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Search results 601 to 700 out of 1119 for Htt

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Hits by Strain

Type Details Score
GXD Expression
GXD Expression
   
Probe: MGI:6294947
Assay Type: RNA in situ
Annotation Date: 2019-04-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1684620
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6295160
Age: embryonic day 12.5
Specimen Label: 6d
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
 
Probe: MGI:6294947
Assay Type: RNA in situ
Annotation Date: 2019-04-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1797528
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6295160
Age: postnatal week 6
Note: Elevated expression restricted to distinct stages of spermatogenic differentiation.
Specimen Label: 10d/e
Detected: true
Specimen Num: 3
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GXD Expression
GXD Expression
   
Probe: MGI:6294945
Assay Type: RNA in situ
Annotation Date: 2019-04-30
Strength: Present
Sex: Not Specified
Emaps: EMAPS:1679722
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6295158
Age: embryonic day 14.5
Specimen Label: 7a/b
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6294945
Assay Type: RNA in situ
Annotation Date: 2019-04-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1707122
Pattern: Not Specified
Stage: TS22
Assay Id: MGI:6295158
Age: embryonic day 14.5
Note: High and specific expression in all neuronal tissues, predominantly is central nervous system (telencephalon, mesencephalon, metencephalon).
Specimen Label: 7a/b
Detected: true
Specimen Num: 2
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GXD Expression
GXD Expression
 
Probe: MGI:6294945
Assay Type: RNA in situ
Annotation Date: 2019-04-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1757720
Pattern: Not Specified
Stage: TS20
Assay Id: MGI:6295158
Age: embryonic day 12.5
Note: Strong, highly specific expression within all neuronal tissue - telencephalon, diencephalon including neurohypophysis, down to spinal cord and spinal ganglia.
Specimen Label: 6a/b
Detected: true
Specimen Num: 1
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GXD Expression
GXD Expression
   
Probe: MGI:6294947
Assay Type: RNA in situ
Annotation Date: 2019-04-30
Strength: Ambiguous
Sex: Not Specified
Emaps: EMAPS:3576128
Pattern: Regionally restricted
Stage: TS28
Assay Id: MGI:6295160
Age: postnatal week 6
Note: Authors report pronounced expression is not observed in outer spermatogenic epithelial cells.
Specimen Label: 10f
Specimen Num: 4
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GXD Expression
GXD Expression
 
Probe: MGI:6294945
Assay Type: RNA in situ
Annotation Date: 2019-04-30
Strength: Strong
Sex: Not Specified
Emaps: EMAPS:1689427
Pattern: Not Specified
Stage: TS27
Assay Id: MGI:6295158
Age: postnatal day 2
Note: Expression becomes more pronounced and more specific for brain.
Specimen Label: 8a/b
Detected: true
Specimen Num: 3
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Publication
11035034 | J:277863
First Author: Peters MF
Year: 2001
Journal: J Biol Chem
Title: Isolation of a 40-kDa Huntingtin-associated protein.
Volume: 276
Issue: 5
Pages: 3188-94
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Publication
28469074 | J:244563
 
First Author: Ma Q
Year: 2017
Journal: JCI Insight
Title: SorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's disease.
Volume: 2
Issue: 9
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Publication
9398841 | J:44391
First Author: White JK
Year: 1997
Journal: Nat Genet
Title: Huntingtin is required for neurogenesis and is not impaired by the Huntington's disease CAG expansion.
Volume: 17
Issue: 4
Pages: 404-10
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Publication
12217951 | J:79126
First Author: Fossale E
Year: 2002
Journal: Hum Mol Genet
Title: Identification of a presymptomatic molecular phenotype in Hdh CAG knock-in mice.
Volume: 11
Issue: 19
Pages: 2233-41
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Publication
21632937 | J:173377
First Author: Saavedra A
Year: 2011
Journal: J Neurosci
Title: Striatal-enriched protein tyrosine phosphatase expression and activity in Huntington's disease: a STEP in the resistance to excitotoxicity.
Volume: 31
Issue: 22
Pages: 8150-62
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Publication
21403395 | J:172008
First Author: Lin YS
Year: 2011
Journal: J Clin Invest
Title: Dysregulated brain creatine kinase is associated with hearing impairment in mouse models of Huntington disease.
Volume: 121
Issue: 4
Pages: 1519-23
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Publication
30587542 | J:271675
First Author: Lin MS
Year: 2019
Journal: J Neurosci
Title: Degeneration of ipRGCs in Mouse Models of Huntington's Disease Disrupts Non-Image-Forming Behaviors Before Motor Impairment.
Volume: 39
Issue: 8
Pages: 1505-1524
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Publication
11145989 | J:67773
First Author: Morton AJ
Year: 2001
Journal: J Neurochem
Title: Progressive depletion of complexin II in a transgenic mouse model of Huntington's disease.
Volume: 76
Issue: 1
Pages: 166-72
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Publication
29534157 | J:263425
First Author: Galvan L
Year: 2018
Journal: Brain
Title: The striatal kinase DCLK3 produces neuroprotection against mutant huntingtin.
Volume: 141
Issue: 5
Pages: 1434-1454
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Publication
35366418 | J:325617
First Author: Ma X
Year: 2022
Journal: Cell
Title: CCT2 is an aggrephagy receptor for clearance of solid protein aggregates.
Volume: 185
Issue: 8
Pages: 1325-1345.e22
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Publication
34648564 | J:311740
First Author: Heikkinen T
Year: 2021
Journal: PLoS One
Title: Global Rhes knockout in the Q175 Huntington's disease mouse model.
Volume: 16
Issue: 10
Pages: e0258486
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Publication
8528205 | J:26500
First Author: Schmitt I
Year: 1995
Journal: Hum Mol Genet
Title: Expression of the Huntington disease gene in rodents: cloning the rat homologue and evidence for downregulation in non-neuronal tissues during development.
Volume: 4
Issue: 7
Pages: 1173-82
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Publication
8264627 | J:16058
First Author: Kozak UC
Year: 1994
Journal: Mol Cell Biol
Title: An upstream enhancer regulating brown-fat-specific expression of the mitochondrial uncoupling protein gene.
Volume: 14
Issue: 1
Pages: 59-67
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Publication
25411494 | J:217389
First Author: Tallaksen-Greene SJ
Year: 2014
Journal: J Neurosci
Title: Differential effects of delayed aging on phenotype and striatal pathology in a murine model of Huntington disease.
Volume: 34
Issue: 47
Pages: 15658-68
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Publication
25180603 | J:217639
First Author: Brito V
Year: 2014
Journal: J Clin Invest
Title: Neurotrophin receptor p75(NTR) mediates Huntington's disease-associated synaptic and memory dysfunction.
Volume: 124
Issue: 10
Pages: 4411-28
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Publication
20053912 | J:164039
First Author: Ribeiro FM
Year: 2010
Journal: J Neurosci
Title: Metabotropic glutamate receptor-mediated cell signaling pathways are altered in a mouse model of Huntington's disease.
Volume: 30
Issue: 1
Pages: 316-24
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Publication
24282028 | J:207093
First Author: Ribeiro FM
Year: 2014
Journal: Hum Mol Genet
Title: Metabotropic glutamate receptor 5 knockout promotes motor and biochemical alterations in a mouse model of Huntington's disease.
Volume: 23
Issue: 8
Pages: 2030-42
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Publication
17124493 | J:200423
First Author: Zhang Y
Year: 2006
Journal: EMBO J
Title: Huntingtin inhibits caspase-3 activation.
Volume: 25
Issue: 24
Pages: 5896-906
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Publication
15496430 | J:94581
First Author: Dragatsis I
Year: 2004
Journal: Hum Mol Genet
Title: Huntingtin-associated protein 1 (Hap1) mutant mice bypassing the early postnatal lethality are neuroanatomically normal and fertile but display growth retardation.
Volume: 13
Issue: 24
Pages: 3115-25
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Publication
10581038 | J:58797
First Author: Manley K
Year: 1999
Journal: Nat Genet
Title: Msh2 deficiency prevents in vivo somatic instability of the CAG repeat in Huntington disease transgenic mice.
Volume: 23
Issue: 4
Pages: 471-3
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Publication
12554681 | J:81666
First Author: Wheeler VC
Year: 2003
Journal: Hum Mol Genet
Title: Mismatch repair gene Msh2 modifies the timing of early disease in Hdh(Q111) striatum.
Volume: 12
Issue: 3
Pages: 273-81
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Publication
24302884 | J:205270
First Author: Mielcarek M
Year: 2013
Journal: PLoS Biol
Title: HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.
Volume: 11
Issue: 11
Pages: e1001717
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Publication
17065224 | J:146707
First Author: Cyr M
Year: 2006
Journal: FASEB J
Title: Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin.
Volume: 20
Issue: 14
Pages: 2541-3
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Publication
32513388 | J:290430
   
First Author: Moreno-Delgado D
Year: 2020
Journal: Elife
Title: Modulation of dopamine D1 receptors via histamine H3 receptors is a novel therapeutic target for Huntington's disease.
Volume: 9
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Publication
34793694 | J:322642
First Author: Capizzi M
Year: 2022
Journal: Neuron
Title: Developmental defects in Huntington's disease show that axonal growth and microtubule reorganization require NUMA1.
Volume: 110
Issue: 1
Pages: 36-50.e5
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Publication
31790427 | J:287860
First Author: Comella Bolla A
Year: 2019
Journal: PLoS One
Title: CD200 is up-regulated in R6/1 transgenic mouse model of Huntington's disease.
Volume: 14
Issue: 12
Pages: e0224901
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Publication
18829967 | J:143463
First Author: Paoletti P
Year: 2008
Journal: J Neurosci
Title: Dopaminergic and glutamatergic signaling crosstalk in Huntington's disease neurodegeneration: the role of p25/cyclin-dependent kinase 5.
Volume: 28
Issue: 40
Pages: 10090-101
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Publication
36029989 | J:328548
 
First Author: Rodríguez-Urgellés E
Year: 2022
Journal: Neurobiol Dis
Title: Postnatal Foxp2 regulates early psychiatric-like phenotypes and associated molecular alterations in the R6/1 transgenic mouse model of Huntington's disease.
Volume: 173
Pages: 105854
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Publication
29355642 | J:315885
 
First Author: Weber JJ
Year: 2018
Journal: Neuropharmacology
Title: Calpastatin ablation aggravates the molecular phenotype in cell and animal models of Huntington disease.
Volume: 133
Pages: 94-106
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Publication
22341442 | J:181549
First Author: Liu CR
Year: 2012
Journal: Cell
Title: Spt4 is selectively required for transcription of extended trinucleotide repeats.
Volume: 148
Issue: 4
Pages: 690-701
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Publication
28970536 | J:255756
First Author: Neueder A
Year: 2017
Journal: Sci Rep
Title: HSF1-dependent and -independent regulation of the mammalian in vivo heat shock response and its impairment in Huntington's disease mouse models.
Volume: 7
Issue: 1
Pages: 12556
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Publication
17018277 | J:116058
First Author: Cui L
Year: 2006
Journal: Cell
Title: Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration.
Volume: 127
Issue: 1
Pages: 59-69
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Publication
12881722 | J:243542
First Author: Zuccato C
Year: 2003
Journal: Nat Genet
Title: Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes.
Volume: 35
Issue: 1
Pages: 76-83
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Publication
18625318 | J:147008
First Author: Lorincz MT
Year: 2009
Journal: Mol Cell Neurosci
Title: Expanded CAG repeats in the murine Huntington's disease gene increases neuronal differentiation of embryonic and neural stem cells.
Volume: 40
Issue: 1
Pages: 1-13
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Publication
18625748 | J:138558
First Author: Björkqvist M
Year: 2008
Journal: J Exp Med
Title: A novel pathogenic pathway of immune activation detectable before clinical onset in Huntington's disease.
Volume: 205
Issue: 8
Pages: 1869-77
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Publication
20945165 | J:175960
First Author: Switonski PM
Year: 2011
Journal: Neuromolecular Med
Title: Mouse ataxin-3 functional knock-out model.
Volume: 13
Issue: 1
Pages: 54-65
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Publication
21785217 | J:176008
First Author: Labbadia J
Year: 2011
Journal: J Clin Invest
Title: Altered chromatin architecture underlies progressive impairment of the heat shock response in mouse models of Huntington disease.
Volume: 121
Issue: 8
Pages: 3306-19
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Publication
26247199 | J:228819
First Author: Budworth H
Year: 2015
Journal: PLoS Genet
Title: Suppression of Somatic Expansion Delays the Onset of Pathophysiology in a Mouse Model of Huntington's Disease.
Volume: 11
Issue: 8
Pages: e1005267
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Publication
23861892 | J:204285
First Author: Proenca CC
Year: 2013
Journal: PLoS One
Title: Atg4b-dependent autophagic flux alleviates Huntington's disease progression.
Volume: 8
Issue: 7
Pages: e68357
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Publication
33601422 | J:339888
First Author: Cozzolino F
Year: 2021
Journal: Hum Mol Genet
Title: ADAM10 hyperactivation acts on piccolo to deplete synaptic vesicle stores in Huntington's disease.
Volume: 30
Issue: 13
Pages: 1175-1187
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Publication
24955833 | J:216828
First Author: Menalled LB
Year: 2014
Journal: PLoS One
Title: Genetic deletion of transglutaminase 2 does not rescue the phenotypic deficits observed in R6/2 and zQ175 mouse models of Huntington's disease.
Volume: 9
Issue: 6
Pages: e99520
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Publication
26195796 | J:226055
First Author: Ahmed I
Year: 2015
Journal: Proc Natl Acad Sci U S A
Title: Huntington's disease: Neural dysfunction linked to inositol polyphosphate multikinase.
Volume: 112
Issue: 31
Pages: 9751-6
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Publication
29688337 | J:263782
First Author: Di Pardo A
Year: 2018
Journal: Hum Mol Genet
Title: Stimulation of S1PR5 with A-971432, a selective agonist, preserves blood-brain barrier integrity and exerts therapeutic effect in an animal model of Huntington's disease.
Volume: 27
Issue: 14
Pages: 2490-2501
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Publication
21969577 | J:177450
First Author: Hu Y
Year: 2011
Journal: Proc Natl Acad Sci U S A
Title: Transcriptional modulator H2A histone family, member Y (H2AFY) marks Huntington disease activity in man and mouse.
Volume: 108
Issue: 41
Pages: 17141-6
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Publication
36044851 | J:328314
First Author: Benraiss A
Year: 2022
Journal: Cell Rep
Title: A TCF7L2-responsive suppression of both homeostatic and compensatory remyelination in Huntington disease mice.
Volume: 40
Issue: 9
Pages: 111291
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Publication
25205109 | J:217212
First Author: Gratuze M
Year: 2015
Journal: Hum Mol Genet
Title: Tau hyperphosphorylation and deregulation of calcineurin in mouse models of Huntington's disease.
Volume: 24
Issue: 1
Pages: 86-99
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Publication
34880223 | J:318006
First Author: Sönmez A
Year: 2021
Journal: Cell Death Dis
Title: Nucleolar stress controls mutant Huntington toxicity and monitors Huntington's disease progression.
Volume: 12
Issue: 12
Pages: 1139
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Publication
25143394 | J:216514
First Author: Blum D
Year: 2015
Journal: Hum Mol Genet
Title: Mutant huntingtin alters Tau phosphorylation and subcellular distribution.
Volume: 24
Issue: 1
Pages: 76-85
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Publication
31068790 | J:284337
 
First Author: Di Pardo A
Year: 2019
Journal: Front Mol Neurosci
Title: Stimulation of Sphingosine Kinase 1 (SPHK1) Is Beneficial in a Huntington's Disease Pre-clinical Model.
Volume: 12
Pages: 100
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Publication
20497470 | J:163791
First Author: Leon R
Year: 2010
Journal: Eur J Neurosci
Title: BimEL as a possible molecular link between proteasome dysfunction and cell death induced by mutant huntingtin.
Volume: 31
Issue: 11
Pages: 1915-25
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Publication
11160912 | J:111323
First Author: Dragatsis I
Year: 2001
Journal: Nucleic Acids Res
Title: A method for the generation of conditional gene repair mutations in mice.
Volume: 29
Issue: 3
Pages: E10
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Publication
37827155 | J:342178
First Author: Gall-Duncan T
Year: 2023
Journal: Cell
Title: Antagonistic roles of canonical and Alternative-RPA in disease-associated tandem CAG repeat instability.
Volume: 186
Issue: 22
Pages: 4898-4919.e25
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Publication
18595722 | J:138707
First Author: Desplats PA
Year: 2008
Journal: Neurobiol Dis
Title: Functional roles for the striatal-enriched transcription factor, Bcl11b, in the control of striatal gene expression and transcriptional dysregulation in Huntington's disease.
Volume: 31
Issue: 3
Pages: 298-308
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Publication
27493027 | J:238564
First Author: Yefimova MG
Year: 2016
Journal: Hum Mol Genet
Title: Myelinosomes act as natural secretory organelles in Sertoli cells to prevent accumulation of aggregate-prone mutant Huntingtin and CFTR.
Volume: 25
Issue: 19
Pages: 4170-4185
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Publication
28555636 | J:250330
 
First Author: Giralt A
Year: 2017
Journal: Nat Commun
Title: Pyk2 modulates hippocampal excitatory synapses and contributes to cognitive deficits in a Huntington's disease model.
Volume: 8
Pages: 15592
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Publication
11442350 | J:70214
First Author: Schilling G
Year: 2001
Journal: Neurobiol Dis
Title: Distinct behavioral and neuropathological abnormalities in transgenic mouse models of HD and DRPLA.
Volume: 8
Issue: 3
Pages: 405-18
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Publication
22542623 | J:184436
First Author: Li X
Year: 2012
Journal: Biochem Biophys Res Commun
Title: Deficient Rab11 activity underlies glucose hypometabolism in primary neurons of Huntington's disease mice.
Volume: 421
Issue: 4
Pages: 727-30
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Publication
28847953 | J:253642
First Author: Zhao T
Year: 2017
Journal: Proc Natl Acad Sci U S A
Title: Differential HspBP1 expression accounts for the greater vulnerability of neurons than astrocytes to misfolded proteins.
Volume: 114
Issue: 37
Pages: E7803-E7811
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Publication
36272099 | J:353085
First Author: Zarate N
Year: 2023
Journal: J Neurochem
Title: Neurochemical correlates of synapse density in a Huntington's disease mouse model.
Volume: 164
Issue: 2
Pages: 226-241
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Publication
30449600 | J:271438
First Author: Zhao Y
Year: 2018
Journal: Biochem Biophys Res Commun
Title: Inhibition of Drp1 hyperactivation reduces neuropathology and behavioral deficits in zQ175 knock-in mouse model of Huntington's disease.
Volume: 507
Issue: 1-4
Pages: 319-323
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Publication
38387080 | J:360873
First Author: Aldous SG
Year: 2024
Journal: Brain
Title: A CAG repeat threshold for therapeutics targeting somatic instability in Huntington's disease.
Volume: 147
Issue: 5
Pages: 1784-1798
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Publication
31920562 | J:310531
 
First Author: Mustafa R
Year: 2019
Journal: Front Cell Neurosci
Title: Targeted Depletion of Primary Cilia in Dopaminoceptive Neurons in a Preclinical Mouse Model of Huntington's Disease.
Volume: 13
Pages: 565
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Publication
30961637 | J:290312
First Author: Abd-Elrahman KS
Year: 2019
Journal: Mol Brain
Title: Modulation of mTOR and CREB pathways following mGluR5 blockade contribute to improved Huntington's pathology in zQ175 mice.
Volume: 12
Issue: 1
Pages: 35
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Publication
33170804 | J:305057
 
First Author: Pluciennik A
Year: 2021
Journal: J Clin Invest
Title: Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy.
Volume: 131
Issue: 1
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Publication
21336284 | J:171134
First Author: Song W
Year: 2011
Journal: Nat Med
Title: Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity.
Volume: 17
Issue: 3
Pages: 377-82
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Publication
19240112 | J:145963
First Author: Luo S
Year: 2009
Journal: J Cell Sci
Title: Huntingtin promotes cell survival by preventing Pak2 cleavage.
Volume: 122
Issue: Pt 6
Pages: 875-85
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Publication
10595501 | J:58566
First Author: Lin X
Year: 1999
Journal: Neuron
Title: Expanding our understanding of polyglutamine diseases through mouse models.
Volume: 24
Issue: 3
Pages: 499-502
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Publication
20185558 | J:159699
First Author: Yamanaka T
Year: 2010
Journal: Hum Mol Genet
Title: Mutant huntingtin fragment selectively suppresses Brn-2 POU domain transcription factor to mediate hypothalamic cell dysfunction.
Volume: 19
Issue: 11
Pages: 2099-112
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Publication
24594939 | J:214700
First Author: Leitman J
Year: 2014
Journal: PLoS One
Title: ER stress-induced eIF2-alpha phosphorylation underlies sensitivity of striatal neurons to pathogenic huntingtin.
Volume: 9
Issue: 3
Pages: e90803
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Publication
25540325 | J:225767
First Author: Lu XH
Year: 2014
Journal: Sci Transl Med
Title: Targeting ATM ameliorates mutant Huntingtin toxicity in cell and animal models of Huntington's disease.
Volume: 6
Issue: 268
Pages: 268ra178
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Publication
26947127 | J:235804
 
First Author: Wehner AB
Year: 2016
Journal: Neuroscience
Title: The p75 neurotrophin receptor augments survival signaling in the striatum of pre-symptomatic Q175(WT/HD) mice.
Volume: 324
Pages: 297-306
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Allele
Htt<tm8(HTT*)Szi> | MGI:7442513
Name: huntingtin; targeted mutation 8, Scott Zeitlin
Allele Type: Targeted
Attribute String: Humanized sequence, Inserted expressed sequence
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Publication
10341082 | J:55078
First Author: Ying HC
Year: 1999
Journal: Mamm Genome
Title: High-resolution mapping of tlt, a mouse mutant lacking otoconia.
Volume: 10
Issue: 6
Pages: 544-8
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Publication
16278683 | J:104350
First Author: Feng Z
Year: 2006
Journal: Oncogene
Title: p53 tumor suppressor protein regulates the levels of huntingtin gene expression.
Volume: 25
Issue: 1
Pages: 1-7
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Publication
19745829 | J:169436
First Author: Saavedra A
Year: 2010
Journal: Cell Death Differ
Title: PH domain leucine-rich repeat protein phosphatase 1 contributes to maintain the activation of the PI3K/Akt pro-survival pathway in Huntington's disease striatum.
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Title: Genetic interaction between expanded murine Hdh alleles and p53 reveal deleterious effects of p53 on Huntington's disease pathogenesis.
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