|  Help  |  About  |  Contact Us

Search our database by keyword

Examples

  • Search this entire website. Enter identifiers, names or keywords for genes, diseases, strains, ontology terms, etc. (e.g. Pax6, Parkinson, ataxia)
  • Use OR to search for either of two terms (e.g. OR mus) or quotation marks to search for phrases (e.g. "dna binding").
  • Boolean search syntax is supported: e.g. Balb* for partial matches or mus AND NOT embryo to exclude a term

Search results 601 to 700 out of 719 for Dnmt3l

<< First    < Previous  |  Next >    Last >>
0.043s

Categories

Hits by Pathway

Hits by Category

Hits by Strain

Type Details Score
Publication
27606421 | J:237277
First Author: Wu Q
Year: 2016
Journal: PLoS Biol
Title: Sexual Fate Change of XX Germ Cells Caused by the Deletion of SMAD4 and STRA8 Independent of Somatic Sex Reprogramming.
Volume: 14
Issue: 9
Pages: e1002553
•
•
•
•
•
Publication
20059948 | J:156018
First Author: Shoji M
Year: 2009
Journal: Dev Cell
Title: The TDRD9-MIWI2 complex is essential for piRNA-mediated retrotransposon silencing in the mouse male germline.
Volume: 17
Issue: 6
Pages: 775-87
•
•
•
•
•
Publication
24036309 | J:203797
First Author: Maatouk DM
Year: 2013
Journal: Dev Biol
Title: Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary.
Volume: 383
Issue: 2
Pages: 295-306
•
•
•
•
•
Publication
22705479 | J:188056
First Author: Jameson SA
Year: 2012
Journal: Dev Biol
Title: Testis development requires the repression of Wnt4 by Fgf signaling.
Volume: 370
Issue: 1
Pages: 24-32
•
•
•
•
•
Publication
32452519 | J:293772
First Author: Bird AD
Year: 2020
Journal: Hum Mol Genet
Title: Ovotesticular disorders of sex development in FGF9 mouse models of human synostosis syndromes.
Volume: 29
Issue: 13
Pages: 2148-2161
•
•
•
•
•
Publication
28938467 | J:250302
First Author: Bagheri-Fam S
Year: 2017
Journal: Endocrinology
Title: Testis Determination Requires a Specific FGFR2 Isoform to Repress FOXL2.
Volume: 158
Issue: 11
Pages: 3832-3843
•
•
•
•
•
Publication
29941866 | J:263202
First Author: Ungewitter EK
Year: 2018
Journal: Sci Rep
Title: Loss of Glis3 causes dysregulation of retrotransposon silencing and germ cell demise in fetal mouse testis.
Volume: 8
Issue: 1
Pages: 9662
•
•
•
•
•
Publication
18784354 | J:145796
First Author: May A
Year: 2009
Journal: Biol Reprod
Title: Multiplex rt-PCR expression analysis of developmentally important genes in individual mouse preimplantation embryos and blastomeres.
Volume: 80
Issue: 1
Pages: 194-202
•
•
•
•
•
Publication
23034635 | J:189072
First Author: Spiller CM
Year: 2012
Journal: Development
Title: Endogenous Nodal signaling regulates germ cell potency during mammalian testis development.
Volume: 139
Issue: 22
Pages: 4123-32
•
•
•
•
•
Publication
20833365 | J:164280
First Author: Bowles J
Year: 2010
Journal: Dev Cell
Title: FGF9 suppresses meiosis and promotes male germ cell fate in mice.
Volume: 19
Issue: 3
Pages: 440-9
•
•
•
•
•
Publication
21991325 | J:179634
First Author: Chassot AA
Year: 2011
Journal: PLoS One
Title: RSPO1/β-catenin signaling pathway regulates oogonia differentiation and entry into meiosis in the mouse fetal ovary.
Volume: 6
Issue: 10
Pages: e25641
•
•
•
•
•
Publication
23473982 | J:196366
First Author: Krentz AD
Year: 2013
Journal: Dev Biol
Title: Interaction between DMRT1 function and genetic background modulates signaling and pluripotency to control tumor susceptibility in the fetal germ line.
Volume: 377
Issue: 1
Pages: 67-78
•
•
•
•
•
Publication
21233130 | J:169234
First Author: Kim JD
Year: 2011
Journal: Hum Mol Genet
Title: Rex1/Zfp42 as an epigenetic regulator for genomic imprinting.
Volume: 20
Issue: 7
Pages: 1353-62
•
•
•
•
•
Publication
25725066 | J:220472
First Author: Zhao L
Year: 2015
Journal: Development
Title: Female-to-male sex reversal in mice caused by transgenic overexpression of Dmrt1.
Volume: 142
Issue: 6
Pages: 1083-8
•
•
•
•
•
Publication
24183668 | J:203762
First Author: Burton A
Year: 2013
Journal: Cell Rep
Title: Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo.
Volume: 5
Issue: 3
Pages: 687-701
•
•
•
•
•
Publication
15317747 | J:93248
First Author: Hamatani T
Year: 2004
Journal: Hum Mol Genet
Title: Age-associated alteration of gene expression patterns in mouse oocytes.
Volume: 13
Issue: 19
Pages: 2263-78
•
•
•
•
•
Publication
24357321 | J:205485
First Author: Yu C
Year: 2013
Journal: Science
Title: CRL4 complex regulates mammalian oocyte survival and reprogramming by activation of TET proteins.
Volume: 342
Issue: 6165
Pages: 1518-21
•
•
•
•
•
Publication
25142465 | J:214809
First Author: Moniot B
Year: 2014
Journal: Development
Title: Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis.
Volume: 141
Issue: 18
Pages: 3561-71
•
•
•
•
•
Publication
32892421 | J:306136
First Author: Manti M
Year: 2020
Journal: FASEB J
Title: Excess of ovarian nerve growth factor impairs embryonic development and causes reproductive and metabolic dysfunction in adult female mice.
Volume: 34
Issue: 11
Pages: 14440-14457
•
•
•
•
•
HT Experiment
E-GEOD-54411 | DNMT3L promotes quiescence in postnatal spermatogonial progenitor cells
Series Id: GSE54411
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Publication
12466855 | J:80501
First Author: Gitton Y
Year: 2002
Journal: Nature
Title: A gene expression map of human chromosome 21 orthologues in the mouse.
Volume: 420
Issue: 6915
Pages: 586-90
•
•
•
•
•
Publication
12466854 | J:80502
First Author: Reymond A
Year: 2002
Journal: Nature
Title: Human chromosome 21 gene expression atlas in the mouse.
Volume: 420
Issue: 6915
Pages: 582-6
•
•
•
•
•
Publication
- | J:238766
     
First Author: Shanghai Model Organisms Center
Year: 2017
Journal: MGI Direct Data Submission
Title: Information obtained from the Shanghai Model Organisms Center (SMOC), Shanghai, China
•
•
•
•
•
Publication
- | J:165964
     
First Author: Mammalian Functional Genomics Centre
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the NorCOMM project by the Mammalian Functional Genomics Centre (Mfgc), University of Manitoba
•
•
•
•
•
Publication
21731673 | J:174767
First Author: Tang F
Year: 2011
Journal: PLoS One
Title: Deterministic and stochastic allele specific gene expression in single mouse blastomeres.
Volume: 6
Issue: 6
Pages: e21208
•
•
•
•
•
Publication
- | J:24194
     
First Author: The Jackson Laboratory Backcross DNA Panel Mapping Resource
Year: 1999
Journal: Database Release
Title: JAX BSS Panel Mapping Data
•
•
•
•
•
Publication
10725249 | J:60984
First Author: Ko MS
Year: 2000
Journal: Development
Title: Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development.
Volume: 127
Issue: 8
Pages: 1737-49
•
•
•
•
•
Publication
- | J:73065
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2001
Title: Gene Ontology Annotation by the MGI Curatorial Staff
•
•
•
•
•
Publication
12904583 | J:85162
First Author: Hansen J
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: A large-scale, gene-driven mutagenesis approach for the functional analysis of the mouse genome.
Volume: 100
Issue: 17
Pages: 9918-22
•
•
•
•
•
Publication
- | J:265051
     
First Author: MGI and IMPC
Year: 2018
Journal: Database Release
Title: MGI Load of Endonuclease-Mediated Alleles (CRISPR) from the International Mouse Phenotyping Consortium (IMPC)
•
•
•
•
•
Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
•
•
•
•
•
Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
•
•
•
•
•
Publication
- | J:204739
     
First Author: International Knockout Mouse Consortium
Year: 2014
Journal: Database Download
Title: MGI download of modified allele data from IKMC and creation of new knockout alleles
•
•
•
•
•
Publication
- | J:57656
     
First Author: Lennon G
Year: 1999
Journal: Database Download
Title: WashU-HHMI Mouse EST Project
•
•
•
•
•
Publication
- | J:204812
     
First Author: International Mouse Strain Resource
Year: 2014
Journal: Database Download
Title: MGI download of germline transmission data for alleles from IMSR strain data
•
•
•
•
•
Publication
- | J:155845
     
First Author: Wellcome Trust Sanger Institute
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Wellcome Trust Sanger Institute
•
•
•
•
•
Publication
- | J:211773
     
First Author: Mouse Genome Informatics and the International Mouse Phenotyping Consortium (IMPC)
Year: 2014
Journal: Database Release
Title: Obtaining and Loading Phenotype Annotations from the International Mouse Phenotyping Consortium (IMPC) Database
•
•
•
•
•
Publication
18799693 | J:142754
First Author: Hansen GM
Year: 2008
Journal: Genome Res
Title: Large-scale gene trapping in C57BL/6N mouse embryonic stem cells.
Volume: 18
Issue: 10
Pages: 1670-9
•
•
•
•
•
Publication
- | J:157065
     
First Author: Helmholtz Zentrum Muenchen GmbH
Year: 2010
Journal: MGI Direct Data Submission
Title: Alleles produced for the EUCOMM and EUCOMMTools projects by the Helmholtz Zentrum Muenchen GmbH (Hmgu)
•
•
•
•
•
Publication
11217851 | J:65060
First Author: Kawai J
Year: 2001
Journal: Nature
Title: Functional annotation of a full-length mouse cDNA collection.
Volume: 409
Issue: 6821
Pages: 685-90
•
•
•
•
•
Publication
38355793 | J:345621
First Author: Adams DJ
Year: 2024
Journal: Nature
Title: Genetic determinants of micronucleus formation in vivo.
Volume: 627
Issue: 8002
Pages: 130-136
•
•
•
•
•
Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
•
•
•
•
•
Publication
- | J:293217
       
First Author: GemPharmatech
Year: 2020
Title: GemPharmatech Website.
•
•
•
•
•
Publication
21677750 | J:173534
First Author: Skarnes WC
Year: 2011
Journal: Nature
Title: A conditional knockout resource for the genome-wide study of mouse gene function.
Volume: 474
Issue: 7351
Pages: 337-42
•
•
•
•
•
Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
•
•
•
•
•
Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
•
•
•
•
•
Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
•
•
•
•
•
Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
•
•
•
•
•
Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
•
•
•
•
•
Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
•
•
•
•
•
Publication
- | J:75000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2002
Title: Mouse Genome Informatics Computational Sequence to Gene Associations
•
•
•
•
•
Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
•
•
•
•
•
Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
•
•
•
•
•
Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
•
•
•
•
•
Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
•
•
•
•
•
Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
•
•
•
•
•
Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
•
•
•
•
•
Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
•
•
•
•
•
Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
•
•
•
•
•
Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
•
•
•
•
•
Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
•
•
•
•
•
Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
•
•
•
•
•
Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
•
•
•
•
•
Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
•
•
•
•
•
HT Experiment
E-GEOD-20241 | Genome-wide analysis of Dnmt3L heterozygous and wildtype spermatocytes and spermatids
Series Id: GSE20241
Experiment Type: transcription profiling by array
Study Type: WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Publication
26911678 | J:233018
First Author: Lu J
Year: 2016
Journal: Hum Mol Genet
Title: Global hypermethylation in fetal cortex of Down syndrome due to DNMT3L overexpression.
Volume: 25
Issue: 9
Pages: 1714-27
•
•
•
•
•
HT Experiment
E-GEOD-7384 | Transcription profiling of mouse Dnmt3L+/- sires compared to offspring of Dnmt3L+/+ sires to investigate the effect of paternal haploinsufficiency for Dnmt3L
Series Id: GSE7384
Experiment Type: transcription profiling by array
Study Type: Baseline
Source: ArrayExpress
•
•
•
•
•
HT Experiment
GSE70889 | Gene and retrotransposon expression analysis for WT, Pld6 KO, and Dnmt3l KO male germ cells during spermatogenesis
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
HT Experiment
GSE78905 | Gene and retrotransposon expression analysis in the F1 hybrid background of B6 and MSM for WT, Pld6 KO, and Dnmt3l KO male germ cells
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
HT Experiment
GSE70891 | The effect of the Pld6 and Dnmt3l mutations on DNA methylation and expression of retrotransposons in mouse male germ cells
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
HT Experiment
GSE57746 | Transposon-derived piRNA production in pre-natal and post-natal stages, in Dnmt3L and Miwi2 mutant tetses [small RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
HT Experiment
GSE238226 | Combinational effect of the ADD domains of DNMT3A and DNMT3L on DNA methylation landscapes in mouse germ cells [RNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
Interaction Experiment
Nimura K (2006)
Description: Dnmt3a2 targets endogenous Dnmt3L to ES cell chromatin and induces regional DNA methylation.
•
•
•
•
•
HT Sample
GSE7384GSM177437_Cy5
Organism Name: mouse, laboratory
Sex: Not Specified
Age: embryonic day 10.5
Stage: 17
Structure . Name: embryo
Notes: whole embryo genomic DNA from wildtype offspring of heterozygous Dnmt3L sire
Curation Status: Curated
•
•
•
•
•
Publication
17060371 | -
First Author: Shovlin TC
Year: 2007
Journal: Hum Reprod
Title: Sex-specific promoters regulate Dnmt3L expression in mouse germ cells.
Volume: 22
Issue: 2
Pages: 457-67
•
•
•
•
•
Allele
Dnmt3l<tm1Smoc> | MGI:7289380
Name: DNA methyltransferase 3-like; targeted mutation 1, Shanghai Model Organisms Center
Allele Type: Targeted
Attribute String: Conditional ready, No functional change
•
•
•
•
•
HT Experiment
GSE162587 | scRNA-seq on germ cells or whole testis at 10dpp
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
Strain
MGI:6354742 | C57BL/6JSmoc-Dnmt3l<tm1Smoc>/Smoc
Attribute String: coisogenic, mutant strain, targeted mutation
•
•
•
•
•
Allele
Tg(CAG-EGFP,-mCherry,-Dnmt3a,-Dnmt3l)akYaob | MGI:6458803
Name: transgene insertion ak, Yayoi Obata
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
•
•
•
•
•
Allele
Tg(CAG-EGFP,-mCherry,-Dnmt3a,-Dnmt3l)qYaob | MGI:6458805
Name: transgene insertion q, Yayoi Obata
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
•
•
•
•
•
Allele
Tg(CAG-EGFP,-mCherry,-Dnmt3a,-Dnmt3l)#Yaob | MGI:6458812
Name: transgene insertion, Yayoi Obata
Allele Type: Transgenic
Attribute String: Conditional ready, Inserted expressed sequence, Reporter
•
•
•
•
•
HT Experiment
GSE148150 | NSD1-deposited H3K36me2 directs de novo methylation in the mouse male germline and counteracts Polycomb-associated silencing
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
HT Experiment
E-GEOD-12757 | A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice
Series Id: GSE12757
Experiment Type: RNA-Seq
Study Type: Baseline and WT vs. Mutant
Source: ArrayExpress
•
•
•
•
•
Publication
29222434 | J:269095
First Author: Kasowitz SD
Year: 2017
Journal: Sci Rep
Title: Embryonic lethality and defective male germ cell development in mice lacking UTF1.
Volume: 7
Issue: 1
Pages: 17259
•
•
•
•
•
Publication
38295174 | J:349297
First Author: Li Y
Year: 2024
Journal: Sci Adv
Title: Rapid and accurate remethylation of DNA in Dnmt3a-deficient hematopoietic cells with restoration of DNMT3A activity.
Volume: 10
Issue: 5
Pages: eadk8598
•
•
•
•
•
Publication
19228594 | J:152947
First Author: Takashima S
Year: 2009
Journal: Biol Reprod
Title: Abnormal DNA methyltransferase expression in mouse germline stem cells results in spermatogenic defects.
Volume: 81
Issue: 1
Pages: 155-64
•
•
•
•
•
Publication
18178305 | J:132019
First Author: Bourc'his D
Year: 2008
Journal: Mol Cell Endocrinol
Title: Sexual dimorphism in parental imprint ontogeny and contribution to embryonic development.
Volume: 282
Issue: 1-2
Pages: 87-94
•
•
•
•
•
Publication
21666677 | -
First Author: Eustermann S
Year: 2011
Journal: Nat Struct Mol Biol
Title: Combinatorial readout of histone H3 modifications specifies localization of ATRX to heterochromatin.
Volume: 18
Issue: 7
Pages: 777-82
•
•
•
•
•
Protein
A0A0G2JFG6
Organism: Mus musculus/domesticus
Length: 135  
Fragment?: true
•
•
•
•
•
Protein
A0A0G2JGH3
Organism: Mus musculus/domesticus
Length: 174  
Fragment?: true
•
•
•
•
•
Publication
21666679 | -
First Author: Iwase S
Year: 2011
Journal: Nat Struct Mol Biol
Title: ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome.
Volume: 18
Issue: 7
Pages: 769-76
•
•
•
•
•
Protein Domain
IPR041430 | ADD_ATRX
Type: Domain
Description: This is a cysteine-rich domain termed ADD (ATRX-DNMT3-DNMT3L, AD-DATRX) found in ATRX proteins. Chromatin-associated human protein ATRX was originally identified because mutations in the ATRX gene cause a severe form of syndromal X-linked mental retardation called ATR-X syndrome. Mutations or knockdown of ATRX expression cause diverse effects, including altered patterns of DNA methylation, a telomere-dysfunction phenotype, aberrant chromosome segregation, premature sister chromatid separation and changes in gene expression. ATRX localizes predominantly to large, tandemly repeated regions (such as telomeres, centromeres and ribosomal DNA) associated with heterochromatin, and studies show that it directs H3.3 deposition to pericentric and telomeric heterochromatin. The ADD domain of ATRX, in which most syndrome-causing mutations occur, engages the N-terminal tail of histone H3 through two rigidly oriented binding pockets, one for unmodified Lys4 and the other for di- or trimethylated Lys9. Mutations in the ATRX ADD domain cause mislocalization of ATRX protein to heterochromatin, and this may contribute to understanding the underlying etiology of ATRX syndrome. Structure analysis of the ADD domain of ATRX revealed that it contains a PHD zinc-finger domain packed against a GATA-like zinc finger. Same structure is also found in the DNMT3 DNA methyltransferases and DNMT3L [, , ].
•
•
•
•
•
HT Experiment
GSE203226 | Mechanisms and function of de novo DNA methylation in placental development [snRNA-seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
HT Experiment
GSE203291 | Mechanisms and function of de novo DNA methylation in placental development [RNA-Seq]
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
HT Experiment
GSE130115 | Allelic histone-to-DNA methylation switch establishes secondary DMR to maintain noncanonical imprinting
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
HT Experiment
GSE131377 | SPOCD1 is a novel executor of piRNA-directed DNA methylation that links MIWI2 to the de novo DNA methylation machinery
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
•
•
•
•
•
Publication
15215868 | J:91108
First Author: Kaneda M
Year: 2004
Journal: Nature
Title: Essential role for de novo DNA methyltransferase Dnmt3a in paternal and maternal imprinting.
Volume: 429
Issue: 6994
Pages: 900-3
•
•
•
•
•
Publication
21481189 | J:193011
First Author: Siddique AN
Year: 2011
Journal: FEBS J
Title: Auto-methylation of the mouse DNA-(cytosine C5)-methyltransferase Dnmt3a at its active site cysteine residue.
Volume: 278
Issue: 12
Pages: 2055-63
•
•
•
•
•
Publication
20132320 | J:272331
First Author: Kaneda M
Year: 2010
Journal: Genes Cells
Title: Genetic evidence for Dnmt3a-dependent imprinting during oocyte growth obtained by conditional knockout with Zp3-Cre and complete exclusion of Dnmt3b by chimera formation.
Volume: 15
Issue: 3
Pages: 169-79
•
•
•
•
•
Publication
16362968 | J:106875
First Author: Yaman R
Year: 2006
Journal: Mol Reprod Dev
Title: Timing of entry of meiosis depends on a mark generated by DNA methyltransferase 3a in testis.
Volume: 73
Issue: 3
Pages: 390-7
•
•
•
•
•




MouseMine is a collaboration between MGI at The Jackson Laboratory and the InterMine project at the Cambridge Systems Biology Centre. MouseMine is funded through a grant from the NIH/NHGRI.The Jackson Laboratory makes no representation about the suitability or accuracy of this software or data for any purpose, and makes no warranties, either express or implied, including merchantability and fitness for a particular purpose or that the use of this software or data will not infringe any third party patents, copyrights, trademarks, or other rights. the software and data are provided "as is". This software and data are provided to enhance knowledge and encourage progress in the scientific community and are to be used only for research and educational purposes. Any reproduction or use for commercial purpose is prohibited without the prior express written permission of the Jackson Laboratory.

Copyright © 2017 by The Jackson Laboratory. All Rights Reserved

© 2002 - 2017 Department of Genetics, University of Cambridge, Downing Street,
Cambridge CB2 3EH, United Kingdom