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Search results 601 to 700 out of 746 for Fgf18

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Type Details Score
Publication
21571225 | J:173239
First Author: Paek H
Year: 2011
Journal: Dev Cell
Title: β-Catenin-dependent FGF signaling sustains cell survival in the anterior embryonic head by countering Smad4.
Volume: 20
Issue: 5
Pages: 689-99
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Publication
24284205 | J:206311
First Author: Zhao T
Year: 2014
Journal: Development
Title: β-catenin regulates Pax3 and Cdx2 for caudal neural tube closure and elongation.
Volume: 141
Issue: 1
Pages: 148-57
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Publication
34091985 | J:316483
First Author: Leek CC
Year: 2021
Journal: Dev Dyn
Title: Deletion of Fibroblast growth factor 9 globally and in skeletal muscle results in enlarged tuberosities at sites of deltoid tendon attachments.
Volume: 250
Issue: 12
Pages: 1778-1795
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Publication
33469032 | J:300883
First Author: Hörnblad A
Year: 2021
Journal: Nat Commun
Title: Dissection of the Fgf8 regulatory landscape by in vivo CRISPR-editing reveals extensive intra- and inter-enhancer redundancy.
Volume: 12
Issue: 1
Pages: 439
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Publication
11500373 | J:71074
First Author: Hirata H
Year: 2001
Journal: EMBO J
Title: Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain.
Volume: 20
Issue: 16
Pages: 4454-66
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Publication
21223962 | J:170649
First Author: Garcia CM
Year: 2011
Journal: Dev Biol
Title: The function of FGF signaling in the lens placode.
Volume: 351
Issue: 1
Pages: 176-85
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Publication
22632802 | J:185530
First Author: Chan KM
Year: 2012
Journal: Dev Cell
Title: MT1-MMP inactivates ADAM9 to regulate FGFR2 signaling and calvarial osteogenesis.
Volume: 22
Issue: 6
Pages: 1176-90
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Publication
21876757 | J:176344
First Author: Ratzka A
Year: 2011
Journal: PLoS One
Title: FGF-2 deficiency does not influence FGF ligand and receptor expression during development of the nigrostriatal system.
Volume: 6
Issue: 8
Pages: e23564
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Publication
23565059 | J:197686
First Author: Shang Y
Year: 2013
Journal: PLoS Biol
Title: Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-β-TAK1-dependent mechanism.
Volume: 11
Issue: 4
Pages: e1001527
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Publication
27180663 | J:234115
First Author: Nik AM
Year: 2016
Journal: Dev Biol
Title: Foxf2 is required for secondary palate development and Tgfβ signaling in palatal shelf mesenchyme.
Volume: 415
Issue: 1
Pages: 14-23
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Publication
36521641 | J:332291
 
First Author: Song H
Year: 2022
Journal: Dev Biol
Title: Tbx2 and Tbx3 regulate cell fate progression of the otic vesicle for inner ear development.
Volume: 494
Pages: 71-84
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Publication
24971735 | J:310317
First Author: Zhang S
Year: 2014
Journal: Cell Res
Title: Uterine Rbpj is required for embryonic-uterine orientation and decidual remodeling via Notch pathway-independent and -dependent mechanisms.
Volume: 24
Issue: 8
Pages: 925-42
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Publication
19544582 | J:150712
First Author: Yaguchi Y
Year: 2009
Journal: Dev Dyn
Title: Fibroblast growth factor (FGF) gene expression in the developing cerebellum suggests multiple roles for FGF signaling during cerebellar morphogenesis and development.
Volume: 238
Issue: 8
Pages: 2058-72
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Publication
28923684 | J:252121
First Author: McCoy AM
Year: 2017
Journal: Am J Pathol
Title: IKKβ Activation in the Fetal Lung Mesenchyme Alters Lung Vascular Development but Not Airway Morphogenesis.
Volume: 187
Issue: 12
Pages: 2635-2644
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Publication
16123981 | J:101025
First Author: Yaylaoglu MB
Year: 2005
Journal: Dev Dyn
Title: Comprehensive expression atlas of fibroblast growth factors and their receptors generated by a novel robotic in situ hybridization platform.
Volume: 234
Issue: 2
Pages: 371-86
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Publication
26441343 | J:228522
First Author: Yang SL
Year: 2015
Journal: Dev Biol
Title: MiR-302/367 regulate neural progenitor proliferation, differentiation timing, and survival in neurulation.
Volume: 408
Issue: 1
Pages: 140-50
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Publication
11165488 | J:67307
First Author: Bachler M
Year: 2001
Journal: Mech Dev
Title: Expression of members of the Fgf family and their receptors during midfacial development.
Volume: 100
Issue: 2
Pages: 313-6
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Publication
11900978 | J:76230
First Author: Hajihosseini MK
Year: 2002
Journal: Mech Dev
Title: Expression patterns of fibroblast growth factors-18 and -20 in mouse embryos is suggestive of novel roles in calvarial and limb development.
Volume: 113
Issue: 1
Pages: 79-83
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Publication
36685938 | J:332918
 
First Author: Cai S
Year: 2022
Journal: Front Genet
Title: Transcriptomic analysis of the upper lip and primary palate development in mice.
Volume: 13
Pages: 1039850
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Publication
16818445 | J:119030
First Author: Später D
Year: 2006
Journal: Development
Title: Wnt9a signaling is required for joint integrity and regulation of Ihh during chondrogenesis.
Volume: 133
Issue: 15
Pages: 3039-49
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Publication
33580754 | J:315014
First Author: Zhou C
Year: 2021
Journal: J Cell Mol Med
Title: FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex.
Volume: 25
Issue: 6
Pages: 3051-3062
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Publication
16782087 | J:112633
First Author: Jukkola T
Year: 2006
Journal: Dev Biol
Title: FGF regulated gene-expression and neuronal differentiation in the developing midbrain-hindbrain region.
Volume: 297
Issue: 1
Pages: 141-57
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Publication
24198358 | J:204192
First Author: Hadjab S
Year: 2013
Journal: J Neurosci
Title: A local source of FGF initiates development of the unmyelinated lineage of sensory neurons.
Volume: 33
Issue: 45
Pages: 17656-66
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Publication
29184203 | J:256001
First Author: Jung EM
Year: 2017
Journal: Nat Neurosci
Title: Arid1b haploinsufficiency disrupts cortical interneuron development and mouse behavior.
Volume: 20
Issue: 12
Pages: 1694-1707
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Publication
35020897 | J:321503
 
First Author: Meuser M
Year: 2022
Journal: Development
Title: FGFR2 signaling enhances the SHH-BMP4 signaling axis in early ureter development.
Volume: 149
Issue: 1
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Publication
15963767 | J:103164
First Author: Minina E
Year: 2005
Journal: Gene Expr Patterns
Title: Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification.
Volume: 6
Issue: 1
Pages: 102-9
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Publication
22682244 | J:186161
First Author: Hu B
Year: 2012
Journal: Cell
Title: Multifocal epithelial tumors and field cancerization from loss of mesenchymal CSL signaling.
Volume: 149
Issue: 6
Pages: 1207-20
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Publication
24952961 | J:215487
First Author: Thompson CL
Year: 2014
Journal: Neuron
Title: A high-resolution spatiotemporal atlas of gene expression of the developing mouse brain.
Volume: 83
Issue: 2
Pages: 309-323
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Publication
14681479 | J:122989
First Author: Visel A
Year: 2004
Journal: Nucleic Acids Res
Title: GenePaint.org: an atlas of gene expression patterns in the mouse embryo.
Volume: 32
Issue: Database issue
Pages: D552-6
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Publication
34321999 | J:313619
 
First Author: Bedogni F
Year: 2021
Journal: Front Mol Neurosci
Title: Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development.
Volume: 14
Pages: 686034
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Publication
- | J:155856
       
First Author: The Gene Ontology Consortium
Year: 2014
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-rat orthologs
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Publication
- | J:342604
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot Subcellular Location vocabulary mapping, accompanied by conservative changes to GO terms applied by UniProt
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Publication
16602821 | J:162220
First Author: Magdaleno S
Year: 2006
Journal: PLoS Biol
Title: BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system.
Volume: 4
Issue: 4
Pages: e86
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Publication
- | J:85000
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2003
Title: MGI Sequence Curation Reference
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Publication
14610273 | J:86696
First Author: Zambrowicz BP
Year: 2003
Journal: Proc Natl Acad Sci U S A
Title: Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention.
Volume: 100
Issue: 24
Pages: 14109-14
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Publication
- | J:141210
     
First Author: Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI)
Year: 2008
Journal: Database Download
Title: Mouse Gene Trap Data Load from dbGSS
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Publication
- | J:326541
       
First Author: Cyagen Biosciences Inc.
Year: 2022
Title: Cyagen Biosciences Website.
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Publication
- | J:60000
       
First Author: UniProt-GOA
Year: 2012
Title: Gene Ontology annotation based on UniProtKB/Swiss-Prot keyword mapping
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Publication
- | J:342605
       
First Author: GOA curators
Year: 2016
Title: Automatic transfer of experimentally verified manual GO annotation data to orthologs using Ensembl Compara
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Publication
- | J:68900
     
First Author: The Jackson Laboratory Mouse Radiation Hybrid Database
Year: 2004
Journal: Database Release
Title: Mouse T31 Radiation Hybrid Data Load
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Publication
12466851 | J:80000
First Author: Okazaki Y
Year: 2002
Journal: Nature
Title: Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.
Volume: 420
Issue: 6915
Pages: 563-73
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Publication
- | J:164563
       
First Author: The Gene Ontology Consortium
Year: 2010
Title: Automated transfer of experimentally-verified manual GO annotation data to mouse-human orthologs
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Publication
21267068 | J:153498
First Author: Diez-Roux G
Year: 2011
Journal: PLoS Biol
Title: A high-resolution anatomical atlas of the transcriptome in the mouse embryo.
Volume: 9
Issue: 1
Pages: e1000582
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Publication
- | J:157972
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2010
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome U74 Array Platform (A, B, C v2).
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Publication
- | J:57747
     
First Author: MGI Genome Annotation Group and UniGene Staff
Year: 2015
Journal: Database Download
Title: MGI-UniGene Interconnection Effort
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Publication
- | J:161428
       
First Author: Marc Feuermann, Huaiyu Mi, Pascale Gaudet, Dustin Ebert, Anushya Muruganujan, Paul Thomas
Year: 2010
Title: Annotation inferences using phylogenetic trees
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Publication
- | J:63103
     
First Author: Mouse Genome Database and National Center for Biotechnology Information
Year: 2000
Journal: Database Release
Title: Entrez Gene Load
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Publication
- | J:262123
     
First Author: Allen Institute for Brain Science
Year: 2004
Journal: Allen Institute
Title: Allen Brain Atlas: mouse riboprobes
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Publication
- | J:144086
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Gene 1.0 ST Array Platform
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Publication
- | J:155721
     
First Author: Mouse Genome Informatics (MGI) and The National Center for Biotechnology Information (NCBI)
Year: 2010
Journal: Database Download
Title: Consensus CDS project
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Publication
- | J:85324
     
First Author: Mouse Genome Informatics Group
Year: 2003
Journal: Database Procedure
Title: Automatic Encodes (AutoE) Reference
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Publication
- | J:53168
     
First Author: Bairoch A
Year: 1999
Journal: Database Release
Title: SWISS-PROT Annotated protein sequence database
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Publication
- | J:91388
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and Loading Genome Assembly Coordinates from Ensembl Annotations
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Publication
- | J:155221
     
First Author: Mouse Genome Informatics
Year: 2010
Journal: Database Release
Title: Protein Ontology Association Load.
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Publication
- | J:90438
       
First Author: Mouse Genome Informatics Scientific Curators
Year: 2005
Title: Obtaining and loading genome assembly coordinates from NCBI annotations
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Publication
- | J:144087
     
First Author: Mouse Genome Informatics Scientific Curators
Year: 2009
Journal: Database Download
Title: Mouse Microarray Data Integration in Mouse Genome Informatics, the Affymetrix GeneChip Mouse Genome 430 2.0 Array Platform
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Publication
27267714 | J:239756
First Author: Flannery CA
Year: 2016
Journal: Endocrinology
Title: Endometrial Cancer-Associated FGF18 Expression Is Reduced by Bazedoxifene in Human Endometrial Stromal Cells In Vitro and in Murine Endometrium.
Volume: 157
Issue: 10
Pages: 3699-3708
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QTL
MGI:5883733 | Fgf23lq4
Type: QTL
Organism: mouse, laboratory
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GXD Expression
GXD Expression
Probe: MGI:2665357
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1901624
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:2665358
Age: embryonic day 16.5
Image: 2D
Note: Expression directly abuts Fgf18 expression.
Specimen Label: 2D
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:2665357
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1901624
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:2665358
Age: embryonic day 16.5
Image: 2E
Note: Expression directly abuts Fgf18 expression.
Specimen Label: 2E
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:2665357
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1901624
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:2665358
Age: embryonic day 16.5
Image: 2F
Note: Expression directly abuts Fgf18 expression.
Specimen Label: 2F
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
Probe: MGI:2665357
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1871524
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:2665358
Age: embryonic day 16.5
Image: 2D
Note: Expression directly abuts Fgf18 expression.
Specimen Label: 2D
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
Probe: MGI:2665357
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1871524
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:2665358
Age: embryonic day 16.5
Image: 2E
Note: Expression directly abuts Fgf18 expression.
Specimen Label: 2E
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
Probe: MGI:2665357
Assay Type: RNA in situ
Annotation Date: 2003-07-15
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1871524
Pattern: Not Specified
Stage: TS24
Assay Id: MGI:2665358
Age: embryonic day 16.5
Image: 2F
Note: Expression directly abuts Fgf18 expression.
Specimen Label: 2F
Detected: true
Specimen Num: 3
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HT Experiment
GSE203035 | Unbiased screening identifies TGF-beta signaling and Creb5 cooperatively regulate FGF18 to control pharyngeal muscle development
 
Experiment Type: RNA-Seq
Study Type: WT vs. Mutant
Source: GEO
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GXD Expression
GXD Expression
Probe: MGI:4438726
Assay Type: Immunohistochemistry
Annotation Date: 2023-01-20
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1757728
Pattern: Not Specified
Stage: TS28
Assay Id: MGI:7427795
Age: postnatal adult
Image: 2A,C,D
Note: Expression co-localized with that of Fgf18 in spinal motor neurons.
Specimen Label: 2A,C,D
Detected: true
Specimen Num: 1
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Allele
Fgf18<tm2.1Dor> | MGI:6382297
Name: fibroblast growth factor 18; targeted mutation 2.1, David M Ornitz
Allele Type: Targeted
Attribute String: Conditional ready
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Allele
Fgf18<tm2.2(cre/ERT2)Dor> | MGI:6382298
Name: fibroblast growth factor 18; targeted mutation 2.2, David M Ornitz
Allele Type: Targeted
Attribute String: Inducible, Null/knockout, Recombinase, Reporter
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Genotype
Genotype
Symbol: Fgf18/Fgf18<+>
Background: Not Specified
Zygosity: ht
Has Mutant Allele: true
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Publication
37640697 | J:340561
First Author: Gong Z
Year: 2023
Journal: Nat Commun
Title: CircRREB1 mediates lipid metabolism related senescent phenotypes in chondrocytes through FASN post-translational modifications.
Volume: 14
Issue: 1
Pages: 5242
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Genotype
Genotype
Symbol: Fgf18/Fgf18<+> Gt(ROSA)26Sor/Gt(ROSA)26Sor<+>
Background: involves: 129S6/SvEvTac * C57BL/6NCrl
Zygosity: cn
Has Mutant Allele: true
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Publication
28581440 | J:244583
First Author: Matsumoto Y
Year: 2017
Journal: J Clin Invest
Title: Ubiquitin ligase RNF146 coordinates bone dynamics and energy metabolism.
Volume: 127
Issue: 7
Pages: 2612-2625
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Publication
17976582 | J:132513
First Author: Takeuchi K
Year: 2008
Journal: Exp Eye Res
Title: Systemic administration of nilvadipine delays photoreceptor degeneration of heterozygous retinal degeneration slow (rds) mouse.
Volume: 86
Issue: 1
Pages: 60-9
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Publication
18625063 | J:160580
 
First Author: Borello U
Year: 2008
Journal: Neural Dev
Title: FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development.
Volume: 3
Pages: 17
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Publication
15073186 | J:91258
First Author: Xiao L
Year: 2004
Journal: J Biol Chem
Title: Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts.
Volume: 279
Issue: 26
Pages: 27743-52
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Publication
27052727 | J:235529
First Author: Karuppaiah K
Year: 2016
Journal: Development
Title: FGF signaling in the osteoprogenitor lineage non-autonomously regulates postnatal chondrocyte proliferation and skeletal growth.
Volume: 143
Issue: 10
Pages: 1811-22
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Publication
26138642 | J:232527
First Author: McGowan SE
Year: 2015
Journal: Am J Physiol Lung Cell Mol Physiol
Title: Fibroblast growth factor signaling in myofibroblasts differs from lipofibroblasts during alveolar septation in mice.
Volume: 309
Issue: 5
Pages: L463-74
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Publication
32201365 | J:297362
 
First Author: Bachvarova V
Year: 2020
Journal: Matrix Biol
Title: Chondrocytes respond to an altered heparan sulfate composition with distinct changes of heparan sulfate structure and increased levels of chondroitin sulfate.
Volume: 93
Pages: 43-59
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Publication
28445472 | J:242977
First Author: Sinha S
Year: 2017
Journal: PLoS Genet
Title: Unsuspected osteochondroma-like outgrowths in the cranial base of Hereditary Multiple Exostoses patients and modeling and treatment with a BMP antagonist in mice.
Volume: 13
Issue: 4
Pages: e1006742
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Publication
16150908 | J:129683
First Author: Barnard JC
Year: 2005
Journal: Endocrinology
Title: Thyroid hormones regulate fibroblast growth factor receptor signaling during chondrogenesis.
Volume: 146
Issue: 12
Pages: 5568-80
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Publication
33193326 | J:308219
 
First Author: Ono Y
Year: 2020
Journal: Front Immunol
Title: CD206+ M2-Like Macrophages Are Essential for Successful Implantation.
Volume: 11
Pages: 557184
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Publication
31400222 | J:281458
First Author: Lopes FM
Year: 2019
Journal: J Pathol
Title: Overactivity or blockade of transforming growth factor-β each generate a specific ureter malformation.
Volume: 249
Issue: 4
Pages: 472-484
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Publication
10713090 | J:61068
First Author: Reilly JF
Year: 2000
Journal: J Biol Chem
Title: Association of fibroblast growth factor receptor 1 with the adaptor protein Grb14. Characterization of a new receptor binding partner.
Volume: 275
Issue: 11
Pages: 7771-8
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Publication
10629055 | -
First Author: Ong SH
Year: 2000
Journal: Mol Cell Biol
Title: FRS2 proteins recruit intracellular signaling pathways by binding to diverse targets on fibroblast growth factor and nerve growth factor receptors.
Volume: 20
Issue: 3
Pages: 979-89
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Publication
7537362 | -
First Author: Karlsson T
Year: 1995
Journal: Oncogene
Title: Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins.
Volume: 10
Issue: 8
Pages: 1475-83
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Publication
11030354 | -
First Author: Schlessinger J
Year: 2000
Journal: Mol Cell
Title: Crystal structure of a ternary FGF-FGFR-heparin complex reveals a dual role for heparin in FGFR binding and dimerization.
Volume: 6
Issue: 3
Pages: 743-50
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Publication
16207751 | J:102949
First Author: Li C
Year: 2005
Journal: Development
Title: FGFR1 function at the earliest stages of mouse limb development plays an indispensable role in subsequent autopod morphogenesis.
Volume: 132
Issue: 21
Pages: 4755-64
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Publication
2162671 | -
First Author: Itoh N
Year: 1990
Journal: Biochem Biophys Res Commun
Title: The complete amino acid sequence of the shorter form of human basic fibroblast growth factor receptor deduced from its cDNA.
Volume: 169
Issue: 2
Pages: 680-5
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Publication
17360555 | -
First Author: Riley BM
Year: 2007
Journal: Proc Natl Acad Sci U S A
Title: Impaired FGF signaling contributes to cleft lip and palate.
Volume: 104
Issue: 11
Pages: 4512-7
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Publication
21331089 | -
First Author: Dixon MJ
Year: 2011
Journal: Nat Rev Genet
Title: Cleft lip and palate: understanding genetic and environmental influences.
Volume: 12
Issue: 3
Pages: 167-78
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Protein Domain
IPR028174 | FGF_rcpt_1
Type: Domain
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].The FGFRs consist of an extracellular ligand-binding domain composed of three immunoglobulin-like domains (D1-D3), a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity []. The three immunoglobin(Ig)-like domains, D1, D2, and D3, present a stretch of acidic amino acids (known as the acid box) between D1 and D2. This acid box can participate in the regulation of FGF binding to the FGFR. Immunoglobulin-like domains D2 and D3 are sufficient for FGF binding. FGFR family members differ from one another in their ligandaffinities and tissue distribution [, ]. Most FGFs can bind to several different FGFR subtypes. Indeed, FGF1 is sometimes referred to as the universal ligand, as it is capable of activating all of the different FGFRs []. However, there are some exceptions. For example, FGF7 only interacts with FGFR2 []and FGF18 was recently shown to only activate FGFR3 []. Fibroblast growth factor receptor 1 (FGFR1) binds both acidic and basic fibroblast growth factors and is involved in limb induction []. FGFR1 has been shown to be associated with Pfeiffer syndrome [], and cleft lip and/or palate [, ]. Fibroblast growth factor receptor 1 has been shown to interact with growth factor receptor-bound protein 14 (GRB14) [], Src homology 2 domain containing adaptor protein B (SHB) [], fibroblast growth factor receptor substrate 2 (FRS2)[]and fibroblast growth factor 1 (FGF1) [, ].This entry represents the catalytic domain of FGFR1.
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Protein Domain
IPR016248 | FGF_rcpt_fam
Type: Family
Description: Fibroblast growth factors (FGFs) [, ]are a family of multifunctional proteins, often referred to as 'promiscuous growth factors' due to their diverse actions on multiple cell types [, ]. FGFs are mitogens, which stimulate growth or differentiation of cells of mesodermal or neuroectodermal origin. The function of FGFs in developmental processes include mesoderm induction, anterior-posterior patterning, limb development, and neural induction and development. In mature tissues, they are involved in diverse processes including keratinocyte organisation and wound healing [, , , , , ]. FGF involvement is critical during normal development of both vertebrates and invertebrates, and irregularities in their function leads to a range of developmental defects [, , , ]. Fibroblast growth factors are heparin-binding proteins and interactions with cell-surface-associated heparan sulfate proteoglycans have been shown to be essential for FGF signal transduction. FGFs have internal pseudo-threefold symmetry (β-trefoil topology) []. There are currently over 20 different FGF family members that have been identified in mammals, all of which are structurally related signaling molecules [, ]. They exert their effects through four distinct membrane fibroblast growth factor receptors (FGFRs), FGFR1 to FGFR4 [], which belong to the tyrosine kinase superfamily. Upon binding to FGF, the receptors dimerize and their intracellular tyrosine kinase domains become active [].The FGFRs consist of an extracellular ligand-binding domain composed of three immunoglobulin-like domains (D1-D3), a single transmembrane helix domain, and an intracellular domain with tyrosine kinase activity []. The three immunoglobin(Ig)-like domains, D1, D2, and D3, present a stretch of acidic amino acids (known as the acid box) between D1 and D2. This acid box can participate in the regulation of FGF binding to the FGFR. Immunoglobulin-like domains D2 and D3 are sufficient for FGF binding. FGFR family members differ from one another in their ligand affinities and tissue distribution [, ]. Most FGFs can bind to several different FGFR subtypes. Indeed, FGF1 is sometimes referred to as the universal ligand, as it is capable of activating all of the different FGFRs []. However, there are some exceptions. For example, FGF7 only interacts with FGFR2 []and FGF18 was recently shown to only activate FGFR3 []. This entry represents the fibroblast growth factor receptor family.
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Publication
16829530 | -
First Author: Duchesne L
Year: 2006
Journal: J Biol Chem
Title: N-glycosylation of fibroblast growth factor receptor 1 regulates ligand and heparan sulfate co-receptor binding.
Volume: 281
Issue: 37
Pages: 27178-89
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Publication
9212826 | -
First Author: Hughes SE
Year: 1997
Journal: J Histochem Cytochem
Title: Differential expression of the fibroblast growth factor receptor (FGFR) multigene family in normal human adult tissues.
Volume: 45
Issue: 7
Pages: 1005-19
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Publication
18216218 | -
First Author: Cotton LM
Year: 2008
Journal: Endocr Rev
Title: Cellular signaling by fibroblast growth factors (FGFs) and their receptors (FGFRs) in male reproduction.
Volume: 29
Issue: 2
Pages: 193-216
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Publication
8576175 | J:30894
First Author: Santos-Ocampo S
Year: 1996
Journal: J Biol Chem
Title: Expression and biological activity of mouse fibroblast growth factor-9.
Volume: 271
Issue: 3
Pages: 1726-31
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Protein
Q3TJ05
Organism: Mus musculus/domesticus
Length: 386  
Fragment?: false
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Publication
8663044 | -
First Author: Ornitz DM
Year: 1996
Journal: J Biol Chem
Title: Receptor specificity of the fibroblast growth factor family.
Volume: 271
Issue: 25
Pages: 15292-7
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Protein
P16092
Organism: Mus musculus/domesticus
Length: 822  
Fragment?: false
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Protein
J3QN85
Organism: Mus musculus/domesticus
Length: 833  
Fragment?: false
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