| Type |
Details |
Score |
| DO Term |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Queiroz AL |
| Year: |
2021 |
| Journal: |
Mol Metab |
| Title: |
The MicroRNA miR-696 is regulated by SNARK and reduces mitochondrial activity in mouse skeletal muscle through Pgc1? inhibition. |
| Volume: |
51 |
|
| Pages: |
101226 |
|
•
•
•
•
•
|
| Allele |
| Name: |
transgene insertion JIL399, GENSAT Project at Rockefeller University |
| Allele Type: |
Transgenic |
| Attribute String: |
Reporter |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang L |
| Year: |
2020 |
| Journal: |
Cell |
| Title: |
A MicroRNA Linking Human Positive Selection and Metabolic Disorders. |
| Volume: |
183 |
| Issue: |
3 |
| Pages: |
684-701.e14 |
|
•
•
•
•
•
|
| Strain |
| Attribute String: |
mutant stock, transgenic |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tanaka H |
| Year: |
2003 |
| Journal: |
Peptides |
| Title: |
Insect diapause-specific peptide from the leaf beetle has consensus with a putative iridovirus peptide. |
| Volume: |
24 |
| Issue: |
9 |
| Pages: |
1327-33 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kouno T |
| Year: |
2007 |
| Journal: |
Biochemistry |
| Title: |
The structure of a novel insect peptide explains its Ca2+ channel blocking and antifungal activities. |
| Volume: |
46 |
| Issue: |
48 |
| Pages: |
13733-41 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Homologous_superfamily |
| Description: |
This superfamily consists of diapausin-related antimicrobial peptides. Diapause during periods of environmental adversity is an essential part of the life cycle of many organisms, with the molecular basis being different among animals. Diapause-specific peptides (DSP) provide anti-fungal activity and act as N-type voltage-gated calcium channel blocker []. The overall structure of DSP is compact due to the three disulfide bridges that indicate a high similarity with insect- and plant-derived antifungal peptides. |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Meekins DA |
| Year: |
2014 |
| Journal: |
Proc Natl Acad Sci U S A |
| Title: |
Phosphoglucan-bound structure of starch phosphatase Starch Excess4 reveals the mechanism for C6 specificity. |
| Volume: |
111 |
| Issue: |
20 |
| Pages: |
7272-7 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ganesh S |
| Year: |
2002 |
| Journal: |
Hum Mol Genet |
| Title: |
Genotype-phenotype correlations for EPM2A mutations in Lafora's progressive myoclonus epilepsy: exon 1 mutations associate with an early-onset cognitive deficit subphenotype. |
| Volume: |
11 |
| Issue: |
11 |
| Pages: |
1263-71 |
|
•
•
•
•
•
|
| Protein Domain |
| Type: |
Domain |
| Description: |
Proteins containing this domain include vertebrate dual specificity protein phosphatase Laforin and plant starch excess4 (SEX4).Laforin (encoded by the EPM2A gene) is a dual-specificity phosphatase that dephosphorylates complex carbohydrates. Mutations in the EPM2A gene cause Lafora disease (LD), a fatal autosomal recessive neurodegenerative disorder characterised by the presence of progressive neurological deterioration, myoclonus, and epilepsy []. Pathologically, LD is characterised by distinctive polyglucosans, which are formations of abnormal glycogen []. Laforin prevents LD by at least two mechanisms: by preventing hyperphosphorylation of glycogen by dephosphorylating it, allowing proper glycogen formation, and by promoting the ubiquitination of proteins involved in glycogen metabolism via its interaction with malin. Laforin contains an N-terminal CBM20 (carbohydrate-binding module, family 20) domain and a C-terminal catalytic dual specificity phosphatase (DSP) domain [].Plant SEX4 (also known as DSP4) regulates starch metabolism by selectively dephosphorylating glucose moieties within starch glucan chains. It contains an N-terminal catalytic DSP domain and a C-terminal Early (E) set domain []. |
|
•
•
•
•
•
|
| HT Experiment |
|
| Experiment Type: |
RNA-Seq |
| Study Type: |
Baseline |
| Source: |
GEO |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Ritchie HH |
| Year: |
1996 |
| Journal: |
Arch Oral Biol |
| Title: |
Partial cDNA sequencing of mouse dentine sialoprotein and detection of its specific expression by odontoblasts. |
| Volume: |
41 |
| Issue: |
6 |
| Pages: |
571-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Koralov SB |
| Year: |
2008 |
| Journal: |
Cell |
| Title: |
Dicer ablation affects antibody diversity and cell survival in the B lymphocyte lineage. |
| Volume: |
132 |
| Issue: |
5 |
| Pages: |
860-74 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang L |
| Year: |
2007 |
| Journal: |
Biochem Biophys Res Commun |
| Title: |
Successful co-immunoprecipitation of Oct4 and Nanog using cross-linking. |
| Volume: |
361 |
| Issue: |
3 |
| Pages: |
611-4 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Raththagala M |
| Year: |
2015 |
| Journal: |
Mol Cell |
| Title: |
Structural mechanism of laforin function in glycogen dephosphorylation and lafora disease. |
| Volume: |
57 |
| Issue: |
2 |
| Pages: |
261-72 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Nakamura K |
| Year: |
1999 |
| Journal: |
Biochem J |
| Title: |
Molecular cloning and characterization of a novel dual-specificity protein phosphatase possibly involved in spermatogenesis. |
| Volume: |
344 Pt 3 |
| Issue: |
Pt 3 |
| Pages: |
819-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lara NLM |
| Year: |
2017 |
| Journal: |
Reproduction |
| Title: |
Neonatal hypothyroidism does not increase Sertoli cell proliferation in iNOS(-/-) mice. |
| Volume: |
154 |
| Issue: |
1 |
| Pages: |
13-22 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lombardi R |
| Year: |
2011 |
| Journal: |
Circ Res |
| Title: |
Nuclear plakoglobin is essential for differentiation of cardiac progenitor cells to adipocytes in arrhythmogenic right ventricular cardiomyopathy. |
| Volume: |
109 |
| Issue: |
12 |
| Pages: |
1342-53 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yuan G |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
Dentin Sialoprotein is a Novel Substrate of Matrix Metalloproteinase 9 in vitro and in vivo. |
| Volume: |
7 |
|
| Pages: |
42449 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Bhushan R |
| Year: |
2019 |
| Journal: |
J Cell Mol Med |
| Title: |
An integrative systems approach identifies novel candidates in Marfan syndrome-related pathophysiology. |
| Volume: |
23 |
| Issue: |
4 |
| Pages: |
2526-2535 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Goldberg M |
| Year: |
2011 |
| Journal: |
Cells Tissues Organs |
| Title: |
Differential effects of fibromodulin deficiency on mouse mandibular bones and teeth: a micro-CT time course study. |
| Volume: |
194 |
| Issue: |
2-4 |
| Pages: |
205-10 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Goldberg M |
| Year: |
2006 |
| Journal: |
J Histochem Cytochem |
| Title: |
Fibromodulin-deficient mice display impaired collagen fibrillogenesis in predentin as well as altered dentin mineralization and enamel formation. |
| Volume: |
54 |
| Issue: |
5 |
| Pages: |
525-37 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Lim WH |
| Year: |
2014 |
| Journal: |
J Bone Miner Res |
| Title: |
Wnt signaling regulates pulp volume and dentin thickness. |
| Volume: |
29 |
| Issue: |
4 |
| Pages: |
892-901 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Suzuki S |
| Year: |
2009 |
| Journal: |
Matrix Biol |
| Title: |
Dentin sialoprotein and dentin phosphoprotein have distinct roles in dentin mineralization. |
| Volume: |
28 |
| Issue: |
4 |
| Pages: |
221-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Gibson MP |
| Year: |
2013 |
| Journal: |
Eur J Oral Sci |
| Title: |
Role of the NH2 -terminal fragment of dentin sialophosphoprotein in dentinogenesis. |
| Volume: |
121 |
| Issue: |
2 |
| Pages: |
76-85 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Yang G |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
BMP-2 induced Dspp transcription is mediated by Dlx3/Osx signaling pathway in odontoblasts. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
10775 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Shi P |
| Year: |
2023 |
| Journal: |
Oral Dis |
| Title: |
Activation of Wnt signaling in Axin2(+) cells leads to osteodentin formation and cementum overgrowth. |
| Volume: |
29 |
| Issue: |
8 |
| Pages: |
3551-3558 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Jamal T |
| Year: |
2024 |
| Journal: |
Prog Neurobiol |
| Title: |
Experience-dependent regulation of dopaminergic signaling in the somatosensory cortex. |
| Volume: |
239 |
|
| Pages: |
102630 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Seo H |
| Year: |
2026 |
| Journal: |
Nat Commun |
| Title: |
Dual platform spatial transcriptomics reveals parvalbumin interneuron subtype vulnerability in mouse models of Alzheimer's disease. |
| Volume: |
17 |
| Issue: |
1 |
|
|
•
•
•
•
•
|
| Publication |
| First Author: |
White SN |
| Year: |
2007 |
| Journal: |
J Biol Chem |
| Title: |
Ectopic expression of dentin sialoprotein during amelogenesis hardens bulk enamel. |
| Volume: |
282 |
| Issue: |
8 |
| Pages: |
5340-5 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Napierala D |
| Year: |
2012 |
| Journal: |
J Bone Miner Res |
| Title: |
Transcriptional repression of the Dspp gene leads to dentinogenesis imperfecta phenotype in Col1a1-Trps1 transgenic mice. |
| Volume: |
27 |
| Issue: |
8 |
| Pages: |
1735-45 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Chen AJ |
| Year: |
2002 |
| Journal: |
J Biol Chem |
| Title: |
The dual specificity JKAP specifically activates the c-Jun N-terminal kinase pathway. |
| Volume: |
277 |
| Issue: |
39 |
| Pages: |
36592-601 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
B?gue-Kirn C |
| Year: |
1998 |
| Journal: |
Eur J Oral Sci |
| Title: |
Dentin sialoprotein, dentin phosphoprotein, enamelysin and ameloblastin: tooth-specific molecules that are distinctively expressed during murine dental differentiation. |
| Volume: |
106 |
| Issue: |
5 |
| Pages: |
963-70 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Narayanan K |
| Year: |
2004 |
| Journal: |
J Biol Chem |
| Title: |
The CCAAT enhancer-binding protein (C/EBP)beta and Nrf1 interact to regulate dentin sialophosphoprotein (DSPP) gene expression during odontoblast differentiation. |
| Volume: |
279 |
| Issue: |
44 |
| Pages: |
45423-32 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Tornberg UC |
| Year: |
1995 |
| Journal: |
EMBO J |
| Title: |
B-1a, B-1b and B-2 B cells display unique VHDJH repertoires formed at different stages of ontogeny and under different selection pressures. |
| Volume: |
14 |
| Issue: |
8 |
| Pages: |
1680-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
D'Souza RN |
| Year: |
1997 |
| Journal: |
J Bone Miner Res |
| Title: |
Gene expression patterns of murine dentin matrix protein 1 (Dmp1) and dentin sialophosphoprotein (DSPP) suggest distinct developmental functions in vivo. |
| Volume: |
12 |
| Issue: |
12 |
| Pages: |
2040-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Rom?-Mateo C |
| Year: |
2007 |
| Journal: |
J Mol Biol |
| Title: |
A novel phosphatase family, structurally related to dual-specificity phosphatases, that displays unique amino acid sequence and substrate specificity. |
| Volume: |
374 |
| Issue: |
4 |
| Pages: |
899-909 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Hagihara H |
| Year: |
2018 |
| Journal: |
Mol Brain |
| Title: |
Immature-like molecular expression patterns in the hippocampus of a mouse model of dementia with Lewy body-linked mutant ?-synuclein. |
| Volume: |
11 |
| Issue: |
1 |
| Pages: |
38 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Li W |
| Year: |
2017 |
| Journal: |
Sci Rep |
| Title: |
Dentin sialoprotein facilitates dental mesenchymal cell differentiation and dentin formation. |
| Volume: |
7 |
| Issue: |
1 |
| Pages: |
300 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xu X |
| Year: |
2025 |
| Journal: |
J Biol Chem |
| Title: |
Dentin sialoprotein acts as an angiogenic factor through association with the membrane receptor endoglin. |
| Volume: |
301 |
| Issue: |
3 |
| Pages: |
108279 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Aoki N |
| Year: |
2001 |
| Journal: |
J Biochem |
| Title: |
A growing family of dual specificity phosphatases with low molecular masses. |
| Volume: |
130 |
| Issue: |
1 |
| Pages: |
133-40 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Auharek SA |
| Year: |
2011 |
| Journal: |
Int J Androl |
| Title: |
Sertoli cell numbers and spermatogenic efficiency are increased in inducible nitric oxide synthase mutant mice. |
| Volume: |
34 |
| Issue: |
6 Pt 2 |
| Pages: |
e621-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Webber CA |
| Year: |
2013 |
| Journal: |
Neuroscience |
| Title: |
Nerve growth factor acts through the TrkA receptor to protect sensory neurons from the damaging effects of the HIV-1 viral protein, Vpr. |
| Volume: |
252 |
|
| Pages: |
512-25 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Holsberger DR |
| Year: |
2005 |
| Journal: |
Biol Reprod |
| Title: |
Cell-cycle inhibitors p27Kip1 and p21Cip1 regulate murine Sertoli cell proliferation. |
| Volume: |
72 |
| Issue: |
6 |
| Pages: |
1429-36 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Zhang X |
| Year: |
2019 |
| Journal: |
J Mol Histol |
| Title: |
Distinctive role of ACVR1 in dentin formation: requirement for dentin thickness in molars and prevention of osteodentin formation in incisors of mice. |
| Volume: |
50 |
| Issue: |
1 |
| Pages: |
43-61 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Kenchegowda D |
| Year: |
2012 |
| Journal: |
PLoS One |
| Title: |
Critical role of Klf5 in regulating gene expression during post-eyelid opening maturation of mouse corneas. |
| Volume: |
7 |
| Issue: |
9 |
| Pages: |
e44771 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Elling CL |
| Year: |
2024 |
| Journal: |
Int J Pediatr Otorhinolaryngol |
| Title: |
The A2ml1-Knockout mouse as an animal model for non-syndromic otitis media. |
| Volume: |
181 |
|
| Pages: |
111980 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Qin C |
| Year: |
2001 |
| Journal: |
J Biol Chem |
| Title: |
Identification and characterization of the carboxyl-terminal region of rat dentin sialoprotein. |
| Volume: |
276 |
| Issue: |
2 |
| Pages: |
904-9 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Wang Y |
| Year: |
2020 |
| Journal: |
Circulation |
| Title: |
Integrin ?1D Deficiency-Mediated RyR2 Dysfunction Contributes to Catecholamine-Sensitive Ventricular Tachycardia in Arrhythmogenic Right Ventricular Cardiomyopathy. |
| Volume: |
141 |
| Issue: |
18 |
| Pages: |
1477-1493 |
|
•
•
•
•
•
|
| Publication |
| First Author: |
Xu C |
| Year: |
2023 |
| Journal: |
Int Endod J |
| Title: |
Axin2-CreERT2 mediated knockout of bone morphogenetic protein receptor type 1A caused abnormal secondary dentine and altered cell fate of Axin2-expressing odontogenic cells. |
| Volume: |
56 |
| Issue: |
8 |
| Pages: |
1000-1010 |
|
•
•
•
•
•
|
| Protein |
| Organism: |
Mus musculus/domesticus |
| Length: |
330
 |
| Fragment?: |
false |
|
•
•
•
•
•
|
| Publication |
| First Author: |
The Gene Expression Nervous System Atlas (GENSAT) Project, The Rockefeller University (New York, NY) |
| Year: |
2005 |
| Journal: |
Database Download |
| Title: |
MGI download of GENSAT transgene data |
|
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•
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•
•
•
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