Journal: J Cell Mol Med
Title: Characterization of the expression of HTm4 (MS4A3), a cell cycle regulator, in human peripheral blood cells and normal and malignant tissues.
Volume: 15
Issue: 1
Pages: 86-93
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Protein Domain
IPR030501 | PURgamma
Type: Family
Description: PURgamma belongs to the purine-rich element binding (PUR) protein family, which consists of PURalpha, PURbeta and PURgamma. Purgamma colocalises with Cdk2 to a specific DNA segment upstream of the c-MYC gene []. It also has been detected upstream of the gene encoding the Werner syndrome helicase, Wrn, at human chromosome band 8p11-12 [].
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Protein Domain
IPR022778 | CDKN3
Type: Domain
Description: This entry represents a domain found in cyclin-dependent kinase inhibitor 3 or kinase associated phosphatase proteins from several mammalian species. The cyclin-dependent kinase (Cdk)-associated protein phosphatase (KAP) is a human dual specificity protein phosphatase that dephosphorylates Cdk2 on threonine 160 in a cyclin-dependent manner [, ]. This domain is also found in MAP kinase phosphatase and esterases.This entry contains both eukaryotic and bacterial proteins.
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Protein Domain
IPR030419 | MS4A3
Type: Family
Description: Membrane-spanning 4-domains subfamily A member 3 (MS4A3), also known as HTm4, is an hematopoietic modulator for the G1-S cell cycle transition []. HTm4 binds to the Cdk-associated Phosphatase (KAP)-Cdk2-Cyclin A complex, triggering the dissociation of cyclin A and facilitating dephosphorylation of Cdk2 by KAP [, ].
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Protein Domain
IPR008425 | CDK_inhib_3
Type: Family
Description: This family consists of cyclin-dependent kinase inhibitor 3 or kinase associated phosphatase proteins from several mammalian species. The cyclin-dependent kinase (Cdk)-associated protein phosphatase (KAP) is a Homo sapiens dual specificity protein phosphatase that dephosphorylates Cdk2 on threonine 160 in a cyclin-dependent manner [, ].
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Allele
Cdk1<tm1(Cdk2)Kald> | MGI:3818306
Name: cyclin dependent kinase 1; targeted mutation 1, Philipp Kaldis
Allele Type: Targeted
Attribute String: Conditional ready, Inserted expressed sequence, Null/knockout, Reporter
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Genotype
Genotype
Symbol: Cdk4/Cdk4 Kras/Kras Polr2a/Polr2a
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Protein
Q9CWI3
Organism: Mus musculus/domesticus
Length: 316  
Fragment?: false
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Publication
12912920 | -
First Author: Audhya A
Year: 2003
Journal: EMBO J
Title: Regulation of PI4,5P2 synthesis by nuclear-cytoplasmic shuttling of the Mss4 lipid kinase.
Volume: 22
Issue: 16
Pages: 4223-36
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Publication
14726710 | -
First Author: Meng X
Year: 2004
Journal: Cell Cycle
Title: Inhibition of G1 to S cell cycle progression by BCCIP beta.
Volume: 3
Issue: 3
Pages: 343-8
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Publication
15713648 | -
First Author: Lu H
Year: 2005
Journal: Mol Cell Biol
Title: The BRCA2-interacting protein BCCIP functions in RAD51 and BRCA2 focus formation and homologous recombinational repair.
Volume: 25
Issue: 5
Pages: 1949-57
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Publication
17947333 | -
First Author: Lu H
Year: 2007
Journal: Nucleic Acids Res
Title: BCCIP regulates homologous recombination by distinct domains and suppresses spontaneous DNA damage.
Volume: 35
Issue: 21
Pages: 7160-70
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Protein Domain
IPR025602 | BCP1_family
Type: Family
Description: This family of proteins includes BRCA2 and CDKN1A-interacting protein (BCCIP) and Bcp1. In fungi, Bcp1 is involved in nuclear export, actin cytoskeleton organisation and vesicular transport []. Its homologue in human and mouse, BCCIP, may promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A/p21 and may be required for repair of DNA damage by homologous recombination in conjunction with BRCA2 [, , , ].
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Publication
18067863 | J:130331
First Author: Kan Q
Year: 2007
Journal: FEBS Lett
Title: Chemical DNA damage activates p21 WAF1/CIP1-dependent intra-S checkpoint.
Volume: 581
Issue: 30
Pages: 5879-84
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Publication
12648451 | J:288166
First Author: Wan YY
Year: 2003
Journal: Immunity
Title: The survival of antigen-stimulated T cells requires NFkappaB-mediated inhibition of p73 expression.
Volume: 18
Issue: 3
Pages: 331-42
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Publication
20466002 | J:161318
First Author: Arakawa-Takeuchi S
Year: 2010
Journal: FEBS Lett
Title: Mammalian target of rapamycin complex 1 signaling opposes the effects of anchorage loss, leading to activation of Cdk4 and Cdc6 stabilization.
Volume: 584
Issue: 13
Pages: 2779-85
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Publication
24747639 | J:212325
First Author: Wallmeier J
Year: 2014
Journal: Nat Genet
Title: Mutations in CCNO result in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia.
Volume: 46
Issue: 6
Pages: 646-51
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Publication
23515676 | J:202069
First Author: Ma JY
Year: 2013
Journal: Biol Reprod
Title: Cyclin O regulates germinal vesicle breakdown in mouse oocytes.
Volume: 88
Issue: 5
Pages: 110
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Protein Domain
IPR028864 | Ccno
Type: Family
Description: Cyclins are eukaryotic proteins that play an active role in controlling nuclear cell division cycles, and regulate cyclin dependent kinases (CDKs) [].This entry represents cyclin-O. In mouse oocytes, it regulates maturation-promoting factor (MPF), which affects oocyte meiotic resumption []. It is required to activate Cdk2 during apoptosis induced by intrinsic stimuli in lymphoid cells []. Its activity is modulated by p53 and members of the Bcl-2 protein family []. This entry also includes cyclin-O protein A/B, also known as CCNO, from Xenopus laevis. Mutations in CCNO result in congenital mucociliary clearance disorder with reduced generation of multiple motile cilia [].
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Publication
21885021 | J:176209
First Author: Matsumoto A
Year: 2011
Journal: Cell Stem Cell
Title: p57 is required for quiescence and maintenance of adult hematopoietic stem cells.
Volume: 9
Issue: 3
Pages: 262-71
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Genotype
Genotype
Symbol: Cdk1/Cdk1<+> Cdk2/Cdk2
Background: involves: 129S1/Sv * C57BL/6
Zygosity: cx
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdk1/Cdk1
Background: involves: 129 * C57BL/6
Zygosity: hm
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdk1/Cdk1<+>
Background: involves: 129 * C57BL/6
Zygosity: ht
Has Mutant Allele: true
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Genotype
Genotype
Symbol: Cdk4/Cdk4 Kras/Kras Polr2a/Polr2a
Background: involves: 129S1/Sv * 129X1/SvJ
Zygosity: cn
Has Mutant Allele: true
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Publication
16458891 | J:106897
First Author: Asefa B
Year: 2006
Journal: FEBS Lett
Title: p205, a potential tumor suppressor, inhibits cell proliferation via multiple pathways of cell cycle regulation.
Volume: 580
Issue: 5
Pages: 1205-14
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Publication
9037071 | J:38602
First Author: Yuan ZM
Year: 1997
Journal: Proc Natl Acad Sci U S A
Title: Regulation of DNA damage-induced apoptosis by the c-Abl tyrosine kinase.
Volume: 94
Issue: 4
Pages: 1437-40
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Publication
17254966 | J:120363
First Author: Grimmler M
Year: 2007
Journal: Cell
Title: Cdk-inhibitory activity and stability of p27Kip1 are directly regulated by oncogenic tyrosine kinases.
Volume: 128
Issue: 2
Pages: 269-80
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Publication
21194982 | J:168749
First Author: Katagiri K
Year: 2011
Journal: Immunity
Title: Deficiency of Rap1-binding protein RAPL causes lymphoproliferative disorders through mislocalization of p27kip1.
Volume: 34
Issue: 1
Pages: 24-38
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Publication
18311148 | J:133681
First Author: Hauck L
Year: 2008
Journal: Nat Med
Title: Protein kinase CK2 links extracellular growth factor signaling with the control of p27(Kip1) stability in the heart.
Volume: 14
Issue: 3
Pages: 315-24
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Publication
16413468 | J:105045
First Author: Landis MW
Year: 2006
Journal: Cancer Cell
Title: Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis.
Volume: 9
Issue: 1
Pages: 13-22
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Publication
26110849 | J:233794
First Author: Zhou JX
Year: 2015
Journal: PLoS One
Title: TNFα signaling regulates cystic epithelial cell proliferation through Akt/mTOR and ERK/MAPK/Cdk2 mediated Id2 signaling.
Volume: 10
Issue: 6
Pages: e0131043
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Publication
31704972 | J:336875
First Author: Nie L
Year: 2019
Journal: Nat Commun
Title: CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer.
Volume: 10
Issue: 1
Pages: 5114
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Publication
11239447 | J:110446
First Author: Greenwald RJ
Year: 2001
Journal: Immunity
Title: CTLA-4 regulates induction of anergy in vivo.
Volume: 14
Issue: 2
Pages: 145-55
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Publication
8646779 | J:33402
First Author: Nakayama K
Year: 1996
Journal: Cell
Title: Mice lacking p27(Kip1) display increased body size, multiple organ hyperplasia, retinal dysplasia, and pituitary tumors.
Volume: 85
Issue: 5
Pages: 707-20
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Publication
15130491 | J:90569
First Author: Nakayama K
Year: 2004
Journal: Dev Cell
Title: Skp2-mediated degradation of p27 regulates progression into mitosis.
Volume: 6
Issue: 5
Pages: 661-72
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Publication
17013388 | J:113560
First Author: Li L
Year: 2006
Journal: Nat Immunol
Title: A pathway regulated by cell cycle inhibitor p27Kip1 and checkpoint inhibitor Smad3 is involved in the induction of T cell tolerance.
Volume: 7
Issue: 11
Pages: 1157-65
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Publication
27991597 | J:243450
 
First Author: Jablonska B
Year: 2016
Journal: Nat Commun
Title: Sirt1 regulates glial progenitor proliferation and regeneration in white matter after neonatal brain injury.
Volume: 7
Pages: 13866
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Publication
15599395 | J:94703
First Author: Miura M
Year: 2004
Journal: J Clin Invest
Title: A crucial role of caspase-3 in osteogenic differentiation of bone marrow stromal stem cells.
Volume: 114
Issue: 12
Pages: 1704-13
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Publication
17553783 | J:124580
First Author: Osborn SL
Year: 2007
Journal: J Biol Chem
Title: Constitutive phosphorylation mutation in Fas-associated death domain (FADD) results in early cell cycle defects.
Volume: 282
Issue: 31
Pages: 22786-92
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Publication
9169494 | J:40920
First Author: Soonpaa MH
Year: 1997
Journal: J Clin Invest
Title: Cyclin D1 overexpression promotes cardiomyocyte DNA synthesis and multinucleation in transgenic mice.
Volume: 99
Issue: 11
Pages: 2644-54
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Publication
36114296 | J:333861
First Author: Qin J
Year: 2023
Journal: Cell Death Differ
Title: Bud31-mediated alternative splicing is required for spermatogonial stem cell self-renewal and differentiation.
Volume: 30
Issue: 1
Pages: 184-194
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Publication
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Year: 2018
Journal: Cell Death Differ
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Journal: FEBS Lett
Title: Cdk1 interplays with Oct4 to repress differentiation of embryonic stem cells into trophectoderm.
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Title: Cyclin A is required at two points in the human cell cycle.
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MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

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